A compound essential oil for resolving stagnation, dredging and relieving pain, a preparation method and application thereof

Abstract

The application discloses a compound essential oil for resolving stagnation, dredging and relieving pain and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine essential oil. The compound essential oil is prepared by compounding base oil, resolving stagnation and detumescence type, warming meridians type, anti-inflammatory and analgesic type and penetration promoting essential oil according to specific weight proportions, and can be further compounded with isopropyl myristate penetration aid and hydrogenated castor oil stabilizer. The triple effects of resolving stagnation, dredging and relieving pain are realized by scientific compounding of multiple essential oils, the components are synergistically enhanced, the ternary base oil is matched with the penetration promoting components to improve the transdermal absorption rate, and the aid improves the compatibility and storage stability of the system, slows down the volatilization of the active ingredients, is suitable for relieving and treating arthromyodynia, dysmenorrhea and other diseases, is pure natural and mild without obvious side effects, and is excellent in stability and application effect.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine essential oil technology, specifically to a compound essential oil with the effects of dispersing nodules, clearing meridians, dispelling wind and relieving pain, as well as its preparation method and application. Background Technology

[0002] Compound essential oils have garnered widespread attention due to their natural origin, excellent transdermal absorption, and multiple pharmacological activities, particularly for relieving musculoskeletal pain, improving blood circulation, and dissolving nodules and lumps. In recent years, with increased health awareness and growing concerns about the side effects of chemically synthesized drugs, the market demand for topical products centered on plant essential oils has grown rapidly.

[0003] In the prior art, various compound preparations containing plant essential oils have also been studied. For example, Chinese patent application CN117338898A discloses a compound essential oil with anti-inflammatory and analgesic activity, composed of Artemisia argyi essential oil, Ligusticum chuanxiong essential oil, ginger essential oil, rose essential oil, turpentine oil, grape seed oil, etc. Patent application CN108653701A discloses a compound Chinese herbal essential oil composition for pain relief, containing frankincense essential oil, myrrh essential oil, Artemisia argyi essential oil, Asarum essential oil, dried ginger essential oil, peppermint essential oil, wintergreen essential oil, etc. However, the essential oil products in the prior art still have the following shortcomings: (1) Single function and poor synergy: Most products or formulas mainly focus on a single effect, such as simple pain relief, simple soothing, or simple blood circulation promotion. Many commercially available compound essential oils are simply a mixture of several essential oils with similar smells or single effects, which cannot exert the synergistic effect between the components, and may even reduce the effect due to improper compatibility. (2) Absorption efficiency and stability issues: The efficacy of compound essential oils depends to a large extent on their transdermal absorption efficiency and the stability of the formula. Some existing formulas do not fully consider the impact of the choice of base oil on the penetration of active ingredients, or the complex components of the compound essential oil itself may have stability issues during storage and use, such as some components being easy to volatilize or oxidize, leading to a decrease in efficacy.

[0004] Therefore, there is an urgent need in this field to develop a pure natural compound essential oil that is synergistic, can simultaneously achieve the triple effects of dispersing nodules, clearing blockages, and relieving pain, and has a good skin feel and is safe and stable, in order to meet the market demand for efficient, convenient and safe local care products. Summary of the Invention

[0005] The purpose of this invention is to provide a compound essential oil for dispersing nodules, clearing blockages, and relieving pain, as well as its preparation method and application. By compounding plant essential oils of specific types and weight ratios, this invention solves the problems of existing external products having single efficacy, obvious side effects, and poor penetration and absorption, and achieves a comprehensive effect of dispersing nodules, clearing blockages, and relieving pain.

[0006] This invention relates to a compound essential oil for dispersing nodules, clearing blockages, and relieving pain, comprising the following raw materials in parts by weight:

[0007] Base oils: 40-50 parts jojoba oil, 10-20 parts olive oil, 10-20 parts sweet almond oil;

[0008] Essential oils for reducing swelling and lumps: 1-5 parts Angelica oil, 1-6 parts Safflower oil;

[0009] Essential oils for warming and unblocking meridians: 1-5 parts of Ligusticum chuanxiong oil, 1-3 parts of nutmeg oil, 1-3 parts of fennel oil, and 2-5 parts of dried ginger oil;

[0010] Anti-inflammatory and analgesic essential oils: 1-6 parts wintergreen oil, 1-5 parts eucalyptus oil, 1-3 parts rosemary oil, 0.5-2 parts lavender oil, and 1-5 parts lemongrass oil;

[0011] Penetration-enhancing essential oils: 2-5 parts orange essential oil, 1-5 parts peppermint essential oil.

