A low-ripple constant-voltage control system for third-generation gene sequencing and a control method thereof

CN122308492APending Publication Date: 2026-06-30TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN UNIV
Filing Date
2026-04-03
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing constant pressure methods cannot maintain stable gas pressure for long periods in biological nanopore gene sequencing experiments, leading to experimental failures and high costs.

Method used

A low-ripple constant pressure control system is constructed by using a microcontroller, a dual-path pneumatic drive subsystem, a sealed pneumatic manifold, a high-precision digital pneumatic sensor, and a nanopore reaction cell holder. This system is combined with a stepper motor and a multi-stage gear reduction mechanism to achieve stable pneumatic pressure control.

Benefits of technology

It significantly reduces the current baseline noise of nanopore systems, improves the success rate of single-molecule detection, reduces hardware costs, and can automatically calibrate mechanical phase drift caused by aging of gas pressure lines.

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Abstract

This invention discloses a low-ripple constant-pressure control system and its control method for third-generation gene sequencing. The system includes: a microcontroller, a dual-path pneumatic drive subsystem, a sealed pneumatic manifold, a high-precision digital pressure sensor, and a nanopore reaction cell holder. The microcontroller is connected to the dual-path pneumatic drive subsystem, the sealed pneumatic manifold, and the high-precision digital pressure sensor. The dual-path pneumatic drive subsystem is arranged symmetrically in parallel and connected to the sealed pneumatic manifold. The sealed pneumatic manifold is connected to the high-precision digital pressure sensor and the nanopore reaction cell holder. This invention utilizes digital phase-shifting technology based on stepper motor microstepping to achieve sub-millimeter-level phase control accuracy, and automatically calibrates upon each power-on, effectively overcoming the mechanical phase drift problem caused by aging and elastic decay of the pneumatic pipeline.
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