A method for preparing 2,5-furandimethanol by multi-enzyme catalytic oxidation of 5-hydroxymethylfurfural

By employing a cascade reaction sequence of transamination-oxidation-transamination and utilizing a multi-enzyme catalyst, 2,5-furandimethylamine was prepared. This method overcomes the problems of harsh reaction conditions and intermediate instability in existing BAMF synthesis routes, achieving high-yield BAMF synthesis and demonstrating good potential for industrial application.

CN122303347APending Publication Date: 2026-06-30BEIJING UNIV OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING UNIV OF CHEM TECH
Filing Date
2026-05-11
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing BAMF synthesis routes suffer from problems such as harsh reaction conditions, numerous side reactions, and unstable or accumulated intermediates, leading to limited yields.

Method used

A cascade reaction sequence of transamination-oxidation-transamination was adopted, using isopropylamine as the amino donor, pyridoxal 5'-phosphate as the coenzyme, and alcohol oxidase, transaminase and catalase as catalysts to catalyze the preparation of 2,5-furandimethylamine from 5-hydroxymethylfurfural, thus avoiding the formation and accumulation of the highly reactive intermediate 2,5-furandicarboxaldehyde.

Benefits of technology

Efficient and stable BAMF synthesis was achieved, with product yields reaching >99%. High conversion rates were maintained even at substrate concentrations up to 200 mM, demonstrating promising prospects for industrial applications.

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Abstract

This invention discloses a method for preparing 2,5-furandimethylamine by multi-enzyme catalytic oxidation of 5-hydroxymethylfurfural, belonging to the field of biocatalysis and biomass conversion technology. The method comprises the following steps: using 5-hydroxymethylfurfural as a substrate, isopropylamine as an amino donor, pyridoxal 5'-phosphate as a cofactor, and alcohol oxidase, transaminase, and catalase as catalysts, the reaction is catalyzed to obtain the reaction product, 2,5-furandimethylamine. This invention achieves kinetic matching of the three-step cascade reaction under mild conditions by precisely controlling the reaction pH, enzyme ratio, and amino donor concentration. Within a substrate concentration range of 200 mM, the yield of 2,5-furandimethylamine can reach 96.6%, with a production rate of 24.4 g / L. The method of this invention features mild reaction conditions, high selectivity, and environmental friendliness, and has good prospects for industrial application.
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