A pathology sample preservation device

Abstract

This application relates to a pathology sample preservation device, belonging to the field of medical device technology. To facilitate the sampling of clinical pathology samples, the preservation device provided in this application includes a bottle body, a cap, a filter assembly, and a staining assembly. The filter assembly includes upper and lower filter layers and a guide rod connecting the upper and lower filter layers. The guide rod is slidably disposed within a slot, and a slot is provided on the side wall of the guide rod. It also includes a magnetic handle into which the guide rod can be inserted; and a rotating ring disposed within the upper filter layer's mounting slot, with a locking block on the rotating ring engaging with the slot. The staining assembly includes a mounting ring disposed within the bottle body, located between the upper and lower filter layers and connected to the lower part of the upper filter layer; and a color developing component movably connected to the inner wall of the mounting ring, allowing the color developing component to be embedded in the inner wall of the mounting ring or extend into the annular space inside the mounting ring. This device meets the needs of efficient, convenient, and accurate sample processing in clinical pathology operations, improving sample testing quality.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a pathology sample preservation device. Background Technology

[0002] In the clinical diagnosis and sample testing process of pathology departments, the collection, preservation, staining, and subsequent processing of tissue samples are core procedures that directly affect the accuracy and efficiency of sample testing. Currently, after obtaining tissue samples from clinicians, pathologists routinely place the samples in ordinary containers and add fixative to maintain the morphology and structure of the tissue samples, prevent sample deterioration, and ensure the reliability of subsequent test results. However, the existing operating mode has significant technical limitations: during the sample preservation stage, since the tissue samples are placed directly in the fixative at the bottom of the container, when the physician needs to remove the samples for subsequent processing, they must repeatedly search for and locate the samples in the fixative, which is not only time-consuming and laborious, increasing the physician's workload, but may also damage the samples due to improper handling during the search process. At the same time, although some existing devices attempt to use filters to separate the samples from the fixative, the filter structure is simple and can only achieve basic separation functions, failing to effectively constrain the tissue samples. When removing the samples, they are prone to shaking and shifting within the filter, making it inconvenient for the physician to grasp them, further affecting operational efficiency.

[0003] Furthermore, staining is an indispensable and crucial step after tissue sample extraction, as the staining effect directly determines the clarity and diagnostic accuracy of subsequent pathological slide observation. Currently, existing pathology sample preservation devices are generally single-function, possessing only basic sample preservation and extraction capabilities, and cannot achieve integrated sampling and staining operations. After extracting tissue samples, physicians must transfer them separately to dedicated staining equipment and then manually add staining agent. This process not only adds a step to sample transfer, making the operation cumbersome and reducing staining efficiency, but may also cause sample contamination or damage during transfer. At the same time, manually adding staining agent makes it difficult to control the amount and uniformity, easily leading to uneven staining, staining that is too light or too dark, affecting subsequent pathological diagnosis. In addition, existing staining structures are mostly independently set up, requiring additional operating space, and cannot be linked with the sample preservation and extraction process, resulting in poor continuity of the entire sample processing flow, further increasing the operational complexity and workload of physicians.

[0004] Meanwhile, the stability of the filter directly affects the staining effect during sample staining. In existing devices, the filter used to separate the sample from the fixative lacks an effective positioning and fixing structure after being pulled up, making it prone to falling back, causing misalignment between the filter and the staining structure, interfering with the smooth progress of the staining process, and affecting the uniformity of staining. In addition, after the tissue sample is stained, a series of subsequent operations such as embedding and sectioning are required, necessitating the rapid removal of the sample from the filter. However, existing filter structures are mostly one-piece designs, making opening cumbersome and lacking convenient disassembly mechanisms. Physicians need to use additional tools to open the filter and remove the sample, which is time-consuming and can easily cause secondary damage to the stained sample during removal, further affecting the smoothness of subsequent testing procedures and the quality of sample testing. In summary, existing pathology sample preservation devices have significant deficiencies in sample preservation, positioning, separation, staining, and subsequent sample removal, failing to meet the high efficiency, convenience, and accuracy requirements of clinical pathology operations. There is an urgent need for an integrated, multi-functional preservation device to solve the above technical problems. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the existing technology and provide a pathology sample preservation device.

