A baby care level shampoo bath foam composition and a method for preparing the same

Abstract

The application discloses a baby-care grade shampoo and bath foam composition and a preparation method thereof. The composition is prepared from deionized water, a fatty acid, an amino acid surfactant, natural preservative multi-compartment liposome nanoparticles prepared from three kinds of preservative-free additive system raw materials, a baby-care grade hair and skin conditioner, a baby-care grade moisturizing agent and a non-sensitizing fragrance. The innovation lies in abandoning traditional cosmetic preservatives, adopting a non-preservative system friendly to babies and children, which can pass the preservative challenge test, ensure that the product is not easily contaminated by microorganisms, and is mild and non-irritating to the delicate skin of babies and children. The non-sensitizing fragrance makes the whole system more mild, non-irritating and non-sensitizing.

Description

Technical Field

[0001] This invention belongs to the field of daily necessities, specifically relating to a baby-care grade shampoo and body wash foam composition and its preparation method. Background Technology

[0002] Children's cosmetics have extremely strict safety requirements in their formulation design. According to the "Regulations on the Supervision and Administration of Children's Cosmetics," children's cosmetics should adhere to the principles of safety first, essential efficacy, and minimalist formulation, and should use cosmetic raw materials with a long history of safe use. Infants' skin has a thin stratum corneum and its barrier function is not yet fully developed, making it extremely sensitive to external stimuli. Therefore, the selection of preservatives, surfactants, fragrances, and other ingredients in children's washing and care products must be extremely gentle, low in irritation, and low in allergens.

[0003] Chemical preservatives widely used in traditional shampoos and body washes, such as phenoxyethanol, parabens, formaldehyde releasers (such as DMDM ​​hydantoin), and isothiazolinones, while showing good antibacterial effects, have faced increasing scrutiny regarding their safety in recent years. Phenoxyethanol at high concentrations may cause skin burning and irritation; parabens are suspected of having potential endocrine-disrupting effects; and formaldehyde releasers are strictly limited in their use in children's toiletries due to their release of free formaldehyde.

[0004] To meet consumer demand for "green," "natural," and "additive-free" products, the industry has attempted to replace traditional chemical preservatives with natural ingredients such as plant extracts and fermentation products. However, existing natural preservative solutions still have many shortcomings: single plant extracts often have limited preservative effects and are difficult to effectively inhibit bacteria and fungi simultaneously; simple combinations of multiple natural ingredients lack a clear synergistic mechanism, resulting in unstable antibacterial effects; some natural extracts themselves contain allergens (such as linalool and limonene in certain plant essential oils), making them unsuitable for the sensitive skin of infants and young children. In addition, commonly used surfactants (such as sodium lauryl ether sulfate) and fragrance systems in existing products can easily cause skin irritation and allergic reactions, making it difficult to meet the gentleness requirements of infant-grade products. Summary of the Invention

[0005] To overcome the shortcomings of existing technologies, one objective of this invention is to provide a baby-grade shampoo and body wash foam composition and its preparation method. This composition utilizes three natural preservatives from different sources to construct a synergistic preservative system. While ensuring broad-spectrum antibacterial properties, it achieves the goals of being gentle, non-irritating, non-allergenic, and free of chemically synthesized preservatives. This addresses the technical deficiencies of traditional chemical preservatives (such as phenoxyethanol, hydroxyphenyl esters, formaldehyde releasers, etc.) in children's personal care products, including skin irritation, allergy risks, narrow antibacterial spectrum, and unstable efficacy.

[0006] One objective of this invention is to provide a baby-care grade shampoo and body wash foam composition comprising the following components: 3-7 parts glutamic acid surfactant, 8-12 parts auxiliary surfactant, 8-12 parts neutral amino acid surfactant, 0.1-1 part natural preservative, 0.1-1 part plant fermentation filtrate, 0.1-1 part fungal fermentation product, 0.5-5 parts phospholipid, 0.1-1 part cholesterol, 0.1-0.5 parts natural fragrance, 0.1-0.5 parts quaternary ammonium salt, 0.2-0.6 parts fatty acid, 1-3 parts moisturizer, and 60-75 parts deionized water.

[0007] Furthermore, the 0.1-1 parts of natural preservative, 0.1-1 parts of plant fermentation filtrate, 0.1-1 parts of fungal fermentation product, 0.5-5 parts of phospholipid, and 0.1-1 parts of cholesterol together form multi-compartment liposome nanoparticles with natural preservative properties.

[0008] Furthermore, the natural preservative is one of shikonin, shikonin root extract, or acetylshikonin; the plant fermentation filtrate is one of radish root fermentation filtrate or soybean extract fermentation product filtrate; and the fungal ferment is one of tremella-ganoderma complex ferment, rice-ganoderma complex ferment, or poria-ganoderma complex ferment.

