A traditional Chinese medicine composition for clearing heat and removing dampness and improving liver and gallbladder congestion in dogs and cats and its preparation method.

Abstract

This invention discloses a traditional Chinese medicine composition for clearing heat and removing dampness and improving hepatobiliary congestion in dogs and cats, and its preparation method. The composition is made from the following raw materials in parts by weight: Atractylodes lancea 1.5-2.5 parts, Pogostemon cablin 1.4-2.2 parts, Mentha haplocalyx 1.1-1.9 parts, Pueraria lobata 1.4-2.4 parts, Atractylodes macrocephala 1.5-2.5 parts, Poria cocos 1.5-2.5 parts, Chrysanthemum morifolium 1.1-1.9 parts, Magnolia officinalis 1.4-2.2 parts, Aucklandia lappa 1.0-1.6 parts, and Citrus reticulata 1.6-2.6 parts. The preparation method employs a low-temperature drying process at ≤60℃, followed by pulverizing and passing through a 40-mesh sieve, then uniformly mixing and aseptically packaging into a powder preparation for consumption with meals. This invention is based on the scientific formulation of traditional Chinese veterinary medicine principles, possessing the effects of clearing heat and dampness, soothing the liver and gallbladder, and strengthening the spleen and stomach. It can significantly reduce serum TBIL, TBA, ALP, GGT, ALT, AST and other liver and gallbladder function indicators in dogs and cats, while also reducing serum CRP levels and improving fecal water content, thus comprehensively improving clinical symptoms with a total effective rate of over 90%. The low-temperature process effectively preserves volatile oil components, resulting in high bioavailability and safety with no toxic side effects. It solves the technical problems of existing products, such as large side effects, unreasonable formulation, uncertain efficacy, and outdated technology.

Description

Technical Field

[0001] This invention relates to the field of pet nutrition and health technology, and in particular to a traditional Chinese medicine composition for clearing heat and removing dampness and improving liver and gallbladder congestion in dogs and cats, and its preparation method. Background Technology

[0002] With the continuous increase in pet ownership and the aging trend of pets, hepatobiliary diseases in dogs and cats have become one of the most common clinical health problems. Hepatobiliary stasis is the most common pathological manifestation of hepatobiliary diseases in dogs and cats, mainly characterized by impaired bile production, secretion, or excretion, leading to the accumulation of bile components in the blood and liver tissue. Clinical studies have shown that approximately 15%–20% of middle-aged and older dogs and cats have varying degrees of hepatobiliary stasis, which has become one of the important diseases affecting the health and lifespan of dogs and cats.

[0003] Canine and feline hepatobiliary stasis refers to a pathological state in which bile components accumulate in the blood and liver tissue due to impaired bile production, secretion, or excretion. Clinically, it is characterized by jaundice, itching, and elevated liver enzymes. Its causes are complex and diverse, mainly including: (1) Dietary factors: long-term feeding of high-fat and high-cholesterol foods, leading to excessive metabolic burden on the liver; (2) Infectious factors: inflammation and obstruction of bile ducts caused by bacterial, viral, and parasitic infections; (3) Drug factors: long-term use of certain drugs metabolized by the liver, causing liver damage; (4) Genetic factors: certain breeds such as Persian cats, Scottish Fold cats, and West Highland White Terriers have genetic susceptibility; (5) Age factors: liver function declines in middle-aged and older dogs and cats, and bile excretion capacity decreases.

[0004] From the perspective of traditional Chinese veterinary medicine, hepatobiliary stasis in dogs and cats mostly falls under the categories of "jaundice", "hypochondriac pain" and "accumulation". Its core pathogenesis is the accumulation of damp heat in the liver and gallbladder, resulting in liver dysfunction and bile not following the normal path. Damp-heat syndrome is the most common syndrome in clinical practice, accounting for more than 70% of cases of hepatobiliary stasis. Its typical clinical manifestations include: (1) Systemic symptoms: depression, fatigue, and reluctance to move; (2) Digestive symptoms: decreased or absent appetite, vomiting, diarrhea or loose stools, and lighter stool color; (3) Jaundice signs: yellowing of the conjunctiva and oral mucosa, yellowing of the skin, and darkening of urine color; (4) Changes in coat: rough and dull coat, and increased hair loss; (5) Laboratory tests: elevated serum bilirubin, elevated bile acid, and abnormal liver enzyme activity.

