Anti-inflammatory and itching-relieving shampoo based on agilawood nano microemulsion technology

Abstract

The present application relates to the technical field of anti-inflammatory and itching-relieving shampoo based on nanometer microemulsion technology of agarwood, in particular to an anti-inflammatory and itching-relieving shampoo based on nanometer microemulsion technology of agarwood, which is composed of the following raw materials in parts by weight: 4-5 parts of nanometer emulsion, 2.7-3.3 parts of repairing essence, and 84-105 parts of shampoo base. The active ingredients are loaded in the nanometer emulsion, which can target the delivery of high-concentration anti-inflammatory ingredients to the deep part of hair follicle and the dermal layer, effectively improving the utilization rate and targeting of the active ingredients. The ceramide NP directly supplements the key ingredient of the scalp keratin layer lipid, orderly arranges with other lipids between cells, rebuilds and reinforces the physical barrier structure of the scalp, significantly improves the water-locking capacity of the scalp, and uses methyl cocoyl sodium taurate and decyl glucoside as the main cleaning system, which can efficiently remove excess oil and dirt, avoiding the barrier damage and dry and tight feeling caused by the traditional sulfate surface active agent.

Description

Technical Field

[0001] This invention relates to the field of anti-inflammatory and anti-itch shampoo technology based on agarwood nano-microemulsion technology, specifically to an anti-inflammatory and anti-itch shampoo based on agarwood nano-microemulsion technology. Background Technology

[0002] Influenced by multiple factors such as environmental stress, lifestyle changes, and mental stress, scalp sensitivity, seborrheic dermatitis, atopic dermatitis accompanied by scalp itching, and chronic inflammation caused by impaired barrier function are becoming increasingly common. Consumers' demand for professional hair care products with clear soothing and repairing effects has grown dramatically. However, many shampoos on the market still rely on relatively traditional technologies, and have significant limitations in terms of efficacy depth, raw material effectiveness, system stability, and long-term value, making it difficult to meet consumer needs.

[0003] Existing shampoos deliver active ingredients in a crude and inefficient manner. During the shampooing process, the active ingredients are evenly distributed throughout the scalp and released at the same rate regardless of whether they are needed, lacking intelligent response and targeted delivery capabilities. Moreover, the efficacy design of such shampoos generally suffers from a single mechanism and short-sightedness. Furthermore, in order to meet consumers' expectations for rich lather, these shampoos use highly irritating sulfate surfactants as the main base, which can lead to excessive degreasing after long-term use, damaging the lipid structure of the scalp's stratum corneum and causing or aggravating dryness, tightness, and barrier damage. Based on this, the present invention provides an anti-inflammatory and anti-itch shampoo based on agarwood nano-microemulsion technology. Summary of the Invention

[0004] The purpose of this invention is to provide an anti-inflammatory and anti-itch shampoo based on agarwood nano-microemulsion technology. The anti-inflammatory and anti-itch shampoo prepared by this invention based on agarwood nano-microemulsion technology effectively improves the utilization rate and targeting of active ingredients, significantly enhances the scalp's water-locking ability, and avoids the barrier damage and dryness and tightness caused by traditional sulfate surfactants.

[0005] To achieve the above objectives, the present invention provides the following technical solution: an anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology, comprising the following raw materials in parts by weight: 4-5 parts nanoemulsion, 2.7-3.3 parts repair essence, and 84-105 parts shampoo base; The preparation steps of the anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology are as follows: S1. Add deionized water to a premix tank, slowly add chitosan and shear it through a sieve to obtain a chitosan solution. Put the chitosan solution into reactor A, and add engineered agaric tetraol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol in sequence. Stir until completely dissolved. Dissolve sodium tripolyphosphate in deionized water and add TPP solution to reactor A. The system changes from clear to pale blue opalescent. S2. Add ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol sequentially to the mixing tank, and stir until completely clear and transparent. Transfer the nanoemulsion in reactor A to reactor B, and add the lipid phase to reactor B. S3. Add deionized water to the main reactor, sprinkle in xanthan gum, and then add sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin in sequence. Stir until completely clear, then add guar gum hydroxypropyltrimethylammonium chloride and polydimethylsiloxane alcohol, and stir evenly. S4. Transfer all the material in reactor B to the main reactor and stir, then add deionized water and preservative and stir. S5. After final quality inspection, the final product shampoo is obtained.

[0006] Further, the nanoemulsion preparation steps are as follows: deionized water is added to the reaction vessel, chitosan is sprinkled in to obtain a clear chitosan solution, engineered agaritol glucoside, dipotassium glycyrrhizate and 1,3-butanediol are added in sequence until all solid or liquid active ingredients are completely dissolved, sodium tripolyphosphate is dissolved in deionized water to prepare a clear solution, the sodium tripolyphosphate solution is added to the liquid stream, and the system gradually changes from a clear state to a milky blue color, waiting to enter the next stage of mixing.

[0007] Furthermore, the mass ratio of deionized water to chitosan is 100:3, and the mass ratio of engineered agaric tetraol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol is 10:8:35.

[0008] Furthermore, the mass ratio of sodium tripolyphosphate to deionized water is 3:40.

[0009] Furthermore, the preparation steps of the repair essence are as follows: ceramide NP, bisabolol, menthol, panthenol and dipropylene glycol are added to a small mixing tank and stirred continuously until completely dissolved to form a clear and transparent oily liquid. The clear lipid phase is added to the warm nanoemulsion to form a uniform, delicate, milky white emulsion, which is then transferred to a sealed container and allowed to mature before final mixing.

