Immuno-chromatographic quantitative detection device based on optical sensing

Abstract

The disclosure provides an optical sensing-based immunochromatography quantitative detection device, and relates to the technical field of immunochromatography detection, which comprises a detection assembly, an entering assembly and a disinfection assembly, the detection assembly comprises a box body and a box door, the box door is provided with an opening assembly, the opening assembly comprises a handle and a hinge, the box body is internally provided with a sensing assembly, the sensing assembly comprises a sensor and a chromatography membrane, the box body is provided with a display assembly, the display assembly comprises a display and a switch group, the box body is provided with a placing assembly, and the placing assembly comprises a groove and a top plate. The optical sensing-based immunochromatography quantitative detection device can make air pass through the filter screen, enter the inside of the wind box, and then be sterilized by a disinfection lamp, so that bacteria in the outside are prevented from entering the inside of the box body, bacteria in the box body are effectively prevented from being polluted, the reliability of a detection result is ensured, and the optical sensing-based immunochromatography quantitative detection device is suitable for quantitative detection.

Description

Technical Field

[0001] This disclosure relates to the field of immunochromatographic quantitative detection equipment technology, and more particularly to an immunochromatographic quantitative detection device based on optical sensing. Background Technology

[0002] Immunochromatography is a rapid detection technique based on the specific reaction of antigens and antibodies. It is mainly used in the field of in vitro diagnostics and is also an important tool for point-of-care testing. It utilizes the movement of liquid samples on a chromatographic membrane, which allows the target analytes in the sample to bind with labeled antibodies pre-immobilized on the conjugate pad to form a complex. This complex is captured and aggregated by the immobilized capture antibody along with the liquid, and then colored by the label. The concentration of the colored substance is detected by an optical sensing device, thus enabling effective quantitative detection of the sample.

[0003] Patent application CN202411709697.X discloses a quantitative detection device for fluorescence immunochromatography. Through the coordinated operation of the sample loading module, fluorescence detection module, temperature control module, and transport module, the device rapidly controls the sample to the required experimental temperature, effectively reducing temperature interference during quantitative detection, ensuring accurate results, and improving detection precision. Furthermore, the high degree of automation further reduces operational difficulty. The enclosure fully encloses the sample loading module, fluorescence detection module, temperature control module, and transport module, maintaining the internal detection environment and preventing external light sources from interfering with the fluorescence detection module's measurements. Patent application CN202311058813.1 discloses a rapid quantitative detection device for fluorescence immunochromatography and its usage method. The reagent kit is placed in a vibrating feeder and transported to a belt conveyor. A first rangefinder is used to measure the reagents passing directly below it. The system uses spatial data to determine whether a reagent kit needs to be flipped. When a kit needs to be flipped, the belt conveyor transports it to the adjustment mechanism and stops. An electric pusher then moves the kit flipping mechanism upwards. During this upward movement, the kit flipping mechanism and the flipping auxiliary mechanism flip the kit 180 degrees. The electric pusher then moves the kit flipping mechanism downwards to reset. The flipped kit moves with the belt conveyor towards the second rangefinder for verification. After verification, the kit is transferred to the sample testing machine. The sample testing machine drops different sample mixtures into the corresponding kits and transports the kits with the sample mixtures to the observation chamber to observe the test results. An adjustment mechanism is installed on the belt conveyor. When a kit needs to be flipped, the electric pusher moves the kit flipping mechanism towards the kit to be flipped, and in conjunction with the flipping auxiliary mechanism, the kit is flipped 180 degrees. The entire process requires only one power source, has a simple overall structure, a rapid flipping response, a small size, and low energy consumption.

[0004] According to its publicly available technical solutions, existing immunochromatographic quantitative detection equipment has several drawbacks. First, during the detection process, bacteria can easily be introduced from the outside during the handling of the chromatography membrane, which can interfere with the test results and compromise their reliability. Second, when the sample is dropped onto the chromatography membrane, the dropper can easily become contaminated with bacteria at the dropper inlet, which can compromise the safety of the sample. Third, when sterilizing the dropper inlet, disinfectant alcohol can easily enter the inside of the equipment, which can prevent the detection process from being performed due to the presence of disinfectant alcohol. Summary of the Invention

[0005] This disclosure aims to at least partially address one of the technical problems in the related art.

[0006] Therefore, the purpose of this disclosure is to provide an immunochromatographic quantitative detection device based on optical sensing.

