Pressurized aerosol composition

By controlling the component content and pH value of cistanodine and formoterol, a stable solution-type inhaled aerosol was prepared, which solved the instability problem of cistanodine and formoterol combination aerosol in the prior art, achieved high dose uniformity and reproducibility, is suitable for small airway delivery, and reduces environmental impact.

CN122398764APending Publication Date: 2026-07-17SHANGHAI SINE PHARMA LAB
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-15
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing aerosol formulations combining ccyclosone and formoterol suffer from chemical instability, particle growth, and unsatisfactory aerosol properties in both solution and suspension formulations, making it difficult to achieve high dose uniformity and reproducibility. Furthermore, the use of halogenated propellants is harmful to the environment.

Method used

By controlling the component content range of cecsonide and formoterol and the apparent pH value between 3 and 5, and using inorganic acid adjustment, combined with a highly polar co-solvent and liquefied propellant, a stable solution-type inhalation aerosol was prepared, ensuring that the particle size is below 1 μm to achieve small airway delivery.

Benefits of technology

This achieves high chemical and physical stability of cyclosone and formoterol, ensuring a high proportion of fine and ultrafine particles are delivered to small airways, improving therapeutic efficacy and reducing lung damage.

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Abstract

加压气雾剂组合物。提供了一种包含环索奈德和福莫特罗的气雾剂组合物，所述组合物包括，以所述组合物的总重量计：0.01‑1重量％的环索奈德，0.001‑0.05重量％的福莫特罗，1‑10重量％的共溶剂，无机酸，其中无机酸的用量使得组合物的pH值控制在3‑5之间，和液化抛射剂。
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Citation Information

Patent Citations

  • Compound preparations with ciclesonide and formoterol as active component and preparation and application thereof

    CN101264092A

  • Pharmaceutical solution formulations for pressurised metereddose inhalers

    CN101389341A

  • Technique for preparing quantitative spray suction agent for treatment of respiratory diseases

    CN102670505A

  • A cyclosporine formoterol dry powder inhaler composition

    CN106880635B

  • Formoterol superfine formulation

    CN1638730A