A probiotic microcapsule continuous embedding system and method

Abstract

The present application relates to a kind of probiotic microcapsule continuous embedding system and method, its system includes: centrifugal atomization device, including variable frequency motor, main shaft and atomization head, atomization head includes inner tube and outer tube, inner tube and outer tube coaxial nesting arrangement, both constitute concentric double-channel structure;Static auxiliary atomization device is arranged in the periphery of the atomization head;Bath is communicated with the discharge end of static auxiliary atomization device by conveying pipeline, for receiving and solidifying charged microcapsule precursor droplet, bath is filled with gel bath liquid;The inner wall bottom of bath is equipped with multi-hole plate, and sterile air inlet cavity is below multi-hole plate;Venturi ejector, its suction port is connected with the top of bath;The feed inlet of cyclone separator is connected with the discharge port of venturi ejector, and the bottom end of cyclone separator is equipped with unloading port;Collecting tank is connected with the bottom end exhaust port of cyclone separator.The present application can realize the efficient, continuous, stable embedding of probiotic, improve microcapsule particle size uniformity and embedding rate.

Description

Technical Field

[0001] This invention relates to the field of probiotic microcapsule preparation technology, and in particular to a continuous encapsulation system and method for probiotic microcapsules. Background Technology

[0002] In the production of probiotic microcapsules, encapsulation efficiency and probiotic activity retention rate are the core factors determining product quality. The uniformity and stability of the encapsulation process directly affect these two key indicators. Therefore, real-time monitoring of the encapsulation process is necessary on the production line, and automated systems should be used for online detection and dynamic control to ensure consistent production quality. Currently, several automated production systems related to probiotic encapsulation have emerged in the industry, with two representative systems disclosed in relevant invention patents.

[0003] A continuous encapsulation system for probiotic microcapsules, disclosed in patent publication number CN202422367586, mainly consists of an encapsulation spray unit and a multi-stage mixing component. The multi-stage mixing component, mounted on the system's main frame, includes multiple interconnected temperature-controlled mixing modules and is connected to the system's temperature control system and fluid delivery system. Each temperature-controlled mixing module has a material outlet with different flow directions. Through the coordinated operation of multiple temperature-controlled mixing modules, the material before encapsulation can undergo multi-stage emulsification and dispersion treatment, thereby achieving uniform atomization of the encapsulation liquid in the airflow and layer-by-layer encapsulation, offering advantages in improving encapsulation uniformity.

[0004] A multimodal probiotic microcapsule encapsulation and storage integrated system, patent publication number CN202510924679, is disclosed. This system employs multiple encapsulation chamber units connected in series with a drying and storage chamber to form a production line assembly. The connections between the encapsulation chamber units are made using adjustable joints, each equipped with a flow channel adjustment mechanism. The drying and storage chamber is equipped with an airflow circulation device. In actual production, when adjustments to the system's encapsulation mode and drying conditions are required, the flow channel adjustment mechanism applies force to the connections to change the flow channel angle, allowing the production line assembly to switch to a production mode suitable for different needs. Simultaneously, the flow direction of the airflow circulation device is changed, thereby achieving multimodal collaborative operation of encapsulation, drying, and storage, and improving the integration of the production process.

[0005] While both systems have their advantages in probiotic encapsulation production, they still suffer from several technical shortcomings that urgently need to be addressed, making it difficult to fully meet the demands of industrial production for encapsulation quality stability, system reliability, and production flexibility. Specifically, regarding the continuous encapsulation system disclosed in CN202422367586, although its multi-stage mixing components can effectively improve encapsulation uniformity, its accuracy in identifying subtle encapsulation defects is insufficient. It cannot effectively detect minor issues such as uneven encapsulation layer thickness and uneven distribution of active substances, still requiring subsequent manual sampling for confirmation, increasing labor costs and hindering real-time defect control. Furthermore, the system's multi-module collaborative operation places extremely high demands on the precision of temperature and airflow control, and parameter matching between different sections of the production line is prone to lag or incoordination, severely limiting the flexibility of adjustments during production.

