A reverse micellar composition and a method for its preparation

Abstract

The present application relates to the field of cosmetics, more particularly to a reverse micelle composition and a preparation method thereof.The reverse micelle composition comprises 0.1-10 parts by mass of HLB polyglycerol emulsifier, 0.01-1 parts of water-soluble active substance, 82-95 parts of reverse micelle oil phase and 0.1-4 parts of water; the emulsifier is preferably polyglycerol-3 diisostearate, and the reverse micelle oil phase adopts a specific ratio of light oil fat group.The preparation adopts a normal temperature step-by-step stirring process, and the water phase is prepared, the emulsifier and the oil phase are added in sequence, and heating is not required.The present application solves the problems that traditional skin care oil is difficult to carry water-soluble active substance and the stability of the reverse micelle system is poor, can stably and compatibly accommodate water-soluble active substance, has excellent high-temperature stability, the formula is simple and mild, the skin feels fresh, has multiple effects of anti-aging, repair, soothing and brightening, the process is simple and easy to industrialize, and is suitable for sensitive skin.

Description

Technical Field

[0001] This invention relates to the field of cosmetics, and more specifically to an antimicelle composition and its preparation method. Background Technology

[0002] In recent years, the "oil-based skincare" concept has rapidly gained popularity in the skincare industry. The sebum film on the surface of human skin, formed by the emulsification of sebum and sweat, is a core structure that locks in moisture, resists external stimuli, and maintains the stability of the skin's microecology. Affected by factors such as aging, UV radiation, environmental pollution, excessive cleansing, and stress, the sebum film is easily damaged, leading to skin barrier problems such as dryness, tightness, sensitivity, fine lines, and redness. Applying topical skincare oils with components similar to the sebum film can mimic and repair the skin's natural protective layer, improving skin condition and becoming an important direction in current functional skincare. However, simple skincare oils are difficult to incorporate water-soluble active ingredients, limiting the expansion and enhancement of product efficacy. How to stably add water-soluble active ingredients to an oil-based system has become a key technical challenge in the development of "oil-based skincare" products.

[0003] Currently, the mainstream technologies for adding water-soluble active ingredients to skincare oils include liquid crystal encapsulation, cyclodextrin encapsulation, oil-soluble derivatives, and physical dispersion. However, each method has significant drawbacks. Liquid crystal encapsulation is complex, requires specific raw materials, and is difficult to scale up. Cyclodextrin encapsulation has strict limitations on the molecular size of active ingredients, resulting in high raw material and production costs. Oil-soluble derivatives require chemical modification of the active ingredient structure, making synthesis difficult and potentially altering the original efficacy and reducing bioavailability. Physical dispersion only produces coarse dispersions, which are prone to sedimentation and stratification after standing, exhibiting extremely poor stability. These technologies cannot simultaneously meet the requirements of low cost, high stability, and high versatility, and are difficult to stably accommodate heat-sensitive and highly charged water-soluble active ingredients, thus hindering the efficacy upgrade and diversification of skincare oil products.

[0004] Reverse micelle technology has become a nanoscale solution for carrying water-soluble active ingredients in oil-phase systems. Reverse micelles can form nanoscale "micro-pools" in the oil phase, encapsulating water-soluble active ingredients and creating a protective environment that isolates them from light, heat, and oxygen, significantly improving the stability of the active ingredients and extending the product's shelf life. However, existing reverse micelle systems have significant technical bottlenecks. The selection, formulation, and dosage of emulsifiers are difficult; the water content and the molar ratio of water to surfactant are difficult to control precisely. Insufficient water loading reduces the encapsulation rate of active ingredients, while excessive water loading easily leads to phase separation. Therefore, developing a reverse micelle cosmetic system that is suitable for highly charged active ingredients, has excellent stability, and a simple formulation has significant market value and technological importance. Summary of the Invention

[0005] To solve the above-mentioned technical problems, the first aspect of the present invention provides a reverse micelle composition, which, by mass parts, comprises 0.1-10 parts of a polyglycerol emulsifier, 0.01-1 parts of a water-soluble active ingredient, 82-95 parts of a reverse micelle oil phase, and 0.1-4 parts of water.