[0012] Furthermore, as a preferred embodiment, the nodule-dispersing and swelling-reducing essential oil may also include 1-8 parts frankincense essential oil and 1-3 parts myrrh essential oil. The combination of the two can synergistically inhibit the release of inflammatory factors by regulating multiple signaling pathways such as PI3K / AKT and MAPK, and produce significant synergistic effects in antiplatelet aggregation, anticoagulation and promoting transdermal penetration of active ingredients.

[0013] Furthermore, as a preferred embodiment, the compound essential oil for dispersing nodules, clearing blockages, and relieving pain comprises the following raw materials in parts by weight: Base oils: 42-48 parts jojoba oil, 10-15 parts olive oil, 15-20 parts sweet almond oil;

[0014] Essential oils for reducing swelling and lumps: 2-4 parts Angelica sinensis oil, 2-5 parts Safflower oil, 1-3 parts Frankincense essential oil, 1-2 parts Myrrh essential oil;

[0015] Essential oils for warming and unblocking meridians: 2-4 parts of Ligusticum chuanxiong oil, 1-2 parts of nutmeg oil, 2-3 parts of fennel oil, and 2-4 parts of dried ginger oil;

[0016] Anti-inflammatory and analgesic essential oils: 2-4 parts wintergreen oil, 2-4 parts eucalyptus essential oil, 2-3 parts rosemary essential oil, 1-2 parts lavender essential oil; 2-3 parts lemongrass essential oil;

[0017] Penetration-enhancing essential oils: 2-3 parts orange essential oil, 1-3 parts peppermint essential oil.

[0018] Furthermore, as a preferred embodiment, the compound essential oil for dispersing nodules, clearing blockages, and relieving pain is composed of the following raw materials in parts by weight:

[0019] Base oils: 42 parts jojoba oil, 15 parts olive oil, 15 parts sweet almond oil;

[0020] Essential oils for reducing swelling and lumps: 2 parts frankincense essential oil, 2 parts myrrh essential oil, 2 parts angelica oil, and 2 parts safflower oil;

[0021] Essential oils for warming and unblocking meridians: 2 parts Ligusticum chuanxiong oil, 2 parts nutmeg oil, 2 parts fennel oil, and 3 parts dried ginger oil;

[0022] Anti-inflammatory and analgesic essential oils: 2 parts wintergreen oil, 2 parts eucalyptus essential oil, 2 parts rosemary essential oil, 1 part lavender essential oil, and 3 parts lemongrass essential oil;

[0023] Penetration-enhancing essential oils: 2 parts orange essential oil, 2 parts peppermint essential oil.

[0024] Furthermore, as a preferred embodiment, the compound essential oil further includes functional additives, namely, 1-6 parts of a penetration enhancer and 2-8 parts of a stabilizer.

[0025] Preferably, the penetration enhancer is isopropyl myristate, and the stabilizer is hydrogenated castor oil.

[0026] The isopropyl myristate penetration enhancer of this invention not only effectively improves the miscibility between different essential oils and prevents stratification caused by the precipitation and floating of components after long-term standing, but also moisturizes and hydrates the skin. It can effectively contact hair follicles within the dermis and penetrate the active components of functional essential oils deep into the dermis, fully maximizing the effects of the active ingredients. Furthermore, the combination of isopropyl myristate and hydrogenated castor oil perfectly blends essential oil components of different polarities, preventing stratification, turbidity, or floating oil. By forming a stable micelle structure, it encapsulates volatile components and slows down the evaporation rate.

[0027] The jojoba oil, olive oil, and sweet almond oil used in this formula serve not only as diluents but also as crucial penetration enhancers. Jojoba oil has a molecular structure similar to human sebum, is stable, and has excellent permeability; olive oil is rich in monounsaturated fatty acids and vitamin E, providing excellent antioxidant and nourishing effects; sweet almond oil has a light and gentle texture, suitable for sensitive skin. Combining these three ingredients in a specific ratio significantly reduces skin barrier dysfunction. Simultaneously, the vitamin E in olive oil neutralizes oxidation reactions and protects the unsaturated components in jojoba oil, forming a multi-layered, synergistic carrier system that lays the physicochemical foundation for the effective delivery of volatile essential oils.

[0028] Furthermore, the present invention also provides a method for preparing a compound essential oil for dispersing nodules, clearing blockages, and relieving pain, comprising the following steps:

[0029] (1) Weigh each ingredient according to the formula amount;

[0030] (2) Stir the base oil evenly and heat it to 30-40℃;

[0031] (3) Add the essential oils for dispersing nodules and reducing swelling, the essential oils for warming and unblocking meridians, the essential oils for reducing inflammation and relieving pain, and the essential oils for promoting penetration in sequence while stirring. Continue stirring until completely mixed and let stand to defoam, and you will get the compound essential oil.

[0032] Preferably, the stirring speed in step S3 is 300-500 rpm and the stirring time is 30-60 min.

[0033] Preferably, the preparation process in step S3 may further include functional additives.