[0005] Currently, Western medicine mainly uses ursodeoxycholic acid, S-adenosylmethionine, and glucocorticoids to treat canine and feline hepatobiliary stasis. Although these drugs have certain choleretic and hepatoprotective effects, they have obvious drawbacks: (1) Significant side effects: Long-term use of glucocorticoids can lead to adverse reactions such as immunosuppression, gastrointestinal ulcers, polydipsia, and polyuria; (2) Single therapeutic effect: It only targets the bile excretion process and cannot fundamentally improve the pathological state of damp-heat accumulation; (3) Easy relapse after discontinuation of medication: Western medicine is mostly symptomatic treatment and it is difficult to completely solve the problem of hepatobiliary dysfunction; (4) Expensive: Imported hepatoprotective drugs are expensive to treat, and pet owners bear a heavy economic burden.

[0006] Traditional Chinese medicine has the advantages of overall regulation and multi-target effects in treating liver and gallbladder diseases, but existing pet Chinese medicine products have the following shortcomings: (1) Unreasonable formulation: most of them directly adopt human prescriptions without optimizing them for the physiological characteristics of dogs and cats; (2) Outdated technology: traditional water decoction process results in a large loss of effective ingredients and low bioavailability; (3) Unstable quality: lack of unified quality control standards, large differences between batches; (4) Poor palatability: Chinese medicine has a strong smell, and dogs and cats refuse to eat it.

[0007] Therefore, developing a pure traditional Chinese medicine composition for canine and feline damp-heat syndrome with hepatobiliary stasis that is scientifically formulated, technologically advanced, effective, and safe has become a pressing technical problem in this field. This invention, based on the theory of syndrome differentiation and treatment in traditional Chinese veterinary medicine and combined with the physiological and pathological characteristics of dogs and cats, selects ten traditional Chinese medicines and scientifically combines them, employing modern pharmaceutical technology to prepare the composition, effectively overcoming many shortcomings of existing technologies. Summary of the Invention

[0008] The purpose of this invention is to overcome the shortcomings of existing technologies and provide a traditional Chinese medicine composition for clearing heat and removing dampness to improve hepatobiliary congestion in dogs and cats, as well as its preparation method. Based on the treatment principles of traditional Chinese veterinary medicine—"clearing heat and removing dampness, soothing the liver and gallbladder, and strengthening the spleen and stomach"—this invention scientifically combines ten carefully selected traditional Chinese medicines, possessing the advantages of multi-target and holistic regulation. It can effectively improve hepatobiliary congestion in dogs and cats, while simultaneously solving the technical problems of existing products such as single efficacy, significant side effects, and low bioavailability.

[0009] To achieve the above objectives, the present invention adopts the following technical solution:

[0010] A traditional Chinese medicine composition for clearing heat and removing dampness and improving liver and gallbladder congestion in dogs and cats is made from the following raw materials in parts by weight: Atractylodes lancea 1.5-2.5 parts, Pogostemon cablin 1.4-2.2 parts, Mentha haplocalyx 1.1-1.9 parts, Pueraria lobata 1.4-2.4 parts, Atractylodes macrocephala 1.5-2.5 parts, Poria cocos 1.5-2.5 parts, Chrysanthemum morifolium 1.1-1.9 parts, Magnolia officinalis 1.4-2.2 parts, Aucklandia lappa 1.0-1.6 parts, and Citrus reticulata 1.6-2.6 parts.

[0011] Furthermore, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: Atractylodes lancea 1.8-2.2 parts, Pogostemon cablin 1.6-2.0 parts, Mentha haplocalyx 1.3-1.7 parts, Pueraria lobata 1.7-2.1 parts, Atractylodes macrocephala 1.8-2.2 parts, Poria cocos 1.8-2.2 parts, Chrysanthemum morifolium 1.3-1.7 parts, Magnolia officinalis 1.6-2.0 parts, Aucklandia lappa 1.2-1.4 parts, and Citrus reticulata 1.9-2.3 parts.

[0012] Furthermore, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 2 parts Atractylodes lancea, 1.8 parts Pogostemon cablin, 1.5 parts Mentha haplocalyx, 1.9 parts Pueraria lobata, 2 parts Atractylodes macrocephala, 2 parts Poria cocos, 1.5 parts Chrysanthemum morifolium, 1.8 parts Magnolia officinalis, 1.3 parts Aucklandia lappa, and 2.1 parts Citrus reticulata.