[0009] Further, the glutamic acid surfactant is one of disodium cocoyl glutamate, sodium cocoyl glutamate, or disodium lauroyl glutamate; the auxiliary surfactant is one of sodium lauroamphoacetate, cocamidopropyl betaine, or lauryl glucoside; and the neutral amino acid surfactant is one of sodium lauroyl glutamate, sodium cocoyl glycinate, or sodium methyl cocoyl taurate.

[0010] Furthermore, the natural fragrance is selected from one of calendula extract, peach extract, or golden chamomile extract.

[0011] Furthermore, the quaternary ammonium salt is one of polyquaternary ammonium salt-10, guar hydroxypropyltrimethylammonium chloride, polyquaternary ammonium salt-7, or polyquaternary ammonium salt-67.

[0012] The fatty acid is selected from any one of coconut oil acid, lauric acid or palmitic acid; Furthermore, the moisturizer is one of glycerin, sodium hyaluronate, or trehalose; The second objective of this invention is to provide a method for preparing a baby-care grade shampoo and body wash foam composition, the preparation process comprising the following steps: (1) Dissolve natural preservatives, phospholipids and cholesterol in anhydrous ethanol and evaporate them in a rotary evaporator at 65-70℃ to form a film; add plant fermentation filtrate to the rotary evaporator and hydrate it in the film in the rotary evaporator at 40-50℃ to form liposomes; mix the bacterial fermentation product with the liposomes and incubate them at 30-40℃ for 50-60 minutes to allow the bacterial fermentation product to be adsorbed on the surface of the liposomes, thus forming multi-compartment liposome nanoparticles; (2) Add the multi-compartment nanoparticles, quaternary ammonium salt and deionized water to a heated stirring pot in sequence, while homogenizing and stirring. The homogenization temperature is 75~85℃ and the stirring speed is 200~600 rpm. After stirring evenly, add the glutamic acid surfactant while stirring, and stir evenly at 75~85℃. Then add the plant fermentation filtrate and fatty acids in sequence, and stir at 75~85℃ until dissolved evenly to obtain the premix. (3) Stop heating, and while stirring continuously, add the auxiliary surfactant to the premix and stir at 75~85℃ for 4~6 minutes until completely dissolved; cool down to 55~65℃, and while stirring continuously, add the neutral amino acid surfactant and stir for 2~6 minutes until dissolved evenly without particles; cool down to 40~50℃, and while stirring, add the moisturizer and natural fragrance and stir for 3~8 minutes until evenly mixed; cool down to room temperature and then discharge the material through a 300~500 mesh filter cloth and let it stand to obtain the baby care grade shampoo and body wash foam composition.

[0013] Compared with the prior art, the present invention has the following beneficial effects: (1) This invention is the first to integrate comfrey-based natural preservatives, plant fermentation filtrate, and fungal fermentation products into the same multi-compartment liposome nanoparticle. The three are loaded in sections at the nanoscale and delivered spatiotemporally synchronously: comfrey-based preservatives are embedded in the hydrophobic region of the lipid bilayer membrane, plant fermentation filtrate is encapsulated in the internal hydrophilic core, and fungal fermentation products are anchored on the surface of the nanoparticle to form a functionalized "canopy". The three form a three-dimensional synergistic antibacterial effect from multiple target levels, such as destroying bacterial membranes, generating organic acids to lower pH, secreting antimicrobial peptides, and regulating osmotic pressure.

[0014] (2) This invention completely eliminates chemically synthesized preservatives such as phenoxyethanol and hydroxyphenyl esters, and adopts a ternary compound system of glutamic acid surfactant, auxiliary surfactant and neutral amino acid surfactant, combined with fatty acid to regulate foaming, which ensures detergency and foaming properties while having extremely low irritation to the skin and eye mucous membranes. The selected natural fragrances such as calendula, peach, and golden chamomile do not contain the 26 fragrance allergens listed in EU regulations.

[0015] (3) The microbial fermentation products anchored on the outer surface of the liposome have excellent stratum corneum adhesion properties. They can stably prolong the residence time of nanoparticles on the skin surface through steric hindrance, enhance the transdermal absorption and retention of shikonin and moisturizers (glycerin, sodium hyaluronate, trehalose), and achieve a delivery gradient of "adhesion, penetration, and deep release". This invention adopts a preparation method that combines multi-compartment liposome nanoparticle prefabrication with phase-separated feeding and segmented temperature control. The parameters of each step are clear, no special expensive equipment is required, and it is highly compatible with conventional washing and care product production lines, making it suitable for large-scale production. Attached Figure Description

[0016] Figure 1 Scanning electron microscope image of multi-compartment liposome nanoparticles, which are natural preservatives.

[0017] Figure 2 Product image of a baby-care grade shampoo and body wash foam composition. Detailed Implementation

[0018] The present invention will be further described in conjunction with the accompanying drawings and specific embodiments. It should be noted that, without conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments. Specific conditions not specified in the embodiments are based on conventional conditions or product instructions. Unless otherwise specified, all reagents or instruments used are conventional products obtained through commercial channels.