[0034] Furthermore, among essential oils that disperse nodules and reduce swelling, Angelica sinensis essential oil nourishes and invigorates blood, while safflower oil breaks up blood stasis and removes blood stasis. The combination of the two can significantly inhibit fibroblast proliferation and collagen deposition, producing a dispersing effect on various types of nodules with blood stasis and blood deficiency that far exceeds the effect of using either one alone.

[0035] Furthermore, in essential oils that warm and unblock meridians, gingerol in ginger oil activates TRPV1 channels to produce a warming and vasodilatory response, while ligustrazine in chuanxiong oil inhibits phosphodiesterase and increases cAMP levels, thereby relaxing vascular smooth muscle. The warming effect initiated by ginger oil can increase the diffusion rate of chuanxiong oil, and the qi-regulating effect of chuanxiong oil amplifies the warming effect along the meridian direction.

[0036] Furthermore, among anti-inflammatory and analgesic essential oils, lemongrass essential oil is rich in citral, which can work synergistically with methyl salicylate in wintergreen oil to produce a synergistic effect of rapid analgesia and long-lasting anti-inflammation by inhibiting COX-2 and TRPV1 channels, with an onset time 40% shorter than that of wintergreen oil alone.

[0037] Furthermore, to further enhance the permeability of functional essential oils, the selected orange essential oil is rich in limonene, which has excellent lipid solubility and can quickly disrupt the barrier structure of the stratum corneum; peppermint essential oil is rich in menthol, which can alter keratin conformation and increase skin blood flow. The simultaneous action of both on the stratum corneum produces a rapid, efficient, and reversible synergistic permeation-enhancing effect, significantly improving the transdermal penetration rate and cumulative penetration of other functional essential oils. At the same time, the cooling sensation of menthol can neutralize any slight irritation from orange essential oil, improving user comfort.

[0038] This invention also provides the application of the compound essential oil for dispersing nodules, clearing blockages, and relieving pain in the preparation of external products for relieving or treating breast hyperplasia nodules, thyroid nodules, swollen lymph nodes, sprains and bruises, joint pain, muscle soreness, and dysmenorrhea.

[0039] Preferably, the dosage form of the external product is one of massage oil, essential oil cream, essential oil gel, essential oil patch, or essential oil spray.

[0040] Preferably, the method of using the external product is as follows: apply the compound essential oil evenly to the body part, massage until fully absorbed, use 2-4 times daily, and the dosage each time is 1-2g / m². 2 .

[0041] The advantages or beneficial effects of the compound essential oil for dispersing nodules, clearing blockages, relieving pain, its preparation method, and its application of the present invention include at least the following:

[0042] 1. This invention breaks through the limitation of existing essential oil formulas with single efficacy. By scientifically compounding four types of functional essential oils—dispersing nodules and reducing swelling, warming and unblocking meridians, reducing inflammation and relieving pain, and promoting penetration—it achieves a comprehensive conditioning effect of "dispersing nodules, unblocking meridians, and relieving pain," and is particularly effective in relieving muscle and joint pain.

[0043] 2. This invention utilizes the synergistic effect between multiple pairs of components, including the synergistic penetration of base oils, the combination of rapid and long-lasting effects of analgesic essential oils, and the multi-target effect of penetration enhancers, so as to maximize the effectiveness of the entire formulation system, rather than simply adding up the effects of each raw material.

[0044] 3. By introducing a specific combination of functional additives, isopropyl myristate and hydrogenated castor oil, this invention not only solves the industry problem of miscibility and long-term storage stability between essential oils of different polarities, but also significantly improves the transdermal absorption rate of active ingredients by forming a stable micelle structure and promoting penetration, thus ensuring the stability and high efficiency of product efficacy.

[0045] 4. This invention uses pure natural plant essential oils throughout, supplemented with gentle plant base oils, avoiding the side effects of chemically synthesized drugs, resulting in high comfort and good patient compliance. Detailed Implementation

[0046] To more clearly illustrate the purpose, technical solution, and advantages of this invention, the technical solution of this invention will be described in detail below through specific embodiments. It should be noted that these embodiments are only for illustrating this invention and not for limiting its scope of protection; the actual scope of protection of this invention should be determined by the claims.

[0047] Unless otherwise specified, the materials and reagents used in the following examples and comparative examples are commercially available. Unless otherwise specified, the amount of each component in the following examples is 1 g per part by weight.

[0048] I. Raw materials used in the following embodiments

[0049] 1. All essential oils used in the examples are commercially available.

[0050] 2. Isopropyl myristate, CAS No.: 110-27-0, purchased from Aladdin.

[0051] 3. Hydrogenated castor oil, PEG-40 hydrogenated castor oil, CAS No.: 61788-85-0, purchased from Guangzhou Taili Chemical Co., Ltd.

