Application of effector protein Fpg9 and its encoding gene in regulating the pathogenicity of Fusarium graminearum

By identifying and knocking out the Fpg9 protein in Fusarium graminearum, the technical challenge of regulating the pathogenicity of Fusarium graminearum was solved, the pathogenicity of Fusarium graminearum was reduced, new control targets and theoretical basis were provided, and the development of novel fungicides was promoted.

CN122302015APending Publication Date: 2026-06-30SHANDONG AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG AGRICULTURAL UNIVERSITY
Filing Date
2026-04-22
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

There are few existing technologies for identifying and functionally validating effector proteins of Fusarium graminearum, and there is an urgent need to develop new effector proteins that regulate the pathogenicity of Fusarium graminearum.

Method used

The effector protein Fpg9 was identified in Fusarium graminearum, and the pathogenicity of Fusarium graminearum was reduced by knocking out or silencing the Fpg9 gene using PEG-mediated homologous recombination knockout technology.

Benefits of technology

After the Fpg9 gene was knocked out, the pathogenicity of Fusarium graminearum was significantly reduced, proving that the Fpg9 protein plays a key role in the pathogenic process. This provides a new target and theoretical basis for the control of Fusarium graminearum, and helps to develop new fungicides, reduce dependence on traditional agents and delay drug resistance.

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Abstract

This invention discloses the application of an effector protein Fpg9 and its encoding gene in regulating the pathogenicity of *Fusarium graminearum*, belonging to the field of biotechnology. This invention confirms that the Fpg9 protein plays a key role in the pathogenicity of *Fusarium graminearum*, and achieves targeted knockout of the Fpg9 gene through PEG-mediated homologous recombination knockout technology. Fpg9 After gene knockout, the pathogenicity of *Fusarium graminearum* mutants against wheat was significantly weakened, indicating that the Fpg9 protein plays an important role in the pathogen's infection of the host and the formation of pathogenicity. Therefore, this invention not only reveals the mechanism of action of *Fusarium graminearum* pathogenicity-related effector proteins at the molecular level, but also provides new targets and theoretical basis for screening and developing small-molecule inhibitors targeting this pathogenic factor. This contributes to providing new technical pathways for the control of wheat diseases caused by *Fusarium graminearum*, and is of great significance for developing novel fungicides, reducing dependence on traditional pesticides, and delaying the development of drug resistance.
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