[0010] Furthermore, the mass ratio of ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol is 10:6:3:10:40.

[0011] Further, the shampoo base preparation steps are as follows: deionized water is added to the main reaction vessel, xanthan gum is sprinkled into the vortex, and sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine and glycerin are added sequentially under stirring until all surfactants are completely dissolved. Guar hydroxypropyl trimethylammonium chloride and polydimethylsiloxane alcohol are added, preservatives are added, and deionized water is added to prepare for final mixing.

[0012] Furthermore, the mass ratio of deionized water to xanthan gum is 100:0.7, and the mass ratio of sodium methylcocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerol is 12:6:5:2.

[0013] Furthermore, the mass ratio of guar hydroxypropyltrimethylammonium chloride to polydimethylsiloxane alcohol is 3:2.

[0014] Furthermore, the mass ratio of the nanoemulsion to the repair essence is 3:2, and the mass ratio of the nanoemulsion to the shampoo base is 1:21.

[0015] Compared with the prior art, the beneficial effects of the present invention are: 1. The active ingredients of this invention are loaded into nanoemulsions, which remain stable in a healthy scalp environment. Once a local abnormality caused by inflammation or fungal growth is detected, the nanocarrier can intelligently disintegrate in the problem area, delivering a high concentration of anti-inflammatory ingredients to the depths of the hair follicle and the dermis. This effectively improves the utilization rate and targeting of the active ingredients, avoids the ineffective release of active ingredients in non-problem areas, and reduces unnecessary scalp burden or tolerance problems that may result from overuse.

[0016] 2. This invention directly replenishes the key lipid component of the scalp stratum corneum through ceramide NP, which arranges itself in an orderly manner with other lipids between cells, rebuilding and strengthening the physical barrier structure of the scalp, significantly improving the scalp's water-locking ability, effectively defending against the invasion of external irritants, restoring the scalp to a strong state, and significantly prolonging the interval between problem recurrences. Menthol instantly activates cold receptors, providing a strong cooling sensation and quickly diverting itching signals. Dipotassium glycyrrhizate inhibits the production and release of inflammatory factors at the biochemical level, and can continuously inhibit the inflammatory response for several hours afterward, ensuring continuous soothing.

[0017] 3. The shampoo base of this invention uses sodium methyl cocoyl taurate and decyl glucoside as the main cleansing system, which can effectively remove excess oil and dirt, avoiding the barrier damage and dryness caused by traditional sulfate surfactants. In addition, the use of guar gum hydroxypropyl trimethylammonium chloride and polydimethylsiloxane alcohol can gently adsorb onto the negatively charged areas of damaged hair, making the hair smooth and tangle-free after washing, and the scalp feels clean rather than dry, bringing a high-end sensory experience to the entire care process. Detailed Implementation

[0018] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0019] It should be noted that the raw materials used in the following embodiments are all commercially available.

[0020] Example 1: An anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology, composed of the following raw materials in parts by weight: 4 parts nanoemulsion, 2.7 parts repair essence, and 84 parts shampoo base; The preparation steps of the anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology are as follows: S1. Add deionized water to a premix tank, slowly add chitosan and shear it through a sieve to obtain a chitosan solution. Put the chitosan solution into reactor A, and add engineered agaric tetraol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol in sequence. Stir until completely dissolved. Dissolve sodium tripolyphosphate in deionized water and add TPP solution to reactor A. The system changes from clear to pale blue opalescent. S2. Add ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol sequentially to the mixing tank, and stir until completely clear and transparent. Transfer the nanoemulsion in reactor A to reactor B, and add the lipid phase to reactor B. S3. Add deionized water to the main reactor, sprinkle in xanthan gum, and then add sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin in sequence. Stir until completely clear, then add guar gum hydroxypropyltrimethylammonium chloride and polydimethylsiloxane alcohol, and stir evenly. S4. Transfer all the material in reactor B to the main reactor and stir, then add deionized water and preservative and stir. S5. After final quality inspection, the final product shampoo is obtained.

[0021] The preparation steps of the nanoemulsion are as follows: Deionized water is added to a reaction vessel, and the temperature is raised to 45°C. While stirring at 800 rpm, low molecular weight chitosan powder is slowly and evenly added. The stirring speed is increased to 1200 rpm, and high-speed shearing is continued for 30 minutes to ensure complete hydration and dissolution of the chitosan, forming a transparent or slightly turbid viscous solution. The solution is filtered through a 200-mesh sieve to remove any possible undissolved particles or impurities, resulting in a clear chitosan solution. The temperature of the chitosan solution is stabilized at 40°C. While stirring at a medium speed of 400-600 rpm, engineered linalool glucoside, dipotassium glycyrrhizate, and 1,3-butanediol are added sequentially, maintaining stirring for approximately 15-20 minutes until all solid or liquid active ingredients are completely dissolved and the system becomes homogeneous. Sodium tripolyphosphate is dissolved in deionized water to prepare a clear solution. Clear the solution and start a high-speed shear press (adjust the speed to above 5000 rpm) to strongly shear the solution in the reactor. Using a precision peristaltic pump, add sodium tripolyphosphate solution dropwise into the high-speed sheared liquid stream at an extremely slow speed. This step is crucial for the formation of uniform nanoparticles. Too rapid a drop speed will lead to excessive local cross-linking and the formation of large particle precipitates. After the drop is completed, continue high-speed shearing for 15 minutes. You can observe that the system gradually changes from a clear state to a translucent or opalescent blue, which is a typical characteristic of nanoparticle formation. Take a sample and use a laser particle size analyzer to ensure that the particle size distribution D90 is within the range of 80-120 nm and the polydispersity index PDI is less than 0.25. Transfer the prepared smart responsive nanoemulsion to a sealed, light-proof storage tank and temporarily store it in an environment below 40°C, waiting for the next stage of mixing.