[0006] To achieve the above objectives, the present invention provides a pathology sample preservation device. Using this pathology sample preservation device, the problem can be effectively prevented. The technical solution adopted by the present invention to solve the above-mentioned technical problem is as follows: A pathology sample preservation device includes a bottle body, a cap, a filter assembly, and a staining assembly, wherein the filter assembly is disposed inside the bottle body.

[0007] Furthermore, the filter assembly includes an upper filter, a lower filter, and a guide rod connecting the upper filter and the lower filter. The guide rod is slidably disposed in the over-groove of the upper filter, and a slot is also provided on the side wall of the guide rod.

[0008] Furthermore, the filter assembly also includes a magnetic handle that can be inserted into the positioning hole of the guide rod.

[0009] Furthermore, the filter assembly also includes a rotating ring, which is disposed in the mounting groove inside the upper filter, and the rotating ring is provided with a locking block that engages with the locking groove.

[0010] Furthermore, the dyeing assembly includes: an installation ring disposed inside the bottle body, located between the upper filter and the lower filter, and connected to the lower part of the upper filter.

[0011] Furthermore, the dyeing assembly also includes a color developing component, which is movably connected to the inner wall of the mounting ring, so that the color developing component can be embedded in the inner wall of the mounting ring or extend into the annular space inside the mounting ring.

[0012] Furthermore, the rotating ring is also equipped with a one-way device disconnector. One end of the one-way device disconnector is connected to the rotating ring, and the other end is equipped with a magnet, which can be magnetically connected to the inner wall of the upper filter screen. When the one-way device disconnector is open, it can restrict the guide rod from falling. When the one-way device disconnector is closed, the upper filter screen and the lower filter screen can be disassembled.

[0013] Furthermore, a positioning ring is provided at the center of the rotating ring, through which the rotating column in the middle of the magnetic handle can pass.

[0014] Furthermore, the lower filter also includes a lower filter surface layer and a lower filter bottom layer connected by a slide rail.

[0015] Furthermore, the upper filter is connected to the cap at the top and to the bottle body at the bottom. The upper filter has several through holes distributed on its plane with grooves to filter liquid and retain tissue samples.

[0016] Furthermore, the lower filter screen also includes a lower filter screen surface layer and a lower filter screen bottom layer, wherein the outer diameter of the lower filter screen surface layer is equal to the inner diameter of the mounting ring.

[0017] Furthermore, the bottom surface of the lower filter screen has several through holes.

[0018] Furthermore, a groove is formed at the bottom of the lower filter screen, a second magnet is provided at the lower end of the groove, a third magnet is provided at the upper end, and a first magnet is provided at the bottom of the surface layer of the lower filter screen to engage with the groove. The first magnet and the third magnet are magnetically connected, and the first magnet and the second magnet repel each other.

[0019] Furthermore, the color developing component includes: a color developing sheet frame, the lower end of which is fixedly mounted on the mounting ring, and the upper end is movably connected to the mounting ring.

[0020] Furthermore, the color developing component also includes a torsion spring connected to the upper and lower ends of the color developing sheet frame, with one end of the color developing sheet frame movably connected inside the mounting ring via a rotating shaft.

[0021] Furthermore, the color development component also includes a color development sheet disposed inside the color development sheet frame.

[0022] Furthermore, the color developing component also includes an unfolding mechanism that connects the upper end of the color developing sheet frame to the mounting ring.

[0023] Furthermore, the unfolding mechanism includes: a positioning block, which is engaged in a slot opened in the inner sidewall of the mounting ring; a flexible rod, one end of which is connected to the positioning block and the other end of which is connected in a slot opened in the upper end of the color developing sheet frame; and a spring, which is disposed on the flexible rod.

[0024] Furthermore, the developing slides are made of a dyeing agent, and their outer layer is coated with a thin film soluble in a fixative.