[0006] While the continuous design of the multimodal integrated system disclosed in CN202510924679 improves production efficiency, its stability is easily affected under multi-component switching and high-intensity continuous production scenarios, making it difficult to maintain a stable production state in the long term. Furthermore, both systems employ complex designs with multiple modules and actuators, leading to cumbersome mechanical structures and control systems, and placing extremely high demands on the accuracy of process collaborative control algorithms. This results in a high system failure rate and significantly increases the difficulty of equipment maintenance. Simultaneously, the system's instability and insufficient defect detection make it difficult to consistently guarantee the activity and encapsulation rate of probiotic microcapsules, failing to meet the stringent requirements for product quality consistency in large-scale industrial production. Summary of the Invention

[0007] Therefore, the technical problem to be solved by the present invention is to overcome the shortcomings of the prior art and provide a continuous encapsulation system and method for probiotic microcapsules, so as to achieve efficient, continuous and stable encapsulation of probiotics, improve the uniformity of microcapsule particle size and encapsulation rate, and simplify the structure and improve production efficiency.

[0008] To address the aforementioned technical problems, this invention provides a continuous encapsulation system for probiotic microcapsules, comprising: A centrifugal atomizing device includes a variable frequency motor, a main shaft, and an atomizing head. The atomizing head includes an inner tube and an outer tube, which are coaxially nested together to form a concentric dual-channel structure. The inner tube is used to deliver probiotic core material liquid, and the outer ring cavity between the inner tube and the outer tube is used to deliver sheath material liquid. An electrostatic assisted atomizing device is disposed around the atomizing head to charge the ejected droplets and directionally split them under the action of an electric field. The bath is connected to the discharge end of the electrostatic assisted atomization device via a delivery pipeline. It is used to receive and solidify the charged microcapsule precursor droplets. The bath contains a gel bath liquid. The bottom of the inner wall of the bath is provided with a perforated plate, and below the perforated plate is a sterile air intake chamber. A Venturi ejector, the suction port of which is connected to the top of the bath; A cyclone separator, whose inlet is connected to the outlet of the Venturi ejector, is used to achieve gas-solid separation under centrifugal force. The bottom end of the cyclone separator is provided with a discharge port. The collection container, connected to the exhaust port at the bottom of the cyclone separator, is used to collect the encapsulated probiotic microcapsules.

[0009] In one embodiment of the present invention, the electrostatic assisted atomization device includes a coaxial core-forming disc, an electrostatic ring, a mushroom head, and a DC generator. The coaxial core-forming disc is disposed below the atomizing head and is used to receive and shear the probiotic droplets sprayed from the atomizing head, refining them into micron-sized microcapsule precursor droplets. The electrostatic ring is fixedly disposed on the outer periphery of the coaxial core-forming disc, maintaining coaxiality with the coaxial core-forming disc and remaining relatively stationary. The mushroom head is disposed at the lower end of the coaxial core-forming disc. The electrostatic ring and the mushroom head are respectively connected to the two poles of the DC generator to form an electrostatic field surrounding the coaxial core-forming disc, used to charge and disperse the droplets after they have been sheared and broken by the coaxial core-forming disc.

[0010] In one embodiment of the present invention, the Venturi ejector is provided with a driving air inlet, which is connected to a fan to generate a Venturi effect to induce airflow.

[0011] In one embodiment of the present invention, a mass flow controller is provided on the air inlet pipe of the sterile air inlet chamber for controlling the clean air introduced into the sterile air inlet chamber.

[0012] In one embodiment of the present invention, a hot air dryer is provided above the bath for pre-drying the gelled microdroplets and for wind-assisted transmission to the Venturi ejector.

[0013] In one embodiment of the present invention, the Venturi ejector is inclined between the bath and the cyclone separator, and the inclination angle of the Venturi ejector is 45°.

[0014] In one embodiment of the present invention, the cyclone separator is a downdraft cyclone separator.

[0015] In a second aspect, the present invention provides a method for continuous encapsulation of probiotic microcapsules, using the system described in the first aspect, comprising the following steps: Step S1: The probiotic core liquid and sheath liquid are respectively introduced into the inner tube and outer ring cavity of the atomizing head. The variable frequency motor is started to drive the main shaft to rotate at high speed. Under the action of centrifugal force, the liquid is sheared into concentric liquid films and liquid filaments at the edge of the atomizing head. At the same time, the electrostatic ring is started, and under the action of low-voltage electrostatic field, the droplets are further refined and charged to form negatively charged pre-embedded microdroplets with a particle size distribution concentrated at 50μm. Step S2: Charged microdroplets are directionally sprayed into the bath under the action of electric field force, fall into the gel bath, and complete gelation under the action of sterile air bubbles bulging out of the porous plate at the bottom, forming microcapsules with core-shell structure. Step S3: After the gelled microcapsules are pre-dried by hot air from above, they are drawn in by a Venturi ejector and the low-speed induced airflow generated by the Venturi effect carries the microcapsules into the cyclone separator. Step S4: The microcapsules enter the cyclone separator with the airflow and achieve gas-solid separation under the action of centrifugal force. The microcapsules are discharged into the collection tank through the discharge port at the bottom, and the waste gas is discharged through the waste outlet at the top.