[0052] II. Examples and Comparative Examples Example 1

[0053] This embodiment provides a compound essential oil for dispersing nodules, clearing blockages, and relieving pain, composed of the following raw materials in parts by weight:

[0054] 42 parts jojoba oil, 15 parts olive oil, 15 parts sweet almond oil; 2 parts angelica oil, 2 parts safflower oil; 2 parts chuanxiong oil, 2 parts nutmeg essential oil, 2 parts fennel oil, 3 parts dried ginger oil; 2 parts wintergreen oil, 2 parts eucalyptus essential oil, 2 parts rosemary essential oil, 1 part lavender essential oil, 3 parts lemongrass essential oil; 2 parts orange essential oil, 2 parts peppermint essential oil.

[0055] Preparation method:

[0056] S1. Weigh each ingredient precisely according to the above formula and set aside.

[0057] S2. Add the base oils (jojoba oil, olive oil, sweet almond oil) into a stainless steel mixing tank, stir at 150 rpm and heat to 35°C, and maintain the temperature.

[0058] S3. While continuously stirring at 400 rpm, add the active essential oils in the following order: essential oils for dispersing nodules and reducing swelling, essential oils for warming and unblocking meridians, essential oils for reducing inflammation and relieving pain, and essential oils for promoting penetration. After adding all of them, continue stirring at 400 rpm for 45 minutes until all components are completely miscible and form a homogeneous liquid.

[0059] S4. Let the obtained mixed essential oil liquid stand for 2 hours to defoam, and the compound essential oil for dispersing nodules, clearing blockages and relieving pain is obtained. Example 2

[0060] This embodiment adds frankincense essential oil and myrrh essential oil to Example 1, providing a preferred compound essential oil composed of the following raw materials in parts by weight:

[0061] 42 parts jojoba oil, 15 parts olive oil, 15 parts sweet almond oil; 2 parts frankincense essential oil, 2 parts myrrh essential oil, 2 parts angelica oil, 2 parts safflower oil; 2 parts chuanxiong oil, 2 parts nutmeg essential oil, 2 parts fennel oil, 3 parts dried ginger oil; 2 parts wintergreen oil, 2 parts eucalyptus essential oil, 2 parts rosemary essential oil, 1 part lavender essential oil, 3 parts lemongrass essential oil; 2 parts orange essential oil, 2 parts peppermint essential oil.

[0062] Preparation method:

[0063] The preparation steps are the same as in Example 1, except that frankincense oil and myrrh oil are added in the "nodule-dispersing and swelling-reducing essential oil" addition step S3. Example 3

[0064] This embodiment provides a compound essential oil for dispersing nodules, clearing blockages, and relieving pain, composed of the following ingredients in parts by weight: 45 parts jojoba oil, 18 parts olive oil, 18 parts sweet almond oil; 1 part frankincense essential oil, 1 part myrrh essential oil, 2 parts angelica oil, 2 parts safflower oil; 2 parts chuanxiong oil, 1 part nutmeg essential oil, 2 parts fennel oil, 2 parts dried ginger oil; 2 parts wintergreen oil, 2 parts eucalyptus essential oil, 2 parts rosemary essential oil, 1 part lavender essential oil, 2 parts lemongrass essential oil; 2 parts orange essential oil, 1 part peppermint essential oil.

[0065] Preparation method: The preparation steps are the same as in Example 2. Example 4

[0066] This embodiment provides a compound essential oil for dispersing nodules, clearing blockages, and relieving pain, composed of the following ingredients in parts by weight: 48 parts jojoba oil, 12 parts olive oil, 20 parts sweet almond oil; 3 parts frankincense essential oil, 2 parts myrrh essential oil, 4 parts angelica oil, 5 parts safflower oil; 4 parts chuanxiong oil, 2 parts nutmeg essential oil, 3 parts fennel oil, 4 parts dried ginger oil; 4 parts wintergreen oil, 4 parts eucalyptus essential oil, 3 parts rosemary essential oil, 2 parts lavender essential oil, 3 parts lemongrass essential oil; 3 parts orange essential oil, 3 parts peppermint essential oil.

[0067] Preparation method: The preparation steps are the same as in Example 2. Example 5

[0068] This embodiment provides a compound essential oil for dispersing nodules, clearing blockages, and relieving pain, composed of the following ingredients in parts by weight: 46 parts jojoba oil, 16 parts olive oil, 17 parts sweet almond oil; 2 parts frankincense essential oil, 1.5 parts myrrh essential oil, 3 parts angelica oil, 3.5 parts safflower oil; 3 parts chuanxiong oil, 1.5 parts nutmeg essential oil, 2.5 parts fennel oil, 3 parts dried ginger oil; 3 parts wintergreen oil, 3 parts eucalyptus essential oil, 2.5 parts rosemary essential oil, 1.5 parts lavender essential oil, 2.5 parts lemongrass essential oil; 2.5 parts orange essential oil, and 2 parts peppermint essential oil.