[0022] The mass ratio of deionized water to chitosan is 100:3. Chitosan, as a natural cationic polymer, is a sensitive material for constructing nanoparticles. It swells and disintegrates in a slightly alkaline environment caused by inflammation, which is key to achieving intelligent targeted release. The mass ratio of engineered agaritol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol is 10:8:35. Engineered agaritol glucoside, as a high-purity active ingredient obtained through synthetic biology, provides potent and stable anti-inflammatory and antioxidant core effects with zero batch-to-batch variation. Its water solubility is significantly improved after glycosylation modification. Dipotassium glycyrrhizate is not only itself... This highly effective classic anti-inflammatory agent's molecular structure can interact with chitosan, helping to stabilize the nanoparticle system. After release, it synergistically enhances the effects of linalool. 1,3-Butanediol serves as an excellent solvent, ensuring that all components are fully dissolved and mixed during preparation. It also possesses excellent moisturizing properties, reducing the need for other polyols in the formulation and making the system more refreshing. The mass ratio of sodium tripolyphosphate to deionized water is 3:40. Sodium tripolyphosphate, as an anion, undergoes ionic cross-linking with positively charged chitosan through electrostatic interaction, instantly forming a stable nanoparticle network structure that firmly encapsulates the active ingredient.

[0023] The preparation steps for the repair essence are as follows: In a small mixing vessel, accurately weigh ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol. Using a water bath or jacket heating method, slowly heat the mixture to 50-55°C while stirring at medium speed. Maintain this temperature and continue stirring until all solid components are completely dissolved, and the mixture becomes a clear, transparent, oily liquid. This step is crucial; any undissolved crystals will affect the uniformity of the final product. Preheat the nanoemulsion prepared in Module 1 to 50°C and add it to another clean mixing vessel. While stirring at approximately 800 rpm, the clear lipid phase prepared in step 1 is slowly added to the warm nanoemulsion in a thin stream. After the addition is complete, the stirrer is switched to a homogenizer and homogenized at 3000 rpm for 3-5 minutes to form a uniform, fine, milky white emulsion. The homogenized emulsion is then cooled to room temperature with gentle stirring (200-300 rpm) and transferred to a sealed container. It is then allowed to stand at room temperature in the dark for 24 hours. This process helps the system reach thermodynamic equilibrium and improves stability. After maturation, it can be used for final mixing.

[0024] The mass ratio of ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol is 10:6:3:10:40. Ceramide NP has a structure completely consistent with the lipid structure of the human stratum corneum, allowing it to directly embed into the damaged scalp stratum corneum, repairing the lipid bilayer like cement. This fundamentally enhances the scalp's water-locking and defense capabilities, reducing inflammation recurrence. Bisabolol, derived from chamomile, not only has anti-inflammatory properties but also promotes skin self-repair. It is gentle and non-irritating, especially suitable for sensitive scalps. Its effect is amplified when used in combination with dipotassium glycyrrhizate. Panthenol activates the skin's cold receptors, producing a strong, instantaneous cooling sensation. It can quickly divert nerve signals that cause itching, providing immediate psychological and physiological satisfaction by relieving itching in a second. Panthenol penetrates the stratum corneum and transforms into pantothenic acid, an important coenzyme for cell repair. It also has a strong hygroscopic and moisturizing ability, which can relieve dryness after cleansing and promote barrier recovery. Dipropylene glycol has excellent solubility for various polar and non-polar active ingredients, ensuring that the essence is clear and uniform, while also providing a refreshing feel to the skin and offering both moisturizing and gentle preservative effects.

[0025] The steps for preparing the shampoo base are as follows: Add deionized water to the main reactor, turn on the jacket heating, raise the water temperature to 75-80℃, start the high-speed disperser (speed about 1500rpm), form a vortex on the water surface, and slowly and evenly sprinkle xanthan gum powder into the vortex to avoid clumping. Continue high-speed shear dispersion for 30 minutes until xanthan gum is completely hydrated, and the system becomes homogeneous, transparent, and viscoelastic. This is a key step that determines the final viscosity and stability of the product. Maintain the temperature at 75°C, and add sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin sequentially while stirring. Continue stirring for about 30 minutes until all surfactants are completely dissolved and the material returns to a clear and transparent state. Turn on the cooling system of the reactor to cool the material at a controlled rate. When the temperature drops to 45°C, add guar gum hydroxypropyl trimethylammonium chloride and polydimethylsiloxane alcohol. Stir at a medium speed for 15-20 minutes to ensure uniform dispersion of the conditioning agents. Continue cooling to 40°C, add preservatives, add deionized water, and stir for 15 minutes to obtain a homogeneous shampoo base. Maintain the temperature at around 40°C in preparation for final mixing.