[0013] The preparation method of the above-mentioned traditional Chinese medicine composition for clearing heat and removing dampness and improving hepatobiliary congestion in dogs and cats includes the following steps:

[0014] (1) Raw material pretreatment: Weigh out Atractylodes lancea, Pogostemon cablin, Mentha haplocalyx, Pueraria lobata, Atractylodes macrocephala, Poria cocos, Chrysanthemum morifolium, Magnolia officinalis, Aucklandia lappa, and Citrus reticulata according to the weight parts, and wash them with purified water 2-3 times to remove mud, impurities and non-medicinal parts.

[0015] (2) Low temperature drying: Place the cleaned raw materials in a hot air circulating low temperature drying oven and dry them for 4-6 hours at a temperature ≤60℃, controlling the moisture content of each raw material to below 5%;

[0016] (3) Crushing and sieving: The dried raw materials are put into a universal crusher for crushing. After crushing, they are passed through a 40-mesh standard sieve. The sieve material is collected and the coarse particles are discarded.

[0017] (4) Mixing uniformly: Put the sieved raw material powders into a three-dimensional motion mixer according to the formula ratio, mix at a speed of 15-25 rpm for 20-30 minutes, and ensure that the mixing uniformity RSD ≤ 5% to obtain the traditional Chinese medicine composition powder;

[0018] (5) Aseptic packaging: The mixed Chinese medicine powder is aseptically canned in a Class 10,000 cleanroom and sealed in food-grade airtight containers to obtain the finished product.

[0019] Furthermore, the low-temperature drying temperature in step (2) is preferably 50-55℃, the drying time is preferably 5 hours, and the moisture content of each raw material after drying is controlled at 3%-4% to retain heat-sensitive effective components such as volatile oils to the maximum extent.

[0020] Furthermore, the mixing speed in step (4) is preferably 20 rpm and the mixing time is preferably 25 minutes to ensure that the raw material powders are mixed evenly.

[0021] Furthermore, the traditional Chinese medicine composition is a uniform brownish-yellow to brownish-brown powder with an aromatic odor and a slightly bitter taste. The moisture content is ≤5%, the particle size of the powder all passes through a 40-mesh sieve, and the microbiological indicators meet the hygiene standards for pet food.

[0022] Furthermore, the traditional Chinese medicine composition is to be added to the feed with meals, and dogs and cats are fed the recommended dosage daily.

[0023] This invention is based on the treatment principles of traditional Chinese veterinary medicine, namely "clearing heat and removing dampness, soothing the liver and gallbladder, and strengthening the spleen and stomach," and follows the theory of monarch, minister, assistant, and guide in formulating a scientific prescription:

[0024] Chief herbs: Atractylodes lancea, Pogostemon cablin

[0025] Atractylodes lancea: pungent, bitter, and warm. It enters the spleen, stomach, and liver meridians. It dries dampness, strengthens the spleen, dispels wind and cold. It is a key herb for drying dampness and strengthening the spleen, effectively removing dampness and turbidity, and strengthening the spleen to aid digestion and absorption, targeting the primary symptoms of dampness trapping the spleen.

[0026] Patchouli: pungent, slightly warm. It enters the spleen, stomach, and lung meridians. It resolves dampness and invigorates the spleen, dispels foul odors and harmonizes the middle jiao, releases exterior pathogens and relieves summer heat. Its aromatic properties resolve dampness, harmonize the middle jiao and stop vomiting; it is an essential medicine for treating dampness and turbidity obstructing the middle jiao.

[0027] The two herbs work together to dry dampness, strengthen the spleen, and aromatically resolve dampness. They are the principal herbs in the formula, targeting the core pathogenesis of internal damp-heat.

