A polypeptide polyphenol nanogel and its coating preparation method and application

By leveraging the dynamic reversible bond synergy of the polypeptide-polyphenol nanogel coating, the problem of insufficient release precision of existing coatings in the tumor microenvironment is solved, achieving dual gate control and self-repair of MMPs and ROS, and improving the adhesion and durability of the coating.

CN122297809APending Publication Date: 2026-06-30CHENGDU TECH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHENGDU TECH UNIV
Filing Date
2026-06-02
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing medical device surface coatings are difficult to achieve dual-signal gating in microenvironments such as tumors and inflammation, resulting in insufficient release precision and spatiotemporal selectivity. Furthermore, the irreversible cross-linking process leads to embrittlement, shedding, and cytotoxicity.

Method used

The peptide-polyphenol nanogel coating utilizes the synergistic effect of dynamic and reversible disulfide bonds, Schiff base bonds, and catechol-boronic acid ester bonds to combine with MMP and ROS-responsive peptides, thereby achieving dual gate control of MMP and ROS and possessing self-healing capabilities.

Benefits of technology

It achieves precise drug release in the tumor microenvironment, reduces spontaneous release from healthy tissue, possesses self-repair capabilities, improves coating adhesion and durability, and adapts to blood flow environments.

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Abstract

This invention discloses a polypeptide-polyphenol nanogel and its coating preparation method and application, belonging to the field of functional coatings for medical device surfaces or local drug delivery carriers. The raw materials include polypeptides, polyphenol components, boric acid and its derivatives, oxidants, and other auxiliary reagents. The polypeptide has an AAS-SAA structure, including an A peptide and a B peptide coupled at the C-terminus via disulfide bonds. The A peptide is an MMP-responsive peptide. The polyphenol component contains catechol structures. The oxidant is a sodium periodate solution. This process forms three reversible dynamic bonds: a dynamically reversible disulfide bond, a dynamically reversible Schiff base bond, and a dynamically reversible catechol-boron ester bond. The synergistic effect of these three reversible dynamic bonds, along with the introduction of an MMP-responsive cleavage peptide into the polypeptide portion, achieves "dual-gate control" of MMP and ROS responses, exhibiting precise selectivity.
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