[0006] Further, the reverse micelle composition, by weight, comprises 3-6 parts of polyglycerol emulsifier, 0.01-0.5 parts of water-soluble active ingredient, 90-95 parts of reverse micelle oil phase, and 0.5-4 parts of water. Preferably, the reverse micelle composition, by weight, comprises 4-5 parts of polyglycerol emulsifier, 0.01-0.2 parts of water-soluble active ingredient, 93-95 parts of reverse micelle oil phase, and 0.5-1 part of water.

[0007] As an implementable example, the reverse micelle composition of the present invention does not contain polyols. The absence of polyols in the raw material system of the present invention allows for a simpler and gentler formulation, reducing the risk of skin irritation and making it suitable for sensitive skin and skin with a damaged barrier. Simultaneously, it avoids polyols interfering with the "micro-pool" structure of the reverse micelles, ensuring the system remains stable over a wide temperature range of -18℃ to 48℃. Furthermore, it enhances the refreshing feel of the oil-phase product, avoiding stickiness and breakouts, and better meeting the skincare needs of "oil-based skincare."

[0008] As an implementable example, the polyglycerol emulsifier is selected from one or two of polyglycerol-3 diisostearate, polyglycerol-2 isostearate, and polyglycerol-3 distearate. As an implementable example, the HLB value (hydrophilic-lipophilic balance value) of the polyglycerol emulsifier is 3.5-6, preferably 4.5-5.5, including but not limited to 4.5, 4.7, 5.0, and 5.5. Optionally, the polyglycerol emulsifier includes one or two of polyglycerol-3 diisostearate (HLB value 4.5), polyglycerol-2 isostearate (HLB value 4.7), polyglycerol-3 distearate (HLB value 5.0), and polyglycerol-2 isostearate (HLB value 5.5). More preferably, the polyglycerol emulsifier is polyglycerol-3 diisostearate.

[0009] This invention effectively solves the problems of stringent emulsifier requirements and easy phase separation in traditional reverse micelle systems by using polyglycerol emulsifiers with HLB values ​​of 3.5-6, preferably 4.5-5.5, combined with 0.1-4 parts of water and water-soluble active ingredients. It overcomes the defects of high-charge or high-viscosity water-soluble active ingredients that easily lead to system instability. Simultaneously, it precisely controls the molar ratio of water to polyglycerol emulsifier, avoiding insufficient water leading to low active ingredient encapsulation and excessive water causing micelle collapse. This fundamentally solves the industry-wide common problem of traditional skincare oils being unable to accommodate water-soluble active ingredients. Furthermore, this formulation system allows the reverse micelle structure to remain stable for a long time in high-temperature environments from -18℃ to 48℃, without layering, turbidity, or precipitation. It is broadly compatible with various water-soluble active ingredients, especially suitable for high-charge and high-viscosity components that are difficult to stabilize in conventional systems. Utilizing a nanoscale "micro-water pool" structure, it significantly improves the stability of active ingredients and transdermal absorption efficiency. The formula is simple, gentle, and suitable for sensitive skin.