[0019] Example 1 A baby-grade shampoo and body wash foam composition comprising the following parts by weight: 5 parts disodium cocoyl glutamate, 10 parts sodium lauroyl amphotericate, 10 parts sodium lauroyl glutamate, 0.5 parts shikonin, 0.5 parts radish root ferment filtrate, 0.5 parts Tremella fuciformis and Ganoderma lucidum complex ferment, 3 parts phospholipids, 0.5 parts cholesterol, 0.3 parts calendula extract, 0.3 parts polyquaternium-10, 0.2 parts coconut oil acid, 0.2 parts lauric acid, 2 parts glycerin, and 67.5 parts deionized water.

[0020] The specific preparation method of the baby-care grade shampoo and body wash foam composition is as follows: (1) Dissolve 0.5 parts of shikonin, 3 parts of phospholipid and 0.5 parts of cholesterol in anhydrous ethanol, and evaporate them into a film in a rotary evaporator at 68℃. Then add 0.5 parts of radish root fermentation filtrate to the rotary evaporator and hydrate it in the film in the rotary evaporator at 45℃ to form liposomes. Mix 0.5 parts of tremella and ganoderma complex fermentation product with liposomes and incubate at 35℃ for 55 minutes to adsorb tremella and ganoderma complex fermentation product on the surface of liposomes, thus forming multi-compartment liposome nanoparticles. (2) The prepared multi-compartment liposome nanoparticles (multi-compartment liposome nanoparticles such as Figure 1(As shown) and 0.3 parts of polyquaternium-10 were added sequentially to 67.5 parts of deionized water, and the mixture was homogenized while stirring. The homogenization temperature was 80℃ and the stirring speed was 400 rpm. After stirring evenly, 5 parts of disodium cocoyl glutamate were added while stirring, and the mixture was stirred evenly at 80℃. 0.2 parts of coconut oil acid and 0.2 parts of lauric acid were added to the mixture, and the mixture was stirred evenly at 80℃ to obtain the premix. (3) Add 10 parts of sodium lauroylamphoacetate to the premix and stir at 80°C for 5 minutes; cool down to 60°C, and while stirring, add 10 parts of sodium lauroyl glutamate and stir for 4 minutes; cool down to 45°C, and while stirring, add 2 parts of glycerin and 0.3 parts of calendula extract and stir for 5 minutes; cool to room temperature and then filter through a 400-mesh filter cloth and let stand to obtain the baby-care grade shampoo and body wash foam composition. The baby-care grade shampoo and body wash foam composition product is as follows: Figure 2 As shown.

[0021] Example 2 A baby-care grade shampoo and body wash foam composition comprises the following components by weight: 3 parts sodium cocoyl glutamate, 8 parts cocamidopropyl betaine, 8 parts sodium cocoyl glycinate, 0.1 part Lithospermum erythrorhizon root extract, 0.1 part soybean extract fermentation product filtrate, 0.1 part rice Ganoderma lucidum complex fermentation product, 0.5 parts phospholipids, 0.1 part cholesterol, 0.1 part peach fruit extract, 0.1 part guar gum hydroxypropyltrimethylammonium chloride, 0.1 part lauric acid, 0.1 part myristic acid, 1 part sodium hyaluronate, and 60 parts deionized water; the specific preparation method of the baby-care grade shampoo and body wash foam composition is as follows: (1) Dissolve 0.1 parts of Lithospermum erythrorhizon root extract, 0.5 parts of phospholipids and 0.1 parts of cholesterol in anhydrous ethanol, and evaporate them into a film in a rotary evaporator at 65°C. Then add 0.1 parts of soybean extract fermentation product filtrate to the rotary evaporator and hydrate it in the film in the rotary evaporator at 40°C to form liposomes. Mix 0.1 parts of rice Ganoderma lucidum complex fermentation product with liposomes and incubate at 30°C for 50 minutes to allow rice Ganoderma lucidum complex fermentation product to be absorbed on the surface of the liposomes, thus forming multi-compartment liposome nanoparticles. (2) Add the multi-compartment nanoparticles and 0.1 part of guar hydroxypropyltrimethylammonium chloride to 60 parts of deionized water in sequence, and stir while homogenizing. The homogenization temperature is 75℃ and the stirring speed is 200 rpm. After stirring evenly, add 3 parts of sodium cocoyl glutamate while stirring, and stir evenly at 75℃. Then add 0.1 part of lauric acid and 0.1 part of myristic acid to it, and stir evenly at 75℃ to obtain the premix. (3) Add 8 parts of cocamidopropyl betaine to premix 1 and stir at 75°C for 4 min; cool down to 55°C and add 8 parts of sodium cocoyl glycinate while stirring for 2 min; cool down to 40°C and add 1 part of sodium hyaluronate and 0.1 parts of peach extract while stirring, and continue to cool down and stir for 3 min; after cooling to room temperature, discharge the material through a 300-mesh filter cloth and let it stand to obtain the baby care grade shampoo and body foam composition.

