A bis(p-fluorophenylpyridine thio-carbazone) zinc(ii) complex and its preparation method and application

By combining the bis(p-fluorophenylpyridine thiocarbazone) zinc(II) complex with exogenous copper(II) ions, the copper death pathway is activated, which solves the problems of insufficient efficacy and poor selectivity in existing anti-tumor treatments and achieves efficient and low-toxicity tumor killing and integrated diagnosis and treatment.

CN122381014APending Publication Date: 2026-07-14THE FIRST AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIVERSITY
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Patent Information

Application Number
CN202610548417.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-23
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

Current anti-tumor therapies suffer from problems such as insufficient efficacy of single-mechanism therapy, poor tumor killing selectivity, significant toxic side effects, and inability to efficiently activate novel cell death pathways.

Method used

A bis(p-fluorophenylpyridine thiocarbazone) zinc(II) complex is provided, which, by combining with exogenous copper(II) ions, synergistically acts on tumor cells to achieve a cascade of lysosomal targeting, mitochondrial damage, energy collapse and oxidative stress, thereby activating the copper death pathway.

Benefits of technology

It significantly enhances anti-tumor activity, achieving highly efficient and low-toxicity killing of various tumor cells, exhibiting good tumor selectivity and in vivo safety. It also possesses lysosomal targeted imaging capabilities, making it suitable for integrated tumor diagnosis and treatment.

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Abstract

The application discloses a kind of double (p-fluorophenyl pyridine thio carbazone) Zn (II) complex (Zn2) and its application in preparation of anticancer drug with exogenous Cu (II).The chemical formula of Zn2 is Zn (L) 2, wherein L is (E) -2- ((4-fluorophenyl) (pyridin-2-yl) methylene) hydrazine dithiocarbamate.The synthesis step of the Zn5 is simple, and the compound has fluorescence characteristics and lysosome targeting ability.In vitro anticancer experiment shows that Zn2 is combined with exogenous Cu (II), and the anticancer activity is significantly improved.Further anticancer mechanism shows that Zn2 can induce cancer cell copper death and activate immunogenic cell death by combining with exogenous Cu (II).Zn2 and exogenous Cu (II) are combined in vivo tissue distribution and toxicity evaluation, and no significant in vivo toxicity is shown.
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