[0010] As an feasible example, the water-soluble active ingredients include fibronectin; NAD (nicotinamide adenine dinucleotide); polypeptide compounds (such as carnosine, acetylcarnosine, acetyl hexapeptide-8, cyclic hexapeptide-9, palmitoyl tripeptide-5, palmitoyl pentapeptide-4, nonapeptide-1, and snake venom-like peptides); highly ionic water-soluble active ingredients (such as sodium DNA and decarboxylated carnosine hydrochloride); and water-soluble active ingredients containing thickeners (such as Ziwei Platinum-200TF (raw materials by weight percentage include 0.01% platinum powder, 0.1% sodium hyaluronate, 2% 1,2-hexanediol, and the balance water; Ziwei Platinum-200TF is available from Shanghai Haotai Biotechnology Co., Ltd.), Golden C (raw materials by weight percentage include 10% sorbitol, 5% 1,3-propanediol, and 1.25%). 1,2-Hexanediol, 1.25% Caprylyl Glycol, 0.032% Vitamin C, 0.012% Gold, 0.012% Glutathione, 0.6% Xanthan Gum, balance water; Golden C is available from Infinite Technologies Co., Ltd.); soothing active ingredients (such as: purslane ( Portulaca oleracea Extract of gentian root ( Gentiana scabra root Extracts, dipotassium glycyrrhizate, asiaticoside; one or more of the following whitening active ingredients (such as VC ethyl ether, tranexamic acid, nicotinamide).

[0011] The water-soluble active ingredients selected in this invention are all highly active, strongly hydrophilic, easily degradable, and difficult to stably add to conventional oil phases. After being encapsulated by reverse micelles "micro-water pools", they can exist stably in the oil-based system and synergistically exert skin care effects, jointly achieving comprehensive effects such as anti-aging and firming, barrier repair, soothing and anti-inflammatory, brightening skin tone, anti-oxidation, and moisturizing and stabilizing. At the same time, it solves the technical problems of such ingredients being difficult to dissolve, easily inactivated, and having poor stability in the oil phase, greatly improving bioavailability and skin care efficacy.

[0012] As an implementable example, the reverse micelle oil phase comprises caprylic / capric triglyceride, coconut oil alcohol-caprylate / capric acid ester, cetyl ethylhexyl ester, squalane, jojoba seed ( Simmondsia chinensis ) oil, meadowfoam ( Limnanthes alba ) seed oil, European hazelnut ( Corylus avellana Oil, isononanoate, octyldodecyl alcohol, hexyldecyl alcohol, triglyceride (ethylhexanoate), pentaerythritol tetra(ethylhexanoate), octyldodecyl myristate, artemisia annua ( Artemisia annua One or more of the following: oils.

[0013] As an implementable example, the reverse micelle oil phase comprises at least octyl dodecyl myristate.

[0014] Octyl dodecyl myristate can precisely regulate the overall polarity of the oil phase, making it highly compatible with polyglycerol emulsifiers with HLB values ​​of 3.5-6, preferably 4.5-5.5, and the nano-reverse micelle structure. This avoids the deformation, breakage, or phase separation of reverse micelles caused by oil phase polarity imbalance. Its long-branched molecular structure has excellent compatibility, which can stabilize the particle size and morphology of reverse micelles and maintain the thermodynamic stability of the system. It effectively solves the industry pain point that water-soluble active ingredients can easily destroy the stability of reverse micelles, and counteracts the interference of charged components on the micelle interface. At the same time, by optimizing the water and emulsifier ratio, the molar ratio of water to surfactant is optimized to prevent micelle overload and collapse. This allows the reverse micelle composition to remain stable, without layering, turbidity, or precipitation under long-term high-temperature conditions of -18℃ to 48℃. It can also broaden the selection range of oil phase, improve the skin feel, further strengthen the "micro-water pool" structure of reverse micelles, and improve the encapsulation rate, stability, and transdermal absorption efficiency of water-soluble active ingredients.

[0015] Furthermore, the reverse micelle oil phase further includes caprylic / capric triglyceride, coconut oil alcohol-caprylic / capric acid ester / capric acid ester, squalane, and artemisia annua oil; the mass ratio of caprylic / capric triglyceride, coconut oil alcohol-caprylic / capric acid ester / capric acid ester, squalane, and artemisia annua oil is (40-50):(40-50):(1-5):(0.1-1); as an example, the mass ratio of octyl dodecyl myristate, caprylic / capric triglyceride, coconut oil alcohol-caprylic / capric acid ester / capric acid ester, squalane, and artemisia annua oil includes, but is not limited to, 2:45:45:2.7, 0.1; 2:45:45:2.89, 0.1; 2:45:45:1.7, 0.1.