[0025] Compared with the prior art, the beneficial effects of the present invention are as follows: Improve sample retrieval efficiency, reduce sample damage, and achieve rapid positioning and constraint through a mesh design, thereby reducing the workload of physicians; This integrates sampling and staining, simplifies the operation process, avoids sample contamination, and ensures staining uniformity. To ensure staining stability, facilitate convenient sample removal, smoothly connect to subsequent testing operations, and improve overall process efficiency; The device is easy to operate, compact in structure, and highly practical. It is well-suited to the clinical needs of pathology departments, effectively addresses the pain points of existing technologies, and improves the quality of sample processing. Attached Figure Description

[0026] Figure 1 This is an exploded schematic diagram of the preservation device provided by the present invention; Figure 2 This is a schematic diagram of the overall storage device provided by the present invention; Figure 3 A cross-sectional view of the storage device AA and a partially enlarged view of the color developing component provided by the present invention; Figure 4 A cross-sectional view of the storage device provided by the present invention (BB section); Figure 5 A schematic diagram of the filter assembly and dyeing assembly of the preservation device provided by the present invention; Figure 6 A cross-sectional view of the storage device provided by the present invention (CC plane). Figure 7 A partial enlarged view of the upper filter screen of the storage device provided by the present invention; Figure 8 A schematic diagram of the upper filter screen component of the storage device provided by the present invention; Figure 9 A schematic diagram of the installation of the magnetic handle and rotating ring of the storage device provided by the present invention; Figure 10 A schematic diagram of the magnetic handle part provided by the present invention; Figure 11 A schematic diagram of the rotating ring component of the storage device provided by the present invention; Figure 12 This is a schematic diagram of the installation of the lower filter screen and guide rod of the magnetic handle rotating ring provided by the present invention; Figure 13 A detailed view of the guide ring of the storage device provided by the present invention; Figure 14 This is a schematic diagram of the installation of the magnetic handle and guide rod of the storage device provided by the present invention; Figure 15 A schematic diagram of the lower filter and guide rod of the storage device provided by the present invention; Figure 16 A perspective view of the lower filter screen of the storage device provided by the present invention; Figure 17 A schematic diagram and a partial enlarged view of the staining component of the preservation device provided by the present invention; Figure 18 A schematic diagram of the color development component of the preservation device provided by the present invention; Figure 19 A schematic diagram of the unfolding mechanism of the storage device provided by the present invention in state 2; Figure 20 A perspective view of the staining component of the preservation device provided by the present invention; Figure 21 A partially enlarged perspective view of the unfolding mechanism of the storage device provided by the present invention.

[0027] Legend: 1-Bottle body; 2-Lid; 3-Filter assembly; 31-Upper filter; 311-Transition groove; 32-Lower filter; 321-Lower filter surface; 3211-First magnet; 322-Lower filter bottom layer; 3221-Slide groove; 3222-Second magnet; 3223-Third magnet; 33-Guide rod; 331-Slot; 34-Magnetic handle; 35-Rotating ring; 351-Clamping block; 36-One-way device disengager; 361-Disengager magnet; 4-Dyeing assembly; 41-Mounting ring; 42-Developing assembly; 421-Developing sheet frame; 422-Torsion spring; 423-Developing sheet; 424-Expansion mechanism; 4241-Positioning block; 4242-Flexible rod; 4243-Spring. Detailed Implementation

[0028] To facilitate understanding of this application, a more complete description will be provided below with reference to the accompanying drawings. Preferred embodiments of this application are shown in the drawings. However, this application can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a thorough and complete understanding of the disclosure of this application.

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the specification of this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0030] When using the terms “including,” “having,” and “comprising” as described herein, another component may be added unless explicitly qualifying terms such as “only,” “consisting of,” etc. are used. Unless otherwise stated, singular terms may include plural forms and should not be construed as having a quantity of one.

[0031] It should be understood that although the terms “first,” “second,” etc., may be used herein to describe various elements, these elements should not be limited by these terms. These terms are used only to distinguish one element from another. For example, without departing from the scope of this application, a first element may be referred to as a second element, and similarly, a second element may be referred to as a first element.

[0032] It should also be understood that, in interpreting an element, although not explicitly described, the element is interpreted as including a range of error, which should be within the acceptable deviation range of a particular value as determined by a person skilled in the art. For example, "approximately," "about," or "substantially" can mean within one or more standard deviations, without limitation herein.

[0033] Furthermore, the accompanying drawings are not drawn to a 1:1 scale, and the relative dimensions of the components are shown in the drawings only as examples and not necessarily to actual scale.

[0034] Example 1: Reference Figure 1-15 As shown, the present invention provides a pathology sample preservation device, which includes a bottle body 1, a cap 2, a filter assembly 3, and a staining assembly 4.

[0035] like Figure 1-2 As shown, the upper end of the filter assembly 3 is spirally connected to the cap 2, and the lower end passes through the dyeing assembly 4 and is set inside the bottle body 1. The bottle body 1 and the filter assembly 3 are rotatably connected.