[0007] To achieve the above objectives, this disclosure provides an immunochromatographic quantitative detection device based on optical sensing, comprising: a detection component, an entry component, and a disinfection component. The detection component includes a housing and a door. An opening component, including a handle and a hinge, is installed on the door. A sensing component, including a sensor and a chromatography membrane, is installed inside the housing. A display component, including a display and a switch assembly, is installed on the housing. A placement component, including a recess and a top plate, is installed on the recess. The moving assembly includes an electromagnet and a spring; a pushing assembly is mounted on the groove, comprising a base plate and a connecting rod; a locking assembly is mounted on the door, comprising a socket and a pin; a suction assembly is mounted on the housing, comprising an electromagnet and a support sleeve; a positioning assembly is mounted on the housing, comprising a baffle and a button; the entering assembly includes a bellows and a sleeve, the bellows being bolted to the outer side of the housing, the sleeve being welded to the top of the housing, and the bellows being installed on the inner side. The system includes a ventilation assembly comprising an air outlet and a fan; a filter assembly comprising a filter screen and a guide plate; a sterilization assembly comprising a disinfection lamp and a vent; a sealing assembly comprising a cylinder cover and a hinged plate; a rotating assembly comprising a bent plate and a rotating rod; a sliding assembly comprising a sliding rod and a circular plate; and a limiting assembly comprising a conical opening and an outer ring. The disinfection assembly includes a water tank and a tank cover. The water tank is welded to the top of the tank body. A hydraulic assembly one is installed on the top of the water tank. The hydraulic assembly one includes an inner sleeve and a piston one. A hydraulic assembly two is installed at the bottom of the water tank. The hydraulic assembly two includes an outer sleeve and a piston two. A connecting assembly is installed on the water tank. The connecting assembly includes a connecting port and a connecting hole. A fixing assembly one is installed on one side of the piston one. The fixing assembly one includes a locking pin one and a spring three. A fixing assembly two is installed on one side of the piston two. The fixing assembly two includes a locking pin two and a spring four.

[0008] Optionally, the sensor is bolted to the inner wall of the top of the housing, the groove is formed on the inner wall of the bottom of the housing, the chromatography membrane is clamped inside the groove, the periphery of the chromatography membrane is clamped to the inner wall of the groove, the display is bolted to the outer side of the housing, the switch assembly is bolted to the outer side of the display, the processor is installed inside the display, the sensor is connected to the processor via wires, and the processor is connected to the display via wires.

[0009] Optionally, the air box is bolted to one side of the housing, the air outlet is opened on one side of the housing, the air box is fitted outside the air outlet, the fan is bolted to the inside of the air outlet, the filter is bolted to the outside of the air box, the guide plate is glued to the inner wall of the air box with sealant, the guide plate is a quartz glass guide plate, the guide plate is evenly distributed on the inside of the air box, the opening is opened on the guide plate, the opening is alternately distributed at the top and bottom of the guide plate, the guide plate has a fixing hole, and the disinfection lamp is clipped inside the fixing hole.

[0010] Optionally, the top plate is clamped inside the groove, the top plate is located at the bottom of the chromatography membrane, the bottom plate is clamped on the inner wall of the bottom of the groove, the electromagnet is installed inside the groove by bolts, the bottom of the electromagnet is connected to the top of the bottom plate by spring, the inner side of the electromagnet is provided with an inner opening, the bottom end of the connecting rod is welded to the top of the bottom plate, and the top end of the connecting rod passes through the inner opening and is installed on the top plate by bolts.

[0011] Optionally, the outer side of the box door is fastened to the inner wall of the other side of the box body, the bottom of the box door is connected to the bottom of the box body via a hinge, the handle is welded to the top of the box body, the socket is opened at the top of the box door, the support sleeve is installed on the top of the other side of the box body by bolts, a slot is opened at the top of the other side of the box body, the second electromagnet is installed on the inner wall of the top of the support sleeve by bolts, the top of the pin is connected to the bottom of the second electromagnet by a second spring, the outer side of the top of the pin is fastened to the inner side of the slot, the bottom of the pin passes through the slot and extends to the inner side of the socket, a baffle is welded on the inner wall of the top of the other side of the box body, a button is installed on the baffle, and the top of the box door is fastened to the outer side of the baffle and the button.

[0012] Optionally, the sleeve is welded to the top of the box body, the top end of the sleeve is located at the top of the box body, the bottom end of the sleeve extends to the inside of the box body, the sleeve is located at the top of one side of the chromatography membrane, the conical opening is integrally formed at the bottom end of the sleeve, the rotating rod is installed on the inside of the box body by bolts, one end of the flap is sleeved on the outside of the rotating rod, the bending plate is integrally formed at one end of the flap, and the top of the other end of the flap is locked at the bottom of the conical opening.

[0013] Optionally, the outer ring is welded to the top of the housing, the outer ring is sleeved on the outside of the top of the sleeve, the cylinder cover is sleeved on the outer side of the outer ring, the top of the housing has a sliding groove, the bottom end of the sliding rod is engaged with the top of one end of the flap, the top end of the sliding rod passes through the sliding groove and extends to the outside of the housing, the bottom of the cylinder cover is pressed against the top end of the sliding rod, the circular plate is integrally formed on the outer side of the sliding rod, and the circular plate is located at the bottom of the sliding groove.

[0014] Optionally, the water tank is welded to the top of the tank body, the tank cover is fitted onto the outer side of the top of the water tank, the connecting port is opened at the top of the tank body, the bottom of the water tank is connected to the inner side of the outer ring through the connecting port, the connecting port is located on the outer side of the sleeve, the inner sleeve is welded to the inner wall of the top of the water tank, the outer sleeve is welded to the outer side of the bottom of the water tank, piston one is engaged on the inner wall of one end of the inner sleeve, piston two is engaged on the inner wall of one end of the outer sleeve, the connecting holes are respectively opened at the other end of the outer sleeve, the side wall of the water tank, and the other end of the inner sleeve, and the other end of the outer sleeve is connected to the other end of the inner sleeve through the connecting holes.