[0016] This invention sets the mass ratio of caprylic / capric triglyceride, coconut oil alcohol-caprylic / capric acid ester, squalane, and artemisia annua oil at (40-50):(40-50):(1-5):(0.1-1), which achieves an optimal balance in the overall polarity, viscosity, skin feel, and stability of the oil phase. It is highly compatible with polyglycerol emulsifiers with an HLB value of 3.5-6 (preferably 4.5-5.5), octyl dodecyl myristate, and reverse micelle nanostructures, ensuring both good solubility and compatibility of the oil phase. This formula avoids the dryness caused by high proportions of light esters or the stickiness caused by heavy oils. It also enhances skin repair and improves system affinity by mimicking the structure of the sebum membrane with squalane. At the same time, a small amount of artemisia oil plays a soothing, antibacterial, and synergistic stabilizing role. While maintaining the stability of the reverse micelle "micro-pool" structure and preventing phase separation, it gives the product a refreshing, non-greasy, easy-to-spread, and fast-absorbing feel, meeting the needs of "oil-based skincare" and further improving the overall stability and user experience of the composition.

[0017] A second aspect of the present invention provides a method for preparing an antimicelle composition, comprising the following steps: S1. Mix water and water-soluble active ingredients to obtain an aqueous phase; S2. Add polyglycerol emulsifier and stir until well mixed; S3. Add the reverse micelle oil phase and stir until homogeneous to obtain the reverse micelle composition.

[0018] This invention employs a step-by-step feeding and stirring sequence: first, a water-soluble active ingredient is prepared; then, a polyglycerol emulsifier is added; and finally, an oil phase is added to complete the system construction. This step-by-step mixing process avoids problems such as uneven concentrations, incomplete micelle formation, and easy stratification and turbidity caused by simultaneous mixing of the water phase, emulsifier, and oil phase. It ensures the stable formation of the reverse micelle structure. Furthermore, this process is simple and controllable, requires no heating, and can be completed with only room-temperature stirring, significantly reducing the difficulty of preparation, improving the feasibility of industrial production, ensuring the stability and uniformity of different batches of products, and enabling the final cosmetic product to exhibit excellent long-term stability under high-temperature conditions.

[0019] As an implementable example, in step S1, the stirring time is 5-20 minutes, including but not limited to 5 minutes, 10 minutes, 15 minutes, and 20 minutes.

[0020] As an implementable example, in step S2, the stirring speed is 100-200 rpm, including but not limited to 100 rpm, 120 rpm, 150 rpm, and 200 rpm.

[0021] As an implementable example, in step S3, the stirring temperature is 20-30℃, including but not limited to 20℃, 21℃, 22℃, 23℃, 24℃, 25℃, 28℃, and 30℃.

[0022] Beneficial effects (I) This invention, through precise selection of polyglycerol emulsifiers with HLB values ​​of 3.5-6 and strict control of water content between 0.1 and 4 parts, ensures a highly stable reverse micelle structure. This allows the micelles to maintain a uniform and transparent state over a wide temperature range of -18℃ to 48℃, without stratification, turbidity, precipitation, or water separation. This system effectively solves the problem of instability in traditional reverse micelles due to temperature, active ingredient charge, and oil phase polarity. In particular, it stabilizes high-charge, high-viscosity water-soluble active ingredients such as sodium DNA, Golden C, and NAD, preventing them from damaging the micelle interface structure. This significantly improves product shelf-life stability and transport and storage adaptability, meeting the stringent requirements of cosmetic industrialization and marketization.

