Traditional Chinese medicine gout pill and preparation method thereof

Abstract

The application discloses a traditional Chinese medicine gout pill and a preparation method thereof, and relates to the technical field of gout clinical treatment, wherein the traditional Chinese medicine gout pill is prepared from the following raw materials in a proportion by weight: Bai Zhi 28-32g, Fuling 28-32g, Zexie 18-22g, Zhimu 18-22g, Fangfeng 18-22g, Guizhi 18-22g, Baishao 19-21g, Huangqi 14-16g, Shengfuzi 10-14g, Zhigancao 8-12g, Mahuang 8-11g, Xixin 9-11g, Zhongwutou 4-6, Shengjiang 4-6. The traditional Chinese medicine gout pill has the effects of invigorating the spleen and kidney, warming yang and dispelling cold, eliminating swelling and resolving mass, dredging the channels and activating the collaterals, and the like; the traditional Chinese medicine gout pill can be used for treating gout and other unknown joint pain, and after 7-15 days of medication, the pain is obviously relieved; after 60-90 days of medication, the patient is basically cured; after 120-150 days of continuous medication, 90% of the patients are stable after stopping the medication, and can return to normal life and work.

Description

[0001] This invention is a divisional application based on the application filed on July 3, 2024, with application number 202410881830.3 and invention title "Novel Traditional Chinese Medicine Gout Pill and Preparation Method Thereof". Technical Field

[0002] This invention relates to the field of clinical treatment technology for gout, specifically to a traditional Chinese medicine gout pill and its preparation method. Background Technology

[0003] Gout is a disease caused by purine metabolism disorders, leading to the accumulation of uric acid. It is a type of arthritis, also known as metabolic arthritis. Women generally do not develop gout before the age of 50 because estrogen inhibits uric acid formation; however, the incidence increases after menopause. High concentrations of uric acid in the blood cause needle-like crystals to form in soft tissues such as joint membranes or tendons, leading to an overreaction of the body's immune system and painful inflammation. Common sites of attack include the big toe joint, ankle joint, and knee joint. Long-term gout patients have experienced attacks in the finger joints and even the soft tissue parts of the ear.

[0004] However, there are very few traditional Chinese medicines for treating gout on the market, and even fewer with good efficacy. Patients still have to rely on taking large amounts of Western medicines with significant side effects to stabilize their condition. Common gout medications, such as colchicine and allopurinol, can only relieve pain symptoms when taken, treating the symptoms but not the root cause. Long-term use can severely damage the kidneys, especially during subsequent relapses, when the condition worsens and the relapse rate becomes more frequent. In addition, these medications require strict dietary restrictions, and their side effects cause great suffering and harm to patients. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine gout pill and its preparation method, thus solving the problems mentioned in the background section.

[0006] To achieve the above objectives, the present invention provides the following technical solution: On one hand, the present invention provides a traditional Chinese medicine gout pill, which is composed of the following raw materials in the indicated weight ratios: Atractylodes macrocephala 28-32g, Poria cocos 28-32g, Alisma plantago-aquatica 18-22g, Anemarrhena asphodeloides 18-22g, Saposhnikovia divaricata 18-22g, Cinnamomum cassia 18-22g, Paeonia lactiflora 19-21g, Astragalus membranaceus 14-16g, processed Aconitum carmichaelii 10-14g, processed Glycyrrhiza uralensis 8-12g, Ephedra sinica 8-11g, Asarum heterotropoides 9-11g, processed Aconitum carmichaelii 4-6 pieces, and fresh ginger 4-6 slices; The prepared raw aconite and prepared aconite root are prepared by the following method: the surface of raw aconite and aconite root is burned to remove the skin, and then they are soaked in Alisma plantago-aquatica wine for 12-14 hours. Finally, the materials are taken out, heated and dried to obtain the prepared raw aconite and prepared aconite root.

[0007] Preferably, the traditional Chinese medicine gout pill is composed of the following ingredients in the indicated weight ratios: 30g of Atractylodes macrocephala, 30g of Poria cocos, 20g of Alisma plantago-aquatica, 20g of Anemarrhena asphodeloides, 20g of Saposhnikovia divaricata, 20g of Cinnamomum cassia, 20g of Paeonia lactiflora, 15g of Astragalus membranaceus, 12g of processed Aconitum carmichaelii, 10g of processed Glycyrrhiza uralensis, 10g of Ephedra sinica, 10g of Asarum heterotropoides, 5 processed Aconitum carmichaelii, and 5 slices of fresh ginger.