[0036] like Figure 3-15 As shown, the filter assembly 3 includes: The upper filter screen 31 is located below the cover 2 and is rotatably connected to the cover 2. The upper filter screen 31 has a groove in the center into which the rotating ring 35 can be inserted. The guide rod 33 passes through the reserved slot on the upper filter screen 31 and is connected to the magnetic handle 34. The lower filter screen 32 includes a lower filter screen surface layer 321 and a lower filter screen bottom layer 322, and the guide rod 33 is fixedly connected to the lower filter screen 32. The guide rod 33 has longitudinally arranged equidistant locking blocks 331. The locking block 351 of the rotating ring 35 is engaged between the equidistant locking blocks 331. The guide rod 33 is slidably arranged in the through groove reserved in the upper filter screen 31. The magnetic handle 34 has a central rotating column that passes through the rotating ring 35. The magnetic handle 34 is inserted into the pre-drilled hole of the guide rod 33 by rotation. The magnetic handle 34 connects the three guide rods 33 together by rotation. Then, the lower filter screen 32 can be lifted by pulling the magnetic handle 34. The rotating ring 35 is set in the groove inside the upper filter screen 31 and is coaxial with the upper filter screen 31. Three sets of locking blocks 351 and three sets of one-way device disengagers 36 are evenly arranged on the rotating ring 35. A positioning hole is set in the center of the rotating ring 35 so that the rotating column in the middle of the magnetic handle 34 can pass through. One-way device dissociator 36 is equidistantly arranged on the rotating ring 35. One end of the one-way device dissociator 36 is fixedly connected to the rotating ring 35, and the other end is provided with a magnet and can touch the side wall of the upper filter screen 31. Dissociator magnets 361 are evenly arranged on the side wall of the upper filter screen 31.

[0037] Preferably, the rotating ring 35 has a positioning hole at its center, through which the rotating column in the middle of the magnetic handle 34 can pass, so as to position the magnetic handle 34 when it is connected to the guide rod 33.

[0038] Preferably, the lower filter 32 also includes a lower filter surface layer 321 and a lower filter bottom layer 322 connected by a slide rail 3221.

[0039] Preferably, the upper filter screen 31 is rotatably connected to the cap 2 on the top and rotatably connected to the bottle body 1 on the bottom. The upper filter screen 31 has several through holes distributed in the plane of the slot 311 to filter liquid and retain tissue samples.

[0040] Preferably, the lower filter screen 32 further includes a lower filter screen surface layer 321 and a lower filter screen bottom layer 322, wherein the outer diameter of the lower filter screen surface layer 321 is equal to the inner diameter of the mounting ring 41, so that when the lower filter screen 32 is pulled to a certain height, the lower filter screen surface layer 321 can squeeze the unfolding mechanism 424 to open the dyeing component 4.

[0041] Preferably, the bottom surface of the lower filter screen 322 has several through holes to filter liquid and retain tissue samples.

[0042] Preferably, the bottom layer 322 of the lower filter screen has a groove 3221. A second magnet 3222 is provided at the lower end of the groove 3221 and a third magnet 3223 is provided at the upper end. A first magnet 3211 is provided at the bottom of the surface layer 321 of the lower filter screen, which engages with the groove 3221. The first magnet 3211 and the third magnet 3223 are magnetically connected, and the first magnet 3211 and the second magnet 3222 repel each other.

[0043] When in use, pulling the magnetic handle 34 moves the lower filter screen 32 upward. At the same time, due to the locking block 351, when the guide rod 33 moves upward, the locking block 351 is driven to reciprocate, which does not affect the upward movement of the guide rod. If the guide rod falls downward, because the locking block 351 cannot swing downward, the guide rod 33 cannot move downward either, that is, the lower filter screen 32 will not fall.

[0044] To separate the upper and lower layers, simply move the one-way device dissociator 36 until it is magnetically attracted to the dissociator magnet 361, rotate the magnetic handle 34 out of the positioning hole of the guide rod 33, and unscrew the filter layer 32 from the bottle to separate the upper and lower filter layers and remove the tissue sample. Because all three one-way device dissociators are located on the rotating ring, moving one one-way device dissociator causes the other two to rotate together. The simultaneous action of the three sets of magnets makes the mechanism more stable.

