白桦脂酸28-O-β-D-葡萄糖苷在制备抗病毒药物及防治病毒感染相关疾病的药物中的应用
By using betulinic acid 28-O-β-D-glucoside (B4-6) to prepare a broad-spectrum antiviral drug, the problems of drug resistance and insufficient efficacy of existing drugs were solved, and effective inhibition of influenza A virus and herpes simplex virus and relief of viral pneumonia were achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SUZHOU UNIV
- Filing Date
- 2026-06-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing antiviral drugs suffer from problems such as strong drug resistance, insufficient efficacy, narrow window of opportunity for use, and significant side effects. In particular, they are difficult to effectively inhibit viral replication and regulate excessive immune responses when treating viral pneumonia.
Betulinic acid 28-O-β-D-glucoside (B4-6) was used as the active ingredient to prepare a broad-spectrum antiviral drug that can effectively inhibit the replication of influenza A virus and herpes simplex virus, and alleviate the symptoms of viral pneumonia by inhibiting key signaling pathways and the release of inflammatory factors.
B4-6 exhibits significant antiviral activity and low cytotoxicity, with a large therapeutic window. It can improve the survival rate of virus-infected mice and reduce lung tissue inflammation, showing superior efficacy compared to clinically positive drugs in alleviating viral pneumonia.
Smart Images
Figure CN122398828A_ABST