Genetically modified microorganisms that promote melanin production efficiency and methods of producing melanin
By using genetically modified microorganisms to form highly soluble dipeptides, the problem of low water solubility of tyrosine was solved, improving the production efficiency of melanin and achieving more efficient melanin synthesis.
CN122303113APending Publication Date: 2026-06-30IND TECH RES INST
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- IND TECH RES INST
- Filing Date
- 2025-05-30
- Publication Date
- 2026-06-30
AI Technical Summary
Technical Problem
In existing technologies, tyrosine has low water solubility in a pH 7 environment suitable for microbial growth, which prevents further improvement in the biosynthesis efficiency of melanin.
Method used
By introducing exogenous nucleic acid-encoded exotropic L-amino acid ligases and tyrosinases into genetically modified microorganisms, highly soluble dipeptides such as L-alanine-L-tyrosine are formed, improving the uptake efficiency of tyrosine and thus promoting melanin production.
Benefits of technology
It improves the utilization efficiency of tyrosine by microorganisms, enhances the biosynthesis efficiency of melanin, and achieves increased melanin production efficiency without the addition of additional dipeptides.
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Figure CN122303113A_ABST
Abstract
The present invention provides a genetically modified microorganism that promotes melanin production efficiency, comprising: a first exogenous nucleic acid, which includes a nucleic acid encoding an exotype L-amino acid ligase, wherein the exotype L-amino acid ligase has the ability to link two amino acids to form a dipeptide; and a second exogenous nucleic acid, which includes a nucleic acid encoding a tyrosinase.
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