[0069] Preparation method: The preparation steps are the same as in Example 2. Example 6

[0070] Functional additives were added based on Example 2 to address stability issues and improve penetration efficiency. The compound essential oil is composed of the following raw materials in parts by weight:

[0071] 42 parts jojoba oil, 15 parts olive oil, 15 parts sweet almond oil; 2 parts frankincense essential oil, 2 parts myrrh essential oil, 2 parts angelica oil, 2 parts safflower oil; 2 parts chuanxiong oil, 2 parts nutmeg essential oil, 2 parts fennel oil, 3 parts dried ginger oil; 2 parts wintergreen oil, 2 parts eucalyptus essential oil, 2 parts rosemary essential oil, 1 part lavender essential oil, 3 parts lemongrass essential oil; 2 parts orange essential oil, 2 parts peppermint essential oil; 4 parts isopropyl myristate, 5 parts hydrogenated castor oil.

[0072] Preparation method:

[0073] S1. Weigh each ingredient precisely according to the above formula and set aside.

[0074] S2. Add the base oils (jojoba oil, olive oil, sweet almond oil) into a stainless steel mixing tank, stir at 150 rpm and heat to 35°C, and maintain the temperature.

[0075] S3. While continuously stirring at 400 rpm, add the following components in the following order: essential oils for dispersing nodules and reducing swelling, essential oils for warming and unblocking meridians, essential oils for reducing inflammation and relieving pain, and essential oils for promoting penetration. Finally, add the functional adjuvants isopropyl myristate and hydrogenated castor oil, and continue stirring at 400 rpm for 45 minutes until a clear, transparent, and homogeneous oil phase system is formed.

[0076] S4. Let the obtained mixed essential oil liquid stand for 2 hours to defoam, and you will get the highly stable and highly permeable compound essential oil for dispersing nodules, clearing blockages and relieving pain.

[0077] Comparative Example 1

[0078] The difference from Example 2 is that olive oil is not added, and the amount of jojoba oil is increased to 57 parts. The other raw material composition and preparation steps are exactly the same as in Example 2.

[0079] Comparative Example 2

[0080] The difference from Example 2 is that jojoba oil is not added, and the amount of olive oil is increased accordingly to 57 parts. The other raw material composition and preparation steps are exactly the same as in Example 2.

[0081] Comparative Example 3

[0082] The difference from Example 2 is that angelica oil is not added, and the amount of safflower oil is increased to 4 parts. The other raw material composition and preparation steps are exactly the same as in Example 2.

[0083] Comparative Example 4

[0084] The difference from Example 2 is that safflower oil is not added, and the amount of angelica oil is increased to 4 parts. The other raw material composition and preparation steps are exactly the same as in Example 2.

[0085] Comparative Example 5

[0086] The difference from Example 2 is that lemongrass essential oil is not added, and the amount of wintergreen oil is increased to 5 parts. The other raw material composition and preparation steps are exactly the same as in Example 2.

[0087] Comparative Example 6

[0088] The difference from Example 2 is that wintergreen oil is not added, and the amount of lemongrass essential oil is increased to 5 parts. The other raw material composition and preparation steps are exactly the same as in Example 2.

[0089] Comparative Example 7

[0090] The difference from Example 2 is that orange essential oil is not added, and the amount of peppermint essential oil is increased to 4 parts. The other raw material composition and preparation steps are exactly the same as in Example 2.

[0091] Comparative Example 8

[0092] The difference from Example 2 is that peppermint oil is not added, and the amount of orange oil is increased to 4 parts. The other ingredients and preparation steps are exactly the same as in Example 2.

[0093] III. Effect Test Examples

[0094] To verify the beneficial effects of the present invention, the compound essential oils prepared in the above embodiments and comparative examples were subjected to the following performance tests.

[0095] Experimental Example 1: Stability and compatibility test.

[0096] 1. Experimental objective:

[0097] The physical stability of compound essential oils under different temperature conditions was evaluated, and the key role of specific functional additives (isopropyl myristate and hydrogenated castor oil) in preventing component stratification, precipitation, and oxidation was verified.

[0098] 2. Experimental Samples:

[0099] Example group: Example 2 (without additives), Example 6 (with additives).

[0100] Control group: Comparative Example 1 (base oil ratio changed), Comparative Example 2 (base oil ratio changed).

[0101] 3. Experimental Methods:

[0102] Each sample was dispensed in equal amounts into transparent glass bottles, sealed, and then placed under three different conditions:

[0103] Low temperature conditions: Store in a refrigerator at 4℃ for 30 days.

[0104] Store at room temperature in a 25℃ constant temperature incubator for 90 days.

[0105] High temperature conditions: Store in a 50℃ constant temperature chamber for 30 days (accelerated test).

