A process for the preparation of 3-(trifluoromethyl)cyclobutan-1-one
3-(trifluoromethyl)cyclobutane-1-one was prepared by cycloaddition reaction of diketene with 1,1,1-trifluoropropylene, which solved the problems of high cost and harsh reaction conditions in the prior art and realized low-cost and environmentally friendly industrial production.
CN122380955APending Publication Date: 2026-07-14ANQING RONGCHUANG BIOTECHNOLOGY CO LTD +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ANQING RONGCHUANG BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-06-11
- Publication Date
- 2026-07-14
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Figure CN122380955A_ABST
Abstract
The application discloses a preparation method of 3-(trifluoromethyl)cyclobutan-1-one and belongs to the technical field of organic synthesis. The method comprises the following steps: under an inert atmosphere, double ethylene ketone is cracked at 550 DEG C to 650 DEG C to generate ethylene ketone gas; under the conditions of the inert atmosphere and light, a cycloaddition reaction of the ethylene ketone gas and 1,1,1-trifluoropropene gas is carried out at a temperature of-50 DEG C to 0 DEG C to generate 3-(trifluoromethyl)cyclobutan-1-one; and the wavelength of the light source of the light is 250 nm to 650 nm. The raw materials of the method are all cheap and easily obtained bulk chemicals, no solvent and catalyst need to be added, the reaction condition is mild, the operation is simple, and the method is suitable for industrial production; and the obtained product 3-(trifluoromethyl)cyclobutan-1-one is an important pharmaceutical intermediate.
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