[0015] Optionally, a slot is provided on the inner wall of the cover, the outer side of the latch is engaged with the inner wall of the slot, one end of the latch is connected to the inner wall of the slot via a spring, the other end of the latch passes through the slot and extends to the inner side of the inner sleeve, and the other end of the latch is pressed against one side of the piston.

[0016] Optionally, the cylinder cover has a second slot, the outer side of the second locking pin is engaged with the inner wall of the second slot, one end of the second locking pin is connected to the inner wall of the slot by a spring four, the other end of the second locking pin passes through the second slot and extends to the inner side of the outer sleeve, the top of the other end of the outer sleeve has a latch, the top of the other end of the second locking pin is engaged with the inner side of the latch, and the bottom of the other end of the second locking pin is pressed against one side of the piston two.

[0017] The technical solution provided in this disclosure may include the following beneficial effects:

[0018] In use, the electromagnet is activated via the switch assembly. The electromagnet attracts the pin, compressing the spring and moving it from the inside of the socket to the inside of the support. Pulling the handle rotates the hinged door. The button on the baffle activates the fan and disinfection lamp. The fan draws air through the vent, creating suction in the airbox. Air, filtered through the filter, enters the airbox and flows up and down through the guide plate. During this flow, the disinfection lamp kills bacteria in the air, allowing clean, sterile air to be introduced into the chamber. This creates an outward airflow within the chamber, effectively... To prevent outside air from directly entering the inner side of the chamber, thus effectively preventing bacteria from entering and contaminating the chamber, and ensuring the reliability of the test results, the personnel place the chromatography membrane inside the groove, close the chamber door, and spring two pushes the pin to insert into the inside of the socket. Then, the baffle blocks the chamber door, closing it. After completing the test, electromagnet one is turned on, generating a magnetic force on the bottom plate. The bottom plate compresses spring one, which in turn moves the top plate upward through the connecting rod, pushing the chromatography membrane upward from the inside of the groove, facilitating the removal of the chromatography membrane.

[0019] In use, turn on the sensor and display via the switch assembly, then pull the cap upwards. The hinged plate rotates downwards under gravity via the rotating rod, and pushes the sliding rod upwards via the curved plate. The sliding rod slides upwards along the inside of the groove until the top of the circular plate moves to the inner wall of the top of the chamber. Insert the sample-drawing dropper into the inside of the sleeve, and limit the bottom of the dropper with the conical nozzle to prevent direct contact between the dropper and the chromatography membrane, thus avoiding damage to the membrane structure. Drop the sample onto the top side of the chromatography membrane, then remove the dropper. The cap is placed on the outer side of the outer ring. The disinfectant alcohol in the water tank enters the inner side of the outer ring through the connector, disinfecting the cap, outer ring, and sleeve to prevent bacterial contamination of the dropper and thus effectively prevent sample contamination, ensuring sample safety. The capillary action of the chromatography membrane causes the sample to move to the right on the membrane and bind with the marker on the membrane, releasing a fluorescent agent. The amount of fluorescent agent is then detected by a sensor, and the detection result is displayed on a monitor, thereby achieving quantitative detection by immunochromatography.

[0020] During use, when the cap is placed on the outer ring, the cap presses down on the sliding rod. The sliding rod slides downwards on the inner side of the groove and pushes the bent plate. The bent plate drives the movable plate to rotate on the rotating rod, thereby sealing the conical opening and preventing volatile alcohol from entering the inside of the tank. When it is necessary to add alcohol to the tank, the cap is pulled upwards. The cap causes the locking pin one to press upwards on the inner sleeve, so that the top of one end of the inner sleeve presses against the locking pin one. The locking pin one compresses the spring three and moves to the inside of the cap, thereby pulling the cap off the tank. After the piston one loses the compression of the locking pin one, the pressure on the piston two is eliminated by the hydraulic oil in the inner sleeve, connecting hole, and outer sleeve. The spring four pushes the locking pin two under the elastic force. The locking pin two moves to the inside of the outer sleeve and moves downwards through the arc surface of the locking opening, thereby driving the cap to... The cylinder cover moves downwards, sealing the top of the sleeve and outer ring. This prevents alcohol in the tank from continuously flowing into the inner side of the outer ring through the connection port, effectively preventing alcohol from directly flowing into the inner side of the sleeve. After replenishing the alcohol, the lid is placed on the tank. Spring three pushes pin one, pin one squeezes piston one, piston one pushes piston two through hydraulic oil, piston two pushes pin two to the left, pin two compresses spring four and moves a portion into the cylinder cover, and moves slightly upwards under the elastic force of the slide rod to ensure that the evaporating alcohol can enter the inner side of the sleeve. When the cylinder cover is removed, pin one is fully inserted into the inner side of the inner sleeve, preventing the cylinder cover and the lid from being removed at the same time. This effectively prevents a large amount of alcohol from entering the inner side of the chamber, avoiding the inability to perform testing operations due to the presence of disinfectant alcohol inside the chamber.

