Medical infusion set kit and method for its pre-use preparation

Abstract

A medical fluid line system, in particular a CSTD infusion set, is described, which has dry break couplings (3, 13) on the end sides, one for connecting an infusion container or an infusion pump and the other for connecting an infusion catheter. In order to improve the filling / priming process of the medical fluid line system, it has a preassembled, market-ready infusion set module (40). The two end-side dry break coupling parts of the infusion set module (40) are each configured as a male dry break (13), wherein the male dry break (13) assigned to the infusion catheter can be connected to a female dry break (3 * ) with a priming stop function.

Description

Technical Field

[0001] This invention relates to a medical fluid tubing system, particularly an infusion set, and a method for preparing it before use. Background Technology

[0002] In the case of medical fluid tubing systems, particularly in the case of infusion set kits, this typically (but not always) involves a tubing system with at least a portion of it being flexible, such as an infusion tubing. One proximal end of this tubing (i.e., the end away from the patient's body), especially in the case of an infusion set kit, can be connected to, for example, an infusion container such as an infusion bag, bottle, or pump via a connector, such as a Luer lock, plug / puncture device, or similar connector. The other distal end of this tubing (i.e., the end facing the patient's body) either has a connector / coupling for an injection catheter or similar patient access, such as one constructed based on a Luer system, or it itself has a patient access (injection catheter) integrated into the infusion set kit.

[0003] Typically, fluid piping systems, particularly infusion set kits, configured as "single-use systems," also feature a so-called drip chamber (with integrated vents) immediately downstream of the proximal connector. This drip chamber is equipped with a flow regulator for controlling and regulating the infusion fluid flow rate, usually mounted on the infusion tubing downstream of the drip chamber. This flow regulator typically consists of a housing that accommodates the infusion tubing. A slider or small handwheel is mounted on the housing, movable along the longitudinal direction of the tubing. For this purpose, the housing defines a guide rail or sliding track at a (sharp) angle relative to the longitudinal direction / longitudinal axis of the tubing. Thus, the flow rate can be adjusted by changing the tubing cross-section by moving the slider or handwheel along the guide rail or sliding track.

[0004] In principle, such fluid tubing systems are not only provided as infusion set kits, but also as extracorporeal circulation tubing kits for blood processing machines, cardiopulmonary bypass machines and similar therapeutic devices, which may also be equipped with corresponding injection interfaces for medical active ingredients or drugs. Summary of the Invention

[0005] CMR drugs, such as those used to treat cancer, can damage actively growing tumor cells, especially during therapeutic applications. Many of these drugs are carcinogenic themselves due to their mechanisms of action. To prevent untreated individuals from accessing CMR drugs, so-called “closed system transfer devices” (CSTDs) are increasingly used in the manufacture and administration of ready-to-use formulations. A key component of a CSTD is the coupling system, also known as a dry disconnect, which safely transfers the CMR drug and dry-closes after disconnection, thus protecting the environment from contamination (e.g., due to leakage or droplet formation on the surfaces of the coupling mating parts after disconnection). Such a dry disconnect coupling consists of two parts: a male dry disconnect and a female dry disconnect. CSTD dry disconnects from various manufacturers are available on the market, such as Chemfort (Simpliva), ChemoLock (ICU Medical), Equashield (Equashield), or PhaSeal (BD).

[0006] Such a “closed-system drug transfer device from vial to vein” (CSTD system), a variant of a closed / self-sealing vial-liquid-extraction / guide device, is exemplarily described in WO 2022 232405 A1 and is shown in Figure 1 and Figure 2 As shown in the document, the content of the disclosure in that document is explicitly incorporated into this application and is hereby cited. Figure 1A and Figure 1B The CSTD system in the decoupled state is shown respectively. Figure 1A ) and coupling state ( Figure 1B (The sectional view below.) Figure 2 The CSTD system is shown in perspective.

[0007] like Figure 1A and Figure 2 As shown, the CSTD system 1 generally has a first connection adapter component 3, referred to below as the female dry disconnect section, which has a housing 4 in which an axially extending through fluid channel or fluid channel component 5 is formed or installed, the through fluid channel or fluid channel component being closed by means of a diaphragm 9 at the proximal flange side 7. The fluid channel component 5, together with the housing 4, forms a (Luer lock) connector 6 on the distal end section of the first connection adapter component 3, which allows the first connection adapter component 3 to be connected to a medical device, such as a vial or ampoule containing a medically active ingredient. The housing 4 or fluid channel component 5 of the first connection adapter component 3 also forms a plurality of locking elements in the shape of grooves 11.

