植物乳植杆菌菌株LP28在制备提高人体免疫力的药物中的应用

The capsule form of the drug prepared by using the Lactobacillus plantarum strain LP28 solves the problem of improving human immunity and preventing the common cold in the existing technology. It significantly enhances NK cell activity and IL-12 levels, reduces the incidence of colds, alleviates upper respiratory symptoms, and maintains a stable proportion of immune cells.

CN122398870APending Publication Date: 2026-07-17SYNBIOTECH BIOTECHNOLOGY YANGZHOU CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SYNBIOTECH BIOTECHNOLOGY YANGZHOU CO LTD
Filing Date
2026-06-05
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies have failed to effectively utilize the uses of Lactobacillus plantarum strain LP28 in enhancing human immunity, promoting NK cell activity, regulating immune-related cytokines, and preventing and/or treating the common cold.

Method used

This invention provides the application of *Lactobacillus plantarum* strain LP28 in the preparation of drugs that enhance human immunity, including solid dosage forms in capsule form. Each capsule contains 5.0*10⁹ CFU of *Lactobacillus plantarum* strain LP28. Clinical trials have verified its effects in enhancing natural killer cell activity, promoting interleukin-12 expression, reducing C-reactive protein levels, alleviating the burden of upper respiratory tract symptoms, and maintaining immune balance.

Benefits of technology

It significantly enhances the cytotoxic activity of NK cells, increases IL-12 levels, reduces the incidence of the common cold, alleviates upper respiratory symptoms, maintains a stable proportion of immune cells, and enhances the immune function of middle-aged and elderly people.

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Abstract

本发明涉及植物乳植杆菌菌株LP28在制备提高人体免疫力的药物中的应用。经人体临床试验验证,受试者连续服用含有植物乳植杆菌菌株LP28的胶囊后,能够在不造成免疫细胞比例异常改变及无明显安全性疑虑的情况下,显著提升自然杀伤细胞活性,并促进与Th1型免疫反应及NK细胞活化相关的IL‑12表现;同时,可降低CRP等发炎相关指标,并未引起IL‑4、IL‑6、TNF‑α或IFN‑γ等细胞因子的异常升高,显示其免疫调节作用具有良好的平衡性;可有助于降低普通感冒发生风险并减轻感冒相关症状负担;可制备为固体制剂,优选为胶囊形式,具有服用方便、剂量明确、适合长期补充等优点,尤其适用于免疫功能较易下降或普通感冒发生风险较高的中老年人群。
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