[0022] Example 3 A baby-care grade shampoo and body wash foam composition comprises the following components by weight: 7 parts disodium lauroyl glutamate, 12 parts lauryl glucoside, 12 parts sodium methyl cocoyl taurate, 1 part acetylshikonin, 1 part radish root fermentation filtrate, 1 part Poria cocos and Ganoderma lucidum complex fermentation product, 5 parts phospholipids, 1 part cholesterol, 0.5 parts golden chamomile extract, 0.5 parts polyquaternium-7, 0.3 parts palmitic acid, 0.3 parts stearic acid, 3 parts trehalose, and 75 parts deionized water; the specific preparation method of the baby-care grade shampoo and body wash foam composition is as follows: (1) Dissolve 1 part acetylshikonin, 5 parts phospholipids and 1 part cholesterol in anhydrous ethanol and evaporate them into a film in a rotary evaporator at 70°C; add 1 part radish root fermentation filtrate to the rotary evaporator and hydrate it in the film in the rotary evaporator at 50°C to form liposomes; mix 1 part Poria cocos and Ganoderma lucidum complex fermentation product with liposomes and incubate at 40°C for 60 minutes to adsorb Poria cocos and Ganoderma lucidum complex fermentation product on the surface of liposomes, thus forming multi-compartment liposome nanoparticles; (2) Add the multi-compartment nanoparticles and 0.5 parts of polyquaternium-7 to 75 parts of deionized water in sequence, and stir while homogenizing. The homogenization temperature is 85℃ and the stirring speed is 600 rpm. After stirring evenly, add 7 parts of disodium lauroyl glutamate while stirring, and stir evenly at 85℃. Then add 0.3 parts of palmitic acid and 0.3 parts of stearic acid to it, and stir evenly at 85℃ to obtain the premix. (3) Add 12 parts of lauryl glucoside to the premix and stir at 85°C for 6 min until completely dissolved; cool down to 65°C and add 12 parts of sodium methyl cocoyl taurate while stirring for 6 min; cool down to 50°C and add 3 parts of trehalose and 0.5 parts of golden chamomile extract while stirring and continue to cool down and stir for 8 min; cool down to room temperature and then discharge the material through a 500 mesh filter cloth and let it stand to obtain the baby care grade shampoo and body foam composition.

[0023] Example 4 A baby-care grade shampoo and body wash foam composition comprising the following parts by weight: 5 parts disodium cocoyl glutamate, 10 parts sodium lauroyl amphotericate, 10 parts sodium lauroyl glutamate, 0.5 parts shikonin, 0.1 part soybean extract fermentation product filtrate, 1 part Poria cocos and Ganoderma lucidum complex fermentation product, 3 parts phospholipids, 1 part cholesterol, 0.3 parts calendula extract, 0.3 parts polyquaternium-10, 0.2 parts coconut oil acid, 0.2 parts lauric acid, 2 parts glycerin, and 67.5 parts deionized water.

[0024] The specific preparation method of the baby-care grade shampoo and body wash foam composition is as follows: (1) Dissolve 0.5 parts of shikonin, 3 parts of phospholipids and 1 part of cholesterol in anhydrous ethanol, and evaporate them into a film in a rotary evaporator at 66℃. Then add 0.1 parts of soybean extract fermentation product filtrate to the rotary evaporator and hydrate it in the film in the rotary evaporator at 47℃ to form liposomes. Mix 1 part of Poria cocos and Ganoderma lucidum complex fermentation product with the liposomes and incubate at 36℃ for 58 minutes to adsorb the Tremella fuciformis and Ganoderma lucidum complex fermentation product on the surface of the liposomes, thus forming multi-compartment liposome nanoparticles. (2) The prepared multi-compartment liposome nanoparticles and 0.3 parts of polyquaternium-10 were added to 67.5 parts of deionized water, and the mixture was homogenized and stirred at a temperature of 80°C and a stirring speed of 400 rpm. After the mixture was stirred evenly, 5 parts of disodium cocoyl glutamate were added and stirred evenly at 80°C. 0.2 parts of cocoyl acid and 0.2 parts of lauric acid were added and stirred evenly at 80°C to obtain the premix. (3) Add 10 parts of sodium lauroyl amphotericate to the premix and stir at 80°C for 5 min; cool down to 60°C and add 10 parts of sodium lauroyl glutamate while stirring and stir for 4 min; cool down to 45°C and add 2 parts of glycerin and 0.3 parts of calendula extract while stirring and stir for 5 min; cool down to room temperature and then discharge the material through a 400-mesh filter cloth and let it stand to obtain the baby care grade shampoo and body foam composition.