[0016] In one embodiment of the present invention, the rotational speed of the variable frequency motor, the voltage of the electrostatic ring, and the flow ratio of the core liquid to the sheath liquid in step S1 are coordinated and regulated to achieve precise control of the microcapsule particle size, the thickness of the encapsulation layer, and the charge.

[0017] In one embodiment of the present invention, the liquid level in the bath in step S2 is kept constant, and the flow rate of sterile air is precisely controlled by a mass flow controller to adjust the lifting force and tumbling intensity of the bubble layer and optimize the gelation effect.

[0018] In one embodiment of the present invention, the driving air pressure and flow rate of the Venturi ejector in step S3 are dynamically adjusted according to the particle size and density of the microcapsules to ensure that the microcapsules maintain their intact shape during delivery.

[0019] Compared with the prior art, the above-described technical solution of the present invention has the following advantages: (1) The probiotic microcapsule continuous encapsulation system of the present invention is based on the integration of centrifugal atomization, gel solidification, airflow conveying and cyclone separation. It achieves precise encapsulation of core material and sheath material through concentric dual-channel atomization, completes gentle solidification with airlift gel bath, achieves non-destructive conveying with Venturi ejector, and finally completes gas-solid separation and product collection through cyclone separation, forming a fully enclosed, continuous and sterile production process from raw materials to finished products.

[0020] (2) The continuous encapsulation method for probiotic microcapsules described in this invention seamlessly connects each step through a bath, a Venturi ejector, and a cyclone separator, achieving full-process continuity from raw material input to product collection in a sterile collection tank. This improves production efficiency, and the process parameters are digitally controlled, resulting in a narrow microcapsule particle size distribution, consistent core-shell ratio, and significantly improved product quality stability. Attached Figure Description

[0021] To make the content of this invention easier to understand, the invention will be further described in detail below with reference to specific embodiments and accompanying drawings.

[0022] Figure 1 This is a schematic diagram of the continuous encapsulation system for probiotic microcapsules in a preferred embodiment of the present invention; Figure 2 This is a schematic diagram of the structure of the variable frequency motor, atomizing head, and electrostatic ring in this invention; Figure 3 This is a schematic diagram of the bath tub in this invention; Explanation of reference numerals in the accompanying drawings: 1. Centrifugal atomizing device; 11. Variable frequency motor; 12. Main shaft; 13. Atomizing head; 131. Inner tube; 132. Outer tube; 2. Electrostatic assisted atomizing device; 21. Coaxial core-forming disc; 22. Electrostatic ring; 23. Mushroom head; 24. DC generator; 3. Bath; 31. Perforated plate; 32. Sterile air inlet chamber; 4. Fan; 5. Venturi ejector; 6. Cyclone separator; 61. Discharge port; 62. Waste outlet; 7. Collection tank; 100. Gel bath solution. Detailed Implementation

[0023] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, so that those skilled in the art can better understand and implement the present invention. However, the embodiments described are not intended to limit the present invention.

[0024] Example 1 like Figure 1-3 As shown, this invention discloses a continuous encapsulation system for probiotic microcapsules, comprising: The centrifugal atomizing device 1 includes a variable frequency motor 11, a main shaft 12, and an atomizing head 13. The atomizing head 13 includes an inner tube 131 and an outer tube 132. The inner tube 131 and the outer tube 132 are coaxially nested and arranged to form a concentric double-channel structure. The inner tube 131 is used to deliver probiotic core material liquid, and the outer annular cavity between the inner tube 131 and the outer tube 132 is used to deliver sheath material.