[0026] The mass ratio of deionized water to xanthan gum is 100:0.7; the mass ratio of sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin is 12:6:5:2; the mass ratio of guar gum hydroxypropyl trimethylammonium chloride and polydimethylsiloxane alcohol is 3:2; the mass ratio of nanoemulsion and repair essence is 3:2; and the mass ratio of nanoemulsion and shampoo base is 1:21. Xanthan gum, as a bio-collagen, can construct a strong three-dimensional network structure, giving the product shear-thinning properties. It can stably suspend nanoparticles for a long time, preventing sedimentation and stratification. Sodium methyl cocoyl taurate, as an amino acid surfactant, has a pH value close to that of a healthy scalp, moderate cleansing power, extremely low irritation, and rich, delicate foam. After washing, the scalp is not dry or tight, creating optimal conditions for subsequent care. Glucoside, derived from natural glucose and coconut oil, is extremely mild and significantly reduces overall formula irritation, while also providing excellent thickening and foam stability. Cocamidopropyl betaine, an amphoteric surfactant, significantly enriches and stabilizes foam, enhancing the washing experience. It also acts as a thickener, helping to achieve the appropriate formula viscosity. Glycerin helps maintain the moisture balance of the scalp and hair cuticle, alleviating potential dryness caused by surfactants. Guar gum hydroxypropyltrimethylammonium chloride cationic polymer gently adheres to the negatively charged surface of damaged hair during rinsing, significantly reducing frizz and static electricity, making hair easier to comb. It is also easier to rinse and more environmentally friendly than traditional silicone oil. Polydimethylsiloxane provides the smoothness and shine needed after hair dries, working synergistically with cationic conditioners to achieve dual smoothness for both wet and dry hair.

[0027] Example 2: An anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology, composed of the following raw materials in parts by weight: 4.5 parts nanoemulsion, 3 parts repair essence, and 94.5 parts shampoo base; The preparation steps of the anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology are as follows: S1. Add deionized water to a premix tank, slowly add chitosan and shear it through a sieve to obtain a chitosan solution. Put the chitosan solution into reactor A, and add engineered agaric tetraol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol in sequence. Stir until completely dissolved. Dissolve sodium tripolyphosphate in deionized water and add TPP solution to reactor A. The system changes from clear to pale blue opalescent. S2. Add ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol sequentially to the mixing tank, and stir until completely clear and transparent. Transfer the nanoemulsion in reactor A to reactor B, and add the lipid phase to reactor B. S3. Add deionized water to the main reactor, sprinkle in xanthan gum, and then add sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin in sequence. Stir until completely clear, then add guar gum hydroxypropyltrimethylammonium chloride and polydimethylsiloxane alcohol, and stir evenly. S4. Transfer all the material in reactor B to the main reactor and stir, then add deionized water and preservative and stir. S5. After final quality inspection, the final product shampoo is obtained.

[0028] The preparation steps of the nanoemulsion are as follows: Deionized water is added to a reaction vessel, and the temperature is raised to 45°C. While stirring at 800 rpm, low molecular weight chitosan powder is slowly and evenly added. The stirring speed is increased to 1200 rpm, and high-speed shearing is continued for 30 minutes to ensure complete hydration and dissolution of the chitosan, forming a transparent or slightly turbid viscous solution. The solution is filtered through a 200-mesh sieve to remove any possible undissolved particles or impurities, resulting in a clear chitosan solution. The temperature of the chitosan solution is stabilized at 40°C. While stirring at a medium speed of 400-600 rpm, engineered linalool glucoside, dipotassium glycyrrhizate, and 1,3-butanediol are added sequentially, maintaining stirring for approximately 15-20 minutes until all solid or liquid active ingredients are completely dissolved and the system becomes homogeneous. Sodium tripolyphosphate is dissolved in deionized water to prepare a clear solution. Clear the solution and start a high-speed shear press (adjust the speed to above 5000 rpm) to strongly shear the solution in the reactor. Using a precision peristaltic pump, add sodium tripolyphosphate solution dropwise into the high-speed sheared liquid stream at an extremely slow speed. This step is crucial for the formation of uniform nanoparticles. Too rapid a drop speed will lead to excessive local cross-linking and the formation of large particle precipitates. After the drop is completed, continue high-speed shearing for 15 minutes. You can observe that the system gradually changes from a clear state to a translucent or opalescent blue, which is a typical characteristic of nanoparticle formation. Take a sample and use a laser particle size analyzer to ensure that the particle size distribution D90 is within the range of 80-120 nm and the polydispersity index PDI is less than 0.25. Transfer the prepared smart responsive nanoemulsion to a sealed, light-proof storage tank and temporarily store it in an environment below 40°C, waiting for the next stage of mixing.