[0025] Example 5 A baby-care grade shampoo and body wash foam composition comprises the following components by weight: 3 parts sodium cocoyl glutamate, 8 parts cocamidopropyl betaine, 8 parts sodium cocoyl glycinate, 0.1 part acetylshikonin, 1 part radish root fermentation filtrate, 0.1 part rice Ganoderma lucidum complex fermentation product, 5 parts phospholipids, 0.1 part cholesterol, 0.1 part peach fruit extract, 0.1 part guar gum hydroxypropyltrimethylammonium chloride, 0.1 part lauric acid, 0.1 part myristic acid, 1 part sodium hyaluronate, and 60 parts deionized water; the specific preparation method of the baby-care grade shampoo and body wash foam composition is as follows: (1) Dissolve 0.1 parts of Lithospermum erythrorhizon root extract, 5 parts of phospholipids and 0.1 parts of cholesterol in anhydrous ethanol, and evaporate them into a film in a rotary evaporator at 70°C. Then add 1 part of radish root fermentation filtrate to the rotary evaporator and hydrate it in the film in the rotary evaporator at 40°C to form liposomes. Mix 0.1 parts of rice Ganoderma lucidum complex fermentation product with the liposomes and incubate at 30°C for 50 minutes to allow the rice Ganoderma lucidum complex fermentation product to be absorbed on the surface of the liposomes, thus forming multi-compartment liposome nanoparticles. (2) Add the multi-compartment nanoparticles and 0.1 part of guar hydroxypropyltrimethylammonium chloride to 60 parts of deionized water in sequence, and stir while homogenizing. The homogenization temperature is 75℃ and the stirring speed is 200 rpm. After stirring evenly, add 3 parts of sodium cocoyl glutamate while stirring, and stir evenly at 75℃. Then add 0.1 part of lauric acid and 0.1 part of myristic acid to it, and stir evenly at 75℃ to obtain the premix. (3) Add 8 parts of cocamidopropyl betaine to premix 1 and stir at 75°C for 4 min; cool down to 55°C and add 8 parts of sodium cocoyl glycinate while stirring for 2 min; cool down to 40°C and add 1 part of sodium hyaluronate and 0.1 parts of peach extract while stirring, and continue to cool down and stir for 3 min; after cooling to room temperature, discharge the material through a 300-mesh filter cloth and let it stand to obtain the baby care grade shampoo and body foam composition.

[0026] Comparative Example 1 A baby-care grade shampoo and body wash foam composition comprising the following parts by weight: 5 parts disodium cocoyl glutamate, 10 parts sodium lauroyl amphotericate, 10 parts sodium lauroyl glutamate, 0.55 parts shikonin, 0.55 parts radish root ferment filtrate, 0.55 parts Tremella fuciformis and Ganoderma lucidum complex ferment, 0.3 parts calendula extract, 0.3 parts polyquaternium-10, 0.2 parts cocoacid, 0.2 parts lauric acid, 2 parts glycerin, and 67.5 parts deionized water.

[0027] The specific preparation method of the baby-care grade shampoo and body wash foam composition is as follows: (1) Add 0.55 parts of shikonin and 0.3 parts of polyquaternium-10 to 67.5 parts of deionized water in sequence, while homogenizing and stirring. The homogenization temperature is 80℃ and the stirring speed is 400 rpm. After stirring evenly, add 5 parts of disodium cocoyl glutamate while stirring, and stir evenly at 80℃. Then add 0.55 parts of radish root fermentation filtrate, 0.2 parts of coconut oil acid and 0.2 parts of lauric acid to it, and stir evenly at 80℃ to obtain premix 1. (2) Add 10 parts of sodium lauroyl amphoteric acid to premix 1 and stir at 80°C for 5 min; cool down to 60°C and add 10 parts of sodium lauroyl glutamate while stirring for 4 min; cool down to 45°C and add 2 parts of glycerin, 0.55 parts of Tremella fuciformis and Ganoderma lucidum compound fermentation product and 0.3 parts of calendula extract while stirring for 5 min; cool down to room temperature and then discharge the material through a 400 mesh filter cloth and let it stand to obtain the baby care grade shampoo and body foam composition.

[0028] Comparative Example 2 A baby-grade shampoo and body wash foam composition comprises the following components by weight: 5 parts disodium cocoyl glutamate, 10 parts sodium lauroyl amphotericate, 10 parts sodium lauroyl glutamate, 0.5 parts shikonin, 0.5 parts radish root fermentation filtrate, 3 parts phospholipids, 0.5 parts cholesterol, 0.3 parts calendula extract, 0.3 parts polyquaternium-10, 0.2 parts coconut acid, 0.2 parts lauric acid, 2 parts glycerin, and 67.5 parts deionized water; the specific preparation method is as follows: the preparation method is the same as in Example 1, except that the Tremella fuciformis and Ganoderma lucidum compound fermentation product is not added in step (1), and the other steps are completely the same.