[0025] An electrostatic-assisted atomizing device 2 is disposed around the atomizing head 13 to charge the sprayed droplets and directionally disperse them under the action of an electric field. The electrostatic-assisted atomizing device 2 includes a coaxial core-forming disk head 21, an electrostatic ring 22, a mushroom head 23, and a DC generator 24. The coaxial core-forming disk head 21 is disposed below the atomizing head 13 to receive and shear the probiotic droplets sprayed from the atomizing head 13, refining them into micron-sized microcapsule precursor droplets. The electrostatic ring 22 is fixedly disposed on the outer periphery of the coaxial core-forming disk head 14, maintaining coaxiality with the coaxial core-forming disk head 14 and remaining relatively stationary. The mushroom head 23 is disposed at the lower end of the coaxial core-forming disk head 21. The electrostatic ring 22 and the mushroom head 23 are respectively connected to the two poles of the DC generator 24 to form an electrostatic field surrounding the coaxial core-forming disk head 21, which is used to charge and disperse the droplets after they have been sheared and broken by the coaxial core-forming disk head 21. The bath 3 is connected to the discharge end of the coaxial cored disc 21 through a conveying pipeline. It is used to receive and solidify the charged microcapsule precursor droplets. The bath 3 contains gel bath liquid 100. The bottom of the inner wall of the bath 3 is provided with a perforated plate 31, and below the perforated plate 31 is a sterile air intake chamber 32. The Venturi ejector 5 has its suction port connected to the top of the bath 3; the Venturi ejector 5 is provided with a driving air inlet, which is connected to the fan 4 to generate the Venturi effect to induce airflow; the inner wall of the Venturi ejector 5 is mirror polished. Cyclone separator 6, whose inlet is connected to the outlet of the Venturi ejector 5, is used to achieve gas-solid separation under centrifugal force. The bottom end of the cyclone separator 6 is provided with a discharge port 61. The collection tank 7 is connected to the exhaust port at the bottom of the cyclone separator 6 and is used to collect the encapsulated probiotic microcapsules.

[0026] Preferably, the porous plate 31 at the bottom of the bath 3 is a sintered titanium porous plate. Titanium has strong corrosion resistance and can withstand long-term erosion in the gel bath liquid 100, extending the service life of the equipment and reducing maintenance costs.

[0027] Furthermore, a mass flow controller is installed on the air inlet pipe of the sterile air inlet chamber 32 to control the clean air introduced into the sterile air inlet chamber 32. By precisely adjusting the sterile air flow rate through the mass flow controller, the lifting force and tumbling intensity of the bubble layer can be accurately controlled, optimizing the fluidization state of the microcapsules in the gel bath 100, ensuring complete gelation and preventing microcapsule deformation or breakage. Moreover, the flow controller enables digital and quantifiable process control, improving the consistency and repeatability of product quality between batches.

[0028] In addition, a hot air dryer is installed above the bath 3 to pre-dry the gelled microdroplets and transport them to the Venturi ejector 5 with the assistance of wind power. The hot air dryer removes residual moisture from the surface of the microcapsules in a timely manner, allowing the gelled microcapsules to quickly solidify and shape, enhancing their mechanical strength and reducing adhesion and deformation during subsequent transport. It also reduces the initial moisture content of the microcapsules, lessening the subsequent drying load and shortening the overall process time. Furthermore, the airflow from the hot air dryer assists the microcapsules in moving towards the Venturi ejector 5, transforming passive transport into active transport, improving transport efficiency, and reducing the residence time of the microcapsules in the bath 4. In this embodiment, the Venturi ejector 5 is inclined between the bath 3 and the cyclone separator 6, and the inclination angle of the Venturi ejector 5 is 45°. The inclination angle of 45° can improve the vertical lifting and horizontal conveying requirements, so that the microcapsules can smoothly transition from the liquid surface of the bath 3 to the cyclone separator 6, reducing the mechanical impact and damage caused by sharp turns.

[0029] Preferably, the cyclone separator 6 is a bottom-exhaust cyclone separator. The bottom-exhaust cyclone separator structure allows the separated microcapsules to fall directly downwards through the discharge port 61 into the sterile collection tank 7, avoiding the damage caused by the collision between the microcapsules and the top of the cyclone in traditional top-exhaust separators.