[0008] The CSTD system 1 also has a second coupling adapter component 13, referred to below as the male dry disconnect, which has a housing 15 forming a plurality of locking elements in the shape of grooves 16, a slider or piston 17 movably mounted in the housing 15, a hollow needle 19 movably mounted in the piston 17, the hollow needle being fixed in the housing 15 by a fixed anchor or anchor sleeve 20 at its proximal (away from the needle tip) end section, and a plurality of elastically deformable locking arms 21 fixed to or formed on the piston 17 and provided and configured to form a locking engagement with both the groove 11 of the first coupling adapter component 3 and the groove 16 of the second coupling adapter component 13.

[0009] In order to allow the hollow needle 19 to be movably mounted in the piston 17, the piston has a (central) through hole 23, which is closed by means of a diaphragm 27 at the distal coupling or flange side 25 of the second coupling adapter component 13.

[0010] according to Figure 2 As shown in the diagram, the arrangement is configured such that the two housing components 4 and 15 can be inserted into each other in a way that prevents rotation. This is achieved by the following method: housing 15 has a rectangular receiving opening 18, in which housing 4 of the first connecting adapter component 3 can be accommodated, wherein the lug 10 of housing 4 interacts with the inner side wall 12 of receiving opening 18 to provide a guiding function and ensure anti-rotation.

[0011] Figure 1B The functions of CSTD system 1 according to Figure 1 are shown.

[0012] Accordingly, in order to establish a fluid connection between the first and second connecting adapter components 3 and 13, during the first movement time window, the diaphragm 27 of the second connecting adapter component 13 is pressed sealingly against the diaphragm 9 of the first connecting adapter component 3. During the second movement time window, the housing 15 of the second connecting adapter component 13 is moved further forward toward the housing 4 of the first connecting adapter component 3, wherein, through this further forward movement, during the second movement time window, the hollow needle 19 pierces the two abutting diaphragms 9 and 27, and hereby establishes a fluid connection between the through fluid channel 5 and the hollow needle 19. The movement of the second connecting adapter component 13 during the second movement time window ends with the locking arm 21 engaging the grooves 11 and 16 of the two connecting adapter components 3 and 13.

[0013] As described above, the hollow needle is held at its proximal end by an anchor sleeve 20, which also represents, for example, an interface / connector for a syringe, and its internal space is in fluid communication with the fluid channel 5 of the first coupling adapter component 3 via the hollow needle 19.

[0014] The disconnection or decoupling of the two coupling adapter components 3, 13 is performed in completely opposite order, wherein, after the locking arm 21 is disengaged by means of a button, the hollow needle 19 is first (i.e., according to the second movement time window described above) pulled out of the two diaphragms 9, 27 by moving the second coupling adapter component 13 away from the first coupling adapter component 3, and then (i.e., according to the first movement time window described above) the two diaphragms 9, 27 are separated from each other without any liquid dripping from the syringe or from the vial or fluid tubing system.

[0015] Therefore, a crucial component of this type of CSTD is two coupling adapter components (dry connection / dry disconnection) that enable the safe transfer of liquids (medications) and dry-close upon disconnection or decoupling, thereby protecting the environment from contamination (e.g., due to leakage or droplet formation on the surface of the coupling mat / adapter component after disconnection). These CSTD coupling adapter components can be mounted on different products and are therefore not limited to vials and syringes. For example, the aforementioned first coupling adapter component can be connected via a Luer lock interface formed thereon to an injection port of, for example, a Luer lock construction type according to this category of infusion kits, so that a syringe with a corresponding second coupling adapter component (mating adapter component / syringe adapter component) can subsequently be connected thereto. Furthermore, it can be inferred that upon disconnection, the two coupling adapter components of the CSTD system dry-close, and the internal channels of the two coupling adapter components remain sealed closed.

[0016] In high-quality infusion set kits (infusion devices) from infusion therapy, people are beginning to use what is known as an infusion stop cap. Figure 3 and 4 An example of such an infusion stop cap is shown. Before connecting the infusion set to the patient, the tubing of the set must be "infused" (filled with liquid without air bubbles) so that no air enters the patient's bloodstream.