[0029] Comparative Example 3 A baby-care grade shampoo and body wash foam composition comprising the following parts by weight: 5 parts disodium cocoyl glutamate, 10 parts sodium lauroyl amphotericate, 10 parts sodium lauroyl glutamate, 0.5 parts shikonin, 3 parts phospholipids, 0.5 parts cholesterol, 0.3 parts calendula extract, 0.3 parts polyquaternium-10, 0.2 parts coconut oil, 0.2 parts lauric acid, 2 parts glycerol and 67.5 parts deionized water; the specific preparation method is the same as in Example 1, but in step (1), radish root fermentation filtrate and tremella-ganoderma complex fermentation product are not added, and the remaining steps are completely the same.

[0030] Comparative Example 4 A baby-care grade shampoo and body wash foam composition comprises the following components by weight: 5 parts disodium cocoyl glutamate, 10 parts sodium lauroyl amphotericate, 10 parts sodium lauroyl glutamate, 0.3 parts calendula extract, 0.3 parts polyquaternium-10, 0.2 parts coconut acid, 0.2 parts lauric acid, 2 parts glycerin and 67.5 parts deionized water; its specific preparation method is the same as in Example 1, but in step (1), shikonin, radish root fermentation filtrate and tremella-ganoderma complex fermentation product, phospholipids and cholesterol are not added, and the remaining steps are completely the same.

[0031] Test case The performance of the foam compositions prepared in Examples 1-5 and Comparative Examples 1-4 was tested. I. According to the evaluation criteria of the 2015 edition of the "Cosmetic Hygiene Standard", a 28-day preservative test was conducted on Examples 1-3 and Comparative Examples 1-3 after a single bacterial inoculation. 20g of the foam compositions prepared in Examples 1-3 and Comparative Examples 1-3 were weighed, and 0.2mL of a suspension of mixed bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, with the inoculation numbers of the three bacteria maintained at the same order of magnitude) and mixed fungi (Aspergillus niger and Candida albicans, two types, ensuring that the bacterial or fungal quantities in the tested samples are at the same order of magnitude) were added respectively. 5 Or 10 6 The bacterial count (CFU / g) was analyzed in samples taken on days 2, 7, and 28 after inoculation. The results are shown in Table 1.

[0032] Table 1 Results of the Corrosion Resistance Challenge Experiment II. Overall Effect Evaluation: Thirty test subjects were randomly selected and divided into 6 groups. The foam compositions prepared in Examples 1-5 and Comparative Examples 1-4 were used for bathing and shampooing, respectively. Use was once daily for 4 weeks. The total score for each effect was 5 points, the highest indicating very good or excellent; 4 points indicated very good; 3 points indicated acceptable; and below 3 points indicated unacceptable. The results are shown in Table 2.

[0033] Table 2 Results of the overall evaluation of the samples Test results show that the technical solution of this invention is significantly better than the comparative example in terms of both corrosion resistance and overall effectiveness. The specific analysis is as follows: As shown in Table 1, in Example 15, the colony count dropped to 0 on the second day after inoculation with mixed bacteria and mixed fungi, and remained at 0 on the 28th day. This fully met the pass criteria for the 2015 edition of the Cosmetic Hygiene Standard for Preservative Challenge Test (bacteria <10 CFU / g on day 7, fungi <10 CFU / g on day 14). This indicates that the multi-compartment liposome nanoparticles used in this invention encapsulate and synergistically deliver the three components of shikonin, plant fermentation filtrate, and fungal fermentation product in separate compartments. The three components exert their effects on multiple targets, such as disrupting cell membranes, generating organic acids and antimicrobial peptides, and regulating osmotic pressure, respectively, achieving a rapid and thorough broad-spectrum antibacterial effect.

[0034] Comparative Example 1 (all three components complete but not nano-sized): A small number of bacteria (50 CFU / g) and fungi (60 CFU / g) still survived on day 2, and were eliminated by day 7, indicating that nano-co-delivery significantly enhanced the antibacterial onset speed. Comparative Example 2 (lacking microbial fermentation products, other components nano-sized): Bacterial and fungal clearance was slower, with residues remaining on day 7. Bacteria were eliminated by day 28, but fungi were zero, failing to fully pass the challenge. Comparative Example 3 (only shikonin retained and nano-sized): Bacteria and fungi multiplied rapidly on day 2 and remained at high levels throughout 28 days, completely failing to meet preservative requirements. Comparative Example 4 (containing no natural preservatives): The colony count continued to increase, indicating that relying solely on surfactants and fragrances cannot inhibit microorganisms.