[0045] The lower filter 32 is divided into a lower filter surface layer 321 and a lower filter bottom layer 322, which are constrained and connected by a slide rail and a magnet. When the upper filter 31 comes into contact with the lower filter surface layer 321, the guide rod 33 moves upward. The magnet will overcome the force generated by the fixed magnet of the lower filter bottom layer 322. However, due to the existence of the one-way mechanism, the upper and lower filters can continue to be pulled closer, further compressing the space where the tissue sample can move and improving the staining effect.

[0046] In this embodiment, three sets of guide rods 33 are provided. When the magnetic handle 34 is pulled, the guide rods 33 move upward, pulling the lower filter screen 32 upward. Because the guide rods 33 are fixedly connected to the lower filter screen 32, and the bottom layer 322 and the top layer 321 of the lower filter screen are connected through the sliding groove 3221 of the bottom layer 322, and the sliding groove 3221 is provided with a second magnet 3222 and a third magnet 3223. The bottom of the top layer 321 of the lower filter screen is provided with... There is a first magnet 3211 that engages with the slide groove 3221. The first magnet 3211 is magnetically connected to the third magnet 3223. The first magnet 3211 and the second magnet 3222 repel each other. Therefore, when the guide rod 33 moves upward, the repulsive magnetic force between the first magnet 3211 and the second magnet 3222 pushes the surface layer 321 of the lower filter screen upward. However, due to the repulsive magnetic force, even when the lower filter screen 32 is pulled to its highest point, there is still space for the sample to move.

[0047] Example 2: Reference Figure 1-6 As shown in Figures 15-21, the present invention provides a pathology sample preservation device, which includes a bottle body 1, a cap 2, a filter assembly 3, and a staining assembly 4.

[0048] The dyeing component 4 is disposed inside the bottle body 1, and the dyeing component 4 includes: The mounting ring 41 is located inside the bottle body 1, between the upper filter screen 31 and the lower filter screen 32, and is connected to the lower part of the upper filter screen 31. The mounting ring 41 has a hollow structure inside, and multiple color developing sheets 42 are arranged in the internal space. The color-developing component 42 is movably connected to the inner wall of the mounting ring 41 so that the color-developing component 42 can be embedded in the inner wall of the mounting ring 41 or extend into the annular space inside the mounting ring 41. When the lower filter screen 32 moves up to a certain height, the surface layer 321 of the lower filter screen is squeezed and unfolded by the mechanism 424, so that the color-developing component 42 can extend into the annular space inside the mounting ring 41.

[0049] The color development component 42 also includes a color development sheet frame 421, a torsion spring 422, a color development sheet 423, and an unfolding mechanism 424. The unfolding mechanism 424 includes a positioning block 4241, a flexible rod 4242, and a spring 4243.

[0050] The lower end of the colorimetric plate frame 421 is fixedly connected to the lower inner wall of the mounting ring 41. The upper end of the colorimetric plate frame 421 is connected to the upper wall of the mounting ring 41 through a flexible rod 4242. The other end of the flexible rod 4242 is connected to a positioning block 4241. A spring is provided on the flexible rod 4242 so that the flexible rod 4242 will rebound when the positioning block 4241 is squeezed.

[0051] In the initial state, the positioning block 4241 compresses the spring 4243 via the flexible rod 4242 and extends into the slot opened in the inner side wall of the mounting ring 41, so that the color developing sheet frame 421 is embedded inside the mounting ring 41.

[0052] The color developing sheet 423 is located inside the color developing sheet frame 421.

[0053] One end of the torsion spring 422 is connected to the upper end of the colorimetric plate frame 421, and the other end is connected to the lower end of the colorimetric plate frame 421. One end of the colorimetric plate frame 421 is movably connected to the inside of the mounting ring 41 through a rotating shaft.

[0054] In the initial state, the colorimetric frame 421 is completely hidden inside the mounting ring 41. The lower layer of the colorimetric frame 421 is fixed to the lower inner wall of the mounting ring 41. The torsion spring 422 is coiled. The upper layer of the colorimetric frame 421 is also not unfolded due to the obstruction of the positioning block 4241, and is also hidden inside the inner wall of the mounting ring 41. Only a part of the positioning block 4241 is exposed, serving as a triggering device.

