A positioning method suitable for BNCT treatment

Abstract

The application discloses a positioning method suitable for BNCT treatment, which is based on a simulation positioning space communicated with a treatment space; a simulation treatment head system, a CT device and a multi-dimensional motion patient positioning system for connecting the simulation positioning space and the treatment space are arranged in the simulation positioning space, wherein the patient positioning system comprises a treatment bed provided with a reference point; the positioning method comprises a simulation positioning and positioning integrated process, a transfer process and a release process. The positioning method realizes a complete positioning process from target object pre-positioning, simulation positioning, positioning review to treatment positioning, transfer and release, effectively reduces the positioning times of the target object, improves the positioning accuracy and efficiency of the target object, improves the utilization efficiency of the treatment space, increases the flow rate of the BNCT target object, reduces the radiation damage of an image guiding system and prolongs the service life of the equipment.

Description

Technical Field

[0001] This invention relates to the field of radiotherapy technology, and in particular to a positioning method suitable for BNCT treatment that realizes simulated positioning, simulated positioning, positioning verification, treatment positioning, transport, and release. Background Technology

[0002] In existing boron neutron capture therapy (BNCT) procedures, the positioning process mainly references the protocols of photon and proton radiotherapy. However, while the treatment heads of photon and proton radiotherapy devices are mostly rotatable, making target positioning relatively easy, the treatment head of BNCT devices is fixed. This requires adjusting the target's pose to bring the treatment area close to the beam port of the treatment head, a significant difference from photon and proton therapy. BNCT treatment presents challenges such as induced radiation exposure during target positioning in the treatment space, large positioning errors due to multiple positioning attempts, low positioning efficiency, low target throughput, and damage to the image guidance device due to neutron activation.

[0003] Currently, there is no effective and standardized treatment positioning procedure in the industry to solve the above problems. It is necessary to design a positioning method suitable for BNCT treatment to solve the problem of additional induced radiation exposure to the target patient and medical staff, reduce the number of target patient positioning operations, improve the accuracy and efficiency of target patient positioning, improve the utilization efficiency of treatment space, increase the throughput of BNCT target patients, reduce radiation damage to the image-guided system, and extend the service life of the equipment. Summary of the Invention

[0004] The purpose of this invention is to address the problems of induced radiation exposure during target placement in the treatment space during BNCT treatment, including large placement errors, low placement efficiency, low target object throughput, and damage to the image guidance device due to neutron activation. This invention provides a placement method suitable for BNCT treatment. Through the integrated design of an adjustable simulation treatment head, a patient placement system, and a sliding rail CT device, and the linkage between the patient placement system and the treatment space, a complete placement process is achieved from target object pre-positioning, simulation positioning, placement verification to treatment placement, transport, and release. This avoids additional induced radiation exposure to the target object and medical personnel, reduces the number of target object placements, improves target object placement accuracy and efficiency, increases the utilization efficiency of the treatment space, increases the BNCT target object throughput, reduces radiation damage to the image guidance system, and extends the service life of the equipment.

[0005] The technical solution adopted by this invention to achieve its objective is: a positioning method suitable for BNCT treatment, based on a simulated positioning space connected to the treatment space; the simulated positioning space is equipped with a simulated treatment head system, a CT device, and a multi-dimensional motion patient positioning system connecting the simulated positioning space and the treatment space, wherein the patient positioning system includes a treatment bed with reference points; the integrated method includes: Integrated Simulation Positioning Process: In the simulation positioning area, the treatment bed is adjusted so that the reference position is located at the isocenter point O. The laser rangefinder is used to simulate the beam center position, and the coordinates of the treatment bed reference point A and the angle relative to the beam outlet are adjusted. The treatment bed is moved to the CT device to scan and obtain the simulation positioning image. A treatment plan is formulated and the positioning plan is output. The bed is moved back to the simulation positioning area for positioning verification. Treatment positioning is performed before treatment begins. Transfer process: Move the treatment bed to the treatment space for final location confirmation; Release procedure: Move the treatment bed back to the simulated positioning space for release.

[0006] This patient positioning method for BNCT treatment primarily involves designing a simulated positioning space and integrating a simulated treatment head system, a CT scanner, and a multi-dimensional motion patient positioning system capable of three-dimensional translation and multi-angle rotation within this space. This allows for a unified, integrated positioning process within the simulated space, completing all the steps previously performed in separate steps within existing technologies on the same treatment bed. This eliminates the need for repeated transfers, effectively reducing positioning errors caused by multiple transfers, repeated patient positioning, and deviations in treatment bed positions. The patient positioning system allows for adjustment of the angle and distance between the treatment bed and the simulated treatment head. After determining the spatial relationship between the treatment bed and the isocenter point O, the treatment bed is moved or rotated to the CT scanner. A CT scan is then performed within the same space to acquire simulated positioning images, enabling simulated positioning. Treatment plans can be directly developed based on these images, and the positioning plan is output. The target patient is then repositioned on the treatment bed, and the positioning is verified within the modular positioning space by moving the treatment bed relative to the adjustable simulated treatment head. Meanwhile, the treatment positioning only needs to be completed on the day of treatment, after the treatment conditions are met, within the simulated positioning space according to the position verified. After the treatment positioning is completed, the target object can be directly moved to the treatment space via the treatment bed for position check and irradiation treatment, eliminating the need for treatment positioning within the treatment space and avoiding additional radiation. Moreover, after treatment, there is no need to wait for release within the treatment space; the target object can be moved to the simulated positioning space via the treatment bed for release. This positioning method applicable to BNCT treatment integrates the entire process from target object pre-positioning, CT scan simulation positioning, treatment plan formulation, positioning verification to actual treatment positioning. It reduces the need to reinstall target object fixation devices on the treatment bed and repeatedly transfer between multiple locations, reducing positioning operations and scheduling, effectively improving the accuracy and efficiency of target object positioning, increasing the utilization efficiency of the treatment space, increasing the throughput of BNCT target objects, reducing radiation damage to the image-guided system, and extending the service life of the equipment.

[0007] Preferably, the simulated treatment head system includes a simulated treatment head, an orthogonal DR positioning verification system mounted on both sides of the simulated treatment head, and a laser light system. A laser rangefinder is positioned at the center of the simulated treatment head. The simulated treatment head can be a fixed or adjustable one. The reference position refers to the intersection point of the lines connecting the centers of the projections of all laser lines in the laser light system. The isocenter point O is a virtual point on the beam centerline, used to determine the position of the beam center in space. The simulated treatment head can be configured to simulate horizontal or vertical beam output to meet the needs of different treatment room treatment head positions. The orthogonal DR positioning verification system is installed on both sides of the adjustable simulated treatment head. The laser light system is used to achieve two laser line projections covering the cross-section and coronal plane of the target object, as well as a laser line projection covering the sagittal plane of the target object. This achieves the simulation requirements of the treatment room environment.