[0017] Without an infusion stop cap, the user must connect the infusion set tubing to the container filled with fluid, remove the protective cap on the patient side, and fill the tubing with fluid (usually by gravity) until the first drop of fluid flows from the patient-side end of the tubing. These drops need to be collected, which adds extra workload for healthcare workers. Furthermore, each individual tubing must wait until it begins to drip.

[0018] If using Figure 3 and Figure 4The infusion stop cap, indicated by reference numeral 29 in the accompanying drawings, replaces the ordinary protective cap. Its advantage lies in that during infusion / filling of the infusion set tubing (reference numeral 30), the liquid is automatically held at the patient-side end of the tubing. Unlike the ordinary protective cap, the infusion stop cap is equipped with an additional hydrophobic filter membrane 31, through which gas can escape from the tubing, but liquid cannot. Therefore, during infusion / filling, the infusion stop cap can remain on the patient-side end of the infusion set tubing without the escape of liquid medication or its aerosols, thus preventing environmental contamination. This protects both the user and the patient and saves valuable time, as tubing filling can be automated and requires no monitoring.

[0019] However, despite preventing liquid leakage, there is still a risk that the gaseous form of dangerous drugs (such as cell inhibitors) may escape into the environment through the hydrophobic filter membrane 31, thereby endangering the user.

[0020] In intravenous therapy, especially when administering CMR drugs, several methods have been devised to address these issues. See below. Figures 5 to 7 The method is described as follows:

[0021] In principle, it is conceivable to use dry disconnectors (preferably male dry disconnectors 13) at both ends of the infusion set tubing 30. Here, as... Figure 5 As shown, the male dry disconnector 13 can be directly mounted on the container side, and a conventional Luer lock patient connector 33 can be provided on the patient side, which can be equipped with an infusion stop cap 29.

[0022] In this state, the infusion set tubing 30 can be filled. This is done on a separate container 35 containing non-toxic infusion fluid. Here, as... Figure 6 As shown, the infusion tubing with a male dry disconnector 13 is connected to the container 35 via a container plug 37 with a female dry disconnector 3 at the end. The filling process is performed on the patient side with or without an infusion stop function, depending on the situation.

[0023] After filling in the information, you can then proceed as follows: Figure 7 As shown, the male dry disconnect part 13 is connected to the patient side via the Luer lock patient connector 33.

[0024] In this way, a pre-filled (infused) infusion tubing, sealed at both ends by male dry-shutdown connectors 13, can be assembled for the infusion process. This tubing can be connected to a container containing toxic drugs via a container plug with a female dry-shutdown connector, and on the patient side to a patient interface with a female dry-shutdown connector. Here, the connection and disconnection of the tubing is safe because the dry-shutdown connector, through its sealed and dry-shutdown function, will not contaminate the environment with toxic drugs, nor will it contaminate the user.

[0025] The objective of this invention is to improve the filling / infusion process of medical fluid tubing systems.

[0026] This task is accomplished by a medical fluid tubing system having the features of claim 1, particularly a CSTD infusion set, and by a method having the features of claim 8.

[0027] The unique feature of this invention lies in providing a pre-assembled, commercially available infusion set kit module, wherein both end dry-connector connectors are configured as male dry-connectors, and the male dry-connector assigned to the infusion catheter can be connected to a female dry-connector with an infusion stop function. In this way, the user is spared the step of subsequently screwing the male dry-connector onto a Luer lock interface, as the infusion set kit module is already supplied with two dry-connectors at the ends. The first female dry-connector allows the medical fluid line system to be opened on the patient side, and the second female dry-connector allows fluid to be drawn from a container via a container plug for infusion or filling of the medical fluid line system. By integrating the infusion stop function into the female dry-connector assigned to the infusion catheter, the infusion / filling process is significantly simplified.

[0028] In this way, the process of infusing the CSTD infusion set can be greatly simplified. The required steps are limited to:

[0029] a) Provides a CSTD infusion set module with end-side dry disconnect connectors, one for connecting an infusion container or infusion pump and the other for connecting an infusion tubing, wherein the CSTD infusion set module exists as a pre-assembled, commercially available infusion set module, wherein both end-side dry disconnect connectors are configured as male dry disconnects.