[0035] Comparing Example 1 and Comparative Example 1, both have identical chemical compositions (containing shikonin, radish root fermentation filtrate, and Tremella fuciformis and Ganoderma lucidum complex fermentation products). The only difference is that the three components in Example 1 are pre-integrated into multi-compartment liposome nanoparticles, while those in Comparative Example 1 are simply physically mixed and directly added to the formulation. However, the data in Table 1 show that on day 2, the number of bacteria and fungi in Example 1 was 0, while on day 2, Comparative Example 1 still had 5060 CFU / g of viable cells. This is because spatial partitioning avoids antagonistic reactions between components: when mixed freely, the organic acids in the radish root fermentation filtrate may non-specifically bind to shikonin, reducing its membrane activity; while the liposomes tightly encapsulate shikonin in a hydrophobic bilayer and isolate the fermentation filtrate in the internal aqueous phase, ensuring that the two do not interfere with each other during storage and are released synchronously during use. The fungal fermentation product is anchored on the surface of the nanoparticles, and the hydroxyl groups on its molecular chains form hydrogen bonds with ceramides in the stratum corneum of the skin, extending the residence time of the nanoparticles by 23 times after application, thus providing sufficient contact time for the active ingredients. In Comparative Example 1, the free Tremella fuciformis and Ganoderma lucidum complex fermentation product was easily washed away during the rinsing process, resulting in reduced utilization.

[0036] As shown in Table 2, Example 15 received extremely high ratings (4.8-5.0 points) in both nourishing and detergency properties. Examples 1 and 3 achieved a perfect score of 5.0 in nourishing properties, Examples 2 and 4 scored 4.9 points, Example 5 scored 4.8 points, and all examples achieved a score of 5.0 in detergency. This indicates that the ternary amino acid surfactant complex system (glutamic acid surfactant + auxiliary surfactant + neutral amino acid surfactant) used in this invention, combined with fatty acid regulation, can produce rich and delicate foam, providing strong cleaning power without leaving skin feeling tight or dry after washing. Simultaneously, the tremella polysaccharide in the multi-compartment liposome nanoparticles exhibits stratum corneum adhesion, enhancing the retention effect of moisturizers and active ingredients, and providing excellent nourishment to the skin and hair.

[0037] Comparative Example 1 (all three components complete but not nano-sized) scored 4.5 points in nourishing properties, slightly lower than Example 15, indicating that nano-delivery helps improve the transdermal absorption and moisturizing effect of active ingredients. Comparative Example 2 (lacking microbial fermentation but nano-sized) saw its nourishing properties decrease to 4.1 points, and its cleansing properties to 4.8 points. Comparative Example 3 (retaining only shikonin and nano-sized) further decreased its nourishing properties to 3.7 points, and its cleansing properties to 4.6 points. Comparative Example 4 (containing no natural preservatives) experienced microbial growth during storage and use, leading to changes in texture and increased irritation; its nourishing properties score was only 2.8 points, and its cleansing properties to 4.2 points.

[0038] The nourishing score of Example 15 (4.85.0) was significantly higher than that of Comparative Example 1 (4.5), indicating that the multi-compartment liposome nanoparticles significantly enhanced the skincare effect of the product. The underlying reason is that after the tremella polysaccharide is anchored on the surface of the nanoparticles, it not only plays a spatial stabilizing role but also possesses excellent moisturizing and film-forming properties, forming a breathable hydrophilic film on the skin surface to lock in moisture. Simultaneously, the phospholipids in the liposomes have a structure similar to the stratum corneum of the skin, replenishing the lipids needed for the skin barrier and reducing transepidermal water loss. In contrast, the freely added tremella and Ganoderma lucidum complex fermented compound (Comparative Example 1) is easily washed away by water in wash-off products, significantly reducing its moisturizing effect.

[0039] The nourishing score of Example 5 was 4.8, slightly lower than that of the other examples. The reason for this may be that the amount of acetylshikonin was only 0.1 parts (compared to 0.5 parts in Example 1), and the amount of plant fermentation filtrate was increased (1 part), while the amount of fungal fermentation product was only 0.1 parts. The ratio of the three components deviated from the optimal synergistic range, leading to a decrease in the loading efficiency of some active ingredients in nanoparticle cells. Simultaneously, the cholesterol content of 0.1 parts was too low, which may affect the stability of the liposome membrane, causing some active substances to leak prematurely during storage or use. This, conversely, verifies the importance of the optimal ratio range.

[0040] Comparative Examples 3 and 4 showed a significant decrease in nourishing scores (3.7 and 2.8), and their detergency was also affected (4.6 and 4.2). Although these samples contained the same surfactant system when uncontaminated, the preservation challenge test confirmed that after inoculation, Comparative Examples 3 and 4 experienced massive microbial proliferation. During actual use, the accumulation of microbial metabolites (such as organic acids, amines, and proteases) led to pH shifts, degradation of active ingredients, and the generation of off-odors and even irritants. During four weeks of continuous use, repeated use after opening resulted in progressively worsening microbial contamination, leading to decreased nourishing and detergency scores. This was not due to surfactant failure, but rather a reflection of overall performance degradation after product deterioration. This further emphasizes the crucial role of a reliable preservation system in maintaining product performance stability throughout its shelf life and usage period.

