一种黄甲软肝颗粒的制备方法
By employing low-temperature ultrafine grinding and gradient pressure dry granulation technology, the problems of material adhesion and loss of heat-sensitive components during the granulation process of astragaloside A granules have been solved, achieving efficient granulation and component protection.
CN122398893APending Publication Date: 2026-07-17ZHEJIANG WECOME MEDICINE IND
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHEJIANG WECOME MEDICINE IND
- Filing Date
- 2026-06-11
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
In the current process of granulating astragaloside A granules, the material adheres severely to the surface of the pressure roller, which makes it difficult to form tablets, results in a low granule formation rate, and makes it easy to lose heat-sensitive components.
Method used
Low-temperature ultrafine grinding technology is used to add fumed silica, combined with gradient pressure dry granulation. Pre-pressure degassing and pressure holding reduce adhesion, protect heat-sensitive components, and improve particle formation rate.
Benefits of technology
It effectively reduces material adhesion, improves particle formation rate and total yield, and protects the effectiveness of heat-sensitive components.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN122398893A_ABST
Abstract
本发明公开了一种黄甲软肝颗粒的制备方法，属于黄甲软肝颗粒制备技术领域；一种黄甲软肝颗粒的制备方法，制备原料的浸膏粉，其包括三份清膏；将三份清膏合并减压浓缩至稠膏，以形成干膏粉；对干膏粉进行粉碎与加入二氧化硅；干膏粉预处理，将减压干燥后的干膏粉进行初步粗碎，去除大块结团；控制干膏粉的水分；将获得的改性浸膏粉中加入部分的糊精和阿司帕坦，并投入球磨机中进行研磨；承接物料，与剩余的糊精混合后，采用梯度压力干法制粒，将粉体压制成连续薄片；将连续薄片，进行破碎、整粒、分级；可以实现减少压制过程中物料粘附在压轮的数量，同时保护热敏性成分，提高颗粒成型率与总收率。
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