一种牡丹花瓣功能组分在制备抗炎产品中的应用

The anti-inflammatory product prepared by extracting ethanol solvent from peony petals using a heating reflux extraction technique effectively improves ulcerative colitis, solves the side effects problem of existing drugs, and achieves a highly effective and safe treatment effect.

CN122398894APending Publication Date: 2026-07-17QILU UNIVERSITY OF TECHNOLOGY (SHANDONG ACADEMY OF SCIENCES)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QILU UNIVERSITY OF TECHNOLOGY (SHANDONG ACADEMY OF SCIENCES)
Filing Date
2026-06-17
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing medications for treating ulcerative colitis have side effects and lack sufficient long-term safety data, necessitating the screening of active ingredients from natural products that combine high efficacy and safety.

Method used

Using ethanol as a solvent, a heating reflux extraction technique was employed to extract active ingredients such as paeonol, paeoniflorin, flavonoids, and polyphenols from peony petals. Anti-inflammatory products were prepared by optimizing the extraction process parameters.

Benefits of technology

It significantly improved the structure of mouse colon tissue, reduced inflammatory cell infiltration, restored mucosal epithelial damage, and improved the safety and efficiency of anti-inflammatory effects.

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Abstract

本发明属于生物医药技术领域，具体涉及一种牡丹花瓣功能组分在制备抗炎产品中的应用。牡丹花瓣功能组分为牡丹花瓣乙醇提取物；牡丹花瓣乙醇提取物的提取方法如下：将牡丹花瓣加入乙醇中，加热回流提取多次，过滤后合并提取液并进行浓缩，即得。本发明通过采用简单、高效的加热回流提取技术，以乙醇作为提取剂对牡丹花瓣进行提取，通过优化提取工艺参数，在提取效率、选择性、安全性、成本和工艺成熟度之间取得了极佳的平衡。通过使用DSS诱导小鼠结肠炎模型，系统评价牡丹花瓣乙醇提取物对小鼠的结肠组织、结构、细胞和炎症等方面都有明显预防及改善作用，使其在医药工业中具有广泛的应用前景。
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