A probiotic microbial preparation with active peptide encapsulation and stabilization and its preparation method

CN122297632APending Publication Date: 2026-06-30BEIJING XINSHENGHE PHARMACEUTICAL TECHNOLOGY CO LTD

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Patent Information

Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner: BEIJING XINSHENGHE PHARMACEUTICAL TECHNOLOGY CO LTD
Filing Date: 2026-04-07
Publication Date: 2026-06-30

AI Technical Summary

Technical Problem

Currently, probiotics are easily damaged in the external environment and have poor stability. Active peptides are easily oxidized and degraded during processing and storage. There is a lack of effective protection and synergistic release methods. Traditional encapsulation materials are difficult to maintain structural stability and functional continuity in complex environments.

Method used

Using casein as a base, triazine crosslinking nodes are constructed through a 2,4,6-trichloro-1,3,5-triazine substitution reaction, and a carbamate network is formed by combining hexamethylene diisocyanate. The network is further enhanced by hydrogen bonding with 1,3-bis(3,5-ditrifluoromethylphenyl)thiourea and by the hydrolysis and condensation of N-(β-aminoethyl)-γ-aminopropyltrimethoxysilane to form a silicon-oxygen network. This multi-layered synergistic modification of the encapsulation matrix material enables the stable encapsulation and protection of probiotics and bioactive peptides.

Benefits of technology

It significantly improves the survival rate and gastrointestinal environment adaptability of probiotics, reduces the oxidative degradation rate of bioactive peptides, and achieves synergistic and stable release of bioactive peptides, thereby enhancing the overall stability and functional synergy of microbial preparations.

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Abstract

This invention relates to the field of microbial preparations and functional biomaterials, and discloses a probiotic microbial preparation with encapsulated and stabilized active peptides and its preparation method. The microbial preparation includes a synergistically modified encapsulating matrix material, probiotic powder, active peptides, trehalose, glycerol, antioxidants, and protectants. The synergistically modified encapsulating matrix material is formed by introducing triazine crosslinking nodes through a substitution reaction between casein and 2,4,6-trichloro-1,3,5-triazine, and further reacting with hexamethylene diisocyanate to form a carbamate network. Simultaneously, it incorporates hydrogen bonding from 1,3-bis(3,5-ditrifluoromethylphenyl)thiourea and a silicon-oxygen network formed by the hydrolysis and condensation of N-(β-aminoethyl)-γ-aminopropyltrimethoxysilane, constructing a multi-layered synergistically modified encapsulating structure. This invention significantly improves the survival rate of probiotics during processing, storage, and in the gastrointestinal environment through a multi-scale synergistic network structure, while simultaneously achieving stable maintenance and sustained release of active peptides, demonstrating promising application prospects.

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