[0021] Additional aspects and advantages of this disclosure will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this disclosure. Attached Figure Description

[0022] The above and / or additional aspects and advantages of this disclosure will become apparent and readily understood from the following description of the embodiments taken in conjunction with the accompanying drawings, in which:

[0023] Figure 1 This is a schematic diagram of the structure of an optically sensing-based immunochromatographic quantitative detection device according to an embodiment of this disclosure. Figure 1 ;

[0024] Figure 2 This is a schematic diagram of the structure of an optically sensing-based immunochromatographic quantitative detection device according to an embodiment of this disclosure. Figure 2 ;

[0025] Figure 3 This is a cross-sectional schematic diagram of an optically sensing-based immunochromatographic quantitative detection device according to an embodiment of this disclosure. Figure 1 ;

[0026] Figure 4This is a cross-sectional schematic diagram of an optically sensing-based immunochromatographic quantitative detection device according to an embodiment of this disclosure. Figure 2 ;

[0027] Figure 5 This is a cross-sectional schematic diagram of an optically sensing-based immunochromatographic quantitative detection device according to an embodiment of this disclosure. Figure 3 ;

[0028] Figure 6 This is a cross-sectional schematic diagram of the sleeve of an immunochromatographic quantitative detection device based on optical sensing according to an embodiment of this disclosure;

[0029] Figure 7 This is a cross-sectional view of an immunochromatographic quantitative detection device based on optical sensing according to an embodiment of this disclosure;

[0030] As shown in the figure: 1. Cabinet; 2. Door; 3. Handle; 4. Hinge; 5. Sensor; 6. Chromatography membrane; 7. Display; 8. Switch assembly; 9. Recess; 10. Top plate; 11. Electromagnet I; 12. Base plate; 13. Connecting rod; 14. Spring I; 15. Baffle; 16. Socket; 17. Support sleeve; 18. Electromagnet II; 19. Pin; 20. Spring II; 21. Button; 22. Bellows; 23. Filter; 24. Air outlet; 25. Fan; 26. 27. Guide plate; 28. Disinfection lamp; 29. ​​Through port; 30. Sleeve; 31. Cylinder cover; 32. Hinged plate; 33. Bend plate; 34. Rotating rod; 35. Slide rail; 36. Round plate; 37. Conical opening; 39. Box cover; 40. Water tank; 41. Outer ring; 42. Connecting port; 43. Inner sleeve; 44. Outer sleeve; 45. Connecting hole; 46. Piston one; 47. Piston two; 48. Locking pin one; 49. Spring three; 50. Locking pin two; 51. Spring four; 52. Bayonet. Detailed Implementation

[0031] Embodiments of this disclosure are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are used only to explain this disclosure, and should not be construed as limiting this disclosure. Rather, embodiments of this disclosure include all variations, modifications, and equivalents falling within the spirit and scope of the appended claims.

[0032] like Figure 1 , Figure 3 , Figure 4 , Figure 5 and Figure 6As shown in the figure, this disclosure proposes an immunochromatographic quantitative detection device based on optical sensing, comprising: a detection component, the detection component including a housing 1 and a door 2, an opening component installed on the door 2, the opening component including a handle 3 and a hinge 4; a sensing component installed inside the housing 1, the sensing component including a sensor 5 and a chromatography membrane 6; a display component installed on the housing 1, the display component including a display 7 and a switch group 8; a placement component installed on the housing 1, the placement component including a groove 9 and a top plate 10; a driving component installed on the groove 9, the driving component including an electromagnet 11 and a spring 14; a pushing component installed on the groove 9, the pushing component including a base plate 12 and a connecting rod 13; a locking component installed on the door 2, the locking component including a socket 16 and a pin 19; a suction component installed on the housing 1, the suction component including an electromagnet 18 and a support sleeve 17; and a device for... The enclosure is equipped with a positioning component, which includes a baffle 15 and a button 21; an entry component, which includes a bellows 22 and a sleeve 29. The bellows 22 is bolted to the outer side of the enclosure 1, and the sleeve 29 is welded to the top of the enclosure 1. A ventilation component is installed on the inner side of the bellows 22, which includes an air outlet 24 and a fan 25. A filter component is installed on the bellows 22, which includes a filter screen 23 and a guide plate 26. A sterilization component is installed on the guide plate 26, which includes a sterilization lamp 27 and a vent 28. A sealing component is installed on the sleeve 29, which includes a cylinder cover 30 and a hinged plate 31. A rotating component is installed on the hinged plate 31, which includes a bending plate 32 and a rotating rod 33. A sliding component is installed on the hinged plate 31, which includes a sliding rod 35 and a circular plate 36. A limiting component is installed on the sleeve 29, which includes a conical opening 37 and an outer ring 41.The disinfection assembly includes a water tank 40 and a tank cover 39. The water tank 40 is welded to the top of the tank body 1. A hydraulic assembly one is installed on the top of the water tank 40, and the hydraulic assembly one includes an inner sleeve 43 and a piston 46. A hydraulic assembly two is installed at the bottom of the water tank 40, and the hydraulic assembly two includes an outer sleeve 44 and a piston 47. A connecting assembly is installed on the water tank 40, and the connecting assembly includes a connecting port 42 and a connecting hole 45. A fixing assembly one is installed on one side of the piston 46, and the fixing assembly one includes a locking pin 48 and a spring 49. A fixing assembly two is installed on one side of the piston 47, and the fixing assembly two includes a locking pin 50 and a spring 51. The sensor 5 is bolted to the inner wall of the top of the tank body 1. A groove 9 is formed on the inner wall of the bottom of the tank body 1, and the chromatography membrane 6 is clamped inside the groove 9. The chromatography membrane 6 is secured to the inner wall of the groove 9. The display 7 is bolted to the outer side of the housing 1. The switch assembly 8 is bolted to the outer side of the display 7. A processor is installed inside the display 7. The sensor 5 is connected to the processor via wires. The processor is connected to the display 7 via wires. The outer ring 41 is welded to the top of the housing 1. The outer ring 41 is fitted onto the outer side of the top of the sleeve 29. The cylinder cover 30 is fitted onto the outer side of the outer ring 41. A sliding groove 34 is formed on the top of the housing 1. The bottom end of the sliding rod 35 is secured to the top of one end of the flap 31. The top end of the sliding rod 35 passes through the sliding groove 34 and extends to the outer side of the housing 1. The bottom of the cylinder cover 30 is pressed against the top end of the sliding rod 35. The circular plate 36 is integrally formed on the outer side of the sliding rod 35 and is located at the bottom of the sliding groove 34.

