一种载卡泊三醇的凋亡囊泡及其在制备治疗银屑病的药物中的应用
By combining apoptotic vesicles derived from HaCaT cells with soluble microneedles, transdermal delivery of calcipotriol is achieved, solving the problem of insufficient efficacy of local calcipotriol in treating psoriasis, improving the drug's regulatory efficiency on DC cells, and providing an efficient and safe treatment option.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHEJIANG UNIV
- Filing Date
- 2026-03-25
- Publication Date
- 2026-07-17
AI Technical Summary
Current topical treatments with calcipotriol for psoriasis are not very effective, as it is difficult to penetrate the skin's stratum corneum barrier, limiting the drug's effective accumulation and bioavailability in the deep dermis.
Calcipotriol was delivered via apoptotic vesicles derived from HaCaT cells, and combined with soluble microneedles to penetrate the stratum corneum, thereby achieving transdermal delivery of drug-loaded apoptotic vesicles and improving the uptake and regulation efficiency of calcipotriol by dendritic cells.
The synergistic effect of apoptotic vesicles and calcipotriol significantly improves the drug's regulatory efficiency on intradermal dendritic cells, enhances the therapeutic effect, and provides a novel local treatment option that is highly effective, safe, and has the potential to prevent recurrence.
Smart Images
Figure CN122398859A_ABST