[0029] The mass ratio of deionized water to chitosan is 100:3. Chitosan, as a natural cationic polymer, is a sensitive material for constructing nanoparticles. It swells and disintegrates in a slightly alkaline environment caused by inflammation, which is key to achieving intelligent targeted release. The mass ratio of engineered agaritol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol is 10:8:35. Engineered agaritol glucoside, as a high-purity active ingredient obtained through synthetic biology, provides potent and stable anti-inflammatory and antioxidant core effects with zero batch-to-batch variation. Its water solubility is significantly improved after glycosylation modification. Dipotassium glycyrrhizate is not only itself... This highly effective classic anti-inflammatory agent's molecular structure can interact with chitosan, helping to stabilize the nanoparticle system. After release, it synergistically enhances the effects of linalool. 1,3-Butanediol serves as an excellent solvent, ensuring that all components are fully dissolved and mixed during preparation. It also possesses excellent moisturizing properties, reducing the need for other polyols in the formulation and making the system more refreshing. The mass ratio of sodium tripolyphosphate to deionized water is 3:40. Sodium tripolyphosphate, as an anion, undergoes ionic cross-linking with positively charged chitosan through electrostatic interaction, instantly forming a stable nanoparticle network structure that firmly encapsulates the active ingredient.

[0030] The preparation steps for the repair essence are as follows: In a small mixing vessel, accurately weigh ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol. Using a water bath or jacket heating method, slowly heat the mixture to 50-55°C while stirring at medium speed. Maintain this temperature and continue stirring until all solid components are completely dissolved, and the mixture becomes a clear, transparent, oily liquid. This step is crucial; any undissolved crystals will affect the uniformity of the final product. Preheat the nanoemulsion prepared in Module 1 to 50°C and add it to another clean mixing vessel. While stirring at approximately 800 rpm, the clear lipid phase prepared in step 1 is slowly added to the warm nanoemulsion in a thin stream. After the addition is complete, the stirrer is switched to a homogenizer and homogenized at 3000 rpm for 3-5 minutes to form a uniform, fine, milky white emulsion. The homogenized emulsion is then cooled to room temperature with gentle stirring (200-300 rpm) and transferred to a sealed container. It is then allowed to stand at room temperature in the dark for 24 hours. This process helps the system reach thermodynamic equilibrium and improves stability. After maturation, it can be used for final mixing.

[0031] The mass ratio of ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol is 10:6:3:10:40. Ceramide NP has a structure completely consistent with the lipid structure of the human stratum corneum, allowing it to directly embed into the damaged scalp stratum corneum, repairing the lipid bilayer like cement. This fundamentally enhances the scalp's water-locking and defense capabilities, reducing inflammation recurrence. Bisabolol, derived from chamomile, not only has anti-inflammatory properties but also promotes skin self-repair. It is gentle and non-irritating, especially suitable for sensitive scalps. Its effect is amplified when used in combination with dipotassium glycyrrhizate. Panthenol activates the skin's cold receptors, producing a strong, instantaneous cooling sensation. It can quickly divert nerve signals that cause itching, providing immediate psychological and physiological satisfaction by relieving itching in a second. Panthenol penetrates the stratum corneum and transforms into pantothenic acid, an important coenzyme for cell repair. It also has a strong hygroscopic and moisturizing ability, which can relieve dryness after cleansing and promote barrier recovery. Dipropylene glycol has excellent solubility for various polar and non-polar active ingredients, ensuring that the essence is clear and uniform, while also providing a refreshing feel to the skin and offering both moisturizing and gentle preservative effects.

[0032] The steps for preparing the shampoo base are as follows: Add deionized water to the main reactor, turn on the jacket heating, raise the water temperature to 75-80℃, start the high-speed disperser (speed about 1500rpm), form a vortex on the water surface, and slowly and evenly sprinkle xanthan gum powder into the vortex to avoid clumping. Continue high-speed shear dispersion for 30 minutes until xanthan gum is completely hydrated, and the system becomes homogeneous, transparent, and viscoelastic. This is a key step that determines the final viscosity and stability of the product. Maintain the temperature at 75°C, and add sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin sequentially while stirring. Continue stirring for about 30 minutes until all surfactants are completely dissolved and the material returns to a clear and transparent state. Turn on the cooling system of the reactor to cool the material at a controlled rate. When the temperature drops to 45°C, add guar gum hydroxypropyl trimethylammonium chloride and polydimethylsiloxane alcohol. Stir at a medium speed for 15-20 minutes to ensure uniform dispersion of the conditioning agents. Continue cooling to 40°C, add preservatives, add deionized water, and stir for 15 minutes to obtain a homogeneous shampoo base. Maintain the temperature at around 40°C in preparation for final mixing.

[0033] The mass ratio of deionized water to xanthan gum is 100:0.7; the mass ratio of sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin is 12:6:5:2; the mass ratio of guar gum hydroxypropyl trimethylammonium chloride and polydimethylsiloxane alcohol is 3:2; the mass ratio of nanoemulsion and repair essence is 3:2; and the mass ratio of nanoemulsion and shampoo base is 1:21. Xanthan gum, as a bio-collagen, can construct a strong three-dimensional network structure, giving the product shear-thinning properties. It can stably suspend nanoparticles for a long time, preventing sedimentation and stratification. Sodium methyl cocoyl taurate, as an amino acid surfactant, has a pH value close to that of a healthy scalp, moderate cleansing power, extremely low irritation, and rich, delicate foam. After washing, the scalp is not dry or tight, creating optimal conditions for subsequent care. Glucoside, derived from natural glucose and coconut oil, is extremely mild and significantly reduces overall formula irritation, while also providing excellent thickening and foam stability. Cocamidopropyl betaine, an amphoteric surfactant, significantly enriches and stabilizes foam, enhancing the washing experience. It also acts as a thickener, helping to achieve the appropriate formula viscosity. Glycerin helps maintain the moisture balance of the scalp and hair cuticle, alleviating potential dryness caused by surfactants. Guar gum hydroxypropyltrimethylammonium chloride cationic polymer gently adheres to the negatively charged surface of damaged hair during rinsing, significantly reducing frizz and static electricity, making hair easier to comb. It is also easier to rinse and more environmentally friendly than traditional silicone oil. Polydimethylsiloxane provides the smoothness and shine needed after hair dries, working synergistically with cationic conditioners to achieve dual smoothness for both wet and dry hair.