[0033] Understandably, by opening the sensor 5 and display 7 via switch group 8, and then pulling the cylinder cover 30 upwards, the hinge 31 rotates downwards under gravity via the rotating rod 33, and pushes the slide rod 35 upwards via the bent plate 32. The slide rod 35 slides upwards inside the slide groove 34 until the top of the circular plate 36 moves to the inner wall of the top of the box 1. Then, the dropper for drawing the sample is inserted into the inner side of the sleeve 29, and the bottom end of the dropper is limited by the conical opening 37 to prevent personnel from directly contacting the dropper with the chromatography membrane 6 and to prevent the dropper from damaging the structure of the chromatography membrane 6. The sample is then dripped into the top of one side of the chromatography membrane 6, and then... The tube is removed, and the cap 30 is placed on the outer side of the outer ring 41. The disinfectant alcohol in the water tank 40 enters the inner side of the outer ring 41 through the connector 42, and disinfects the cap 30, outer ring 41 and sleeve 29 to prevent bacterial contamination of the dropper, thereby effectively preventing bacterial contamination of the sample and ensuring sample safety. The sample moves to the right on the chromatography membrane 6 by the capillary action of the chromatography membrane 6 and releases fluorescent agent after binding with the marker on the chromatography membrane 6. The amount of fluorescent agent is then detected by the sensor 5 and the detection result is displayed on the display 7, thereby realizing the quantitative detection of immunochromatography.

[0034] like Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6 As shown, the air box 22 is bolted to one side of the housing 1, the air outlet 24 is opened on one side of the housing 1, the air box 22 is sleeved on the outside of the air outlet 24, the fan 25 is bolted to the inside of the air outlet 24, the filter screen 23 is bolted to the outside of the air box 22, the guide plate 26 is glued to the inner wall of the air box 22 with sealant, the guide plate 26 is a quartz glass guide plate, the guide plates 26 are evenly distributed on the inside of the air box 22, and the opening 28 is opened on the guide plate 26. Above, the openings 28 are alternately distributed at the top and bottom of the guide plate 26. The guide plate 26 has a fixing opening. The sterilization lamp 27 is secured inside the fixing opening. The top plate 10 is secured inside the groove 9. The top plate 10 is located at the bottom of the chromatography membrane 6. The bottom plate 12 is secured to the inner wall of the bottom of the groove 9. The electromagnet 11 is bolted to the inside of the groove 9. The bottom of the electromagnet 11 is connected to the top of the bottom plate 12 via a spring 14. The inner side of the electromagnet 11 is provided with… The box has an inner opening. The bottom end of the connecting rod 13 is welded to the top of the base plate 12, and the top end of the connecting rod 13 passes through the inner opening and is bolted to the top plate 10. The outer side of the box door 2 is clipped onto the inner wall of the other side of the box body 1. The bottom of the box door 2 is connected to the bottom of the box body 1 via a hinge 4. The handle 3 is welded to the top of the box body 1. The insertion port 16 is opened at the top of the box door 2. The support sleeve 17 is bolted to the top of the other side of the box body 1. The top of the other side of the box body 1 has an insertion port. The electromagnet 18 is bolted to the inner wall of the top of the support sleeve 17. The top of the pin 19 is connected to the bottom of the electromagnet 18 by the spring 20. The outer side of the top of the pin 19 is locked inside the slot. The bottom of the pin 19 passes through the slot and extends to the inner side of the socket 16. A baffle 15 is welded to the inner wall of the top of the other side of the housing 1. A button 21 is installed on the baffle 15. The top of the door 2 is locked to the outer side of the baffle 15 and the button 21.

