Bionic nanoparticles based on alkaliophilic granulocyte membranes, preparation method thereof and application thereof in preparation of drugs for treating allergic diseases

CN122342736APending Publication Date: 2026-07-07THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
Filing Date
2026-06-05
Publication Date
2026-07-07

AI Technical Summary

Technical Problem

Existing treatments for allergic diseases cannot effectively block IgE-mediated allergic cascade reactions, and existing drugs such as omalizumab have short half-lives, making it difficult to completely control asthma.

Method used

Biomimetic nanoparticles based on basophil membranes were used to reduce IgE concentration and alleviate the allergic cascade reaction through the high affinity binding of the FcεRI protein to IgE. These biomimetic nanoparticles were made by encapsulating the cell membrane of a rat basophilic leukemia cell line with a PLGA support and prepared using gradient centrifugation and water bath sonication techniques.

Benefits of technology

It significantly reduces IgE concentration, blocks the allergy cascade, and relieves allergy symptoms. It has a highly effective allergy-blocking effect and good biocompatibility.

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Abstract

The application discloses a kind of biomimetic nanoparticles based on alkaliophilic granulocyte membrane and its preparation method, application in preparation treating allergic disease drug, mainly include support, the cell membrane of rat alkaliophilic leukemic cell line is wrapped in the outside of support, the surface of the cell membrane has Fc epsilon RI protein.Biomimetic nanoparticles is formed by supporting cell membrane by support, so that it has relatively stable shape, form biomimetic nanoparticles.By the high affinity combination of Fc epsilon RI protein and IgE, reduce IgE concentration, alleviate IgE-mediated allergic cascade reaction.
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