A method and application for preparing uric acid-lowering complex peptides using sesame meal and peony seed meal.

Abstract

This invention discloses a method and application for preparing a uric acid-lowering complex peptide using sesame meal and peony seed meal, belonging to the field of biotechnology. The complex peptide comprises peony polypeptide and sesame seed meal polypeptide, with a mass ratio of peony polypeptide to sesame seed meal polypeptide of 3:2 to 4:1. This invention is the first to combine peony polypeptide and sesame seed meal polypeptide, finding that when the mass ratio is 3:2 to 4:1, the two polypeptides synergistically reduce uric acid production by regulating the activity of key enzymes in uric acid synthesis, thereby significantly lowering serum uric acid levels. Furthermore, the complex peptide of this invention can inhibit multiple targets upstream and downstream of the uric acid synthesis pathway, simultaneously repairing damaged liver and kidney function and alleviating oxidative stress while lowering uric acid, achieving comprehensive intervention for hyperuricemia, with a safety profile superior to existing chemical drugs.

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