一种皮肤间质液中卵清蛋白IgG的在体检测微针贴片技术及其制备方法
By employing techniques such as plasma surface treatment and polyethylene glycol grafting on microneedle patches, combined with a negative pressure microneedle fixation device, a non-invasive, painless, highly sensitive, and specific detection of ovalbumin IgG in interstitial fluid of the skin was achieved, solving the problems of complexity and sample contamination associated with traditional blood tests.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-06-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies are insufficient for non-invasive, painless, and highly sensitive detection of ovalbumin IgG in interstitial fluid of the skin. Traditional blood testing methods are complex, samples are easily contaminated, and testing costs are high. Existing microneedle technology involves complex sample extraction and processing and has poor specificity.
Special surface treatments, including plasma surface treatment, polyethylene glycol grafting, and L-polylysine grafting, were used to treat microneedle patches to improve protein coating ability. Combined with a negative pressure microneedle fixation device, ovalbumin IgG in the interstitial fluid of the skin was detected directly in vivo.
It achieves highly sensitive, accurate, and specific detection without the need for sample extraction. It is simple to operate, has a short testing time, solves patients' resistance to traditional blood tests, and improves testing efficiency.
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