Use of probiotics in the preparation of a medicament or food for preventing or treating radiation damage

By regulating gut microbiota and hippocampal metabolites through probiotic preparations, the treatment challenge of nerve damage after irradiation has been solved, achieving safe and effective repair of radiation damage.

CN122398866APending Publication Date: 2026-07-17THE NAVAL MEDICAL UNIV OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE NAVAL MEDICAL UNIV OF PLA
Filing Date
2026-04-24
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

There is a lack of effective treatments for radiation-induced nerve damage, especially radiation-induced neuronal apoptosis, demyelination, and abnormal nerve conduction. Existing treatments have limited efficacy and significant side effects.

Method used

Using probiotic preparations, including Bifidobacterium animalis subsp. lactis, Lactobacillus plantarum, Lactobacillus rhamnosus, and Pediococcus lactis, combined with prebiotics and fruit powder, mice were treated orally to repair radiation-induced cognitive impairment, regulate gut microbiota and hippocampal metabolites, and reverse radiation-induced intestinal and brain nerve damage.

Benefits of technology

It significantly repairs cognitive impairment in irradiated mice, restores normal levels of gut microbiota and metabolites, improves nerve conduction function, reduces neuroinflammation and oxidative stress, and provides a safe and gentle therapeutic effect.

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Abstract

本发明涉及生物医药领域，提供了益生菌在制备预防或治疗辐射损伤药物或食品中的应用。各项行为学实验显示，辐照后实验动物认知功能水平下降，益生菌干预后此损伤效应显著逆转，多组学分析揭示了益生菌对辐射导致的肠道菌群和代谢物紊乱的调控作用，以及中枢神经保护机制。与此同时，作为常规保健品的活性成分，益生菌几乎无毒副作用且提纯工艺相对成熟，有利于降低使用成本。因此，本发明为辐射损伤治疗提供了一种新的参考。
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Citation Information

Patent Citations

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