[0030] b) A dual-sided female dry disconnector, wherein the female dry disconnector that can be connected to the male dry disconnector assigned to the infusion catheter is equipped with an infusion stop function; and

[0031] c) Infuse the CSTD infusion set module.

[0032] The infusion stop function can be advantageously provided by equipping the female dry disconnect portion of the infusion catheter with an infusion stop cap that is known in itself, thereby simplifying the construction of medical fluid tubing systems.

[0033] In one variant, the infusion stop cap can be detachably connected to the female dry disconnector, simplifying the modular construction of medical fluid routing systems. This variant also allows the infusion stop cap and female dry disconnector to be connected into a single, uniformly operable unit.

[0034] Here, the filling stop cap can be glued, welded, crimped, or otherwise connected to the dry disconnect part of the female head in a way that is not easily detachable, such as by means of a snap-fit ​​connection.

[0035] The infusion stop function is advantageously provided by a hydrophobic filter membrane integrated into the dry disconnect section of the female head or the infusion stop cap.

[0036] This hydrophobic filter membrane can also be combined with an activated carbon filter.

[0037] In this case, the procedure can be further simplified because, in this variant, the CSTD infusion kit module can be infused with any, even dangerous, medication.

[0038] Alternatively, the activated carbon filter itself can be constructed to be hydrophobic and integrated either into the female dry disconnect section or into the filling stop cap.

[0039] According to an advantageous variant, the dry disconnect connector is equipped with mating surfaces that provide an anti-rotation function when the dry disconnect connectors are inserted together. Therefore, the dry disconnect connectors maintain precise alignment during the engagement process. Attached Figure Description

[0040] Embodiments of the present invention will now be explained in more detail with reference to the accompanying drawings. In the drawings:

[0041] Figure 1A , Figure 1B and Figure 2 A CSTD system with known construction and known function is shown;

[0042] Figure 3 and Figure 4 An illustration shows the installation of a known filling stop cap (29, 129) on a Luer lock connector;

[0043] Figures 5 to 7 The stages of assembling the CSTD infusion set kit for providing an infusion system are shown;

[0044] Figure 8An infusion set module is shown as a component of a medical fluid tubing system according to the present invention;

[0045] Figure 9 It shows Figure 8 The infusion kit module shown is completed according to the first variant for use in perfusion medical fluid tubing systems;

[0046] Figure 10 It shows Figure 8 The infusion kit module shown is further completed according to another variant for use in medical fluid tubing systems.

[0047] Figure 11 A female dry disconnect connector (3, 3) with a filling stop function according to a first embodiment is shown. * (view)

[0048] Figure 12 It shows Figure 10 Sectional view XII-XII in the middle;

[0049] Figure 13 A female dry disconnect connector (3, 3) with a filling stop function according to a second embodiment is shown. * (view)

[0050] Figure 13A It shows Figure 13 AA section view in the middle;

[0051] Figure 14 A female dry disconnect connector (3, 3) with a filling stop function according to a third embodiment is shown. * (view)

[0052] Figure 14A It shows Figure 14 AA section view in the middle;

[0053] Figure 15 A female dry disconnect connector (3, 3) with a filling stop function according to a fourth embodiment is shown. * (view)

[0054] Figure 15A It shows Figure 15 AA section view in the middle;

[0055] Figure 16 A female dry disconnect connector (3, 3) with a filling stop function according to the fifth embodiment is shown. * (view)

[0056] Figure 16A It shows Figure 16 AA section view in the middle;

[0057] Figure 17 A female dry disconnect connector (3, 3) with a filling stop function according to the sixth embodiment is shown. * The view of ) and

[0058] Figure 17A It shows Figure 17 AA section view in the image. Detailed Implementation

[0059] exist Figure 8 In the accompanying drawing, reference numeral 40 denotes a section of a medical fluid tubing system, namely a CSTD infusion set kit, wherein this section is constructed as a pre-assembled, commercially available infusion set kit module. This infusion set kit module has a male dry-joint connector 13 on each side of the fluid tubing 30 (in which, for example, a drip chamber 42 and a flow regulator 44 are provided), the function of which has been described above with reference to Figure 1 and... Figure 2 The diagram is explained, and one of them, the one on the container side, is used to connect the infusion container or infusion pump, while the other, the one on the patient side, is used to connect the infusion tubing.