[0055] When the lower filter 32 is pulled upward by the guide rod 33, the surface layer 321 of the lower filter will pass through the color developing component 42. Since the outer diameter of the surface layer 321 of the lower filter is equal to the inner diameter of the mounting ring 41, and the positioning block 4241 is partially exposed, when the surface layer 321 of the lower filter passes through the color developing component 42, the positioning block 4241 is pressed into the mounting ring 41. Under the action of the spring 4243, the flexible rod 4242 drives the positioning block 4241 to move downward. At this time, the upper restriction of the color developing sheet frame 421 is released. After the lower filter 32 has completely passed through, the color developing sheet 423 unfolds in a fan shape. At this time, the three color developing sheets 423 unfold and just cover the entire plane. At this time, the internal device of the bottle body 1 consists of the filter component 3, the color developing sheet 423 and the fixative from top to bottom. At this time, the fixative in the bottle is poured out, and the staining agent in the fixative is released and carries the staining agent through the tissue sample to complete the staining of the sample.

[0056] The installation method of the preservation device of the present invention is as follows: In the initial state, the lower filter screen 32 is placed inside the bottle body 1, filled with fixative, and the tissue is placed in. The positioning groove 311 of the upper filter screen 31 is passed through the guide rod 33, and the rotating ring 35 is placed in the mounting groove inside the upper filter screen 31. At this time, the one-way device dissociator 36 and the dissociator magnet 361 are in a magnetic attraction state. Rotate the one-way device dissociator 36 counterclockwise to separate it from the dissociator magnet 361. The locking block 351 can be locked between the locking groove 331 on the side of the guide rod 33. The locking block 351 swings in one direction and cannot swing downward. The magnetic suction handle 34 is positioned and locked into the positioning hole in the center of the rotating ring 35. The magnetic suction handle 34 can be rotated and inserted into the reserved hole in the guide rod 33, so that the upper and lower filters are connected as one unit. At this time, the lid 2 is closed to preserve the tissue block.

[0057] When it is necessary to remove the tissue block, open the cover 2 and pull the magnetic handle 34 to move the lower filter 32 upward. At the same time, due to the locking block 351, the guide rod 33 is moved upward and the locking block 351 is driven to make reciprocating motion, which does not affect the upward movement of the guide rod 33. If the guide rod 33 falls down, the guide rod 33 cannot move down because the locking block 351 cannot swing downward, that is, the lower filter 32 will not fall.

[0058] Raise the lower filter 32 to a suitable height. The surface layer 321 of the lower filter will pass through the staining component 4, pressing the positioning block 4241 into the mounting ring 41. Under the action of the spring 4243, the flexible rod 4242 drives the positioning block 4241 to move downward. At this time, the upper restriction of the chromogenic plate frame 421 is released. After the lower filter 32 has passed through, the chromogenic plate 423 unfolds in a fan shape. At this time, the three chromogenic plates 423 unfold and just cover the entire plane. At this time, the device in the bucket consists of the filter component 3, the chromogenic plate 42 and the fixative from top to bottom. Pour the fixative in the bottle. The fixative just passes through the chromogenic plate and dissolves the film on the chromogenic plate, releasing the staining agent and carrying the staining agent through the tissue sample to complete the staining of the sample.

[0059] To separate the upper and lower filter layers, simply rotate the magnetic handle 34 out of the pre-drilled hole in the guide rod 33, remove the magnetic handle 34, and then rotate the one-way device disengager 36 clockwise to the front of the disengager magnet 361 to open the one-way mechanism. The rotating ring 35 can then be removed, allowing the upper filter 31 to be unscrewed from the bottle, thus separating the upper and lower filter layers and removing the tissue sample.

[0060] In this embodiment, the preservation device can be completely immersed in disinfectant for disinfection and then reused. The color development component 42 is a disposable device. After the preservation device is used up, the staining component 4 can be unscrewed and the middle color development component 42 can be replaced. The color development sheet 423 is made of staining agent and its outer layer is wrapped with a thin film that is soluble in fixative, which makes it easy to pour the preservation device to stain the tissue.

