A polyurethane-modified silica gel particle, its preparation method and application

CN122302309APending Publication Date: 2026-06-30LANZHOU INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LANZHOU INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
Filing Date
2026-04-27
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Traditional silica gel stationary phases are not very effective in separating highly polar substances such as nucleoside bases and carbohydrate compounds, making it difficult to achieve efficient separation.

Method used

A polyurethane network is formed on the surface of silica particles by chemical bonding or physical coating, which is obtained by the reaction of aromatic diisocyanate, polyethylene glycol and ethylenediamine. This forms a polyurethane network rich in amino, amide and ester groups, and achieves multiple retention mechanisms by combining π-π interactions and hydrophilic interactions.

Benefits of technology

It achieves excellent and versatile separation performance for nucleosides/bases, sugars, polycyclic aromatic hydrocarbons, alkylbenzenes and aniline compounds, simplifies the preparation process, improves separation efficiency and stability, and is suitable for drug analysis and environmental monitoring.

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Abstract

This invention discloses polyurethane-modified silica gel particles, their preparation method, and applications. The stationary phase uses silica gel particles as a matrix, and a polyurethane network obtained by reacting aromatic diisocyanate, polyethylene glycol, and ethylenediamine is formed on the surface of the silica gel particles through chemical bonding and / or physical coating. The hydroxyl groups on the surface of the polyethylene glycol or the silica gel particles react with the isocyanate groups of the aromatic diisocyanate to form the polyurethane network, and unreacted isocyanate groups are end-capped with ethylenediamine. This invention successfully modifies the surface of silica gel with polyurethane through chemical bonding and physical coating in a one-pot process. The polyurethane network has π-π interactions and hydrophilic and hydrophobic interaction sites, enabling efficient separation of nucleoside bases, alkylbenzenes, polycyclic aromatic hydrocarbons, aniline, and carbohydrate compounds. This stationary phase exhibits high stability and is of significant importance in the fields of drug analysis and environmental monitoring.
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