[0034] Example 3: An anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology, composed of the following raw materials in parts by weight: 5 parts nano-emulsion, 3.3 parts repair essence, and 105 parts shampoo base; The preparation steps of the anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology are as follows: S1. Add deionized water to a premix tank, slowly add chitosan and shear it through a sieve to obtain a chitosan solution. Put the chitosan solution into reactor A, and add engineered agaric tetraol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol in sequence. Stir until completely dissolved. Dissolve sodium tripolyphosphate in deionized water and add TPP solution to reactor A. The system changes from clear to pale blue opalescent. S2. Add ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol sequentially to the mixing tank, and stir until completely clear and transparent. Transfer the nanoemulsion in reactor A to reactor B, and add the lipid phase to reactor B. S3. Add deionized water to the main reactor, sprinkle in xanthan gum, and then add sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin in sequence. Stir until completely clear, then add guar gum hydroxypropyltrimethylammonium chloride and polydimethylsiloxane alcohol, and stir evenly. S4. Transfer all the material in reactor B to the main reactor and stir, then add deionized water and preservative and stir. S5. After final quality inspection, the final product shampoo is obtained.

[0035] The preparation steps of the nanoemulsion are as follows: Deionized water is added to a reaction vessel, and the temperature is raised to 45°C. While stirring at 800 rpm, low molecular weight chitosan powder is slowly and evenly added. The stirring speed is increased to 1200 rpm, and high-speed shearing is continued for 30 minutes to ensure complete hydration and dissolution of the chitosan, forming a transparent or slightly turbid viscous solution. The solution is filtered through a 200-mesh sieve to remove any possible undissolved particles or impurities, resulting in a clear chitosan solution. The temperature of the chitosan solution is stabilized at 40°C. While stirring at a medium speed of 400-600 rpm, engineered linalool glucoside, dipotassium glycyrrhizate, and 1,3-butanediol are added sequentially, maintaining stirring for approximately 15-20 minutes until all solid or liquid active ingredients are completely dissolved and the system becomes homogeneous. Sodium tripolyphosphate is dissolved in deionized water to prepare a clear solution. Clear the solution and start a high-speed shear press (adjust the speed to above 5000 rpm) to strongly shear the solution in the reactor. Using a precision peristaltic pump, add sodium tripolyphosphate solution dropwise into the high-speed sheared liquid stream at an extremely slow speed. This step is crucial for the formation of uniform nanoparticles. Too rapid a drop speed will lead to excessive local cross-linking and the formation of large particle precipitates. After the drop is completed, continue high-speed shearing for 15 minutes. You can observe that the system gradually changes from a clear state to a translucent or opalescent blue, which is a typical characteristic of nanoparticle formation. Take a sample and use a laser particle size analyzer to ensure that the particle size distribution D90 is within the range of 80-120 nm and the polydispersity index PDI is less than 0.25. Transfer the prepared smart responsive nanoemulsion to a sealed, light-proof storage tank and temporarily store it in an environment below 40°C, waiting for the next stage of mixing.

[0036] The mass ratio of deionized water to chitosan is 100:3. Chitosan, as a natural cationic polymer, is a sensitive material for constructing nanoparticles. It swells and disintegrates in a slightly alkaline environment caused by inflammation, which is key to achieving intelligent targeted release. The mass ratio of engineered agaritol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol is 10:8:35. Engineered agaritol glucoside, as a high-purity active ingredient obtained through synthetic biology, provides potent and stable anti-inflammatory and antioxidant core effects with zero batch-to-batch variation. Its water solubility is significantly improved after glycosylation modification. Dipotassium glycyrrhizate is not only itself... This highly effective classic anti-inflammatory agent's molecular structure can interact with chitosan, helping to stabilize the nanoparticle system. After release, it synergistically enhances the effects of linalool. 1,3-Butanediol serves as an excellent solvent, ensuring that all components are fully dissolved and mixed during preparation. It also possesses excellent moisturizing properties, reducing the need for other polyols in the formulation and making the system more refreshing. The mass ratio of sodium tripolyphosphate to deionized water is 3:40. Sodium tripolyphosphate, as an anion, undergoes ionic cross-linking with positively charged chitosan through electrostatic interaction, instantly forming a stable nanoparticle network structure that firmly encapsulates the active ingredient.

[0037] The preparation steps for the repair essence are as follows: In a small mixing vessel, accurately weigh ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol. Using a water bath or jacket heating method, slowly heat the mixture to 50-55°C while stirring at medium speed. Maintain this temperature and continue stirring until all solid components are completely dissolved, and the mixture becomes a clear, transparent, oily liquid. This step is crucial; any undissolved crystals will affect the uniformity of the final product. Preheat the nanoemulsion prepared in Module 1 to 50°C and add it to another clean mixing vessel. While stirring at approximately 800 rpm, the clear lipid phase prepared in step 1 is slowly added to the warm nanoemulsion in a thin stream. After the addition is complete, the stirrer is switched to a homogenizer and homogenized at 3000 rpm for 3-5 minutes to form a uniform, fine, milky white emulsion. The homogenized emulsion is then cooled to room temperature with gentle stirring (200-300 rpm) and transferred to a sealed container. It is then allowed to stand at room temperature in the dark for 24 hours. This process helps the system reach thermodynamic equilibrium and improves stability. After maturation, it can be used for final mixing.