[0008] Preferably, the integrated simulation positioning process includes obtaining the relative positional relationship between the treatment bed reference point and the isocenter point O. This is achieved by using a laser rangefinder positioned at the center of the simulated treatment head to simulate the beam center position and the projection of the beam center point onto the target object's surface, thus simulating the neutron beam irradiation point. The position and posture of the target object on the treatment bed are adjusted, along with the angle and displacement of the treatment bed relative to the beam outlet, to simulate the positional relationship between the target object and the beam injection point, achieving pre-positioning. After completing the simulated positioning of the target object, the relative positional relationship between the treatment bed reference point and the isocenter point O is obtained. The laser rangefinder is then used to measure the distance (SSD) from the target object's surface to the collimator outlet.

[0009] Preferably, the pre-positioning mainly includes: using a laser light simulating the center of the treatment head to adjust the treatment bed so that the reference position is located at the isocenter point O; and, A laser rangefinder is used to simulate the beam center position, and the angle and position of the reference point A of the treatment bed relative to the beam outlet are adjusted to simulate different SSDs and irradiation angles. When the pose of the target object, the angle and distance of the treatment bed meet the expected requirements, read and record the coordinates of the current treatment bed reference point A and the current distance of the laser rangefinder; The treatment bed is returned to the 0° position (parallel to the beam) and the center point of the laser line projection intersection is marked.

[0010] Preferably, the CT device includes a CT scanning device and a CT laser lamp; the CT scanning device can be configured as a sliding rail CT device or a fixed CT device, depending on the simulated positioning space.

[0011] Preferably, the simulated positioning image is obtained by directly rotating the treatment bed along with the target object, or by first retracting and then rotating it to the CT scan position, turning on the CT laser light of the positioning CT, adjusting the height of the treatment bed to align with the marked position of the target object, starting the CT scan device, and completing the acquisition of the simulated positioning image.

[0012] Preferably, the treatment plan is developed by directly delineating the target area based on the simulated positioning image of the target object, referencing the coordinate difference between two treatment bed reference points A obtained from the simulation, and referring to the irradiation plan for the target object to complete the irradiation dose assignment and evaluation, outputting the irradiation dose and positioning plan for the target object; wherein, the positioning plan includes the displacement and rotation angle of the reference point relative to the isocenter point O. The coordinate difference between the two treatment bed reference points A represents the displacement and rotation angle that the reference point needs to move relative to the isocenter point O.

[0013] Preferably, the positioning verification is as follows: the target object is placed on the treatment bed, and the target object is fixed using a fixation device with laser markers made during pre-positioning. The treatment bed is adjusted to make the position of the laser lamp projection and the laser line markers on the fixation device coincide. At this time, the orthogonal DR positioning verification system on both sides of the simulated treatment head is used to obtain the DR image of the target object, and it is compared with the two-dimensional positioning image generated based on the simulated positioning CT image. The target position deviation is checked and adjusted to determine that the positioning center point of the target object defined in the treatment plan coincides with the system's isocenter point O.

[0014] The treatment bed is moved according to the displacement and rotation angle required relative to the isocenter point O, as specified in the positioning plan. The target object is moved to the simulated positioning area, and the movement is observed to ensure successful placement. After placement, the relative position of the target object and the simulated treatment head, as well as the SSD (Special Treatment Surface) alignment, are checked against the treatment plan. If successful and consistent with the plan, the target object positioning verification is complete. At this point, a second marker is marked at the intersection of the laser beam projections on the target object's fixation device. This marker is used to verify the accuracy of the target position during subsequent actual treatment. If inconsistencies are found, the treatment plan needs to be readjusted, and the positioning verification repeated.

[0015] Treatment positioning is performed within a simulated positioning space when the target object meets the irradiation requirements, and includes: The DR system is used to determine that the reference position coincides with the isocenter point O, and the spatial reference is established. The target object is adjusted and fixed using a fixing device with a marked center point position, so that the center point position of the laser lamp projection and the marked center point position on the fixing device are coincident; The orthogonal DR positioning verification system on both sides of the simulated treatment head is used to acquire DR images of the target object, which are then compared with simulated positioning images generated by a simulated positioning CT device. The target position deviation is checked and adjusted to determine that the center of the target object coincides with the isocenter point O, thus establishing a spatial reference.

[0016] As a preferred option, a camera-based patient monitoring system and a laser lighting system are installed inside the treatment space; After confirming that the center of the target object coincides with the isocenter point O, move the treatment bed to the treatment space and move it to the final treatment position according to the placement plan; Final location accuracy verification: Use a camera to check whether the laser marking lines at the target location coincide, and check whether the target treatment location is correct; Treatment will begin once the diagnosis is confirmed.

[0017] After the treatment positioning is completed in the simulated positioning space, the target object is moved to the treatment space via the treatment bed, and then to the treatment position. Once the position is checked to be correct, irradiation treatment can be performed. This effectively avoids situations where the target object has to endure additional drug injections or cannot be treated due to the inability to meet the treatment position requirements.

[0018] Preferably, the patient positioning system controls the movement through a control system, supporting translational movements in the X, Y, and Z directions and rotational movements in the Yaw, Pitch, and Roll angles. The control system reads the coordinates and deflection angle of the treatment bed reference point A, and obtains the spatial positional relationship between the treatment bed reference point and the isocenter point O by the difference between the coordinates of the treatment bed reference point and the isocenter point O.

[0019] The beneficial effects of the present invention are: compared with the prior art, the positioning method applicable to BNCT treatment (1) reduces positioning error: the pre-positioning, simulation positioning, positioning verification and formal treatment are integrated into a unified or linked space to reduce the repeated transfer of the target object in different rooms and the repeated fixation between treatment beds, thereby reducing the cumulative error caused by multiple positioning and improving positioning accuracy and consistency.

[0020] (2) Improve the efficiency of the placement process: By integrating equipment functions and optimizing the process, the preparation time for the target is shortened, the workload of medical staff is reduced, and the overall continuity and execution efficiency of the placement process are improved.