[0023] (II) The reverse micelle system of this invention can stably carry a variety of hydrophilic active ingredients such as NAD, fibronectin, carnosine, niacinamide, acetyl hexapeptide-8, cyclic hexapeptide-9, sodium DNA, Golden C, purslane extract, gentian root extract, VC ethyl ether, and dipotassium glycyrrhizate, overcoming the technical limitations of traditional skincare oils in incompatible with water-soluble substances. The nanoscale "micro-water pool" structure provides a stable protective space for active ingredients, eliminating the need for chemical modification or complex encapsulation processes, thus enabling multi-functional formulations that address multiple skincare needs such as anti-aging, firming, brightening, repairing, soothing, and anti-oxidation, significantly improving the flexibility and efficacy extensibility of product formulations.

[0024] (III) The nano-encapsulated structure of reverse micelles can effectively isolate the degradation of water-soluble active ingredients by external factors such as light, heat, and oxygen, prolonging the half-life of active ingredients and ensuring the stability of product efficacy within its shelf life. At the same time, nano-sized micelles have excellent compatibility with the lipid bilayer of the stratum corneum of the skin, enabling them to efficiently penetrate the skin barrier, precisely deliver and release the encapsulated active ingredients to the target site, significantly improving transdermal absorption and bioavailability, allowing the active ingredients to truly exert their effects, and solving the problems of poor penetration, slow onset of action, and low utilization rate of active ingredients in traditional oil-phase systems.

[0025] (iv) This invention employs a thermodynamically stable reverse micelle system, eliminating the need for large amounts of emulsifiers, thickeners, stabilizers, and other auxiliary ingredients. The formula is more streamlined and safer, reducing the risk of skin irritation and making it suitable for long-term use on sensitive skin, skin with a damaged barrier, and other fragile skin types. The oil phase is primarily composed of light oils such as caprylic / capric triglycerides, coconut oil alcohol-caprylate / capric acid ester, and squalane, combined with a reasonable ratio and polarity adjustment. The product has a refreshing, easy-to-spread texture, absorbs quickly, is non-sticky, and does not clog pores. It combines the moisturizing properties of "oil-based skincare" with the lightweight feel preferred by modern consumers, providing a significantly superior user experience compared to traditional oil-based products.

[0026] (V) This invention employs a room-temperature stepwise stirring process, sequentially preparing the aqueous phase, adding the emulsifier, and finally adding the oil phase for uniform mixing. The entire process requires no heating, no special equipment, and no complex process conditions. It is simple to operate, highly controllable, and highly efficient, effectively reducing energy consumption and production costs, making it suitable for large-scale industrial production. The strict sequence of steps and feeding method ensures consistent and stable product quality across batches, avoiding problems such as poor micelle formation and system turbidity caused by uneven mixing, thus providing reliable technical support for large-scale product deployment. Attached Figure Description

[0027] Figure 1 The diagram shows the stability of the products in Examples 1-7. Detailed Implementation

[0028] Example 1 The first aspect of this example provides a reverse micelle composition comprising, by weight parts, 4 parts polyglycerol-3 diisostearate (HLB value 4.5), 0.2 parts carnosine, 94.8 parts reverse micelle oil phase, and 1 part water.

[0029] The reverse micelle oil phase, by mass parts, comprises 45 parts of coconut oil alcohol-caprylate / capric acid ester, 45 parts of caprylic acid / capric acid triglyceride, 4.7 parts of squalane and 0.1 parts of artemisia annua oil.

[0030] The second aspect of this example provides a method for preparing an antimicelle composition, comprising the following steps: S1. Mix water and carnosine, stir at 25°C and 150 rpm for 10 min to obtain the aqueous phase; S2. Add polyglycerol-3 diisostearate and stir at 25°C and 150 rpm for 10 min. S3. Add the reverse micelle oil phase, stir at 25°C and 150 rpm for 10 min to obtain the reverse micelle composition.

[0031] The antimicelle composition prepared in this example is designated as Composition I.