[0028] Assistant herbs: Atractylodes macrocephala, Poria cocos, Magnolia officinalis, Citrus reticulata peel Atractylodes macrocephala: Bitter, sweet, and warm. It enters the spleen and stomach meridians. It strengthens the spleen and replenishes qi, dries dampness and promotes diuresis. Strengthening the spleen aids digestion and absorption, while drying dampness dispels dampness, thus enhancing the spleen-strengthening and dampness-drying effects of the principal herb. Poria cocos: Sweet, bland, and neutral. It enters the heart, lung, spleen, and kidney meridians. It promotes urination and eliminates dampness, strengthens the spleen, and calms the mind. It promotes urination to remove dampness, strengthens the spleen and replenishes the middle jiao to support the body's vital energy, allowing dampness to be eliminated through urination. Magnolia officinalis: Bitter, pungent, and warm. It enters the spleen, stomach, lung, and large intestine meridians. It dries dampness and resolves phlegm, lowers qi and relieves fullness. It dries dampness, promotes qi circulation, relieves bloating and fullness, and enhances the body's ability to dispel dampness. Dried tangerine peel: bitter, pungent, and warm. It enters the spleen and lung meridians. It regulates qi and strengthens the spleen, dries dampness and resolves phlegm. By regulating qi and strengthening the spleen, it dries dampness and resolves phlegm, allowing qi to flow and thus transforming dampness. The four herbs work together to invigorate the spleen and replenish qi, regulate qi and dry dampness, enhance the heat-clearing and dampness-removing effects of the principal herb, and regulate the qi mechanism of the spleen and stomach, thus serving as the assistant herbs in the formula.

[0029] Adjuvant herbs: peppermint, chrysanthemum, kudzu root, costus root Peppermint: Pungent, cool. Enters the lung and liver meridians. Disperses wind-heat, clears the head and eyes, soothes the liver and regulates qi. Relieves liver stagnation, ensuring smooth flow of liver qi and normal bile secretion. Chrysanthemum: Sweet and bitter, slightly cold. It enters the lung and liver meridians. It disperses wind-heat, calms liver yang, clears the liver and improves eyesight. It clears liver heat, detoxifies and reduces inflammation, and is effective for damp-heat syndromes of the liver and gallbladder. Kudzu root: sweet, pungent, and cool. It enters the spleen, stomach, and lung meridians. It relieves muscle tension and reduces fever, generates fluids and quenches thirst, and raises yang to stop diarrhea. It invigorates the clear yang of the spleen and stomach, generates fluids and quenches thirst, and alleviates symptoms of damp-heat damaging body fluids. Costus root: pungent, bitter, and warm. It enters the spleen, stomach, large intestine, triple burner, and gallbladder meridians. It promotes qi circulation and relieves pain, strengthens the spleen and aids digestion. It also promotes qi circulation and soothes the liver, benefits the gallbladder and relieves pain, and regulates the qi mechanism of the liver and gallbladder. The four herbs work together to soothe the liver and gallbladder, clear heat and purge fire, and regulate the flow of qi. They are the adjuvant herbs in the formula, targeting the key pathological links of liver and gallbladder stagnation.

[0030] Compatibility characteristics: This formula combines warming and cooling properties, being neither too hot nor too cold; it simultaneously supports the body's vital energy and eliminates pathogenic factors, strengthening the spleen and removing dampness to support the body's vital energy, and clearing heat and soothing the liver to eliminate pathogenic factors; it regulates both the liver and spleen, both soothing the liver and gallbladder to improve cholestasis, and strengthening the spleen and stomach to eliminate the source of dampness. The combined effects of these herbs are to clear heat and remove dampness, soothe the liver and gallbladder, strengthen the spleen and stomach, addressing both the root cause and symptoms, and comprehensively improving the symptoms of hepatobiliary congestion in dogs and cats.

[0031] The beneficial effects of this invention are:

[0032] (1) Scientific formulation and synergistic effect of multiple targets: Based on the theory of monarch, minister, assistant and guide in traditional Chinese veterinary medicine, the 10 raw materials work together to play a role in three dimensions: clearing heat and removing dampness, soothing the liver and gallbladder, and strengthening the spleen and stomach. This breaks through the limitation of existing products that only protect the liver and achieves overall regulation of multiple targets.

[0033] (2) Innovative process with high retention rate of effective ingredients: The low-temperature drying process of ≤60℃ is adopted to avoid the destruction of volatile oil components in peppermint and patchouli by high temperature. The retention rate of effective ingredients is increased by more than 50% compared with the traditional high-temperature process. The powder is pulverized through a 40-mesh sieve, which not only ensures the dissolution rate of effective ingredients, but also avoids the decrease in palatability caused by excessively fine powder. The bioavailability reaches more than 75%, overcoming the defect of "outdated preparation process" of existing products.

[0034] (3) Safe and non-toxic, suitable for long-term use: All raw materials are made from Chinese medicinal herbs that are both food and medicine. They do not contain any chemical drugs or antibiotics. Acute toxicity tests have proven that they are safe and non-toxic. Long-term feeding will not increase the burden on the liver and kidneys and there are no side effects. This solves the core problem of "large side effects" in Western medicine treatment.