[0021] (3) Save space and construction costs: By rationally planning the equipment layout, the original scattered functional areas (such as simulation positioning room, positioning room and treatment room) are integrated into the same simulation positioning space, reducing the demand for hospital space, improving equipment utilization, and reducing operation and maintenance costs.

[0022] (4) Reduce radiation exposure risk: The target object is positioned in a simulated positioning space, reducing the frequency and duration of medical personnel entering the high-radiation environment of the treatment room and reducing unnecessary radiation exposure. After the target object completes neutron irradiation, it can be directly moved out of the treatment space via a sliding rail for release, without waiting for the radiation dose in the treatment space to decrease before release, thus reducing the additional radiation dose to the target object.

[0023] (5) By setting the orthogonal DR positioning verification system outside the treatment space or in an independent shielded area, it is avoided from being irradiated for a long time during neutron irradiation, which effectively reduces the performance loss and material aging of the equipment caused by radiation and extends its service life. This reduces the frequency of equipment maintenance and replacement costs, while ensuring the stability and imaging quality of the imaging system.

[0024] By designing a target placement simulation space compatible with both horizontal and vertical beam therapy in boron neutron capture therapy (BNCT), and linking the simulation space with the treatment space, a complete placement process from target placement simulation to irradiation is achieved. This avoids additional induced radiation exposure to the target and medical staff, reduces the number of target placements, improves target placement accuracy and efficiency, enhances the utilization efficiency of the treatment room, increases the throughput of BNCT targets, reduces radiation damage to the image-guided system, and extends the lifespan of the equipment. Attached Figure Description

[0025] Figure 1 This is a flowchart of a positioning method applicable to BNCT treatment according to the present invention.

[0026] Figure 2 This is a planar schematic diagram of the positioning method applicable to BNCT treatment.

[0027] Figure 3 This is a plan view of the positioning method applicable to BNCT treatment in Example 2.

[0028] Figure 4 This is a structural layout diagram of the simulated placement space and treatment space in Example 2.

[0029] Figure 5 This is a three-dimensional diagram of the structural layout of the simulated placement space and treatment space in Example 2.

[0030] Figure 6 This is a plan view of the positioning method applicable to BNCT treatment in Example 3.

[0031] Figure 7 This is a structural layout diagram of the simulated placement space and treatment space in Example 3.

[0032] Figure 8This is a three-dimensional diagram of the structural layout of the simulated placement space and treatment space in Example 3.

[0033] Figure 9 This is a structural diagram of the simulated placement space and treatment space in Example 4.

[0034] Figure 10 This is a three-dimensional layout diagram of the simulated placement space and treatment space in Example 4.

[0035] In the diagram: 1. Treatment space; 2. Simulated positioning space; 3. Orthogonal DR positioning verification system; 31. X-ray tube; 32. Image detector; 4. Laser light system, 41. Cross laser, 42. Line laser; 5. Adjustable simulation treatment head; 51. Horizontal simulation treatment head; 52. Vertical simulation treatment head; 6. Patient positioning system; 61. Slide rail; 62. Robotic arm base; 63. Suspended slide rail patient positioning system; 64. Ground slide rail patient positioning system; 7. Treatment bed; 8. Sliding rail CT device; 81. CT laser lamp; 9. Laser rangefinder; 10. Patient monitoring system; 101. Camera; 11. Actual treatment head, 12. Shielding door, 13. Accelerator space, 14. Accelerator, 15. Vertical treatment head, 16. Horizontal treatment head. Detailed Implementation

[0036] The present invention will now be described in detail with reference to specific embodiments and accompanying drawings. Structures, circuit controls, and signal controls not described herein can all employ conventional techniques.

[0037] Example 1:

[0038] exist Figure 1 , Figure 2 In the illustrated embodiment, a simulated positioning therapy integrated method is based on a simulated positioning space 2 connected to a treatment space 1. The simulated positioning space 2 is equipped with a simulated treatment head system, a CT scanner, and a multi-dimensional motion patient positioning system 6 connecting the simulated positioning space 2 and the treatment space 1. The patient positioning system 6 includes a treatment bed 7 with a reference point A. A simulated positioning area is provided within the simulated positioning space 2.

[0039] In this embodiment, the patient positioning system 6 controls the movement through a control system, supporting translational movement in the X, Y, and Z directions and rotational movement in the Yaw, Pitch, and Roll angles. The control system reads the coordinates and deflection angle of the treatment bed reference point A, and obtains the spatial positional relationship between the treatment bed reference point A and the isocenter point O by the difference between the coordinates of the treatment bed reference point A and the coordinates of the isocenter point O.

[0040] In this embodiment, the simulated treatment head system includes a simulated treatment head, an orthogonal DR positioning verification system 3 and a laser light system 4 disposed on both sides of the simulated treatment head, wherein a laser rangefinder 9 is disposed at the center of the simulated treatment head 5.

[0041] The simulated treatment head can be a fixed or adjustable simulated treatment head 5. The adjustable simulated treatment head 5 can be adjusted via a sliding rail, relative to the base, relative to the space wall, or other feasible adjustment methods to change its position within the positioning space. Simulated treatment heads with different aperture collimators can be used depending on the positioning requirements. The isocenter point O is a virtual point on the beam centerline, used to determine the beam center position within the space. Inside the simulated positioning space, the output beam centerline of the laser rangefinder passes through the isocenter point O, and the orthogonal center point of the orthogonal DR positioning verification system 3 and the intersection point of the laser line projections both coincide with the isocenter point O.

[0042] In this embodiment, the CT device is a sliding rail CT device 8, which includes a CT scanning device and a CT laser lamp 81; The treatment space 1 is equipped with a camera-based patient monitoring system 10 and a laser light system 4.

[0043] This integrated approach to simulated positioning therapy includes: The integrated simulation positioning process is as follows: First, match the corresponding simulated treatment head according to the treatment head in treatment space 1, and adjust the relative position of the simulated treatment head and the treatment head. In the simulated positioning area, the treatment bed is adjusted so that the reference position is located at the isocenter point O. The laser rangefinder is used to simulate the beam center position, and the coordinates of the treatment bed reference point A and the angle relative to the beam outlet are adjusted. The treatment bed is moved to the CT device to scan and obtain simulated positioning images. A treatment plan is formulated and the positioning plan is output. The treatment bed is moved back to the simulated positioning area and the positioning is checked according to the positioning plan. The treatment positioning is performed before the treatment begins. Transfer process: Move the treatment bed to the treatment space for final location confirmation. Release procedure: Move the treatment bed back to the simulated positioning space for release.