[0061] In this embodiment, considering the usage scenario of the pathology sample preservation device, and taking into account ease of operation, manufacturing cost, and clinical practicality, the optimal materials for each core component of the device are recommended as follows: The bottle body and cap are made of high borosilicate glass, which has excellent chemical stability, is corrosion-resistant and high temperature resistant, and can be in contact with fixatives, staining agents and other chemical reagents for a long time without chemical reaction or release of harmful substances to contaminate the sample. In addition, high borosilicate glass has high hardness, is not easy to break, has a long service life, is easy to clean and disinfect, and can be reused, reducing the cost of clinical use. The filter assembly is made of medical-grade 316L stainless steel, which has strong chemical stability, is corrosion-resistant, and acid and alkali-resistant. It can be in contact with fixatives and staining agents for a long time without rusting or releasing harmful substances, ensuring that the sample is uncontaminated. At the same time, 316L stainless steel has high hardness and good toughness, which can be made into a fine filter structure. It can effectively hold the sample while allowing the fixative and staining agents to pass through smoothly without affecting the sample preservation and staining effect. In addition, 316L stainless steel is easy to clean and disinfect, can be reused, and has a smooth surface that does not easily stick to the sample, making it easy to remove the sample and avoiding sample damage. The guide rod, rotating ring, magnetic handle, positioning block, and flexible rod are made of medical-grade 316L stainless steel and medical-grade permanent magnets. The guide rod, rotating ring, and other structures need to have high structural strength and wear resistance, which 316L stainless steel can meet. At the same time, it is corrosion-resistant, pollution-free, and suitable for clinical use. The magnetic handle and the magnet of the one-way device dissociator are made of medical-grade permanent magnets. They are magnetically stable, not easy to demagnetize, and can achieve stable magnetic connection and positioning. There is no release of harmful substances and it does not affect the sample quality. The torsion springs and springs are made of medical-grade stainless steel spring wire. Medical-grade stainless steel spring wire is corrosion-resistant and has good elasticity. It can be used for a long time in the environment of fixative and staining agent. It is not easy to rust or fatigue damage. This ensures that the torsion springs and springs can provide elastic force stably for a long time, ensuring that the functions of the color development component, such as expansion and contraction and positioning block reset, are realized normally, thus extending the service life of the device. The colorimetric slide frame and mounting ring are made of medical-grade 316L stainless steel, the same material as the filter assembly, ensuring structural strength and corrosion resistance. They are also easy to connect with other components, easy to clean and disinfect, and reusable, avoiding structural damage or sample contamination due to the material's lack of corrosion resistance. The developing slides use medical-grade biodegradable film and clinical-grade pathological staining agents. The medical-grade biodegradable film must have good solubility, be quickly dissolved by the fixative, release the staining agent, and leave no harmful residues after dissolution, so as not to affect the sample detection. The staining agents used are clinical-grade pathological staining agents, such as hematoxylin-eosin staining agents, to ensure stable staining effects, meet pathological diagnostic standards, and do not damage sample tissues.

[0062] All materials must meet medical-grade standards to ensure no harmful substances are released and that the sample test results are not affected.

[0063] In this embodiment, the preservation device adopts an integrated structure to reduce sample transfer steps and minimize contamination caused by sample contact with the external environment. A sealed design prevents leakage of fixative and staining agents, avoiding contamination of the work surface. A soluble film protects the staining agents from contaminating the fixative, ensuring a clean sample preservation environment. From the flexible constraint during sample placement and the stable positioning during lifting to the non-destructive removal after staining, each step avoids direct contact and mechanical damage to the sample from manual operation, ensuring the morphological integrity and biological characteristics of the sample from preservation to subsequent processing, providing a reliable sample basis for pathological diagnosis. All moving parts of the device are equipped with protective structures to prevent pinching injuries caused by accidental hand contact during operation. Simultaneously, it reduces direct contact between physicians and fixatives and staining agents, lowering the potential harm of chemical reagents to the human body and improving the safety of clinical operations.

[0064] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0065] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A pathology sample preservation device, comprising a bottle body (1) and a cap (2), wherein the bottle body (1) contains a fixative, characterized in that: It also includes a filter assembly (3) and a dyeing assembly (4), wherein the filter assembly (3) is disposed inside the bottle body (1); The filter assembly (3) includes: Upper filter (31); The sample is located on the lower filter screen (32); A guide rod (33) connects the upper filter screen (31) and the lower filter screen (32), and the guide rod (33) is slidably disposed in the over-groove (311) of the upper filter screen (31). A slot (331) is also provided on the side wall of the guide rod (33). A magnetic handle (34) is inserted into the positioning hole of the guide rod (33); The rotating ring (35) is movably set in the mounting groove inside the upper filter screen (31). The magnetic handle (34) is connected to the rotating ring (35). The rotating ring (35) is provided with a card block (351) that engages with the card slot (331). The staining component (4) stores staining agent. The staining component (4) is triggered by the lower filter (32) to release the staining agent, which is then used to stain the sample via the fixative.

