A directional perfusion space-on-a-chip
By using organ-on-a-chip design with directional perfusion and multiple functional chamber structures, the problems of cell function decline and cross-contamination in existing technologies have been solved, enabling long-term dynamic research and efficient experimental monitoring, and improving the simulation of cell function and control capabilities.
CN122381918APending Publication Date: 2026-07-14SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
- Filing Date
- 2026-04-16
- Publication Date
- 2026-07-14
Smart Images
Figure FT_1 
Figure FT_2 
Figure FT_3
Abstract
The application provides a directional perfusion space-contrast organ chip, and relates to the field of microfluidic chip design and processing.The space-contrast organ chip comprises a bottom chip and a top chip arranged in sequence, the bottom chip is provided with a plurality of groups of functional cavities, the functional cavities at least include a main cavity, an inflow channel and an outflow channel, at least one group of the functional cavities further includes an auxiliary cavity, the auxiliary cavity is communicated with the main cavity, the inflow channel and the outflow channel are communicated with the main cavity or the auxiliary cavity, and the top chip includes a liquid inlet channel and a liquid outlet channel.The embodiment of the application can continuously supply nutrients to cells and remove metabolic waste through directional perfusion, significantly prolongs a culture cycle, supports long-term dynamic research, simulates a fluid environment under a physiological state, is significantly superior to static culture in maintaining cell physiological homeostasis, improving a cell function phenotype simulation degree and analyzing a biological effect mechanism.
Need to check novelty before this filing date? Find Prior Art