A process for the preparation of indobufen
By using a heating and reflux reaction with an alkali metal salt catalyst, the problems of long synthesis routes, low yields, and difficult waste disposal in indobufen synthesis have been solved, enabling safe and simple preparation of indobufen and improving yield and purity.
CN122404201APending Publication Date: 2026-07-17SHANDONG NEW TIME PHARMA CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANDONG NEW TIME PHARMA CO LTD
- Filing Date
- 2026-04-23
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing indobufen synthesis processes suffer from problems such as long routes, low yields, limited sources of starting materials, harsh reaction conditions, and difficulty in waste disposal, making industrial-scale production difficult.
Method used
By using alkali metal salts as catalysts, and through heating and reflux reaction combined with a solvent system, the use of metal reducing agents is avoided, simplifying post-reaction processing steps and improving product yield.
Benefits of technology
A safe and simple synthesis of indobufen was achieved, avoiding the use of metal reducing agents, reducing production costs, simplifying waste disposal, and improving product yield and purity.
✦ Generated by Eureka AI based on patent content.
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Abstract
本发明属于医药合成技术领域，具体涉及一种吲哚布芬的制备方法。本发以2‑(溴甲基)苯甲酸甲酯和2‑(4‑氨基苯基)丁酸为起始物料，在催化剂作用下环合得吲哚布芬，该技术制备简单，避免了昂贵催化剂的使用，安全环保并避免重金属含量超标的风险，适合工艺大生产。
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