2. The pathology sample preservation device according to claim 1, characterized in that: The rotating ring (35) is also provided with a one-way device disconnector (36). One end of the one-way device disconnector (36) is connected to the rotating ring (35), and the other end is provided with a magnet, which can be magnetically connected to the inner wall of the upper filter screen (31).

3. The pathology sample preservation device according to claim 2, characterized in that: The rotating ring (35) is provided with a locking block (351) at equal intervals. The locking block (351) swings upward in one direction and engages with the locking slot (331).

4. The pathology sample preservation device according to claim 1, characterized in that: The magnetic handle (34) is located above the rotating ring (35). A rotating column for positioning is provided in the middle of the magnetic handle (34), which can be inserted into the positioning ring provided in the middle of the rotating ring (35). A connecting block for inserting the positioning hole of the guide rod (33) is provided around the magnetic handle (34).

5. The pathology sample preservation device according to claim 1, characterized in that: The lower filter (32) also includes a lower filter surface layer (321) and a lower filter bottom layer (322), wherein the outer diameter of the lower filter surface layer (321) is equal to the inner diameter of the mounting ring (41).

6. The pathology sample preservation device according to claim 5, characterized in that: The bottom layer (322) of the lower filter screen has a groove (3221). A second magnet (3222) is provided at the lower end of the groove (3221) and a third magnet (3223) is provided at the upper end. A first magnet (3211) is provided at the bottom of the surface layer (321) of the lower filter screen and engages with the groove (3221). The first magnet (3211) and the third magnet (3223) are magnetically connected, and the first magnet (3211) and the second magnet (3222) repel each other.

7. The pathology sample preservation device according to claim 1, characterized in that: The staining component (4) includes: The mounting ring (41) is located inside the bottle body (1), between the upper filter screen (31) and the lower filter screen (32), and is connected to the lower part of the upper filter screen (31); The color-developing component (42) is movably connected to the inner wall of the mounting ring (41) so that the color-developing component (42) can be embedded in the inner wall of the mounting ring (41) or extend into the annular space inside the mounting ring (41).

8. The pathology sample preservation device according to claim 7, characterized in that: The color-developing component (42) includes: The colorimetric plate frame (421) has its lower end fixedly mounted on the mounting ring (41) and its upper end movably connected to the mounting ring (41); A torsion spring (422) is connected to the upper and lower ends of the colorimetric plate frame (421), and one end of the colorimetric plate frame (421) is movably connected to the inside of the mounting ring (41) through a rotating shaft; The color developing sheet (423) is located inside the color developing sheet frame (421). The color developing sheet (423) is made of a dyeing agent wrapped in a thin film and can unfold inside the bottle (1) along with the color developing sheet frame (421). The unfolding mechanism (424) connects the upper end of the colorimetric plate frame (421) to the mounting ring (41).

9. The pathology sample preservation device according to claim 8, characterized in that: The deployment mechanism (424) includes: The positioning block (4241) is engaged in the slot opened on the inner side wall of the mounting ring (41); The flexible rod (4242) is connected at one end to the positioning block (4241) and at the other end to the slot opened at the upper end of the colorimetric sheet frame (421); Spring (4243) is mounted on flexible rod (4242).

10. A method for staining pathology samples, characterized in that, Implemented using the apparatus according to any one of claims 1-9, the method comprises: Unscrew the cap (2); Pull up the magnetic handle (34) to move the guide rod (33) upward, thereby moving the lower filter screen (32) upward; When the lower filter (32) rises through the color display component (42), the surface layer (321) of the lower filter presses the positioning block (4241) into the mounting ring (41), triggering the unfolding mechanism (424). After the lower filter (32) has completely passed through the dyeing component (4), the color developing sheet (423) unfolds in a fan shape and covers the entire plane; Pour the bottle (1) over so that the fixative in the bottle (1) passes through the developing plate (423), dissolves the film on the developing plate (423), releases the staining agent and carries the staining agent through the tissue sample to complete the staining.

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