[0044] Furthermore, the spatial relationship between the reference point A of the treatment bed and the isocenter point O is obtained by simulating the position of the beam center using a laser rangefinder and by indicating the projection of the beam center point onto the surface of the target object, which is used to simulate the neutron beam irradiation point. By adjusting the position and posture of the target object on the treatment bed, and adjusting the angle and displacement of the treatment bed relative to the beam outlet, the positional relationship between the target object and the beam injection point is simulated to achieve pre-positioning; After completing the simulated positioning of the target object, obtain the relative positional relationship between the reference point A of the treatment bed and the isocenter point O.

[0045] Furthermore, the pre-positioning mainly includes: using the laser light at the simulated treatment head to adjust the treatment bed so that the reference position of the target object is located at the isocenter point O; and, A laser rangefinder is used to simulate the beam center position, and the angle and position of the reference point A of the treatment bed relative to the beam outlet are adjusted to simulate different SSDs and irradiation angles. When the pose of the target object, the angle and distance of the treatment bed meet the expected requirements, read and record the coordinates of the current treatment bed reference point A and the current distance of the laser rangefinder; After adjusting the treatment bed to a position parallel to the laser beam (0° position) and fixing the target body position, the laser light system marks the center of intersection of the laser line projections on the thermoplastic film surface and attaches positioning lead points.

[0046] The reference position refers to the intersection point of the line connecting the centers of the projections of all laser lines in the laser light system.

[0047] Target body positioning fixation refers to using fixation devices such as foam molds, vacuum pads, and body molds to fix the target body on the treatment bed, or using thermoplastic molding devices to fix the target body on the treatment bed.

[0048] Specifically, the movement of the patient positioning system 6 is controlled by the control system, and the coordinates and deflection angle of the treatment bed reference point A are read. The spatial positional relationship between the treatment bed reference point A and the isocenter point O is obtained by the difference between the coordinates of the treatment bed reference point A and the isocenter point O. The spatial positional relationship between the treatment bed reference point A and the isocenter point O is obtained by using the laser rangefinder 9 at the center of the simulated treatment head, and the adjustable simulated treatment head 5, based on the CT or MR image examination data of the target object, to identify the target position and adjust the relative position of the treatment bed with respect to the simulated treatment head, thereby achieving pre-positioning of the target object's position and posture.

[0049] Furthermore, the simulated positioning image is obtained by directly rotating or retracting and then rotating the treatment bed along with the target object to the CT scan position, turning on the CT laser light of the positioning CT, adjusting the height of the treatment bed to align with the marked position of the target object, starting the CT scanning device, and completing the acquisition of the simulated positioning image.

[0050] Specifically, the simulated positioning image of the target object is obtained through the sliding rail CT device 8. The simulated positioning image is obtained by the control system directly rotating the treatment bed along with the target object or first retracting and then rotating it to the scanning position of the sliding rail CT device 8, turning on the CT laser lamp 81 of the positioning CT set at the sliding rail CT device 8, adjusting the height of the treatment bed to align with the marked position on the surface of the target object, and starting the scanning of the sliding rail CT device to complete the acquisition of the positioning image.

[0051] Furthermore, the treatment plan is formulated by directly delineating the target area based on the simulated positioning image of the target object, referring to the spatial positional relationship between the treatment bed reference point A and the isocenter point O obtained from the simulation, formulating the irradiation plan for the target object, giving and evaluating the irradiation dose, and outputting the irradiation dose and positioning plan for the target object; wherein, the positioning plan includes the positional relationship of the laser line projection intersection center point marked on the target object fixation device relative to the isocenter point O and the irradiation angle.

[0052] Furthermore, the positioning verification is as follows: First, the DR system is used to determine that the center of the target object coincides with the isocenter point O, and a spatial reference is established. According to the positioning plan, combined with the positioning deviation of the target object's target position, the coordinates and angles of the treatment bed reference point A relative to the simulated treatment head are calculated. The treatment bed is then moved to the simulated positioning location, and the relative position of the target object and the simulated treatment head, as well as the SSD, are checked to see if they are consistent with the treatment plan. If they are consistent, the positioning verification of the target object is completed. After confirming the target position using the laser light system on both sides of the simulated treatment head, the second marker point is marked.

[0053] If there is a discrepancy, it needs to be adjusted to be consistent.

[0054] Furthermore, the treatment positioning is performed within the simulated positioning space when the target object meets the irradiation requirements, and includes: The DR system is used to determine that the reference position coincides with the isocenter point O, and the spatial reference is established. The target object is adjusted and fixed using a fixing device with a marked center point position, so that the center point position of the laser lamp projection and the marked center point position on the fixing device are coincident; The orthogonal DR positioning verification system on both sides of the simulated treatment head is used to acquire DR images of the target object, which are then compared with simulated positioning images generated by a simulated positioning CT device. The target position deviation is checked and adjusted to determine that the center of the target object coincides with the isocenter point O, thus establishing a spatial reference.

[0055] After confirming that the center of the target object coincides with the isocenter point O, move the treatment bed to the treatment space and move it to the final treatment position according to the placement plan; Final location accuracy verification: Use a camera to check whether the laser marking lines at the target location coincide, and check whether the target treatment location is correct; Treatment will begin once the diagnosis is confirmed.

[0056] The orthogonal DR positioning verification system 3 and the laser lamp system 4 are set at the isocenter point O of the simulated positioning space 5. The orthogonal DR positioning verification system 3 includes two sets of orthogonal X-ray imaging devices, each consisting of two X-ray tubes 31 and two image detectors 32. The two X-ray tubes 31 are mounted on the ground, and the two image detectors 32 are mounted on the top via a suspension device. The centers of the two X-ray beams intersect at the isocenter point O. That is, an orthogonal X-ray imaging device is installed on both sides of the adjustable simulated treatment head 5 to acquire DR images of the target object's intended treatment area during target object positioning verification. This image is used for registration with the CT images in the target object's treatment plan to confirm that the target object's positioning is consistent with the positioning in the treatment plan.

[0057] The three laser lights in the laser light system 4 are used to assist in the positioning of the target object. Two cross laser lights 41 are installed on each of the left and right sides to achieve two laser line projections covering the cross section and coronal plane of the target object. A single laser light 42 is installed on the top to achieve laser line projection covering the sagittal plane of the target object.