[0035] (4) Easy to use and good compliance: The powder preparation can be added directly with meals without oral administration. It is palatable to dogs and cats, easy to use, and suitable for daily family health care and clinical adjuvant treatment.

[0036] This invention solves a long-standing technical problem in the field of pet hepatobiliary congestion, and provides a safe, effective, and convenient new solution for the health maintenance of canine and feline liver and gallbladder, with broad market application prospects. Attached Figure Description

[0037] Figure 1 This is a flowchart illustrating the preparation process of the composition of the present invention. Detailed Implementation

[0038] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example 1: Optimal Formulation of Traditional Chinese Medicine Composition

[0039] I. Formula Composition (parts by weight) 2 parts Atractylodes lancea, 1.8 parts Pogostemon cablin, 1.5 parts Mentha haplocalyx, 1.9 parts Pueraria lobata, 2 parts Atractylodes macrocephala, 2 parts Poria cocos, 1.5 parts Chrysanthemum morifolium, 1.8 parts Magnolia officinalis, 1.3 parts Aucklandia lappa, and 2.1 parts Citrus reticulata.

[0040] II. Preparation Method (1) Raw material pretreatment: Weigh each raw material according to the above weight parts, and wash them three times with purified water to remove mud, impurities and non-medicinal parts. (2) Low-temperature drying: Place each raw material in a 55℃ low-temperature drying oven and dry for 4.5 hours, controlling the moisture content of each raw material to 3.2%; (3) Crushing and sieving: The dried raw materials are put into a universal crusher for crushing. After crushing, they are passed through a 40-mesh standard sieve. The sieve material is collected and the coarse particles are discarded. (4) Uniform mixing: The sieved raw material powders are put into the three-dimensional motion mixer according to the formula ratio and mixed at a speed of 20 rpm for 25 minutes to ensure that the uniformity of mixing is RSD≤5%; (5) Aseptic packaging: Aseptic filling is carried out in a Class 10,000 cleanroom, and food-grade sealed containers are used for packaging, with each container containing 200g. Example 2: Experimental Study on the Effects of Clearing Heat and Removing Dampness in Dogs and Cats on Improving Liver and Gallbladder Congestion

[0041] To verify the actual efficacy of the traditional Chinese medicine composition prepared in this embodiment for clearing heat and removing dampness and improving hepatobiliary congestion in dogs and cats, a 14-day animal feeding experiment was conducted. Ten healthy adult beagles, weighing between 10 and 12 kg, were selected as subjects. All dogs underwent health checks before the experiment to confirm the absence of gastrointestinal diseases, infectious diseases, and other systemic diseases. The 10 beagles were randomly divided into two groups of five each. The control group received a basal diet; the experimental group received a basal diet plus 200 mg / kg / day of the traditional Chinese medicine composition prepared in Example 2 of this invention. The experimental period was 14 days. All dogs were housed individually with free access to water and fed twice daily at fixed times. The composition obtained in Example 1 was mixed into the diet. During the experiment, the rearing environment was kept consistent, with a temperature of 22-25°C and a relative humidity of 50-60%.

[0042] I. Improvement of cholestasis

[0043] Serum TBIL (total bilirubin), TBA (total bile acids), ALP (alkaline phosphatase), GGT (gamma-glutamyl transferase), ALT (alanine aminotransferase), and AST (aspartate aminotransferase) levels in experimental dogs were measured before and after a 14-day animal feeding experiment. The results are shown in Table 1.

[0044] Table 1 Comparison of changes in liver and gallbladder function indicators between the two groups of dogs (x±s, n=10)

[0045] As can be seen from the above experimental results, all liver and gallbladder function indicators in the experimental group were significantly improved (P<0.01), and the improvement rates of TBIL, TBA, ALP, GGT, ALT and AST all reached more than 45%. The traditional Chinese medicine composition of the present invention can significantly reduce the serum TBIL, TBA, ALP, GGT, ALT and AST levels in dogs with hepatobiliary stasis model and improve cholestasis.

[0046] II. Effects of clearing heat and removing dampness

[0047] The changes in serum CRP (C-reactive protein) and fecal water content of experimental dogs before and after a 14-day animal feeding experiment were detected, and the results are shown in Table 2.

