一种序贯协同复合敷料及其制备方法与应用
By using a sequential synergistic composite dressing with a bilayer structure spun by electrospinning, the lower layer Cu2+ catalyzes the generation of endogenous NO, while the upper layer EGCG is released on demand. This solves the problem that existing dressings cannot remove exogenous pyrogens and regulate inflammation, thus achieving efficient wound repair.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- DONGHUA UNIV
- Filing Date
- 2026-06-22
- Publication Date
- 2026-07-17
AI Technical Summary
Existing anti-biofilm dressings cannot effectively remove exogenous pyrogens, causing wounds to remain in the inflammatory phase for a long time. They also lack endogenous NO donor catalysis and microenvironment-responsive drug release, resulting in chemical incompatibility and a lack of functional integration.
Employing an electrospun bilayer structure, the lower fiber membrane is loaded with copper ions (Cu2+) to catalyze the generation of endogenous NO, while the upper fiber membrane is loaded with epigallocatechin gallate (EGCG) for microenvironmental response and release. The functional zoning and interface integration are achieved through a dopamine coating, thus constructing a dual anti-inflammatory system of "source adsorption + internal regulation".
It achieves efficient disruption of biofilms, simultaneously adsorbs exogenous pyrogens and regulates inflammatory responses, thereby improving wound repair efficiency and reducing the risk of drug resistance and cytotoxicity.
Smart Images
Figure CN122399079A_ABST