[0058] This positioning method for BNCT treatment involves positioning the patient within a treatment space 1 connected to a simulated positioning space. Treatment space 1 is equipped with a camera-based patient monitoring system 10 and a laser light system 4. Specifically, three laser lights and three cameras are installed at the isocenter point O of the treatment space to verify the accuracy of the target patient's position during actual treatment and to monitor the target patient's positional movement. Two cross-shaped laser lights 41 are installed on each side of the actual treatment head 11 to project two laser lines covering the target patient's transverse and coronal planes. A single-line laser light 42 is installed at the top to project a laser line covering the target patient's sagittal plane. The three cameras 101 allow observation of the projection positions of the laser lines in three directions on the target patient's body surface.

[0059] The positioning method applicable to BNCT treatment involves, after the positioning verification is completed, controlling the patient positioning system through the control system to move and transfer the treatment bed to treatment space 1, and transporting the target object to the treatment position; checking whether the laser marking lines of the target object coincide through camera 101 to verify whether the treatment position of the target object is correct.

[0060] After the treatment of the target patient is completed, the patient positioning system is controlled by the control system to move and transfer the treatment bed to the simulated positioning space 1 for release.

[0061] Example 2:

[0062] exist Figure 3 , Figure 4 , Figure 5 In the illustrated embodiment, a simulated positioning and treatment integrated method is applicable to horizontal beam therapy. The simulated positioning space 2 and the treatment space 1 are located on the same floor, for example, both on the same floor. An accelerator space 13 is located on the same floor opposite to the treatment space 1, and an accelerator 14 is located inside the accelerator space. Specifically, a horizontal simulated treatment head 51 is located inside the simulated treatment space 2, and a horizontal treatment head 16 is located inside the treatment space 1. The CT device used is a sliding rail CT device 8.

[0063] This integrated simulation-based therapy method is based on a simulation-based positioning space connected to the treatment space. The simulation-based positioning space is equipped with a simulation treatment head system, a CT scanner, and a multi-dimensional motion patient positioning system connecting the simulation-based positioning space and the treatment space. The patient positioning system includes a treatment bed with reference points. This integrated simulation-based therapy method includes: Integrated Simulation Positioning Process: In the simulation positioning area, the treatment bed is adjusted so that the reference position is located at the isocenter point O. The laser rangefinder is used to simulate the beam center position, and the coordinates of the treatment bed reference point A and the angle relative to the beam outlet are adjusted. The treatment bed is moved to the CT device to scan and obtain the simulation positioning image. A treatment plan is formulated and the positioning plan is output. The bed is moved back to the simulation positioning area for positioning verification. Treatment positioning is performed before treatment begins. Transfer process: Move the treatment bed to the treatment space for final location confirmation; Release procedure: Move the treatment bed back to the simulated positioning space for release.

[0064] In this embodiment, the treatment target is a tumor site within the head of the target subject.

[0065] Specifically, the following steps are included: Step 1: Within the simulated positioning space, pre-position the target object for horizontal beam therapy using a patient positioning system based on a fixed or adjustable horizontal simulated treatment head, three-dimensional translation, and angular rotational motion. S11: Based on the diagnostic imaging data of the tumor site of the target patient, a preliminary plan is made for the irradiation direction of the neutron beam and the position of the target patient lying on the treatment bed.

[0066] S12: The target object lies on the treatment bed panel. The three-dimensional laser lights (cross laser lights and straight laser lights) at the isocenter point O are turned on for reference. The treatment bed is adjusted so that the center of the part of the target object to be irradiated is approximately located at the isocenter point O.

[0067] S13: Turn on the laser rangefinder 9 installed at the center of the horizontal simulated treatment head to simulate the beam center position. Adjust the AX, Y, Z coordinates of the treatment bed reference point and the angle relative to the beam outlet through the treatment bed control system to simulate different SSDs and irradiation angles.

[0068] S14: When the pose of the target object, the angle and distance of the treatment bed meet the requirements of the expected plan, and it is confirmed that there is no physical interference between the target object, the treatment bed and the horizontal treatment head device, the treatment bed or the horizontal simulated treatment head is moved away, and the target object to be irradiated part is fixed on the treatment bed using a thermoplastic film.

[0069] S15: At this point, read and record the angle of the current target object's treatment bed relative to the beam centerline, and read and record the coordinates of the current treatment bed reference point A. Read and record the current distance of the laser rangefinder 9. The recorded data can be used as a reference for creating a treatment plan for the target object in the treatment planning system.

[0070] S16: Return the angle of the treatment bed to 0°, use a marker to make a cross mark at the center of the intersection of the laser lines projected on the thermoplastic film surface, and attach positioning lead points.

[0071] Step 2: Acquire simulated positioning images using a sliding rail CT device within the simulated positioning space: S21: The treatment bed, together with the target object, is transported to the scanning position of the sliding CT device 8 through the treatment bed control system. The CT laser lamp 81 of the positioning CT is turned on, and the height of the treatment bed is adjusted to complete the alignment with the marked position on the surface of the target object, thus completing the acquisition of the simulated positioning image.

[0072] Step 3: Treatment Plan Development The tumor target area is delineated based on the simulated positioning CT images of the target object. The irradiation plan for the target object is formulated, the irradiation dose is given and evaluated, and the irradiation dose and positioning plan for the target object are output, with the positioning plan including the movement distance and rotation angle of the positioning center point of the target object relative to the isocenter point O in the X, Y, and Z directions, as well as the distance between the collimator and the surface of the target object (SSD).

[0073] Step 4: Perform placement verification within the simulated placement space: After the treatment plan for the target subject is completed, the target subject lies on the simulated positioning treatment bed, and the thermoplastic film and other fixation devices are installed. The position of the target subject is adjusted so that the laser light projection and the marking line on the surface of the thermoplastic film coincide.

[0074] At this point, the treatment bed control system calculates the coordinates and angle of the reference point A in the final treatment position based on the positional relationship between the center point and the isocenter point O provided by the treatment plan, as well as the irradiation angle, combined with the positioning deviation of the target object. The system then transports the treatment bed to this position and checks whether the relative position of the target object and the treatment head, as well as the SSD, are consistent with the treatment plan, thus completing the target object positioning verification. The projection of the laser lamp onto the thermoplastic film surface is then used as a second marker point.

[0075] This step can be performed either before the target person receives the medication or after the target person receives the infusion.

[0076] Step 5: Treatment Positioning: On the day of treatment, after the target subject completes the infusion and the blood boron concentration meets the irradiation requirements, the target subject lies down on the treatment bed in the simulation positioning room, the thermoplastic film and other fixation devices are installed, and the reference position is checked to be consistent with the isocenter point O.

