A gastro-retentive sustained-release tablet of meloxicam besylate and a preparation method thereof

By preparing a gastric retention sustained-release tablet, the problem of insufficient residence time of melogabalin besylate in the gastrointestinal tract was solved by utilizing the sustained-release gel matrix material to float and expand in the stomach, thus achieving long-acting drug release and stable blood drug concentration, and improving medication adherence and safety.

CN122376548APending Publication Date: 2026-07-14TEAM ACAD OF PHARMA SCI
View PDF 6 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TEAM ACAD OF PHARMA SCI
Filing Date
2025-01-14
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

Existing melogabalin besylate formulations cannot remain in the gastrointestinal tract for an extended period, resulting in insufficient drug release and absorption, requiring frequent dosing, and causing large fluctuations in blood drug concentration, which affects medication adherence and safety.

Method used

A sustained-release gel matrix was formed by a mixture of polyvinyl acetate and povidone, cross-linked povidone, polyoxyethylene and carbomer to prepare a gastric retention sustained-release tablet, which allows the drug to float and expand in the stomach, prolonging the retention time, and the drug release rate is controlled by the sustained-release gel matrix.

Benefits of technology

This technology enables long-term release of merogabarine besylate in the stomach and small intestine, maintaining stable blood drug concentrations, reducing adverse reactions, and improving medication adherence and safety.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure BDA0005241846610000011
    Figure BDA0005241846610000011
  • Figure BDA0005241846610000061
    Figure BDA0005241846610000061
  • Figure BDA0005241846610000071
    Figure BDA0005241846610000071
Patent Text Reader

Abstract

The present application provides a kind of meloxicam benzene sulfonic acid gastric retention sustained-release tablets and its preparation method.The gastric retention sustained-release tablets include meloxicam benzene sulfonic acid, slow-release skeleton material, swelling agent, gel agent, diluent and other pharmaceutical adjuvant.Slow-release skeleton material includes polyvinyl acetate povidone mixture, swelling agent includes crosslinked povidone and polyoxyethylene, gel agent includes carbomer, and diluent includes lactose.The present application also discloses the preparation method of meloxicam benzene sulfonic acid gastric retention sustained-release tablets, and the meloxicam benzene sulfonic acid sustained-release tablets prepared using the method have slow-release characteristics, can slowly release drug in 24h, so as to reduce drug adverse reaction while reducing drug daily administration frequency and improving drug administration compliance.
Need to check novelty before this filing date? Find Prior Art