[0038] The mass ratio of ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol is 10:6:3:10:40. Ceramide NP has a structure completely consistent with the lipid structure of the human stratum corneum, allowing it to directly embed into the damaged scalp stratum corneum, repairing the lipid bilayer like cement. This fundamentally enhances the scalp's water-locking and defense capabilities, reducing inflammation recurrence. Bisabolol, derived from chamomile, not only has anti-inflammatory properties but also promotes skin self-repair. It is gentle and non-irritating, especially suitable for sensitive scalps. Its effect is amplified when used in combination with dipotassium glycyrrhizate. Panthenol activates the skin's cold receptors, producing a strong, instantaneous cooling sensation. It can quickly divert nerve signals that cause itching, providing immediate psychological and physiological satisfaction by relieving itching. Panthenol penetrates the stratum corneum and transforms into pantothenic acid, an important coenzyme for cell repair. It also has a strong hygroscopic and moisturizing ability, which can relieve dryness after cleansing and promote barrier recovery. Dipropylene glycol has excellent solubility for various polar and non-polar active ingredients, ensuring that the essence is clear and uniform, while also providing a refreshing feel and combining moisturizing and gentle preservative effects.

[0039] The steps for preparing the shampoo base are as follows: Add deionized water to the main reactor, turn on the jacket heating, raise the water temperature to 75-80℃, start the high-speed disperser (speed about 1500rpm), form a vortex on the water surface, and slowly and evenly sprinkle xanthan gum powder into the vortex to avoid clumping. Continue high-speed shear dispersion for 30 minutes until xanthan gum is completely hydrated, and the system becomes homogeneous, transparent, and viscoelastic. This is a key step that determines the final viscosity and stability of the product. Maintain the temperature at 75°C, and add sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin sequentially while stirring. Continue stirring for about 30 minutes until all surfactants are completely dissolved and the material returns to a clear and transparent state. Turn on the cooling system of the reactor to cool the material at a controlled rate. When the temperature drops to 45°C, add guar gum hydroxypropyl trimethylammonium chloride and polydimethylsiloxane alcohol. Stir at a medium speed for 15-20 minutes to ensure uniform dispersion of the conditioning agents. Continue cooling to 40°C, add preservatives, add deionized water, and stir for 15 minutes to obtain a homogeneous shampoo base. Maintain the temperature at around 40°C in preparation for final mixing.

[0040] The mass ratio of deionized water to xanthan gum is 100:0.7; the mass ratio of sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin is 12:6:5:2; the mass ratio of guar gum hydroxypropyl trimethylammonium chloride and polydimethylsiloxane alcohol is 3:2; the mass ratio of nanoemulsion and repair essence is 3:2; and the mass ratio of nanoemulsion and shampoo base is 1:21. Xanthan gum, as a bio-collagen, can construct a strong three-dimensional network structure, giving the product shear-thinning properties. It can stably suspend nanoparticles for a long time, preventing sedimentation and stratification. Sodium methyl cocoyl taurate, as an amino acid surfactant, has a pH value close to that of a healthy scalp, moderate cleansing power, extremely low irritation, and rich, delicate foam. After washing, the scalp is not dry or tight, creating optimal conditions for subsequent care. Glucoside, derived from natural glucose and coconut oil, is extremely mild and significantly reduces overall formula irritation, while also providing excellent thickening and foam stability. Cocamidopropyl betaine, an amphoteric surfactant, significantly enriches and stabilizes foam, enhancing the washing experience. It also acts as a thickener, helping to achieve the appropriate formula viscosity. Glycerin helps maintain the moisture balance of the scalp and hair cuticle, alleviating potential dryness caused by surfactants. Guar gum hydroxypropyltrimethylammonium chloride cationic polymer gently adheres to the negatively charged surface of damaged hair during rinsing, significantly reducing frizz and static electricity, making hair easier to comb. It is also easier to rinse and more environmentally friendly than traditional silicone oil. Polydimethylsiloxane provides the smoothness and shine needed after hair dries, working synergistically with cationic conditioners to achieve dual smoothness for both wet and dry hair.

[0041] Comparative Example 1: The difference between this comparative example and Example 1 is that this example uses intelligently responsive nanoemulsions.

[0042] Comparative Example 2 differs from Example 1 in that dipotassium glycyrrhizate is used in this example to inhibit the inflammatory response.

[0043] Comparative Example 3 differs from Example 1 in that this example generates a clean system.

[0044] Performance testing: The performance of the anti-inflammatory and antipruritic shampoos based on agarwood nano-microemulsion technology provided in Examples 1-3 and Comparative Examples 1-3 was tested respectively, and the test data are recorded in the table below:

[0045] Among them, the pH-responsive release rate of anti-inflammatory and antipruritic shampoos based on agarwood nano-microemulsion technology was tested using the test methods in GB / T 22235-2008 in Experiment 1, Experiment 2, Experiment 3, Comparative Example 1, Comparative Example 2 and Comparative Example 3. The scalp barrier repair rate of anti-inflammatory and antipruritic shampoos based on agarwood nano-microemulsion technology was tested using the test methods in GB / T 29665-2013 in Experiment 1, Experiment 2, Experiment 3, Comparative Example 1, Comparative Example 2 and Comparative Example 3. Low-temperature stability tests were conducted on anti-inflammatory and antipruritic shampoos based on agarwood nanoemulsion technology prepared according to the test methods in GB / T 13531.1-2008, including Experiment 1, Experiment 2, Experiment 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3.