[0030] The working principle of the probiotic microcapsule continuous encapsulation system based on the above structure is as follows: the probiotic core liquid and sheath liquid are synchronously transported through the inner tube 131 and outer ring cavity of the atomizing head 13, respectively. The variable frequency motor 11 drives the main shaft 12 to drive the atomizing head 13 to rotate at high speed. Under the action of centrifugal force, the concentric liquid film is sheared into liquid filaments at the edge of the atomizing head 13 and initially atomized. The electrostatic ring 22 and the mushroom head 23 form an electrostatic field on the outer periphery of the coaxial core encapsulation disk head 21, which causes the refined microcapsule precursor droplets to be charged, dispersed and directional. Charged microdroplets are directionally sprayed into the gel bath 100 in the bath tank 3 under the action of electric field force. They are gelled by the sterile air bubbles bulging from the bottom titanium metal sintered porous plate, forming microcapsules with a core-shell structure. The sterile air flow rate is precisely controlled by a mass flow controller to optimize the gelation effect. After gelation, the microcapsules are pre-dried and shaped by the hot air dryer 8 above the bath tank 3. They are then drawn in by the Venturi ejector 5, which is set at a 45° angle. The low-speed induced airflow generated by the Venturi effect carries the microcapsules into the down-draft cyclone separator 6. The microcapsules achieve gas-solid separation under the action of centrifugal force in the cyclone separator 6. They are discharged into the sterile collection tank 7 through the bottom discharge port 61, and the waste gas is discharged through the upper waste outlet 62, thus completing the continuous encapsulation preparation of probiotic microcapsules.

[0031] Example 2 A method for continuous encapsulation of probiotic microcapsules, using the system described in Example 1, includes the following steps: Step S1: The probiotic core liquid and sheath liquid are respectively introduced into the inner tube and outer ring cavity of the atomizing head 13. The variable frequency motor 11 is started to drive the main shaft 12 to rotate at high speed. Under the action of centrifugal force, the liquid is sheared into concentric liquid films and liquid filaments at the edge of the atomizing head 13. At the same time, the electrostatic ring 22 is started. Under the action of low-voltage electrostatic field, the droplets are further refined and charged to form negatively charged pre-embedded microdroplets with a particle size distribution concentrated at 50μm. Step S2: Charged microdroplets are directionally sprayed into bath 3 under the action of electric field force and fall into gel bath liquid 100. Under the action of sterile air bubbles bulging out of the porous plate 31 at the bottom, gelation is completed to form microcapsules with core-shell structure. Step S3: The gelled microcapsules are drawn in by the Venturi ejector 5, and the low-speed induced airflow generated by the Venturi effect carries the microcapsules into the cyclone separator 6. Step S4: The microcapsules enter the cyclone separator 6 with the airflow and achieve gas-solid separation under the action of centrifugal force. The microcapsules are discharged into the collection tank 7 through the discharge port 61 at the bottom, and the waste gas is discharged through the waste outlet 62 at the top.

[0032] In step S1, the rotational speed of the variable frequency motor 11, the voltage of the electrostatic ring 22, and the flow ratio of the core liquid to the sheath liquid are coordinated and controlled to achieve precise control of the microcapsule particle size, encapsulation layer thickness, and charge. By coupling and adjusting the three key parameters of rotational speed, voltage, and flow ratio, the particle size, shell thickness, and charge of the microcapsules can be independently controlled within a large range, enabling fine customization of product performance.

[0033] In step S2, the liquid level in the bath 3 is maintained at a constant height, and the flow rate of sterile air is precisely controlled by a mass flow controller to adjust the lifting force and tumbling intensity of the bubble layer, thereby optimizing the gelation effect. A constant liquid level ensures that the microcapsules have a consistent residence time in the gel bath 100, avoiding uneven gelation, excessive cross-linking, or insufficient cross-linking caused by liquid level fluctuations.

[0034] In step S3, the driving air pressure and flow rate of the Venturi ejector 5 are dynamically adjusted according to the particle size and density of the microcapsules to ensure that the microcapsules maintain their integrity during delivery. Precisely matching the driving air pressure and flow rate of the Venturi ejector 5 to microcapsules of different particle sizes and densities can prevent deposition blockage due to insufficient power or microcapsule breakage due to excessive power.

