羊乳寡糖通过黏蛋白O-糖链重塑在炎症性肠病防治方面的应用
By extracting and purifying oligosaccharides of specific structural types from goat milk, enhancing mucin O-glycosylation, and regulating gut microbiota, the side effects and cost issues of existing IBD treatments are resolved, achieving safe and effective relief of inflammatory bowel disease.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- NORTHWEST UNIV
- Filing Date
- 2026-03-30
- Publication Date
- 2026-07-17
AI Technical Summary
Existing drugs for treating inflammatory bowel disease (IBD) have significant side effects, high treatment costs, and are not suitable for long-term use. Furthermore, the artificially synthesized oligosaccharides in existing infant formula milk powder cannot simulate the diversity and functional characteristics of oligosaccharides in breast milk.
Oligosaccharides with specific structural types, including fucose modification and sulfated sialylated O-glycans, are extracted and purified from sheep milk to enhance mucin O-glycosylation, regulate gut microbiota and mucosal barrier function, and prepare drugs and functional foods for the prevention and treatment of inflammatory bowel disease.
Purified goat milk oligosaccharides can significantly alleviate DSS-induced colitis, increase the abundance of beneficial bacteria, inhibit potential pathogenic bacteria, modify mucin O-glycan chains, improve intestinal barrier integrity, reduce inflammatory symptoms, and provide a safe and economical treatment option.
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Figure CN122398824A_ABST
Abstract
Citation Information
Patent Citations
Application of acidic goat milk oligosaccharide composition in preparation of anti-allergic medicine or food
CN116942685A