[0060] The infusion set module 40 can be prepared for infusion through simple operation. For this purpose, as... Figure 9 As shown, the male dry disconnector 13, which is assigned to the infusion catheter on the patient side, is connected to the female dry disconnector 3, which has an infusion stop function. * On the other side, the fluid line 30 is connected to the container 35 via a male dry disconnect 13 and a container plug 37 with a conventional female dry disconnect 3 at one end. In this state, the medical fluid line system can be infused, i.e., filled with liquid.

[0061] The necessary infusion stop function can be provided by a hydrophobic filter membrane integrated into the dry disconnect section of the female connector or the infusion stop cap.

[0062] exist Figure 9 In the embodiment shown, the infusion stop function is integrated into the female head dry disconnect section 3. * In this configuration, a hydrophobic barrier element is installed within the dry-type disconnect section of the female connector. This type of dry-type disconnect section 3... * Details in Figure 13 and Figure 13A As shown in the figure, the hydrophobic filter membrane 31 is located on the end face of the housing 4 away from the axial extension 46 of the diaphragm 9.

[0063] Figures 10 to 12 A variation is shown in which the perfusion stop function is connected to a conventional (e.g., Figure 2The filling stop cap 29 (shown) is provided on the female dry disconnect part 3, and a hydrophobic filter membrane 31 is provided in the filling stop cap. The filling stop cap 29 can be detachably connected to the female dry disconnect part, preferably connected as a unified operating unit. It can be glued, welded, crimped or otherwise not easily detachable connected to the female dry disconnect part 3, for example by means of a snap-fit ​​connection.

[0064] Using these variations, it is necessary to use non-toxic infusion solutions to perfuse medical fluid lines.

[0065] To further improve the operation of medical fluid tubing systems and allow for the immediate infusion of medications (such as cell inhibitors) whose gases must not enter the environment and thus could endanger the user, an activated carbon filter can be integrated into the female dry disconnector. These variations of the female dry disconnector are... Figures 14 to 17 As shown in the image.

[0066] according to Figure 14 Dry disconnection part 3 of the female head * Implementation methods and basis Figure 13 The difference in the implementation is that the extension 46 of the housing 4 protrudes outward beyond the hydrophobic filter membrane 31 to form an extension 48 for forming a chamber in which an activated carbon filter 52 is accommodated.

[0067] According to Figure 15 Dry disconnection part 3 of the female head * In the variant, its shell and Figure 14 The housing is basically the same, but a modified, hydrophobic activated carbon filter 152 is used, which enables it to achieve a stop-infusion function. Therefore, the hydrophobic filter membrane can be omitted.

[0068] Figure 16 and Figure 17 The variant is characterized by the integration of an activated carbon filter into a modified infusion stop cap.

[0069] according to Figure 16 The embodiment shows an infusion stop cap 131, which houses the hydrophobic filter membrane 31 as described above, but it forms an axial extension 148 for housing the activated carbon filter 52.

[0070] Finally, according to Figure 17 The implementation method is similar to the design of the infusion stop cap 129. Figure 16 The implementation method corresponds to this. However, a hydrophobic activated carbon filter 152 is used here, which eliminates the need for a hydrophobic filter membrane. Therefore, the infusion stop function is provided solely by the activated carbon filter 152.

[0071] All the variations of the dry-type disconnection section shown share the common feature that they preferably have a housing with an axially oriented lug 10, such as Figure 2 As shown. These lugs are accommodated in the polygonal or rectangular openings 18 of the male dry disconnect 13 when engaging the dry disconnect connecting parts, thereby providing an anti-rotation function.

[0072] Of course, modifications can be made to the described embodiments without departing from the basic idea of ​​the invention. When it comes to simplifying the infusion process, the medical fluid tubing system can also be used in other locations within the infusion system. The medical fluid tubing system can also, for example, be combined with an infusion set module with an injection port.

[0073] Therefore, this invention creates a medical fluid tubing system, particularly a CSTD infusion set kit, having end-side dry disconnect connectors, one for connecting to an infusion container or infusion pump and the other for connecting to an infusion catheter. To improve the filling / infusion process of the medical fluid tubing system, it features a pre-assembled, commercially available infusion set kit module. Both end-side dry disconnect connectors of this infusion set kit module are constructed as male dry disconnects, wherein the male dry disconnect assigned to the infusion catheter can connect to a female dry disconnect with an infusion stop function.

