A biomimetic nanoparticle, a biomimetic delivery system, and a preparation method and application thereof in anti-parkinsonian depression

CN122399043APending Publication Date: 2026-07-17SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
Filing Date
2026-04-29
Publication Date
2026-07-17

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Abstract

The application discloses a kind of bionic nanoparticles, bionic delivery system and its preparation method and application in anti-parkinson disease depression, belong to medical technology field.CP@Cu 2‑x Se NPs, by regulating TLR4 / NLRP3 / Caspase-1 inflammatory pathway, inhibit microglial cell M1 polarization, reduce nerve inflammation, thereby protecting DA neuron, improving the action mechanism of DPD model mouse movement and depressive symptoms.Further, on this basis, the bionic nano delivery system CP@Cu 2‑x Se NPs-BV2 further improves the brain delivery efficiency and therapeutic effect of the drug by homologous targeting, providing a new strategy and candidate drug for DPD intervention.
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