[0046] By comparing and analyzing the relevant data in the table, it can be seen that the anti-inflammatory and anti-itch shampoo based on agarwood nanoemulsion technology prepared in this invention effectively improves the utilization rate and targeting of active ingredients through its nanoemulsion system. Ceramide NP significantly enhances the scalp's moisture retention and barrier repair capabilities, while the gentle cleansing system ensures cleansing power while avoiding barrier damage. This indicates that the preparation method of the anti-inflammatory and anti-itch shampoo based on agarwood nanoemulsion technology provided by this invention has a broader market prospect and is more suitable for promotion.

[0047] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0048] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. An anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology, characterized in that, It is composed of the following ingredients by weight: 4-5 parts nano-emulsion, 2.7-3.3 parts repair essence, and 84-105 parts shampoo base; The preparation steps of the anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology are as follows: S1. Add deionized water to a premix tank, slowly add chitosan and shear it through a sieve to obtain a chitosan solution. Put the chitosan solution into reactor A, and add engineered agaric tetraol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol in sequence. Stir until completely dissolved. Dissolve sodium tripolyphosphate in deionized water and add TPP solution to reactor A. The system changes from clear to pale blue opalescent. S2. Add ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol sequentially to the mixing tank, and stir until completely clear and transparent. Transfer the nanoemulsion in reactor A to reactor B, and add the lipid phase to reactor B. S3. Add deionized water to the main reactor, sprinkle in xanthan gum, and then add sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerin in sequence. Stir until completely clear, then add guar gum hydroxypropyltrimethylammonium chloride and polydimethylsiloxane alcohol, and stir evenly. S4. Transfer all the material in reactor B to the main reactor and stir, then add deionized water and preservative and stir. S5. After final quality inspection, the final product shampoo is obtained.

2. The anti-inflammatory and antipruritic shampoo based on agarwood nanoemulsion technology according to claim 1, characterized in that, The nanoemulsion preparation steps are as follows: Deionized water is added to the reaction vessel, chitosan is sprinkled in to obtain a clear chitosan solution, engineered agaritol glucoside, dipotassium glycyrrhizate and 1,3-butanediol are added in sequence until all solid or liquid active ingredients are completely dissolved, sodium tripolyphosphate is dissolved in deionized water to prepare a clear solution, the sodium tripolyphosphate solution is added to the liquid stream, and the system gradually changes from a clear state to a milky blue color, waiting to enter the next stage of mixing.

3. The anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology according to claim 2, characterized in that, The mass ratio of deionized water to chitosan is 100:3, and the mass ratio of engineered agaric tetraol glucoside, dipotassium glycyrrhizate, and 1,3-butanediol is 10:8:

35.

4. The anti-inflammatory and antipruritic shampoo based on agarwood nanoemulsion technology according to claim 2, characterized in that, The mass ratio of sodium tripolyphosphate to deionized water is 3:

40.

5. The anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology according to claim 1, characterized in that, The repair essence is prepared as follows: Ceramide NP, bisabolol, menthol, panthenol and dipropylene glycol are added to a small mixing tank and stirred continuously until completely dissolved to form a clear and transparent oily liquid. The clear lipid phase is added to the warm nanoemulsion to form a uniform, delicate, milky white emulsion, which is then transferred to a sealed container and allowed to mature before final mixing.

6. The anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology according to claim 5, characterized in that, The mass ratio of ceramide NP, bisabolol, menthol, panthenol, and dipropylene glycol is 10:6:3:10:

40.

7. The anti-inflammatory and antipruritic shampoo based on agarwood nanoemulsion technology according to claim 1, characterized in that, The preparation steps of the shampoo matrix are as follows: Deionized water is added to the main reaction vessel, xanthan gum is sprinkled into the vortex, and sodium methyl cocoyl taurate, decyl glucoside, cocamidopropyl betaine and glycerin are added in sequence under stirring until all surfactants are completely dissolved. Guar hydroxypropyl trimethylammonium chloride and polydimethylsiloxane alcohol are added, preservatives are added, and deionized water is added to prepare for final mixing.

8. The anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology according to claim 7, characterized in that, The mass ratio of deionized water to xanthan gum is 100:0.7, and the mass ratio of sodium methylcocoyl taurate, decyl glucoside, cocamidopropyl betaine, and glycerol is 12:6:5:

2.

9. The anti-inflammatory and antipruritic shampoo based on agarwood nano-microemulsion technology according to claim 7, characterized in that, The mass ratio of guar hydroxypropyltrimethylammonium chloride to polydimethylsiloxane alcohol is 3:

2.

10. The anti-inflammatory and antipruritic shampoo based on agarwood nanoemulsion technology according to claim 1, characterized in that, The mass ratio of the nanoemulsion to the repair essence is 3:2, and the mass ratio of the nanoemulsion to the shampoo base is 1:21.

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