[0008] Preferably, the traditional Chinese medicine gout pill is composed of the following ingredients in the indicated weight ratios: Atractylodes macrocephala 31g, Poria cocos 39g, Alisma plantago-aquatica 21g, Anemarrhena asphodeloides 20g, Saposhnikovia divaricata 19g, Cinnamomum cassia 19g, Paeonia lactiflora 19g, Astragalus membranaceus 16g, processed Aconitum carmichaelii 14g, processed Glycyrrhiza uralensis 12g, Ephedra sinica 10g, Asarum heterotropoides 9g, processed Aconitum carmichaelii 6 pieces, and fresh ginger 6 slices.

[0009] On the other hand, the present invention also provides a method for preparing the traditional Chinese medicine gout pill described in any of the above claims, comprising the following steps: Step 1: Place Atractylodes macrocephala, Poria cocos, Alisma plantago-aquatica, Anemarrhena asphodeloides, Saposhnikovia divaricata, Cinnamomum cassia, Paeonia lactiflora, Astragalus membranaceus, Glycyrrhiza uralensis (processed), Ephedra sinica, Asarum sieboldii, Zingiber officinale (fresh), Aconitum carmichaelii (processed), and Aconitum carmichaelii (processed) into a grinder in sequence, grind and mix them, and sieve to obtain a mixture; Step 2: Add honey to the mixture, stir and mix well, then spread it evenly in a steamer and steam. Step 3: After the mixture has cooled naturally, it is processed into pellets using a pellet rolling machine; Step 4: Place the pills in a cool, ventilated place to cool naturally to room temperature and air dry, and you will get the Chinese herbal gout pills.

[0010] Preferably, in step one, the rotation speed of the pulverizer is 300-500 r / min.

[0011] Preferably, in step one, the sieving is done through a 100-120 mesh sieve.

[0012] Preferably, in step two, the mass ratio of the honey to the mixture is 1:2.5-5.

[0013] Preferably, in step two, the steaming time is 100-120 minutes.

[0014] Preferably, in step three, the natural cooling is cooling to 35-40°C.

[0015] Preferably, in step three, the diameter of the pellet is 0.9-1.1 mm.

[0016] This invention provides a traditional Chinese medicine gout pill and its preparation method, which has the following beneficial effects: This traditional Chinese medicine, Gout Pill, has the effects of strengthening the spleen and kidneys, warming yang and dispelling cold, reducing swelling and dissipating nodules, and promoting blood circulation. In clinical treatment of gout and other joint pain of unknown cause, the pain is generally significantly relieved after 7-15 days of medication, and basically cured after 60-90 days. After continuous use for 120-150 days, 90% of patients have stable conditions after stopping the medication and can resume normal life and work. Detailed Implementation

[0017] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0018] The traditional Chinese medicine gout pill provided by this invention is composed of the following ingredients: ephedra, white peony root, astragalus root, prepared licorice root, prepared aconite root, cinnamon twig, atractylodes rhizome, anemarrhena rhizome, saposhnikovia root, prepared raw aconite root, ginger, alisma rhizome, poria cocos, and asarum root.

[0019] The specific ingredients are as follows, according to quality: Atractylodes macrocephala 28-32g, Poria cocos 28-32g, Alisma plantago-aquatica 18-22g, Anemarrhena asphodeloides 18-22g, Saposhnikovia divaricata 18-22g, Cinnamomum cassia 18-22g, Paeonia lactiflora 19-21g, Astragalus membranaceus 14-16g, processed Aconitum carmichaelii 10-14g, processed Glycyrrhiza uralensis 8-12g, Ephedra sinica 8-11g, Asarum heterotropoides 9-11g, processed Aconitum carmichaelii 4-6 pieces, and fresh ginger 4-6 slices.

[0020] Example 1 The Chinese herbal gout pill is composed of the following ingredients in the indicated weight ratios: Atractylodes macrocephala 30g, Poria cocos 30g, Alisma plantago-aquatica 20g, Anemarrhena asphodeloides 20g, Saposhnikovia divaricata 20g, Cinnamomum cassia 20g, Paeonia lactiflora 20g, Astragalus membranaceus 15g, processed Aconitum carmichaelii 12g, processed Glycyrrhiza uralensis 10g, Ephedra sinica 10g, Asarum heterotropoides 10g, processed Aconitum carmichaelii 5 pieces, and fresh ginger 5 slices.

