一种儿茶酚型异喹啉类化合物在制备多巴胺D1受体调节剂中的应用
The preparation of dopamine D1 receptor modulators by catechol-type isoquinoline compounds solves the problem of dopamine D1 receptor regulation in existing technologies, and achieves precise regulation of dopamine D1 receptors, which can be used to prepare drugs for various neurological diseases.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SUN YAT SEN UNIV
- Filing Date
- 2026-06-18
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies lack dopamine D1 receptor agonists and antagonists that possess both high safety and high selectivity with a clear mechanism of action, making it difficult to achieve precise and gentle regulation of dopamine receptor function.
Provides catechol-type isoquinoline compounds with specific structures for the preparation of dopamine D1 receptor modulators, including dopamine D1 receptor agonists and antagonists, for the preparation of drugs for the prevention and/or treatment of dopamine D1 receptor-related diseases.
It achieves targeted regulation of dopamine D1 receptors and has DRD1 receptor protection and repair functions, and can be used to prepare drugs for the prevention and/or treatment of Parkinson's disease, negative schizophrenia, depression, drug addiction, Huntington's disease, Alzheimer's disease, Rett syndrome, attention deficit hyperactivity disorder and other related diseases.
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Figure CN122398802A_ABST