[0035] Understandably, when the electromagnet 18 is turned on by the switch assembly 8, the electromagnet 18 attracts the pin 19 through magnetic force. The pin 19 compresses the spring 20 and moves from the inside of the socket 16 to the inside of the support 17. Pulling the handle 3 causes the door 2 to rotate via the hinge 4. The button 21 on the baffle 15 turns on the fan 25 and the disinfection lamp 27. The fan 25 generates suction on the air box 22 through the air outlet 24, causing air to enter the inside of the air box 22 after being filtered by the filter screen 23. Then, the air flows back and forth inside the air box 22 through the opening 28 on the guide plate 26. During the flow, the disinfection lamp 27 kills bacteria in the air. Then, pure sterile air is introduced into the inside of the box 1, causing the air inside the box 1 to generate a vortex. The external airflow effectively prevents outside air from directly entering the inside of the chamber 1, thereby effectively preventing bacteria from entering the inside of the chamber 1 and preventing bacterial contamination of the chamber 1, ensuring the reliability of the test results. After the personnel place the chromatography membrane 6 inside the groove 9, they close the chamber door 2. Spring 20 pushes the pin 19 into the inside of the socket 16, and then the baffle 15 blocks the chamber door 2, thus closing the chamber door 2. After completing the test, the electromagnet 11 is turned on. The electromagnet 11 generates a suction force on the bottom plate 12. The bottom plate 12 compresses the spring 14 and drives the top plate 10 to move upward through the connecting rod 13, pushing the chromatography membrane 6 upward from the inside of the groove 9, facilitating the removal of the chromatography membrane 6.

[0036] like Figure 1 , Figure 3 , Figure 4 , Figure 5 and Figure 7As shown, the sleeve 29 is welded to the top of the housing 1, with its top end located at the top of the housing 1 and its bottom end extending to the inside of the housing 1. The sleeve 29 is located on the top of one side of the chromatography membrane 6. The conical opening 37 is integrally formed at the bottom end of the sleeve 29. The rotating rod 33 is bolted to the inside of the housing 1. One end of the hinged plate 31 is fitted onto the outer side of the rotating rod 33. The bent plate 32 is integrally formed at one end of the hinged plate 31, and the top of the other end of the hinged plate 31 is engaged with the bottom of the conical opening 37. The water tank 40 is welded to the top of the tank body 1. The tank cover 39 is fitted onto the outer side of the top of the water tank 40. The connecting port 42 is opened at the top of the tank body 1. The bottom of the water tank 40 is connected to the inner side of the outer ring 41 through the connecting port 42. The connecting port 42 is located on the outer side of the sleeve 29. The inner sleeve 43 is welded to the inner wall of the top of the water tank 40. The outer sleeve 44 is welded to the outer side of the bottom of the water tank 40. The first piston 46 is engaged with the inner wall of one end of the inner sleeve 43. The second piston 47 is engaged with the outer sleeve 44. On the inner wall of one end, the connecting holes 45 are respectively opened at the other end of the outer sleeve 44, the side wall of the water tank 40, and the other end of the inner sleeve 43. The other end of the outer sleeve 44 is connected to the other end of the inner sleeve 43 through the connecting holes 45. A slot 1 is opened on the inner wall of the tank cover 39. The outer side of the locking pin 48 is locked in the inner wall of the slot 1. One end of the locking pin 48 is connected to the inner wall of the slot 1 through the spring 3 49. The other end of the locking pin 48 passes through the slot 1 and extends to the inner side of the inner sleeve 43. The other end is pressed against one side of piston 46. The cylinder cover 30 has a groove 2. The outer side of the second locking pin 50 is locked on the inner wall of the groove 2. One end of the second locking pin 50 is connected to the inner wall of the groove 2 through spring 41. The other end of the second locking pin 50 passes through the groove 2 and extends to the inner side of the outer sleeve 44. The top of the other end of the outer sleeve 44 has a slot 52. The top of the other end of the second locking pin 50 is locked on the inner side of the slot 52. The bottom of the other end of the second locking pin 50 is pressed against one side of piston 47.

[0037] Understandably, when the cap 30 is placed on the outer ring 41, the cap 30 presses down on the slide rod 35. The slide rod 35 slides downward on the inner side of the slide groove 34 and pushes the bent plate 32. The bent plate 32 drives the hinged plate 31 to rotate on the rotating rod 33, thereby sealing the conical opening 37 and preventing evaporating alcohol from entering the inner side of the tank 1. When it is necessary to replenish the water tank 40 with alcohol, the tank cover 39 is pulled upward. The tank cover 39 drives the locking pin 48 to press upward on the inner sleeve 43, causing the top of one end of the inner sleeve 43 to... The compression of the locking pin 48 causes the locking pin 48 to compress the spring 49 and move to the inside of the tank cover 39, thereby pulling the tank cover 39 off the water tank 40. After the piston 46 loses the compression of the locking pin 48, the pressure on the piston 47 caused by the hydraulic oil in the inner sleeve 43, connecting hole 45 and outer sleeve 44 disappears. The spring 41 pushes the locking pin 50 under its elastic force, and the locking pin 50 moves to the inside of the outer sleeve 44. The arc surface of the locking hole 52 causes the locking pin 50 to move downward. This causes the cap 30 to move downwards, sealing the top of the sleeve 29 and the outer ring 41. This prevents alcohol in the water tank 40 from continuously flowing into the inner side of the outer ring 41 through the connecting port 42, effectively preventing alcohol from directly flowing into the inner side of the sleeve 29. After replenishing the alcohol, the cap 39 is placed on the water tank 40, and the spring 3 49 pushes the locking pin 1 48. The locking pin 1 48 squeezes the piston 1 46, and the piston 1 46 pushes the piston 2 47 through the hydraulic oil. 7. Push the second locking pin 50 to the left. The second locking pin 50 compresses the fourth locking spring 51 and moves a part of it into the cylinder cover 30. Under the elastic force of the slide rod 35, it moves slightly upward to ensure that the evaporating alcohol can enter the inside of the sleeve 29. When the cylinder cover 30 is pulled off, the first locking pin 48 is fully inserted into the inside of the inner sleeve 43 to prevent the cylinder cover 30 and the box cover 39 from being pulled off at the same time. This effectively prevents a large amount of alcohol from entering the inside of the box 1 and prevents the testing operation from being impossible due to the presence of disinfectant alcohol inside the box 1.

