An antimicrobial peptide X1-3, a pharmaceutical composition and its uses

CN122302004APending Publication Date: 2026-06-30NORTHWEST A & F UNIV

Patent Information

Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner: NORTHWEST A & F UNIV
Filing Date: 2026-04-09
Publication Date: 2026-06-30

AI Technical Summary

Technical Problem

Existing antimicrobial peptides have a narrow antimicrobial spectrum against multidrug-resistant bacteria such as MRSA and NDM-CRE, and a single mechanism of action. They cannot effectively eliminate intracellular bacteria and cannot reverse resistance to β-lactam antibiotics.

Method used

By performing specific site-specific combinatorial modifications on the precursor peptide X1 derived from the human microbiome, amino acids were replaced to enhance membrane targeting, penetration, and stabilize the α-helix conformation, resulting in the antimicrobial peptide X1-3. This peptide was then combined with β-lactam antibiotics to inhibit bacterial efflux pumps and β-lactamase activity.

Benefits of technology

Antimicrobial peptide X1-3 exhibits broad-spectrum and potent antimicrobial activity, can penetrate host cell membranes to eliminate intracellular bacteria, and acts as a potentiator for β-lactam antibiotics, significantly restoring the therapeutic effects of classic antibiotics.

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Abstract

This invention relates to the field of biomedical technology, specifically to an antimicrobial peptide X1-3, a pharmaceutical composition, and its uses. This antimicrobial peptide is obtained by introducing arginine into its sequence to enhance positive charge and cell penetration, and by replacing key amino acids to stabilize the α-helix conformation and balance hydrophobicity. Experiments show that antimicrobial peptide X1-3 exhibits potent and rapid bactericidal activity against superbugs such as MRSA, NDM-CRE, and VRE; it can penetrate the host cell membrane to eliminate latent intracellular bacteria; more importantly, it can act as a highly effective β-lactam antibiotic potentiator, significantly restoring the therapeutic effect of classic antibiotics by inhibiting bacterial efflux pumps and β-lactamase activity, providing a novel candidate drug for the comprehensive management of drug-resistant bacterial infections.

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