一种羊膜来源的干态复层生物材料及其制备方法和应用
By decellularizing and cross-linking the amniotic membrane, a dry multilayer biomaterial was prepared, which solved the problems of easy delamination and insufficient mechanical properties of the amniotic membrane, and achieved high toughness and multilayer adhesion of the material, promoting wound healing and angiogenesis.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENYANG EMIAO BIOENGINEERING TECH R & D CENT CO LTD
- Filing Date
- 2026-06-22
- Publication Date
- 2026-07-17
AI Technical Summary
Existing amniotic membrane materials are prone to delamination, have insufficient mechanical properties, and require low-temperature storage and transportation, making it difficult to meet the clinical needs of tissue repair.
Dry multilayer biomaterials were prepared through decellularization, cross-linking reaction, and multilayer composite. Small molecule substances with amino groups, carbodiimide, and N-hydroxysuccinimide were cross-linked and combined with dextran, trehalose, gelatin, and polyethylene glycol to form a three-dimensional network structure, which avoids delamination and improves toughness.
It improves the mechanical properties of the amniotic membrane, enhances the adhesion and bioactivity of multilayer amniotic membranes, extends the service life, facilitates storage and transportation, and promotes wound healing and angiogenesis.
Smart Images
Figure CN122399115A_ABST