[0041] As can be seen from the results in Tables 1 and 2, Example 15 of the present invention is significantly better than Comparative Example 14 in terms of both anti-corrosion effect and performance, which proves the necessity and superiority of the synergistic combination of three natural anti-corrosion components for multi-compartment liposome nanoparticle delivery.

[0042] The above embodiments are merely preferred embodiments of the present invention and should not be construed as limiting the scope of protection of the present invention. Any non-substantial changes and substitutions made by those skilled in the art based on the present invention shall fall within the scope of protection claimed by the present invention.

Claims

1. A baby-care grade shampoo and body wash foam composition, characterized in that, By weight, it comprises the following components: 3-7 parts glutamic acid surfactant, 8-12 parts auxiliary surfactant, 8-12 parts neutral amino acid surfactant, 0.1-1 part natural preservative, 0.1-1 part plant fermentation filtrate, 0.1-1 part fungal fermentation product, 0.5-5 parts phospholipid, 0.1-1 part cholesterol, 0.1-0.5 parts natural fragrance, 0.1-0.5 parts quaternary ammonium salt, 0.2-0.6 parts fatty acid, 1-3 parts humectant, and 60-75 parts deionized water.

2. A baby-care grade shampoo and body wash foam composition, characterized in that, The 0.1-1 part natural preservative, 0.1-1 part plant fermentation filtrate, 0.1-1 part fungal fermentation product, 0.5-5 parts phospholipid, and 0.1-1 part cholesterol together form multi-compartment liposome nanoparticles with natural preservative properties.

3. The baby-care grade shampoo and body wash foam composition according to claim 1, characterized in that, The natural preservative is one of shikonin, shikonin root extract, or acetylshikonin; the plant fermentation filtrate is one of radish root fermentation filtrate or soybean extract fermentation product filtrate; the fungal fermentation product is one of tremella-ganoderma complex fermentation product, rice-ganoderma complex fermentation product, or poria-ganoderma complex fermentation product.

4. The baby-care grade shampoo and body wash foam composition according to claim 1, characterized in that, The glutamic acid surfactant is one of disodium cocoyl glutamate, sodium cocoyl glutamate, or disodium lauroyl glutamate; the auxiliary surfactant is one of sodium lauroyl amphoteric acetate, cocamidopropyl betaine, or lauryl glucoside; and the neutral amino acid surfactant is one of sodium lauroyl glutamate, sodium cocoyl glycinate, or sodium methyl cocoyl taurate.

5. The baby-care grade shampoo and body wash foam composition according to claim 1, characterized in that, The natural fragrance is selected from one of the following: calendula extract, peach extract, or golden chamomile extract.

6. The baby-care grade shampoo and body wash foam composition according to claim 1, characterized in that, The quaternary ammonium salt is one of polyquaternary ammonium salt-10, guar hydroxypropyltrimethylammonium chloride, polyquaternary ammonium salt-7, or polyquaternary ammonium salt-67.

7. The baby-care grade shampoo and body wash foam composition according to claim 1, characterized in that, The fatty acid is selected from any one of coconut oil acid, lauric acid, or palmitic acid.

8. The baby-care grade shampoo and body wash foam composition according to claim 1, characterized in that, The moisturizer is one of glycerin, sodium hyaluronate, or trehalose.

9. A method for preparing a baby-care grade shampoo and body wash foam composition according to any one of claims 1-8, characterized in that, Includes the following steps: (1) Dissolve natural preservatives, phospholipids and cholesterol in anhydrous ethanol and evaporate them in a rotary evaporator at 65-70℃ to form a film; add plant fermentation filtrate to the rotary evaporator and hydrate it in the film in the rotary evaporator at 40-50℃ to form liposomes; mix the bacterial fermentation product with the liposomes and incubate them at 30-40℃ for 50-60 minutes to allow the bacterial fermentation product to be adsorbed on the surface of the liposomes, thus forming multi-compartment liposome nanoparticles; (2) Add the multi-compartment nanoparticles, quaternary ammonium salt and deionized water to a heated stirring pot in sequence, while homogenizing and stirring. The homogenization temperature is 75~85℃ and the stirring speed is 200~600 rpm. After stirring evenly, add the glutamic acid surfactant while stirring, and stir evenly at 75~85℃. Then add the plant fermentation filtrate and fatty acids in sequence, and stir at 75~85℃ until dissolved evenly to obtain the premix. (3) Stop heating, and while stirring continuously, add the auxiliary surfactant to the premix and stir at 75~85℃ for 4~6 minutes until completely dissolved; cool down to 55~65℃, and while stirring continuously, add the neutral amino acid surfactant and stir for 2~6 minutes until dissolved evenly without particles; cool down to 40~50℃, and while stirring, add the moisturizer and natural fragrance and stir for 3~8 minutes until evenly mixed; cool down to room temperature and then discharge the material through a 300~500 mesh filter cloth and let it stand to obtain the baby care grade shampoo and body wash foam composition.

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