[0021] The preparation method of the traditional Chinese medicine gout pill includes the following steps: Step 1: Place Atractylodes macrocephala, Poria cocos, Alisma plantago-aquatica, Anemarrhena asphodeloides, Saposhnikovia divaricata, Cinnamomum cassia, Paeonia lactiflora, Astragalus membranaceus, Glycyrrhiza uralensis (processed), Ephedra sinica, Asarum heterotropoides, Zingiber officinale (processed), Aconitum carmichaelii (processed), and Aconitum carmichaelii (processed) into a grinder and grind and mix them. Pass the mixture through a 100-120 mesh sieve. The speed of the grinder is 300-500 r / min. The specific preparation steps for processed raw aconite and processed monkshood are as follows: (1) Burn the surface of raw aconite and monkshood to remove the skin; (2) Then soak it in Alisma wine for 12-14 hours; (3) Remove the material and heat it to dry; (4) Obtain processed raw aconite and processed aconitum; Step 2: Add honey to the mixture obtained in Step 1, stir and mix well, then spread it evenly in a steamer and steam for 100-120 minutes. The mass ratio of honey to the mixture is 1:2.5-5. Step 3: Allow the cooked mixture to cool naturally to 35-40℃, then use a pellet rolling machine to process it into pellets with a diameter of 0.9-1.1mm; Step 4: Place the meatballs in a cool, ventilated place to cool naturally to room temperature and air dry.

[0022] Example 2 The Chinese herbal gout pill is composed of the following ingredients in the indicated weight ratios: Atractylodes macrocephala 31g, Poria cocos 39g, Alisma plantago-aquatica 21g, Anemarrhena asphodeloides 20g, Saposhnikovia divaricata 19g, Cinnamomum cassia 19g, Paeonia lactiflora 19g, Astragalus membranaceus 16g, processed Aconitum carmichaelii 14g, processed Glycyrrhiza uralensis 12g, Ephedra sinica 10g, Asarum heterotropoides 9g, processed Aconitum carmichaelii 6 pieces, and fresh ginger 6 slices.

[0023] The preparation method of the traditional Chinese medicine gout pill includes the following steps: Step 1: Place Atractylodes macrocephala, Poria cocos, Alisma plantago-aquatica, Anemarrhena asphodeloides, Saposhnikovia divaricata, Cinnamomum cassia, Paeonia lactiflora, Astragalus membranaceus, Glycyrrhiza uralensis (processed), Ephedra sinica, Asarum heterotropoides, Zingiber officinale (processed), Aconitum carmichaelii (processed), and Aconitum carmichaelii (processed) into a grinder and grind and mix them. Pass the mixture through a 100-120 mesh sieve. The speed of the grinder is 300-500 r / min. The specific preparation steps for processed raw aconite and processed monkshood are as follows: (1) Burn the surface of raw aconite and monkshood to remove the skin; (2) Then soak it in Alisma wine for 12-14 hours; (3) Remove the material and heat it to dry; (4) Obtain processed raw aconite and processed aconitum; Step 2: Add honey to the mixture obtained in Step 1, stir and mix well, then spread it evenly in a steamer and steam for 100-120 minutes. The mass ratio of honey to the mixture is 1:2.5-5. Step 3: Allow the cooked mixture to cool naturally to 35-40℃, then use a pellet rolling machine to process it into pellets with a diameter of 0.9-1.1mm; Step 4: Place the meatballs in a cool, ventilated place to cool naturally to room temperature and air dry.

[0024] Case 1: Tang, male, 48 years old, from Dongba Street, Lizhou District, Guangyuan City. In 2000, he suffered from gout with redness, swelling and pain in both knee joints and the inner side of the big toe joints in both feet. His blood uric acid level was 650 at Guangyuan People's Hospital. He received repeated treatment at tertiary hospitals and secondary hospitals for more than 3 years, but the condition recurred repeatedly. In May 2000, after treatment with this Chinese medicine pill, the pain was significantly relieved on the 5th day, the activity returned to normal on the 25th day, the uric acid level was 440 on the 60th day, and the uric acid level was 380 after 100 days of medication. After continuing to take the medicine for another 2 months, there has been no recurrence for more than 20 years.

[0025] Case 2: Liu, male, 50 years old, a cadre of a group in Shaanxi Province, was hospitalized in a tertiary hospital in Shanghai in March 2014 for gout and high blood pressure. His kidney function was grade 2. The hospital used various advanced treatment methods but none of them had a significant effect, which made it very difficult for him to move. At that time, the patient had edema all over his body, red and swollen knee joints, and unbearable redness, swelling and pain in the ankle joints of both lower limbs. In March 2014, the patient took this Chinese medicine pill. After 15 days, the pain was relieved, the swelling throughout the body subsided, and the patient was able to get out of bed and walk on his own. Around the 40th day, the redness and swelling of the knee and ankle joints completely disappeared, with only slight pain remaining. After about 65 days of medication, the patient came for a follow-up visit. The knee and ankle joints sometimes experienced slight pain when the weather changed. After about 150 days of medication, the uric acid level returned to normal. After 210 days of medication, the kidney function fully recovered to normal, and there has been no recurrence to date. The patient's life and work are now completely normal.