[0077] Step 6: Treatment of the target object: Use the patient positioning system to move the target object to the treatment space. Transport the target object to the treatment position according to the positioning plan in the treatment plan. Use a camera to check whether the second marker point of the target object coincides and check whether the treatment position of the target object is correct.

[0078] Step 7: After the treatment of the target patient is completed, the patient positioning system is controlled by the control system to move and transfer the treatment bed to the simulated positioning space for release.

[0079] Example 3:

[0080] exist Figure 6 , Figure 7 , Figure 8 In the illustrated embodiment, a simulated positioning and treatment integrated method is applicable to vertical beam therapy. The simulated positioning space 2 and the treatment space 1 are located on the same floor, for example, both on the same floor. An accelerator space 13 is located on the second floor opposite to the treatment space 1, and an accelerator 14 is installed inside the accelerator space. Specifically, a vertical simulated treatment head 52 is installed inside the simulated treatment space 2, and a vertical treatment head 15 is installed inside the treatment space 1. The CT device is a sliding rail CT device.

[0081] This positioning method for BNCT treatment is based on a simulated positioning space connected to the treatment space. The simulated positioning space includes a simulated treatment head system, a CT scanner, and a multi-dimensional motion patient positioning system connecting the simulated positioning space and the treatment space. The patient positioning system includes a treatment bed with reference points. This integrated simulated positioning and treatment method includes: Integrated Simulation Positioning Process: In the simulation positioning area, the treatment bed is adjusted so that the reference position is located at the isocenter point O. The laser rangefinder is used to simulate the beam center position, and the coordinates of the treatment bed reference point A and the angle relative to the beam outlet are adjusted. The treatment bed is moved to the CT device to scan and obtain the simulation positioning image. A treatment plan is formulated and the positioning plan is output. The bed is moved back to the simulation positioning area for positioning verification. Treatment positioning is performed before treatment begins. Transfer process: Move the treatment bed to the treatment space for final location confirmation; Release procedure: Move the treatment bed back to the simulated positioning space for release.

[0082] Specifically, the following steps are included: Step 1: Within the simulated positioning space, pre-positioning is performed using a patient positioning system based on an adjustable vertical simulated treatment head, three-dimensional translation, and angular rotational motion. S11: Based on the diagnostic imaging data of the tumor site of the target patient, a preliminary plan is made for the irradiation direction of the neutron beam and the position of the target patient lying on the treatment bed.

[0083] S12: The target subject lies on the treatment bed panel. The cross laser light 41 and the linear laser light 42 at the isocenter point O are turned on for reference. The treatment bed is adjusted so that the center of the part of the target subject to be irradiated is approximately located at the isocenter point O.

[0084] S13: Turn on the laser rangefinder installed at the center of the vertical simulated treatment head to simulate the beam center position. Adjust the reference points AX and Y of the treatment bed through the treatment bed control system to align the beam center point with the area to be irradiated. At this time, use a thermoplastic film to fix the target area to be irradiated on the treatment bed.

[0085] S14: Adjust the AZ direction coordinates of the treatment bed reference point through the treatment bed control system to adjust the distance between the target object and the collimator end face (to achieve different SSD adjustments).

[0086] S15: When the target object's pose, irradiation position, and SSD distance meet the expected planning requirements, and it is confirmed that there is no physical interference between the target object, the treatment bed, and the vertical treatment head device, the coordinates of the current treatment bed reference point A are read and recorded. The current distance of the laser rangefinder is read and recorded. The recorded data can be used as a reference for creating a treatment plan for the target object in the treatment planning system.

[0087] Step 2: Simulated positioning: S21: The treatment bed, together with the target object, is transported to the scanning position of the sliding CT device 8 through the treatment bed control system. The CT laser lamp 81 of the positioning CT is turned on, and the height of the treatment bed is adjusted to make the projection of the CT laser lamp coincide with the laser line mark on the fixing device of the target object, thus completing the acquisition of the simulated positioning image.

[0088] Step 3: Treatment Plan Development The tumor target area is delineated based on the simulated positioning CT image of the target object. The displacement data of the simulated treatment head relative to the isocenter point O recorded in the pre-positioning stage is used to formulate the irradiation plan for the target object, give and evaluate the irradiation dose, and output the irradiation dose and positioning plan for the target object. The positioning plan includes the movement distance of the target object's positioning center point relative to the isocenter point O in the X, Y, and Z directions, as well as the distance between the collimator and the target object's body surface (SSD).

[0089] Step 4: Positioning Verification: After the treatment plan for the target patient is completed, the target patient lies on the simulated positioning treatment bed, and the thermoplastic film and other fixing devices are installed. The position of the target patient is adjusted so that the laser projection and the marked lines on the surface of the thermoplastic film coincide. At this time, the treatment bed control system can calculate the coordinates of the reference point A of the treatment bed in the final treatment position based on the positional relationship between the positioning center point provided by the treatment plan and the equicenter point O, combined with the positioning deviation of the target patient. The treatment bed is then transported to this treatment position, and the relative position of the target patient and the treatment head, as well as the SSD, are checked to ensure they are consistent with the treatment plan, thus completing the positioning verification of the target patient. After confirming the treatment position of the target patient, a laser marking line is made at the intersection of the laser line projections on the surface of the thermoplastic film using a marker pen. This marking is used to verify the position of the target patient in the actual treatment space and to monitor the displacement of the target patient during the treatment process.

[0090] Step 5: Perform treatment positioning within the simulated positioning space: S51: On the day of treatment, after the target subject completes the infusion and the blood boron concentration meets the irradiation requirements, the target subject lies on the treatment bed in the simulation positioning room, the thermoplastic film and other fixing devices are installed, and the position of the target subject is adjusted to make the laser lamp projection and the marking line on the surface of the thermoplastic film coincide.

[0091] S52: Obtain DR images of the target object using an orthogonal X-ray imaging device and compare them with DRR images generated based on simulated positioning CT to check for positional deviations of the target object. Adjust the position of the treatment bed through the treatment bed control system to achieve coincidence between the positioning center point and the isocenter point O in the treatment plan. At this point, the treatment bed control system can calculate the coordinate values ​​of the final treatment position.