[0106] 4. Observation indicators and evaluation criteria:

[0107] Observe and record on day 0, day 7, day 30 (and day 90):

[0108] Appearance: Is it clear and transparent? Layering: Is there oil phase separation, sediment, or suspended matter? Odor: Is there a rancid or off-odor?

[0109] Appearance description

[0110] Advantages: Clear and transparent, without layering or sediment, with a pure odor.

[0111] Good: Slightly cloudy, no layering, no sediment, normal odor.

[0112] Medium: A small amount of sediment or suspended matter may appear, or there may be slight stratification. This can be reversed by shaking.

[0113] Poor: Obvious layering, sedimentation, or turbidity, and altered odor.

[0114]

[0115] Many essential oils have different polarities. Under prolonged static conditions or high temperatures, endogenous terpenes, phenols, and other components may aggregate or precipitate due to differences in intermolecular forces. Without adjuvants, the system is merely a simple mixture and is thermodynamically unstable. The hydrogenated castor oil added in Example 6 is a nonionic surfactant that significantly reduces the oil-water interfacial tension, encapsulating essential oil components of different polarities to form stable micelles or microemulsions and preventing stratification. Isopropyl myristate, as an excellent oil-soluble solvent, enhances the miscibility between components; its ester structure can insert between molecules of different polarities, acting as a "molecular bridge." Together, they form a thermodynamically stable homogeneous system.

[0116] A comparison of Comparative Examples 1-2 with Example 2 reveals that Comparative Example 1 lacks olive oil, which is rich in natural antioxidants such as vitamin E and phenols. Components rich in unsaturated double bonds (such as fatty acids in jojoba oil) are more prone to oxidative polymerization, leading to precipitation. Simultaneously, the composite ratio of the three base oils is disrupted, losing the original polar gradient and decreasing component compatibility. Jojoba oil is a unique liquid wax ester with a simple molecular structure, extremely low polarity, and extremely stable chemical properties. It is an excellent diluent and solvent, effectively dissolving various essential oil components. In Comparative Example 2, the absence of jojoba oil increases the system viscosity, and the solubility of some highly polar components, such as certain alcohols and phenols, decreases, making them prone to precipitation over time or with temperature changes.

[0117] Experimental Example 2: In vitro transdermal absorption efficiency test.

[0118] 1. Experimental objective:

[0119] By comparing the transdermal penetration enhancement effects of different formulations on active ingredients, the synergistic effect of the base oil combination and the penetration-enhancing essential oils (orange essential oil + peppermint essential oil) of this invention was verified.

[0120] 2. Experimental Samples:

[0121] Example group: Example 1, Example 2, Example 6.

[0122] Control group: Comparative Example 7, Comparative Example 8, and the prior art (CN113521237A Example 1).

[0123] 3. Experimental Method (Franz Diffusion Cell Method):

[0124] In vitro transdermal absorption experiments were conducted using the Franz diffusion cell method. Ex vivo abdominal skin from SD rats was used as the permeability barrier. PBS (pH 7.4) was used as the receiving solution. 1.5 mL of each essential oil was evenly applied to the stratum corneum of the skin. Receiving solution samples were collected at predetermined time points (0.5, 1, 2, 4, 8, 12, 24 h), and an equal volume of blank receiving solution at the same temperature was added. The concentrations of limonene and methyl salicylate in the receiving solution were determined by HPLC, and the cumulative permeation per unit area at time point 24 h (Q, μg / cm²) was calculated.

[0125]

[0126] Comparing Examples 1-2 with Examples 6, Example 6 showed an increase of approximately 3.2 μg / cm² in methyl salicylate and approximately 6.2 μg / cm² in limonene. This is because the addition of isopropyl myristate in Example 6 allows it to penetrate the lipid bilayer of the stratum corneum, promoting the penetration of active ingredients. The cumulative penetration amount was significantly higher than that in Examples 1 and 2 without isopropyl myristate.

[0127] In Example 2, the methyl salicylate content was approximately 2.3 times that of Comparative Example 1 and 2.7 times that of Comparative Example 2; the limonene content was approximately 2.6 times that of Comparative Example 1 and 3.0 times that of Comparative Example 2. This is because Comparative Example 1 lacked olive oil, which is rich in monounsaturated fatty acids and vitamin E, resulting in the loss of the base oil polarity gradient and antioxidant protection; Comparative Example 2 lacked low-polarity jojoba oil, which is an excellent solvent and diluent, leading to increased system viscosity and decreased solubility of some polar components. The ternary compound system in Example 2 synergistically perturbs the lipid structure of the stratum corneum through fatty acids of different chain lengths and polarities; the absence of any base oil component severely weakens this synergistic penetration effect.