[0026] Case 3: Mr. He, male, 52 years old, from Shenzhen, Guangdong Province, had suffered from gout for more than 6 years. At that time, his wrist joint was red, swollen and painful, and the inner side of the big toe joint of both lower limbs was obviously red and swollen. His uric acid was 680+, and he had high blood pressure, high blood sugar, and high cholesterol. He had difficulty moving. In 2021, he used this Chinese medicine pill. The pain was relieved on the 4th day, and his activity returned to normal on the 30th day. On the 60th day, his uric acid was 420. After continuing to take the medicine for 150 days, his uric acid was 340. He has not relapsed since then, and his life and work have returned to normal.

[0027] Based on the above cases, it can be concluded that this traditional Chinese medicine composition has the effects of strengthening the spleen and kidneys, warming yang and dispelling cold, reducing swelling and dissipating nodules, and promoting blood circulation. In clinical treatment of gout and other joint pain of unknown cause, the pain is generally significantly relieved after 7-15 days of medication, and basically cured after 60-90 days. After continuous use for 120-150 days, 90% of patients have stable conditions after stopping the medication and can resume normal life and work.

[0028] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine gout pill, characterized in that, The ingredients are composed of the following ingredients in the indicated weight ratios: Atractylodes macrocephala 28-32g, Poria cocos 28-32g, Alisma plantago-aquatica 18-22g, Anemarrhena asphodeloides 18-22g, Saposhnikovia divaricata 18-22g, Cinnamomum cassia 18-22g, Paeonia lactiflora 19-21g, Astragalus membranaceus 14-16g, processed Aconitum carmichaelii 10-14g, processed Glycyrrhiza uralensis 8-12g, Ephedra sinica 8-11g, Asarum heterotropoides 9-11g, processed Aconitum carmichaelii 4-6 pieces, and fresh ginger 4-6 slices. The prepared raw aconite and prepared aconite root are prepared by the following method: the surface of raw aconite and aconite root is burned to remove the skin, and then they are soaked in Alisma plantago-aquatica wine for 12-14 hours. Finally, the materials are taken out, heated and dried to obtain the prepared raw aconite and prepared aconite root.

2. The traditional Chinese medicine gout pill according to claim 1, characterized in that, The ingredients are composed of the following ingredients in the indicated weight ratios: Atractylodes macrocephala 30g, Poria cocos 30g, Alisma plantago-aquatica 20g, Anemarrhena asphodeloides 20g, Saposhnikovia divaricata 20g, Cinnamomum cassia 20g, Paeonia lactiflora 20g, Astragalus membranaceus 15g, processed Aconitum carmichaelii 12g, processed Glycyrrhiza uralensis 10g, Ephedra sinica 10g, Asarum heterotropoides 10g, processed Aconitum carmichaelii 5 pieces, and fresh ginger 5 slices.

3. The traditional Chinese medicine gout pill according to claim 1, characterized in that, The ingredients are composed of the following ingredients in the indicated weight ratios: Atractylodes macrocephala 31g, Poria cocos 39g, Alisma plantago-aquatica 21g, Anemarrhena asphodeloides 20g, Saposhnikovia divaricata 19g, Cinnamomum cassia 19g, Paeonia lactiflora 19g, Astragalus membranaceus 16g, processed Aconitum carmichaelii 14g, processed Glycyrrhiza uralensis 12g, Ephedra sinica 10g, Asarum heterotropoides 9g, processed Aconitum carmichaelii 6 pieces, and fresh ginger 6 slices.

4. A method for preparing the traditional Chinese medicine gout pill according to any one of claims 1-3, characterized in that, Includes the following steps: Step 1: Place Atractylodes macrocephala, Poria cocos, Alisma plantago-aquatica, Anemarrhena asphodeloides, Saposhnikovia divaricata, Cinnamomum cassia, Paeonia lactiflora, Astragalus membranaceus, Glycyrrhiza uralensis (processed), Ephedra sinica, Asarum sieboldii, Zingiber officinale (fresh), Aconitum carmichaelii (processed), and Aconitum carmichaelii (processed) into a grinder in sequence, grind and mix them, and sieve to obtain a mixture; Step 2: Add honey to the mixture, stir and mix well, then spread it evenly in a steamer and steam. Step 3: After the mixture has cooled naturally, it is processed into pellets using a pellet rolling machine; Step 4: Place the pills in a cool, ventilated place to cool naturally to room temperature and air dry, and you will get the Chinese herbal gout pills.

5. The preparation method of the traditional Chinese medicine gout pill according to claim 4, characterized in that, In step one, the rotation speed of the pulverizer is 300-500 r / min, and the sieving is done through a 100-120 mesh sieve.

6. The method for preparing the traditional Chinese medicine gout pill according to claim 4, characterized in that, In step two, the mass ratio of honey to the mixture is 1:2.5-5, and the cooking time is 100-120 minutes.

7. The preparation method of the traditional Chinese medicine gout pill according to claim 4, characterized in that, In step three, the natural cooling is to cool to 35-40℃, and the diameter of the pellet is 0.9-1.1mm.