[0032] Example 2 The first aspect of this example provides a reverse micelle composition comprising, by weight parts, 4 parts polyglycerol-3 diisostearate (HLB value 4.5), 0.2 parts carnosine, 94.8 parts reverse micelle oil phase, and 1 part water.

[0033] The reverse micelle oil phase, by mass parts, comprises 45 parts of coconut oil alcohol-caprylate / capric acid ester, 45 parts of caprylic acid / capric acid triglyceride, 2.7 parts of squalane, 2 parts of octyldodecyl myristate ester and 0.1 parts of artemisia annua oil.

[0034] The second aspect of this example provides a method for preparing an antimicelle composition, comprising the following steps: S1. Mix water and carnosine, stir at 25°C and 150 rpm for 10 min to obtain the aqueous phase; S2. Add polyglycerol-3 diisostearate and stir at 25°C and 150 rpm for 10 min. S3. Add the reverse micelle oil phase, stir at 25°C and 150 rpm for 10 min to obtain the reverse micelle composition.

[0035] The antimicelle composition prepared in this example is designated as Composition II.

[0036] Example 3 The first aspect of this example provides a reverse micelle composition comprising, by weight, 4 parts polyglycerol-3 diisostearate (HLB value 4.5), 0.01 parts sodium DNA, 94.99 parts reverse micelle oil phase, and 1 part water.

[0037] The reverse micelle oil phase, by mass parts, comprises 45 parts of coconut oil alcohol-caprylate / capric acid ester, 45 parts of caprylic acid / capric acid triglyceride, 2.89 parts of squalane, 2 parts of octyldodecyl myristate ester and 0.1 parts of artemisia annua oil.

[0038] The second aspect of this example provides a method for preparing an antimicelle composition, comprising the following steps: S1. Mix water and sodium DNA, stir at 25°C and 150 rpm for 10 min to obtain the aqueous phase; S2. Add polyglycerol-3 diisostearate and stir at 25°C and 150 rpm for 10 min. S3. Add the reverse micelle oil phase, stir at 25°C and 150 rpm for 10 min to obtain the reverse micelle composition.

[0039] The antimicelle composition prepared in this example is designated as Composition III.

[0040] Example 4 The first aspect of this example provides a reverse micelle composition comprising, by weight parts, 5 parts polyglycerol-3 diisostearate (HLB value 4.5), 0.2 parts Golden C (purchased from Infinite Technologies Inc.), 93.8 parts reverse micelle oil phase, and 1 part water.

[0041] The reverse micelle oil phase, by mass parts, comprises 45 parts of coconut oil alcohol-caprylate / capric acid ester, 45 parts of caprylic acid / capric acid triglyceride, 1.7 parts of squalane, 2 parts of octyldodecyl myristate ester and 0.1 parts of artemisia annua oil.

[0042] The second aspect of this example provides a method for preparing an antimicelle composition, comprising the following steps: S1. Mix water and Golden C, stir at 25°C and 150 rpm for 10 min to obtain the aqueous phase; S2. Add polyglycerol-3 diisostearate and stir at 25°C and 150 rpm for 10 min. S3. Add the reverse micelle oil phase, stir at 25°C and 150 rpm for 10 min to obtain the reverse micelle composition.

[0043] The antimicelle composition prepared in this example is designated as Composition IV.

[0044] Example 5 The first aspect of this example provides a reverse micelle composition comprising, by weight parts, 5 parts polyglycerol-3 diisostearate (HLB value 4.5), 10 parts dipropylene glycol, 0.01 parts sodium DNA, and 80 parts olive oil ( Olea europaea L. 0.5 parts oil, 0.5 parts water.

