A piezoelectric micro-electric field regulated oral polypeptide absorption enhancing microcapsule preparation, and a preparation method and application thereof

Abstract

The application discloses a kind of oral polypeptide absorption enhancement microcapsule preparation of piezoelectric micro electric field regulation and its preparation method and application, the microcapsule preparation includes polypeptide active ingredient of inner core layer of being enclosed, enteric specific degradation piezoelectric hydrogel shell layer being covered in inner core layer outside, and cationic polysaccharide adhesion layer being arranged on the surface of shell layer.The piezoelectric hydrogel shell layer is dispersed with piezoelectric material particles, can generate local micro electric field under the action of exogenous ultrasound stimulation, regulate intestinal epithelial cell membrane potential, to enhance the trans-epithelial transport efficiency of polypeptide.The microcapsule preparation can be prepared by coaxial electrospinning technology, has the advantages such as controllable core-shell structure, piezoelectric response stability and interface adhesion enhancement.The piezoelectric micro electric field regulation mechanism is introduced into oral polypeptide delivery system for the first time, realizes physical controllable trans-epithelial transport enhancement, significantly improves the oral bioavailability of polypeptide drug, and is suitable for a variety of oral absorption limited polypeptide drugs.

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