An analgesic and antiemetic granular medicament and a preparation method thereof

Abstract

The application relates to the technical field of medicine preparation, and discloses a pain-relieving and vomiting-relieving granule medicament and a preparation method thereof. In order to solve the problems that the pain-relieving and vomiting-relieving granule medicament in the prior art is prone to loosening, has a bitter taste and a astringent taste, is not easy to be accepted and swallowed by patients, the bitter taste and the astringent taste are shielded by compounding a taste-correcting agent, trichloro sucrose, maltitol, citric acid and occlusion-state menthol, directional taste-masking technology of combining hydroxypropyl-beta-cyclodextrin occlusion tannin and chitosan micro-coating alkaloid is used to avoid taste rebound; microcrystalline cellulose and hydroxypropyl methyl cellulose are selected as a composite excipient, dry granulation and film coating technology are matched to solve the problems of difficult forming of extracts, loosening and unevenness, the volume and weight of the granules are increased to adapt to the processing and packaging requirements; the shape stability of the granules in the storage process is improved through coating film protection, optimization of drying and storage parameters, and finally the preparation of the granules with improved taste, convenient forming, stability and controllability is realized.

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