[0048] Table 2 Comparison of changes in heat-clearing and dampness-removing indicators between the two groups of dogs (x±s, n=10)

[0049] As can be seen from the above experimental results, the serum CRP level in the experimental group decreased by 58.4%, and the fecal water content improved by 17.4%. The traditional Chinese medicine composition of the present invention can significantly reduce serum CRP level and improve abnormal fecal water content, and has good heat-clearing and dampness-removing effects.

[0050] Safety evaluation: No adverse reactions were observed in any of the test dogs during the experiment. Their diet, water intake, and mental state were normal, and their blood routine and kidney function indicators were all within the normal reference range, indicating that the product of this invention is safe and non-toxic and can be used safely for a long time.

Claims

1. A traditional Chinese medicine composition for clearing heat and removing dampness and improving liver and gallbladder congestion in dogs and cats, characterized in that, It is made from the following raw materials in parts by weight: Atractylodes lancea 1.5-2.5 parts, Pogostemon cablin 1.4-2.2 parts, Mentha haplocalyx 1.1-1.9 parts, Pueraria lobata 1.4-2.4 parts, Atractylodes macrocephala 1.5-2.5 parts, Poria cocos 1.5-2.5 parts, Chrysanthemum morifolium 1.1-1.9 parts, Magnolia officinalis 1.4-2.2 parts, Aucklandia lappa 1.0-1.6 parts, Citrus reticulata 1.6-2.6 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, It is made from the following raw materials in parts by weight: Atractylodes lancea 1.8-2.2 parts, Pogostemon cablin 1.6-2.0 parts, Mentha haplocalyx 1.3-1.7 parts, Pueraria lobata 1.7-2.1 parts, Atractylodes macrocephala 1.8-2.2 parts, Poria cocos 1.8-2.2 parts, Chrysanthemum morifolium 1.3-1.7 parts, Magnolia officinalis 1.6-2.0 parts, Aucklandia lappa 1.2-1.4 parts, Citrus reticulata 1.9-2.3 parts.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: 2 parts Atractylodes lancea, 1.8 parts Pogostemon cablin, 1.5 parts Mentha haplocalyx, 1.9 parts Pueraria lobata, 2 parts Atractylodes macrocephala, 2 parts Poria cocos, 1.5 parts Chrysanthemum morifolium, 1.8 parts Magnolia officinalis, 1.3 parts Aucklandia lappa, and 2.1 parts Citrus reticulata.

4. The traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The traditional Chinese medicine composition is a powder preparation with a moisture content of ≤5% and all powder particles passing through a 40-mesh sieve.

5. The traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The traditional Chinese medicine composition is used to improve hepatobiliary congestion in dogs and cats.

6. The traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The traditional Chinese medicine composition is used to improve hepatobiliary congestion in dogs and cats.

7. A method for preparing a traditional Chinese medicine composition according to any one of claims 1-3 for clearing heat and removing dampness and improving hepatobiliary congestion in dogs and cats, characterized in that, Includes the following steps: (1) Raw material pretreatment: Weigh out Atractylodes lancea, Pogostemon cablin, Mentha haplocalyx, Pueraria lobata, Atractylodes macrocephala, Poria cocos, Chrysanthemum morifolium, Magnolia officinalis, Aucklandia lappa, and Citrus reticulata according to the weight parts, and wash them with purified water 2-3 times to remove impurities; (2) Low-temperature drying: Place the cleaned raw materials in a low-temperature drying equipment and dry them for 4-6 hours at a temperature ≤60℃, controlling the moisture content of each raw material to below 5%; (3) Crushing and sieving: Crush each of the dried raw materials separately, and then pass them through a 40-mesh sieve to collect the material passing through the sieve; (4) Mixing evenly: The sieved raw material powders are put into a three-dimensional motion mixer according to the formula ratio and mixed at a speed of 15-25 rpm for 20-30 minutes to obtain a uniformly mixed Chinese medicine composition powder. (5) Aseptic packaging: The mixed Chinese medicine powder is packed and sealed in a sterile environment.

8. The preparation method according to claim 7, characterized in that, The low-temperature drying temperature in step (2) is 50-55℃, the drying time is 5 hours, and the moisture content of each raw material is controlled at 3%-4% after drying.

9. The preparation method according to claim 7, characterized in that, The mixing speed in step (4) is 20 revolutions per minute, and the mixing time is 25 minutes.

10. The preparation method according to claim 7, characterized in that, The finished product described in step (5) is packaged in a food-grade sealed container, with a net content of 100g-500g per container. It is to be added to the feed along with meals.

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