[0038] In the description of this disclosure, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance. Furthermore, in the description of this disclosure, unless otherwise stated, "a plurality of" means two or more.

[0039] Any process or method description in the flowchart or otherwise herein can be understood as representing a module, segment, or portion of code comprising one or more executable instructions for implementing a particular logical function or process, and the scope of preferred embodiments of this disclosure includes additional implementations in which functions may be performed not in the order shown or discussed, including substantially simultaneously or in reverse order depending on the function involved, as will be understood by those skilled in the art to which embodiments of this disclosure pertain.

[0040] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this disclosure. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0041] Although embodiments of the present disclosure have been shown and described above, it is to be understood that the above embodiments are exemplary and should not be construed as limiting the present disclosure. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present disclosure.

Claims

1. An immunochromatographic quantitative detection device based on optical sensing, characterized in that, include: The detection assembly includes a housing (1) and a door (2). An opening assembly is installed on the door (2), including a handle (3) and a hinge (4). A sensing assembly is installed inside the housing (1), including a sensor (5) and a chromatography membrane (6). A display assembly is installed on the housing (1), including a display (7) and a switch assembly (8). A placement assembly is installed on the housing (1), including a recess (9) and a top plate (10). A device is installed on the recess (9). There is a drive assembly, which includes an electromagnet (11) and a spring (14). A push assembly is installed on the groove (9), which includes a base plate (12) and a connecting rod (13). A lock assembly is installed on the door (2), which includes a socket (16) and a pin (19). A suction assembly is installed on the box body (1), which includes an electromagnet (18) and a support (17). A positioning assembly is installed on the box body (1), which includes a baffle (15) and a button (21). An entry component is provided, comprising a bellows (22) and a sleeve (29). The bellows (22) is bolted to the outer side of the housing (1), and the sleeve (29) is welded to the top of the housing (1). A ventilation component is installed inside the bellows (22), comprising an air outlet (24) and a fan (25). A filter component is installed on the bellows (22), comprising a filter screen (23) and a guide plate (26). A sterilization component is installed on the guide plate (26). The components include a disinfection lamp (27) and a port (28). A sealing assembly is installed on the sleeve (29). The sealing assembly includes a cylinder cover (30) and a flap (31). A rotating assembly is installed on the flap (31). The rotating assembly includes a bent plate (32) and a rotating rod (33). A sliding assembly is installed on the flap (31). The sliding assembly includes a sliding rod (35) and a circular plate (36). A limiting assembly is installed on the sleeve (29). The limiting assembly includes a conical opening (37) and an outer ring (41). The disinfection assembly includes a water tank (40) and a tank cover (39). The water tank (40) is welded to the top of the tank body (1). A hydraulic assembly is installed on the top of the water tank (40). The hydraulic assembly includes an inner sleeve (43) and a piston (46). A hydraulic assembly is installed on the bottom of the water tank (40). The hydraulic assembly includes an outer sleeve (44) and a piston (47). A connecting assembly is installed on the water tank (40). The connecting assembly includes a connecting port (42) and a connecting hole (45). A fixing assembly is installed on one side of the piston (46). The fixing assembly includes a locking pin (48) and a spring (49). A fixing assembly is installed on one side of the piston (47). The fixing assembly includes a locking pin (50) and a spring (51).

2. The immunochromatographic quantitative detection device based on optical sensing according to claim 1, characterized in that: The sensor (5) is bolted to the inner wall of the top of the housing (1). The groove (9) is formed on the inner wall of the bottom of the housing (1). The chromatography membrane (6) is clamped inside the groove (9). The periphery of the chromatography membrane (6) is clamped to the inner wall of the groove (9). The display (7) is bolted to the outer side of the housing (1). The switch assembly (8) is bolted to the outer side of the display (7). The processor is installed inside the display (7). The sensor (5) is connected to the processor via a wire. The processor is connected to the display (7) via a wire.

3. The immunochromatographic quantitative detection device based on optical sensing according to claim 2, characterized in that: The air box (22) is bolted to one side of the box body (1). The air outlet (24) is opened on one side of the box body (1). The air box (22) is sleeved on the outside of the air outlet (24). The fan (25) is bolted to the inside of the air outlet (24). The filter screen (23) is bolted to the outside of the air box (22). The guide plate (26) is glued to the inner wall of the air box (22) with sealant. The guide plate (26) is a quartz glass guide plate. The guide plate (26) is evenly distributed on the inside of the air box (22). The opening (28) is opened on the guide plate (26). The opening (28) is alternately distributed on the top and bottom of the guide plate (26). The guide plate (26) has a fixing port. The disinfection lamp (27) is stuck inside the fixing port.

