High-embedding enterobacterium composite microcapsule and preparation process thereof
By using a modified sodium alginate and chitosan composite microcapsule preparation process, the problems of low probiotic survival rate and uncontrollable release were solved, achieving high encapsulation rate and intestinal targeted protection, thus improving the clinical efficacy of probiotic preparations.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- NANJING HEALSOUL LIFE SCI & TECH CO LTD
- Filing Date
- 2026-05-14
- Publication Date
- 2026-07-17
AI Technical Summary
Existing microcapsule preparation technologies suffer from problems such as low probiotic survival rate, poor acid resistance, and uncontrollable release, making it difficult to achieve high encapsulation rates and targeted intestinal protection.
A composite microcapsule preparation process using modified sodium alginate and chitosan was adopted. Through oxidation reaction and amidation grafting modification, combined with endogenous gel and polyelectrolyte composite membrane, a dense core-shell structure was formed. The high encapsulation of bacteria and intestinal-targeted release were achieved by utilizing electrostatic composite membrane and nano-montmorillonite physical barrier.
It significantly improves the encapsulation rate and survival rate of probiotics, enhances the acid resistance and intestinal targeting of the composite microcapsules, and ensures stability in gastric juice and precise release in the intestine.
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