用GDF8抑制剂增加力量和功能的方法
By providing subjects with an exercise program and administering a combination of GDF-8 inhibitors, the problem of reduced lean muscle mass was addressed, resulting in increased muscle mass and improved function, while avoiding side effects on cardiac tissue.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- REGENERON PHARMACEUTICALS INC
- Filing Date
- 2016-04-15
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies are not effective at increasing lean muscle mass, especially in older adults and individuals with certain diseases or conditions where sarcopenia and muscle atrophy are severe, and the use of GDF8 inhibitors may produce undesirable side effects on cardiac tissue function.
Lean muscle mass can be enhanced by providing subjects with an exercise program and administering a composition containing an effective amount of GDF-8 inhibitor, including antibodies or antigen-binding fragments that specifically bind to GDF8, through resistance training or other forms of exercise, combined with intravenous, subcutaneous, or oral administration of GDF8 inhibitors.
It significantly increases lean muscle mass, improves muscle function, and is suitable for older adults and individuals with diseases, while avoiding adverse effects on cardiac tissue function.
Smart Images
Figure CN122399013A_ABST