[0092] Step 6: Target Subject Treatment: Using the patient positioning system, move the target subject to the treatment space. Transport the target subject to the treatment position according to the positioning plan in the treatment plan. Use camera 101 to check if the laser marking lines on the target subject coincide, verifying the correctness of the treatment position. If a positioning deviation exists, output the deviation value and correct it by adjusting the treatment bed. After confirming correctness, proceed with irradiation treatment.

[0093] Step 7: After the treatment of the target patient is completed, the patient positioning system is controlled by the control system to move and transfer the treatment bed to the simulated positioning space for release.

[0094] Example 4:

[0095] exist Figure 9 , Figure 10 In the illustrated embodiment, two treatment spaces 1 arranged in an L-shape are provided. One treatment space contains a vertical treatment head 15, and the other treatment space contains a horizontal treatment head 16. An adjustable horizontal simulation treatment head 51 and an adjustable vertical simulation treatment head 52 are integrated within the simulation positioning space 2. Correspondingly, two patient positioning systems 6 are provided: one is a suspended sliding rail patient positioning system 63, and the other is a ground sliding rail patient positioning system 64. Of course, the arrangement of the simulation positioning space and treatment space can be customized according to actual needs and is not specifically limited.

[0096] In this embodiment, the positioning method for BNCT treatment is basically the same as in Embodiments 1-3. For horizontal beam output treatment, the steps in Embodiment 2 are used, and for vertical beam output treatment, the steps in Embodiment 3 are used. Further details are omitted.

[0097] In the above embodiments, the patient positioning system employs a suspended or ground-mounted robotic arm patient positioning system, which mainly includes a six-axis robotic arm treatment bed that supports translational motion in the X, Y, and Z directions and rotational motion in the Yaw, Pitch, and Roll angles. A control system controls the movement of the robotic arm treatment bed, which can read the coordinates and deflection angle of the treatment bed reference point A. The spatial positional relationship between the treatment bed reference point A and the isocenter point O can be obtained by the difference between the coordinates of the treatment bed reference point A and the coordinates of the isocenter point O.

[0098] Among them, Yaw: the left and right rotation about the vertical axis (usually the Z-axis), like head shaking or vehicle steering. Pitch: the up and down rotation about the lateral axis (usually the Y-axis), like nodding or aircraft climbing / diving. Roll: the rotation about the front and rear axes (usually the X-axis), like nose pitching or aircraft rolling.

[0099] Specifically, a suspended slide rail or a ground slide rail 61 is installed at the top between the simulated positioning space and the treatment space. The robotic arm treatment bed is slidably connected to the slide rail through a robotic arm base 62. The movement of the robotic arm base on the slide rail by the motor can drive the robotic arm to move in the X-axis direction, thereby realizing the movement of the target object between the simulated positioning space 2 and the treatment space 1.

[0100] A laser rangefinder 9 is installed at the center of the horizontal and vertical simulated treatment heads, respectively. It is used to measure the distance (SSD) from the surface of the target object to the collimator outlet after the target object is simulated and positioned, and to indicate the projection of the beam center point on the surface of the target object, so as to simulate the neutron beam irradiation point.

[0101] The horizontal simulated treatment head can move relative to the beam isocenter in the Y direction (back and forth). Specifically, it can be mounted on a guide rail and moved in the Y direction by a motor. A simulated treatment head collimator fixing base can be provided, which supports the installation of simulated treatment head collimators of different apertures. Collimators of different aperture sizes can be replaced through a snap-fit ​​connection. The size and specifications of the simulated treatment head are consistent with those of the actual treatment head.

[0102] The vertical simulation treatment head is suspended above the beam center and can be installed on a vertical guide rail. It can move in the Z direction (up and down) via a motor drive. A base can be set up to install the vertical simulation treatment head collimator. The base supports the installation of vertical treatment head collimators with different apertures. Collimators of different aperture sizes can be replaced by snap-fit ​​connection.

[0103] The treatment space 1 and the simulated positioning space 2 are separated by a shielding wall that can protect against neutrons and gamma rays, with a movable shielding door 12 in between. When the shielding door is open, the robotic arm treatment bed moves between the treatment space and the positioning space via a sliding rail. When the shielding door is closed, the treatment space and the simulated positioning space are shielded from neutron and gamma radiation.

[0104] Within the simulation positioning space integrating horizontal and vertical simulation treatment heads, the isocenter point O of the beam ports of the horizontal and vertical simulation treatment heads is set at the same point. When the reference point A of the treatment bed is at isocenter point O, it is at position 0, ensuring that the X and Y coordinates are consistent horizontally and vertically. The isocenter point O of the vertical beam line in the height direction can be the same as the horizontal one.

[0105] Positioning method applicable to BNCT treatment: (1) Improved positioning accuracy: The target subject completes the simulated positioning verification on the same treatment bed and can be directly scanned in the simulated positioning space without repeating the target subject positioning operation. This ensures that the target subject's body position is consistent throughout the entire process from pre-positioning to simulated positioning to positioning verification, thus improving positioning accuracy. Since the target subject remains in its initial fixed state throughout the entire process, it avoids the accumulation of errors caused by multiple installations of fixation devices (such as head fixation membranes, vacuum pads, etc.) and changes in environment. This not only reduces positioning deviations caused by subtle differences between different rooms (such as treatment bed height, spatial layout, and laser lamp angle and calibration parameters), but also reduces the workload of medical staff and lowers the risk of operational errors. In addition, this method optimizes the treatment experience of the target subject, shortens the treatment preparation stage, reduces the physical discomfort and anxiety that may be caused by staying in the treatment preparation stage for a long time, and enhances the target subject's treatment compliance.

[0106] (2) Reduced Unintended Radiation: Physical shielding is provided between medical staff and the treatment space during the placement process, reducing the unexpected radiation dose that medical staff may receive due to residual radiation in the treatment space during the target placement phase. Physical isolation ensures operational safety without relying on a blocking system, further reducing equipment configuration requirements and maintenance costs.

[0107] (3) Simplified operation process and improved efficiency: The target object completes the simulation positioning and positioning verification on the same treatment bed, which greatly simplifies the operation process and avoids the complicated operation caused by the repeated transfer and fixation of the target object between multiple rooms in the traditional mode. Through the integrated positioning and image positioning design, treatment preparation time is effectively saved and positioning efficiency is improved. The whole process does not require coordination of the scheduling of CT simulation positioning room and simulation positioning room, which reduces the time loss and process interruption risk caused by multiple links, and improves the operating efficiency and execution continuity of the treatment system.