[0045] The second aspect of this example provides a method for preparing an antimicelle composition, comprising the following steps: S1. Mix water, dipropylene glycol, and sodium DNA, and stir at 25°C and 150 rpm for 10 min to obtain the aqueous phase. S2. Add polyglycerol-3 diisostearate and stir at 25°C and 150 rpm for 10 min. S3. Add olive oil and stir at 25°C and 150 rpm for 10 minutes to obtain the reverse micelle composition.

[0046] The antimicelle composition prepared in this example is denoted as composition V.

[0047] Example 6 The first aspect of this example provides a reverse micelle composition comprising, by weight, 5 parts of polyglycerol-2 isostearate (HLB value 5.5, purchased from New Sanko Materials Technology (Shanghai) Co., Ltd.), 0.2 parts of Golden C (purchased from Infinite Technologies Co., Ltd.), 93.8 parts of reverse micelle oil phase, and 1 part of water.

[0048] The reverse micelle oil phase, by mass parts, comprises 45 parts of coconut oil alcohol-caprylate / capric acid ester, 45 parts of caprylic acid / capric acid triglyceride, 1.7 parts of squalane, 2 parts of octyldodecyl myristate ester and 0.1 parts of artemisia annua oil.

[0049] The second aspect of this example provides a method for preparing an antimicelle composition, comprising the following steps: S1. Mix water and Golden C, stir at 25°C and 150 rpm for 10 min to obtain the aqueous phase; S2. Add polyglycerol-3 diisostearate and stir at 25°C and 150 rpm for 10 min. S3. Add the reverse micelle oil phase, stir at 25°C and 150 rpm for 10 min to obtain the reverse micelle composition.

[0050] The antimicelle composition prepared in this example is designated as composition VI.

[0051] Example 7 The first aspect of this example provides a reverse micelle composition comprising, by weight, 4 parts polyglycerol-2 tetraisostearate (HLB value 3.0, purchased from Nantong Zhonghe Chemical New Materials Co., Ltd.), 0.2 parts carnosine, 94.8 parts reverse micelle oil phase, and 1 part water.

[0052] The reverse micelle oil phase, by mass parts, comprises 45 parts of coconut oil alcohol-caprylate / capric acid ester, 45 parts of caprylic acid / capric acid triglyceride, 2.7 parts of squalane, 2 parts of octyldodecyl myristate ester and 0.1 parts of artemisia annua oil.

[0053] The second aspect of this example provides a method for preparing an antimicelle composition, comprising the following steps: S1. Mix water and carnosine, stir at 25°C and 150 rpm for 10 min to obtain the aqueous phase; S2. Add polyglycerol-2 tetraisostearate and stir at 25°C and 150 rpm for 10 min. S3. Add the reverse micelle oil phase, stir at 25°C and 150 rpm for 10 min to obtain the reverse micelle composition.

[0054] The antimicelle composition prepared in this example is designated as composition VII.

[0055] Example 8 The first aspect of this example provides a reverse micelle composition comprising, by weight, 20 parts of polyglycerol-3 diisostearate (HLB value 4.5), 0.2 parts of carnosine, 74.8 parts of reverse micelle oil phase, and 5 parts of water.

[0056] The reverse micelle oil phase, by mass parts, comprises 35 parts of coconut oil alcohol-caprylate / capric acid ester, 35 parts of caprylic acid / capric acid triglyceride, 2.7 parts of squalane, 2 parts of octyldodecyl myristate ester and 0.1 parts of artemisia annua oil.

[0057] The second aspect of this example provides a method for preparing an antimicelle composition, comprising the following steps: S1. Mix water and carnosine, stir at 25°C and 150 rpm for 10 min to obtain the aqueous phase; S2. Add polyglycerol-3 diisostearate and stir at 25°C and 150 rpm for 10 min. S3. Add the reverse micelle oil phase, stir at 25°C and 150 rpm for 10 min to obtain the reverse micelle composition.

[0058] The antimicelle composition prepared in this example is designated as composition VIII.