[0035] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A continuous encapsulation system for probiotic microcapsules, characterized in that, include: A centrifugal atomizing device includes a variable frequency motor, a main shaft, and an atomizing head. The atomizing head includes an inner tube and an outer tube, which are coaxially nested together to form a concentric dual-channel structure. The inner tube is used to deliver probiotic core liquid, and the outer annular cavity between the inner tube and the outer tube is used to deliver sheath liquid. An electrostatic assisted atomizing device is installed around the atomizing head to charge the sprayed droplets and direct them under the action of an electric field. The bath is connected to the discharge end of the electrostatic assisted atomization device via a delivery pipeline. It is used to receive and solidify the charged microcapsule precursor droplets. The bath contains a gel bath liquid. The bottom of the inner wall of the bath is provided with a perforated plate, and below the perforated plate is a sterile air intake chamber. A Venturi ejector, the suction port of which is connected to the top of the bath; A cyclone separator, whose inlet is connected to the outlet of the Venturi ejector, is used to achieve gas-solid separation under centrifugal force. The bottom end of the cyclone separator is provided with a discharge port. The collection container, connected to the exhaust port at the bottom of the cyclone separator, is used to collect the encapsulated probiotic microcapsules.

2. The system according to claim 1, characterized in that, The electrostatic assisted atomization device includes a coaxial core-forming head, an electrostatic ring, a mushroom head, and a DC generator. The coaxial core-forming head is located below the atomizing head and is used to receive and shear the probiotic droplets sprayed from the atomizing head, refining them into micron-sized microcapsule precursor droplets. The electrostatic ring is fixedly located on the outer periphery of the coaxial core-forming head, maintaining coaxiality with the coaxial core-forming head and remaining relatively stationary. The mushroom head is located at the lower end of the coaxial core-forming head. The electrostatic ring and the mushroom head are respectively connected to the two poles of the DC generator, forming an electrostatic field surrounding the coaxial core-forming head, which is used to charge and disperse the droplets after they have been sheared and broken by the coaxial core-forming head.

3. The system according to claim 1, characterized in that, The Venturi ejector is provided with a driving air inlet, which is connected to a fan to generate a Venturi effect to induce airflow.

4. The system according to claim 1, characterized in that, A mass flow controller is installed on the air inlet pipe of the sterile air inlet chamber to control the clean air introduced into the sterile air inlet chamber.

5. The system according to claim 1, characterized in that, A hot air dryer is installed above the bath to pre-dry the gelled microdroplets and transport them to the Venturi ejector with the assistance of wind power.

6. The system according to claim 1, characterized in that, The Venturi ejector is inclined between the bath and the cyclone separator, and the inclination angle of the Venturi ejector is 45°.

7. A method for continuous encapsulation of probiotic microcapsules, using the system described in any one of claims 1-6, characterized in that, Includes the following steps: Step S1: The probiotic core liquid and sheath liquid are respectively introduced into the inner tube and outer ring cavity of the atomizing head. The variable frequency motor is started to drive the main shaft to rotate at high speed. Under the action of centrifugal force, the liquid is sheared into concentric liquid films and liquid filaments at the edge of the atomizing head. At the same time, the electrostatic ring is started, and under the action of low-voltage electrostatic field, the droplets are further refined and charged to form negatively charged pre-embedded microdroplets with a particle size distribution concentrated at 50μm. Step S2: Charged microdroplets are directionally sprayed into the bath under the action of electric field force, fall into the gel bath, and complete gelation under the action of sterile air bubbles bulging out of the porous plate at the bottom, forming microcapsules with core-shell structure. Step S3: After the gelled microcapsules are pre-dried by hot air from above, they are drawn in by a Venturi ejector and the low-speed induced airflow generated by the Venturi effect carries the microcapsules into the cyclone separator. Step S4: The microcapsules enter the cyclone separator with the airflow and achieve gas-solid separation under the action of centrifugal force. The microcapsules are discharged into the collection tank through the discharge port at the bottom, and the waste gas is discharged through the waste outlet at the top.

8. The method according to claim 7, characterized in that, In step S1, the rotational speed of the variable frequency motor, the voltage of the electrostatic ring, and the flow ratio of the core liquid to the sheath liquid are coordinated and controlled to achieve precise control of the microcapsule particle size, the thickness of the encapsulation layer, and the charge.

9. The method according to claim 8, characterized in that, In step S2, the liquid level in the bath is kept constant, and the flow rate of sterile air is precisely controlled by a mass flow controller to adjust the lifting force and tumbling intensity of the bubble layer and optimize the gelation effect.

10. The method according to claim 8, characterized in that, In step S3, the driving air pressure and flow rate of the Venturi ejector are dynamically adjusted according to the particle size and density of the microcapsules to ensure that the microcapsules maintain their intact shape during delivery.

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