一种具有梯度释放特性的润肤乳与特护膏组合物及其制备工艺

By combining nanoscale liposome vesicles and laminar liquid crystal phases, the problem of uneven release of active ingredients in the combination of moisturizing lotion and special care cream is solved, realizing the gradient release of active ingredients, improving the immediate soothing and long-lasting repair effects, and enhancing transdermal absorption and user experience.

CN122398697APending Publication Date: 2026-07-17BEIJING ZHONGYAN CHUANGKE MEDICAL TECH CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING ZHONGYAN CHUANGKE MEDICAL TECH CO LTD
Filing Date
2026-06-18
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

The existing combination of moisturizing lotion and special care cream cannot achieve the gradient release of active ingredients, resulting in an uneven release of active substances on the skin surface. This makes it impossible to achieve both immediate soothing and long-lasting repair effects at the same time, and there are also problems with the aggregation or oxidation and inactivation of active substances.

Method used

By employing the design of nano-sized liposome vesicles and laminar liquid crystal phases, a skin moisturizing gel is prepared through high-pressure microfluidic homogenization, and then combined with staged cooling crystallization to form a skin care cream, thus constructing a composition with gradient release characteristics. The nano-sized liposome vesicles rapidly release active ingredients in the initial stage, while the laminar liquid crystal phase slowly releases repairing ingredients in the long term.

Benefits of technology

It achieves rapid and immediate soothing and long-lasting repair effects of active ingredients, improves product efficacy and skin feel, avoids the aggregation and oxidation of active ingredients, and enhances transdermal absorption.

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Abstract

本发明公开了一种具有梯度释放特性的润肤乳与特护膏组合物及其制备工艺,属于化妆品技术领域;本发明的具有梯度释放特性的润肤乳与特护膏组合物,包括含有纳米级脂质体囊泡的润肤剂凝胶、含有层状液晶相的皮肤护理膏;所述纳米级脂质体囊泡是先将多元醇水相、神经酰胺、活性成分进行混合,然后进行高压微射流均质处理得到;所述含有层状液晶相的皮肤护理膏是将油相与乳相乳化后分阶段降温结晶制得;所述润肤剂凝胶与皮肤护理膏分隔存储于双腔包装容器中,使用时润肤剂凝胶与皮肤护理膏依次涂抹于皮肤,形成先快速释放后持续缓释的梯度释放曲线,兼具即时舒缓与长效修护的效果。
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