[0074] List of reference numerals

[0075] 1 CSTD System

[0076] 3, 3 * First connection adapter component (female dry disconnect part)

[0077] 4. Shell

[0078] 5. Fluid Channel Components

[0079] 6 (Luer lock) connector

[0080] 7. Proximal flange side

[0081] 9. Diaphragm

[0082] 10 Lugs serving as guide surfaces in housing 4

[0083] 11 Grooves

[0084] 12. Inner side wall

[0085] 13 Second connecting adapter component (male dry disconnect part)

[0086] 15. Housing

[0087] 16 Grooves

[0088] 17 Pistons

[0089] 18 Receiving opening in housing 15

[0090] 19 Hollow needles

[0091] 20 Anchor sleeve

[0092] 21 Locking Arm

[0093] 23 (Central) Through Hole

[0094] 25 The connection or flange side of the second connection adapter component 13

[0095] 27. Diaphragm

[0096] 29, 129 Injection Stop Cap

[0097] 30 Fluid Piping

[0098] 31 Hydrophobic Filter Membrane

[0099] 33 Luer lock patient connector

[0100] 35 containers

[0101] 37 Container plug

[0102] 40 Infusion Set Kit Modules

[0103] 42. Dropping chamber

[0104] 44 Flow Regulator

[0105] 46 Extension

[0106] 48, 148 extension

[0107] 50 chambers

[0108] 52, 152 Activated Carbon Filters.

Claims

1. A medical fluid tubing system, particularly a CSTD infusion set kit, having end-side dry disconnect couplings, one for connecting an infusion container or infusion pump and the other for connecting an infusion tubing, characterized in that... The infusion set module (40) is configured as a pre-assembled, commercially available infusion set, wherein the dry disconnect connection components on both ends are configured as male dry disconnects (13), wherein the male dry disconnect (13) assigned to the infusion tubing can be connected to a female dry disconnect (3*) with an infusion stop function.

2. The medical fluid piping system according to claim 1, characterized in that, The infusion stop function is provided by a hydrophobic filter membrane (31) integrated in the female dry disconnect section (3) or the infusion stop cap (29).

3. The medical fluid piping system according to claim 2, characterized in that, The hydrophobic filter membrane (31) is combined with the activated carbon filter (52).

4. The medical fluid piping system according to claim 1, characterized in that, The infusion stop function is provided by a hydrophobic activated carbon filter (152) integrated in the dry disconnect section (3*) of the female head or the infusion stop cap (29).

5. The medical fluid piping system according to any one of claims 2 to 4, characterized in that, The infusion stop cap (29) is detachably connected to the dry disconnect part (3*) of the female head, preferably connected as a unit that can be operated uniformly.

6. The medical fluid piping system according to any one of claims 2 to 4, characterized in that, The infusion stop cap (29) is bonded, welded, crimped, or otherwise connected to the female head dry disconnect portion (3*) in a way that is not easily detachable, such as by means of a snap-fit ​​connection.

7. The medical fluid piping system according to any one of claims 1 to 6, characterized in that, The dry disconnection section (3, 13) has axially extending mating surfaces (lug 10, inner side wall 12) arranged in a polygonal pattern.

8. A method for operating a CSTD infusion set kit, comprising the following steps: a) Provide a CSTD infusion set kit module with end-side dry disconnect connectors, one for connecting an infusion container or infusion pump and the other for connecting an infusion tubing, wherein the CSTD infusion set kit module exists as a pre-assembled, commercially available infusion set kit module (40), wherein both end-side dry disconnect connectors are configured as male dry disconnects (13). b) A dual-sided female dry disconnector (3), wherein the female dry disconnector (3) that can be connected to the male dry disconnector (13) assigned to the infusion catheter is equipped with an infusion stop function; and c) Infuse the CSTD infusion set module (40).

9. The method according to claim 8, characterized in that, The infusion is performed using a non-toxic infusion solution.

10. The method according to claim 8, characterized in that, The female dry disconnect (3), which can be connected to the male dry disconnect (13) assigned to the infusion catheter, is equipped with an activated carbon filter (52; 152), and the infusion of the CSTD infusion set module (40) is performed using the drug to be administered.

11. The method according to claim 10, characterized in that, The activated carbon filter (152) is constructed to be hydrophobic.

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