Thymol and polymyxin e-loaded composite chitosan hydrogel, and preparation method and application thereof

CN122321099APending Publication Date: 2026-07-03ANHUI AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-22
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

In existing technologies, traditional antibiotic treatment for endometritis has problems with drug resistance and the risk of drug residues. Furthermore, existing combinations of natural drugs have limited antibacterial spectrum and efficacy, making them difficult to effectively treat acute or severe endometritis, and they fail to specifically destroy the outer membrane of Gram-negative bacteria.

Method used

A composite chitosan hydrogel loaded with thymol and polymyxin E was used. The chitosan/β-glycerophosphate thermosensitive hydrogel system forms a three-dimensional network structure at physiological temperature, which enables local retention and controlled release of the drug. Thymol disrupts the bacterial cell membrane, and polymyxin E disrupts the outer membrane of Gram-negative bacteria, thus achieving a synergistic antibacterial effect.

Benefits of technology

It prolongs the drug's residence time at the target site, achieves biphasic drug release, significantly enhances the antibacterial effect against Escherichia coli, reduces the frequency of drug use, lowers the risk of drug resistance, and reduces drug residues, exhibiting good biosafety.

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Abstract

This invention relates to the field of chitosan hydrogel preparation technology, and discloses a composite chitosan hydrogel loaded with thymol and polymyxin E, its preparation method, and its application. The invention is achieved through the following technical solution: One objective of this invention is to propose a composite chitosan hydrogel loaded with thymol and polymyxin E, composed of chitosan solution, sodium β-glycerophosphate solution, thymol, and polymyxin E; the chitosan solution is prepared by dissolving chitosan at a mass-volume percentage concentration of 2.0% in a 0.1 mol / L acetic acid solution. This invention constructs a composite drug-loaded hydrogel suitable for intrauterine local drug delivery by loading thymol and polymyxin E into a chitosan / β-glycerophosphate (CS / β-GP) thermosensitive hydrogel.
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