[0128] The methyl salicylate content in Example 2 was higher than that in Comparative Examples 7-8, which proves that the best transdermal absorption effect is achieved when the two penetration-enhancing essential oils are present at the same time. This fully demonstrates the strong synergistic effect of limonene in orange essential oil and menthol in peppermint essential oil in promoting penetration.

[0129] Experimental Example 3: Comprehensive efficacy evaluation (dispersing nodules, clearing blockages, relieving pain).

[0130] 1. Experimental objective:

[0131] Human trials were conducted to evaluate the comprehensive effects of the compound essential oil of this invention in dissolving nodules and relieving pain, and to verify the synergistic effect of key components.

[0132] 2. Experimental Samples:

[0133] Example group: Example 2, Example 3, Example 6.

[0134] Control group: Comparative examples 3-6.

[0135] Blank control group: base oil (jojoba oil + olive oil + sweet almond oil, in the proportions of Example 2).

[0136] 3. Experimental subjects and grouping:

[0137] We are recruiting volunteers aged 30-50 who have symptoms such as frozen shoulder, lower back pain, or dowager's hump. Volunteers will be randomly divided into 8 groups of 10 each.

[0138] 4. Experimental Methods:

[0139] The experimental group used the compound essential oils from the examples and comparative examples, applying them to the sore areas twice a day, with each application using 5ml. Each application involved massaging the body for 15 minutes, and the treatment continued for 60 days.

[0140] Evaluation indicators:

[0141] Clinical efficacy (pain): The degree of shoulder, neck, and lower back pain before and 60 days after use was assessed using the Visual Analogue Scale (VAS, 0-10, where 0 is no pain, 1-3 is mild, 4-6 is moderate, and 7-10 is severe, with higher scores indicating more severe pain). The average score of each group of volunteers was used in this study.

[0142] Overall effectiveness:

[0143] Significant effect: VAS pain score decreases by ≥70%. Effective: VAS pain score decreases by 30%-69%. Ineffective: The above criteria are not met.

[0144]

[0145] Compared with Examples 2 and 3, Example 6 showed a pain relief rate that was approximately 5.2 percentage points higher than Example 2 and approximately 3.1 percentage points higher than Example 3. This is because Example 6 included isopropyl myristate and hydrogenated castor oil. Isopropyl myristate can intercalate into the lipid bilayer of the stratum corneum, promoting the transdermal absorption of the active ingredients, resulting in stronger analgesic and anti-inflammatory effects. The overall therapeutic effect was significantly higher than that of Examples 2 and 3, which did not contain functional additives.

[0146] The pain relief rate of Example 2 was approximately 21.3 percentage points higher than that of Comparative Example 3 and approximately 28.0 percentage points higher than that of Comparative Example 4. This is because Angelica sinensis oil and safflower oil have a synergistic effect in dispersing nodules and reducing swelling: safflower oil breaks up blood stasis and is good at dispersing existing blood stasis and pain; Angelica sinensis oil nourishes blood and promotes blood circulation, nourishes local tissues and enhances their repair ability. The combined use of the two significantly improves the pain relief rate.

[0147] The relief rate of Example 2 was approximately 15.6 percentage points higher than that of Comparative Example 5 and approximately 14.9 percentage points higher than that of Comparative Example 6. This is because methyl salicylate in wintergreen oil and citral in lemongrass essential oil have a synergistic effect in anti-inflammatory and analgesic properties: wintergreen oil provides rapid analgesia by inhibiting COX-2, while lemongrass essential oil produces a sustained anti-inflammatory effect by inhibiting the TRPV1 channel. When used together, they can quickly relieve pain and control inflammation in the long term, with efficacy far exceeding that of simply adding up the single components.

[0148] The blank control group used only base oils (jojoba oil + olive oil + sweet almond oil) and contained no active essential oils. Its limited relief effect mainly came from the moisturizing and lubricating effects of the base oils and the physical stimulation of massage techniques. In contrast, Example 2 contained a complete combination of essential oils that disperse nodules and reduce swelling, warm the meridians, reduce inflammation and pain, and promote penetration. It could work simultaneously from multiple pharmacological targets, thus its efficacy was significantly better than that of the blank control group.

[0149] It should be clarified that the above embodiments are merely illustrative of specific implementations of the present invention and do not constitute a limitation on the scope of protection of the present invention. Based on the technical content disclosed in this invention, those skilled in the art can make various modifications, adjustments, or equivalent substitutions within its basic principles and design concepts. These modifications and improvements need not be listed exhaustively, but should all be considered to fall within the scope of protection of this invention.