[0059] Performance testing The product compositions I to VIII corresponding to Examples 1-8 were placed at 48°C to observe whether precipitation occurred. Detailed test results can be found in [link to relevant documentation]. Figure 1 .

[0060] Composition I failed the 12-week high-temperature stability test and became cloudy after three weeks, indicating that octyl dodecyl myristate has a significant impact on the stability of the product.

[0061] Composition II passed the high-temperature 12-week stability test and showed good stability.

[0062] Composition III passed the high-temperature 12-week stability test and showed good stability.

[0063] Composition IV passed the high-temperature 12-week stability test and showed good stability.

[0064] Composition V failed the 12-week high-temperature stability test and became turbid after one week, indicating that the stability of the conventional oil phase is lower than that of the reverse micelle oil phase.

[0065] Composition VI passed the high-temperature 12-week stability test, demonstrating excellent stability.

[0066] Composition VII failed the 12-week high-temperature stability test and became cloudy after two weeks, indicating that a low HLB value of the emulsifier is not conducive to improving the stability of the product.

[0067] Composition VIII failed the 12-week high-temperature stability test, and became turbid after two weeks, indicating that the high water and emulsifier content is not conducive to improving product stability.

Claims

1. A reverse micelle composition, characterized in that, By weight, it includes 0.1-10 parts polyglycerol emulsifier, 0.01-1 part water-soluble active ingredient, 82-95 parts reverse micelle oil phase, and 0.1-4 parts water; The polyglycerol emulsifier has an HLB value of 3.5-6.

2. The reverse micelle composition according to claim 1, characterized in that, The polyglycerol emulsifiers include one or two of polyglycerol-3 diisostearate, polyglycerol-2 isostearate, and polyglycerol-3 distearate.

3. The reverse micelle composition according to claim 1, characterized in that, The water-soluble active ingredients include one or more of the following: NAD, fibronectin, carnosine, acetylcarnosine, decarboxylated carnosine hydrochloride, tranexamic acid, nicotinamide, acetyl hexapeptide-8, cyclic hexapeptide-9, sodium DNA, crape myrtle platinum-200TF, Golden C, purslane extract, gentian root extract, VC ethyl ether, dipotassium glycyrrhizate, snake venom-like peptides, asiaticoside, palmitoyl tripeptide-5, palmitoyl pentapeptide-4, and nonapeptide-1.

4. The reverse micelle composition according to claim 1, characterized in that, The reverse micelle oil phase comprises one or more of the following: caprylic / capric triglyceride, coconut oil-caprylate / capric acid ester, cetyl ethylhexyl ester, squalane, jojoba seed oil, meadowfoam seed oil, European hazelnut oil, isononanoate, octyldodecyl alcohol, hexyldecyl alcohol, triglyceride (ethylhexanoate), pentaerythritol tetra(ethylhexanoate), octyldodecyl myristate, and artemisia annua oil.

5. The reverse micelle composition according to claim 4, characterized in that, The reverse micelle oil phase includes caprylic / capric triglyceride, coconut oil alcohol-caprylic / capric ester, squalane, and artemisia annua oil.

6. The reverse micelle composition according to claim 5, characterized in that, The mass ratio of caprylic / capric triglyceride, coconut oil alcohol-caprylic / capric acid ester, squalane, and artemisia annua oil is (40-50):(40-50):(1-5):(0.1-1).

7. A method for preparing the antimicelle composition according to any one of claims 1-6, characterized in that, Includes the following steps: S1. Mix water and water-soluble active ingredients to obtain an aqueous phase; S2. Add polyglycerol emulsifier and stir until well mixed; S3. Add the reverse micelle oil phase and stir until homogeneous to obtain the reverse micelle composition.

8. The method for preparing the antimicelle composition according to claim 7, characterized in that, In step S1, the stirring time is 5-20 minutes.

9. The method for preparing the antimicelle composition according to claim 7, characterized in that, In step S2, the stirring speed is 100-200 rpm.

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