一种基于载锌锶硼基生物活性玻璃的敷料及制备方法
By preparing a dressing based on zinc-loaded strontium-boron-based bioactive glass, and utilizing LTTM to form a stable gel system with gelatin, the problems of slow degradation, insufficient antibacterial properties, and pain associated with blending traditional bioglasses were solved, achieving rapid antibacterial, angiogenesis-promoting, and painless cold dissection wound repair effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
- Filing Date
- 2026-06-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing 45S5 series silicate bioactive glass degrades too slowly, failing to meet the needs of early inflammatory phase of acute wounds. It lacks antibacterial elements and is prone to inactivation of biomolecules when combined with organic matrices. Furthermore, the blending of zinc-loaded strontium-boron-based bioactive glass with gelatin/chitosan presents problems such as particle aggregation, sudden release, and pain during dressing changes.
A stable gel system was formed by combining a low glass transition temperature mixture (LTTM) with zinc-loaded strontium-boron-based bioactive glass, gelatin, and 1,3-propanediol diglycidyl ether. After mixing betaine, tannic acid, and 1,2-propanediol, the mixture was vacuum dehydrated and then the bioactive glass was added. Combined with gelatin swelling and vacuum degassing treatment, a dressing with rapid antibacterial, angiogenesis-promoting, and painless cold peeling properties was prepared.
It achieves an integrated wound repair effect of rapid antibacterial action, promoting angiogenesis, painless cold dissection, and high moisture permeability, solving the problems of particle aggregation, ion burst release, and pain during dressing changes, and improving wound repair efficiency.
Smart Images
Figure CN122399098A_ABST