A mo o 3-x nano-enzyme composite hydrogel as well as a preparation method and application thereof
By preparing MoO3-X nanozyme composite hydrogels, combining photothermal, catalytic, and immunomodulatory effects, the uneven distribution and single function of nanozymes in multidrug-resistant bacterial infections were solved, achieving efficient removal of biofilms and multiple therapeutic effects on wounds.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ANHUI POLYTECHNIC UNIV
- Filing Date
- 2026-06-16
- Publication Date
- 2026-07-17
AI Technical Summary
Existing nanozymes suffer from reduced catalytic activity, uneven distribution, short retention time, difficulty in penetrating biofilms, and lack of multifunctional synergistic therapeutic capabilities when treating multidrug-resistant bacterial infections. Furthermore, hydrogel carriers are not sensitive to changes in the microenvironment and are difficult to regulate intelligently.
By preparing MoO3-X nanozyme composite hydrogels, L-glutamine-grafted chitosan and oxidized dextran are used to form a gel framework, on which MoO3-X nanozymes are loaded, constructing a photothermal, catalytic, and immunomodulatory synergistic therapeutic system that combines dynamic Schiff base bond response to the infection microenvironment.
It achieves comprehensive treatment of multidrug-resistant bacterial infections, biofilm barriers, and wound hypoxia. It has synergistic effects of photothermal destruction of biofilms, catalytic oxidative stress, and immune regulation, and possesses self-repair capabilities and good wound adaptability.
Smart Images
Figure CN122399097A_ABST