Hydantoinase mutants and their use in the preparation of (r)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid

CN122303204APending Publication Date: 2026-06-30SYNCOZYMES SHANGHAI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SYNCOZYMES SHANGHAI
Filing Date
2024-12-27
Publication Date
2026-06-30

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Abstract

This invention discloses a hydantoin mutant and its application in the preparation of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid. The hydantoin mutant disclosed in this invention can convert 3-isobutylglutarimide to (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid, with a substrate concentration of up to 360 g / L, a conversion rate >99%, and a product chiral purity >99%. This method significantly improves the substrate concentration for conversion and has good industrial application value.
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