A fermented composition of sonchus oleraceus-larix kaempferi with synergistic uric acid-lowering effect, and a preparation method and application thereof

The fermentation process using specific compound microbial strains to prepare sow thistle and hawthorn ferments solves the problems of bioavailability and single function of sow thistle and hawthorn ferments, and achieves a synergistic effect of lowering uric acid through dual targets, which is suitable for the development of functional foods and drugs.

CN122398877APending Publication Date: 2026-07-17BEIJING XUANZHIDA BIOTECHNOLOGY CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING XUANZHIDA BIOTECHNOLOGY CO LTD
Filing Date
2026-06-02
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies have failed to effectively utilize the uric acid-lowering potential of sow thistle and hawthorn. Sow thistle ferment has low bioavailability, and hawthorn ferment has a single effect. There is a lack of a synergistic uric acid-lowering mechanism between sow thistle and hawthorn ferment, resulting in poor efficacy of existing natural uric acid-lowering products.

Method used

A specific combination of microbial strains and fermentation process was used to prepare fermented products of sow thistle and hawthorn. The combination achieved a synergistic effect in lowering uric acid. The synergistic effect was verified by the Chou-Talalay co-index method, providing a dual-target mechanism for lowering uric acid.

Benefits of technology

It significantly enhances the uric acid-lowering activity of sow thistle and hawthorn, and produces a highly significant synergistic effect when combined, which is superior to existing drugs. It is safe and has no side effects, and is suitable for the development of functional foods and drugs.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明公开了一种具有协同降尿酸作用的苦苣菜‑山楂发酵组合物及其制备方法和应用,属于生物发酵技术领域,所述苦苣菜发酵物的制备方法包括:以苦苣菜为原料,经预处理后,以植物乳杆菌CGMCC 1.12934、鼠李糖乳杆菌CGMCC 1.120和青春双歧杆菌CGMCC 1.2190组成的复合菌种进行厌氧发酵,发酵液经离心、浓缩、干燥即得。所述山楂发酵物的制备方法包括:以山楂为原料,以植物乳杆菌CGMCC 1.12934、干酪乳杆菌CICC 6114和酿酒酵母CGMCC 2.1037组成的复合菌种进行微有氧发酵,后处理得山楂发酵物干粉。本发明还提供了一种包含上述两种发酵物的复配组合物。本发明的复配组合物可同时抑制黄嘌呤氧化酶活性并调控肾脏尿酸转运体表达,实现双靶点协同降尿酸,可用于制备降尿酸功能食品、保健品或药物。
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