4. The immunochromatographic quantitative detection device based on optical sensing according to claim 3, characterized in that: The top plate (10) is fitted inside the groove (9). The top plate (10) is located at the bottom of the chromatography membrane (6). The bottom plate (12) is fitted on the inner wall of the bottom of the groove (9). The electromagnet (11) is installed inside the groove (9) by bolts. The bottom of the electromagnet (11) is connected to the top of the bottom plate (12) by spring (14). The inner side of the electromagnet (11) is provided with an inner opening. The bottom end of the connecting rod (13) is welded to the top of the bottom plate (12). The top end of the connecting rod (13) passes through the inner opening and is installed on the top plate (10) by bolts.

5. The immunochromatographic quantitative detection device based on optical sensing according to claim 1, characterized in that: The outer side of the door (2) is fastened to the inner wall of the other side of the box body (1). The bottom of the door (2) is connected to the bottom of the box body (1) via a hinge (4). The handle (3) is welded to the top of the box body (1). The socket (16) is located on the top of the door (2). The support sleeve (17) is bolted to the top of the other side of the box body (1). A slot is provided on the top of the other side of the box body (1). The electromagnet (18) is bolted to the top of the support sleeve (17). On the inner wall, the top of the pin (19) is connected to the bottom of the electromagnet (18) via the second spring (20). The outer side of the top of the pin (19) is locked inside the slot. The bottom of the pin (19) passes through the slot and extends to the inside of the socket (16). A baffle (15) is welded on the inner wall of the top of the other side of the box (1). A button (21) is installed on the baffle (15). The top of the box door (2) is locked on the outer side of the baffle (15) and the button (21).

6. The immunochromatographic quantitative detection device based on optical sensing according to claim 5, characterized in that: The sleeve (29) is welded to the top of the box (1). The top of the sleeve (29) is located at the top of the box (1). The bottom of the sleeve (29) extends to the inside of the box (1). The sleeve (29) is located at the top of one side of the chromatography membrane (6). The conical opening (37) is integrally formed at the bottom of the sleeve (29). The rotating rod (33) is installed on the inside of the box (1) by bolts. One end of the flap (31) is sleeved on the outside of the rotating rod (33). The bent plate (32) is integrally formed at one end of the flap (31). The top of the other end of the flap (31) is locked at the bottom of the conical opening (37).

7. The immunochromatographic quantitative detection device based on optical sensing according to claim 6, characterized in that: The outer ring (41) is welded to the top of the box body (1). The outer ring (41) is sleeved on the outside of the top of the sleeve (29). The cylinder cover (30) is sleeved on the outside of the outer ring (41). The top of the box body (1) is provided with a sliding groove (34). The bottom end of the sliding rod (35) is stuck on the top of one end of the flap (31). The top end of the sliding rod (35) passes through the sliding groove (34) and extends to the outside of the box body (1). The bottom of the cylinder cover (30) is pressed against the top end of the sliding rod (35). The circular plate (36) is integrally formed on the outside of the sliding rod (35). The circular plate (36) is located at the bottom of the sliding groove (34).

8. The immunochromatographic quantitative detection device based on optical sensing according to claim 7, characterized in that: The water tank (40) is welded to the top of the tank body (1), the tank cover (39) is fitted onto the outer side of the top of the water tank (40), the connecting port (42) is opened on the top of the tank body (1), the bottom of the water tank (40) is connected to the inner side of the outer ring (41) through the connecting port (42), the connecting port (42) is located on the outer side of the sleeve (29), the inner sleeve (43) is welded to the inner wall of the top of the water tank (40), and the outer sleeve (44) is welded to the inner wall of the top of the water tank (40). 4) Welded to the outer side of the bottom of the water tank (40), the piston one (46) is stuck on the inner wall of one end of the inner sleeve (43), the piston two (47) is stuck on the inner wall of one end of the outer sleeve (44), the connecting hole (45) is respectively opened on the other end of the outer sleeve (44), the side wall of the water tank (40) and the other end of the inner sleeve (43), and the other end of the outer sleeve (44) is connected to the other end of the inner sleeve (43) through the connecting hole (45).

9. The immunochromatographic quantitative detection device based on optical sensing according to claim 8, characterized in that: The inner wall of the box cover (39) is provided with a slot 1. The outer side of the locking pin 1 (48) is locked on the inner wall of the slot 1. One end of the locking pin 1 (48) is connected to the inner wall of the slot 1 through the spring 3 (49). The other end of the locking pin 1 (48) passes through the slot 1 and extends to the inner side of the inner sleeve (43). The other end of the locking pin 1 (48) is pressed against one side of the piston 1 (46).

10. The immunochromatographic quantitative detection device based on optical sensing according to claim 9, characterized in that: The cylinder cover (30) has a slot 2. The outer side of the locking pin 2 (50) is locked on the inner wall of the slot 2. One end of the locking pin 2 (50) is connected to the inner wall of the slot 2 through the spring 4 (51). The other end of the locking pin 2 (50) passes through the slot 2 and extends to the inner side of the outer sleeve (44). The top of the other end of the outer sleeve (44) has a slot (52). The top of the other end of the locking pin 2 (50) is locked on the inner side of the slot (52). The bottom of the other end of the locking pin 2 (50) is pressed against one side of the piston 2 (47).

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