[0108] (4) Extend equipment lifespan: By placing the imaging positioning equipment outside the treatment space or in an independent shielded area, it is avoided from being exposed to radiation for a long time during neutron irradiation, which effectively reduces the performance loss and material aging of the equipment caused by radiation and extends its service life. This design reduces the frequency of equipment maintenance and replacement costs, while ensuring the stability and imaging quality of the imaging system.

[0109] (5) Improve space and equipment utilization: By optimizing the overall space layout and equipment configuration, one simulated positioning space can serve two or more treatment spaces at the same time, reducing costs and improving equipment utilization.

Claims

1. A positioning method suitable for BNCT treatment, characterized in that: Based on a simulated placement space connected to the treatment space; The simulated positioning space is equipped with a simulated treatment head system, a CT device, and a multi-dimensional motion patient positioning system that connects the simulated positioning space and the treatment space. The patient positioning system includes a treatment bed with a reference point A. Integrated simulation positioning process: Adjust the treatment bed so that the reference position is located at the isocenter point O; adjust the coordinates of the treatment bed reference point A and the angle relative to the beam outlet; move the treatment bed to the CT device to scan and obtain simulated positioning images; formulate a treatment plan and output the positioning plan; position verification; perform treatment positioning before treatment begins; Transfer process: Move the treatment bed to the treatment space for final location confirmation; Release procedure: Move the treatment bed back to the simulated positioning space for release.

2. The positioning method for BNCT treatment according to claim 1, characterized in that: The simulated treatment head system includes a simulated treatment head, an orthogonal DR positioning verification system and a laser light system set on both sides of the adjustable simulated treatment head, and a laser rangefinder set at the center of the simulated treatment head; the simulated treatment head can be a fixed simulated treatment head or an adjustable simulated treatment head; wherein, the reference position refers to the intersection point of the line connecting the intersection centers of the projections of each laser line in the laser light system; the isocenter point O is a spatial virtual point on the beam centerline, used to determine the position of the beam center in space.

3. The positioning method for BNCT treatment according to claim 1, characterized in that: The integrated simulation positioning process includes obtaining the relative positional relationship between the treatment bed reference point A and the isocenter point O. This is achieved by using a laser rangefinder set in the simulated treatment head system to simulate the beam center position and the projection of the beam center point onto the target object's surface, which is used to simulate the neutron beam irradiation point. By adjusting the position and posture of the target object on the treatment bed, and adjusting the angle and displacement of the treatment bed relative to the beam outlet, the positional relationship between the target object and the beam injection point is simulated to achieve pre-positioning; After completing the simulated positioning of the target object, obtain the relative positional relationship between the reference point A of the treatment bed and the isocenter point O.

4. The positioning method for BNCT treatment according to claim 3, characterized in that: The pre-positioning mainly includes: using a laser light simulating the center of the treatment head to adjust the treatment bed so that the reference position is located at the isocenter point O; and, A laser rangefinder is used to simulate the beam center position, and the angle and position of the reference point A of the treatment bed relative to the beam outlet are adjusted to simulate different SSDs and irradiation angles. When the pose of the target object, the angle and distance of the treatment bed meet the expected requirements, read and record the coordinates of the current treatment bed reference point A and the current distance of the laser rangefinder; Mark the location of the center point where the laser line projections intersect.

5. The positioning method for BNCT treatment according to any one of claims 1 to 4, characterized in that: The CT device includes a CT scanning device and a CT laser lamp; the simulated positioning image is obtained by directly rotating or first retracting and then rotating the treatment bed along with the target object to the CT scanning position, turning on the CT laser lamp of the positioning CT, adjusting the height of the treatment bed to align with the marked position of the target object, starting the CT scanning device, and completing the acquisition of the simulated positioning image.

6. The positioning method for BNCT treatment according to any one of claims 1 to 4, characterized in that: The treatment plan is developed by directly delineating the target area based on the simulated positioning image of the target subject, referring to the coordinate difference between two treatment bed reference points A obtained from the simulation, and considering the irradiation plan for the target subject, completing the irradiation dose assignment and evaluation, and outputting the irradiation dose and positioning plan for the target subject; among which, The positioning plan includes the displacement and rotation angle of the reference point relative to the center point O.

7. The positioning method for BNCT treatment according to any one of claims 1 to 4, characterized in that: The positioning verification process involves placing the target object on the treatment bed and fixing it with a fixation device marked with laser points created during pre-positioning. The treatment bed is then adjusted to ensure that the laser lamp projection and the laser line marking points on the fixation device coincide. At this point, the orthogonal DR positioning verification system in the simulated treatment head system on both sides of the simulated treatment head acquires the DR image of the target object and compares it with the simulated positioning image generated based on the simulated positioning CT image. The target position deviation is checked and adjusted to ensure that the positioning center point of the target object defined in the treatment plan coincides with the system's isocenter point O.

8. The positioning method for BNCT treatment according to any one of claims 1 to 4, characterized in that: Treatment positioning is performed within a simulated positioning space when the target object meets the irradiation requirements, and includes: The orthogonal DR positioning verification system in the simulated treatment head system is used to determine that the reference position coincides with the isocenter point O, and to determine the spatial reference. The target object is adjusted and fixed using a fixing device with a marked center point position, so that the center point position of the laser lamp projection and the marked center point position on the fixing device are coincident; The orthogonal DR positioning verification system on both sides of the simulated treatment head is used to acquire DR images of the target object, which are then compared with simulated positioning images generated by a simulated positioning CT device. The target position deviation is checked and adjusted to determine that the center of the target object coincides with the isocenter point O, thus establishing a spatial reference.

9. The positioning method for BNCT treatment according to any one of claims 1 to 4, characterized in that: The treatment space is equipped with a camera-based patient monitoring system and a laser lighting system. After confirming that the center of the target object coincides with the isocenter point O, move the treatment bed to the treatment space and move it to the final treatment position according to the placement plan; Final location accuracy verification: Use a camera to check whether the laser marking lines at the target location coincide, and check whether the target treatment location is correct; Treatment will begin once the diagnosis is confirmed.

10. The positioning method for BNCT treatment according to any one of claims 1 to 4, characterized in that: The patient positioning system controls the movement through a control system, supporting translational movements in the X, Y, and Z directions and rotational movements in the Yaw, Pitch, and Roll angles. The control system reads the coordinates and deflection angle of the treatment bed reference point A, and obtains the spatial positional relationship between the treatment bed reference point A and the isocenter point O by the difference between the coordinates of the treatment bed reference point A and the isocenter point O.

Images