Claims

1. A compound essential oil for dispersing nodules, clearing blockages, and relieving pain, characterized in that: Including the following parts by weight of raw materials: Base oils: 40-50 parts jojoba oil, 10-20 parts olive oil, 10-20 parts sweet almond oil; Essential oils for reducing swelling and lumps: 1-5 parts Angelica oil, 1-6 parts Safflower oil; Essential oils for warming and unblocking meridians: 1-5 parts of Ligusticum chuanxiong oil, 1-3 parts of nutmeg oil, 1-3 parts of fennel oil, and 2-5 parts of dried ginger oil; Anti-inflammatory and analgesic essential oils: 1-6 parts wintergreen oil, 1-5 parts eucalyptus essential oil, 1-3 parts rosemary essential oil, 0.5-2 parts lavender essential oil, and 1-5 parts lemongrass essential oil; Penetration-enhancing essential oils: 2-5 parts orange essential oil, 1-5 parts peppermint essential oil.

2. The compound essential oil for dispersing nodules, clearing blockages, and relieving pain according to claim 1, characterized in that, The essential oils for dispersing nodules and reducing swelling also include 1-8 parts frankincense essential oil and 1-3 parts myrrh essential oil.

3. The compound essential oil for dispersing nodules, clearing blockages, and relieving pain according to claim 2, characterized in that, Including the following parts by weight of raw materials: Base oils: 42-48 parts jojoba oil, 12-18 parts olive oil, and 15-20 parts sweet almond oil; Essential oils for reducing swelling and lumps: 2-4 parts Angelica sinensis oil, 2-5 parts Safflower oil, 1-3 parts Frankincense essential oil, 1-2 parts Myrrh essential oil; Essential oils for warming and unblocking meridians: 2-4 parts of Ligusticum chuanxiong oil, 1-2 parts of nutmeg oil, 2-3 parts of fennel oil, and 2-4 parts of dried ginger oil; Anti-inflammatory and analgesic essential oils: 2-4 parts wintergreen oil, 2-4 parts eucalyptus essential oil, 2-3 parts rosemary essential oil, 1-2 parts lavender essential oil, and 2-3 parts lemongrass essential oil; Essential oils to enhance penetration: 2-3 parts orange essential oil, 1-3 parts peppermint essential oil.

4. The compound essential oil for dispersing nodules, clearing blockages, and relieving pain according to claim 3, characterized in that, The compound essential oil also includes functional additives, namely, 1-6 parts of isopropyl myristate as a penetration enhancer and 2-8 parts of hydrogenated castor oil as a stabilizer.

5. The compound essential oil for dispersing nodules, clearing blockages, and relieving pain according to claim 4, characterized in that, It consists of the following raw materials in parts by weight: Base oils: 42 parts jojoba oil, 15 parts olive oil, 15 parts sweet almond oil; Essential oils for reducing swelling and lumps: 2 parts frankincense essential oil, 2 parts myrrh essential oil, 2 parts angelica oil, and 2 parts safflower oil; Essential oils for warming and unblocking meridians: 2 parts Ligusticum chuanxiong oil, 2 parts nutmeg oil, 2 parts fennel oil, and 3 parts dried ginger oil; Anti-inflammatory and analgesic essential oils: 2 parts wintergreen oil, 2 parts eucalyptus essential oil, 2 parts rosemary essential oil, 1 part lavender essential oil, and 3 parts lemongrass essential oil; Penetration-enhancing essential oils: 2 parts orange essential oil, 2 parts peppermint essential oil; Penetration enhancer: Isopropyl myristate 4 parts; Stabilizer: 5 parts hydrogenated castor oil.

6. A method for preparing a compound essential oil for dispersing nodules, clearing blockages, and relieving pain as described in any one of claims 1-5, characterized in that, Includes the following steps: (1) Weigh each ingredient according to the formula amount; (2) Mix the base oil thoroughly and heat it to 30-40°C; (3) While stirring, add the essential oils for dispersing nodules and reducing swelling, the essential oils for warming and unblocking meridians, the essential oils for reducing inflammation and relieving pain, the essential oils for promoting penetration, and the optional functional additives in sequence. Mix them thoroughly and let them stand to defoam, and you will get the compound essential oil for dispersing nodules, clearing the meridians and relieving pain.

7. The preparation method of the compound essential oil for dispersing nodules, clearing blockages, and relieving pain as described in claim 6, characterized in that, The stirring speed in step (3) is 300-500 rpm and the stirring time is 30-60 min.

8. The use of the compound essential oil for dispersing nodules, clearing blockages, and relieving pain as described in any one of claims 1-5 in the preparation of external products for relieving or treating breast hyperplasia nodules, thyroid nodules, swollen lymph nodes, sprains and bruises, joint pain, muscle soreness, and dysmenorrhea.

9. The application according to claim 8, characterized in that, The dosage form of the external product is at least one of massage oil, essential oil cream, essential oil gel, essential oil patch, or essential oil spray.

10. The application according to claim 8 or 9, characterized in that, The method of using the external product is as follows: Apply the compound essential oil evenly to the body part and massage until fully absorbed. Use 2-4 times daily, with each application amount being 1-2g / m². 2 .

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