Veterinary vaccine adjuvant, method of making and use thereof

A veterinary vaccine adjuvant was prepared by combining lactic acid-glycolic acid copolymer, saponins, and pine pollen, which solved the problems of high viscosity and serious side effects of existing adjuvants, and achieved a highly efficient, safe immune response and long-term protection.

CN122376727APending Publication Date: 2026-07-14JINYUBAOLING BIO PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JINYUBAOLING BIO PHARMA CO LTD
Filing Date
2026-04-17
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

Existing veterinary vaccine adjuvants suffer from problems such as high viscosity, severe side effects, and short duration of immune protection, making it difficult to meet the requirements of good stability, high safety, and strong immunogenicity.

Method used

A combination of lactic acid-glycolic acid copolymer, saponins, mannose and pine pollen was used to prepare veterinary vaccine adjuvants through a specific process. The PLGA nanoparticle delivery system was used to enhance the immune response and reduce drug loss.

Benefits of technology

The prepared vaccine adjuvant significantly enhances the speed and intensity of specific immune responses, activates non-specific defense mechanisms, improves disease resistance, and has high safety, long duration of immune response, strong stability, and is suitable for the application of multiple antigens.

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Abstract

The present application belongs to the technical field of veterinary vaccine adjuvant, and particularly relates to a veterinary vaccine adjuvant, a preparation method and application thereof, which comprises the following components in mass fraction: 20-40 parts of lactic acid-glycolic acid copolymer, 20-40 parts of saponin, 10-30 parts of mannose and 10-40 parts of pine pollen; the veterinary vaccine adjuvant, the preparation method and the application thereof creatively combine saponin, mannose and pine pollen, can significantly enhance the speed and intensity of specific immune response of the veterinary vaccine, can accurately identify and start the non-specific defense mechanism, improve the resistance and enhance the disease resistance; in addition, the vaccine adjuvant provided by the present application is extremely hydrophilic, good in absorption, free of any side reaction; the veterinary vaccine prepared further has high stability, high safety, is easy to inject, and can induce the body to produce long-lasting and high-efficiency immune response.
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